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pelos
pares,
membros
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Conselho
Editorial
desta
Editora,
tendo
sido
aprovados
publicação
com
base
critérios
neutralidade
imparcialidade
acadêmica
The Journal of Physiological Sciences,
Год журнала:
2024,
Номер
74(1)
Опубликована: Май 11, 2024
L-Ascorbic
acid,
commonly
known
as
vitamin
C,
has
been
used
not
only
for
disease
prevention
and
in
complementary
alternative
medicine,
but
also
anti-aging
purposes.
However,
the
scientific
evidence
is
yet
sufficient.
Here,
we
review
physiological
functions
of
C
its
relationship
with
various
pathological
conditions,
including
our
previous
findings,
discuss
prospects
application
healthy
longevity.
In
summary,
levels
are
associated
lifespan
several
animal
models.
Furthermore,
clinical
studies
have
shown
that
blood
lower
middle-aged
older
adults
than
younger
adults.
Lower
observed
conditions
such
chronic
kidney
obstructive
pulmonary
elderly.
These
observations
suggest
implications
age-related
mechanisms
owing
to
functions.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1333 - 1333
Опубликована: Фев. 4, 2025
Neurodegenerative
diseases
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
amyotrophic
lateral
sclerosis
(ALS),
and
multiple
(MS),
which
are
a
consequence
of
the
progressive
loss
neuronal
function
structure,
cause
significant
cognitive
impairment.
The
incidence
these
in
world’s
population
is
constantly
increasing
result
an
aging
population.
Although
genetic
environmental
factors
most
often
mentioned
pathogenetic
diseases,
evidence
points
to
important
role
proper
nutrition
prevention
support
treatment
disorders.
A
healthy,
balanced
diet
can
mitigate
risks
associated
with
risk
above
slow
progression
by
reducing
oxidative
stress
inflammation.
Vitamins
B,
D,
E,
C,
K,
have
been
shown
functions
protect
nervous
system.
This
review
demonstrates
importance
vitamins
preventing
supporting
therapy
neurodegenerative
diseases.
Information
regarding
health-promoting
properties
must
be
effectively
communicated
consumers
seeking
their
health,
particularly
context
Consequently,
this
also
examines
authorized
health
claims
under
EU
food
law
related
vitamins,
assessing
promoting
awareness
vitamins’
potential
benefits
for
neuroprotection
management
Molecules,
Год журнала:
2025,
Номер
30(3), С. 748 - 748
Опубликована: Фев. 6, 2025
Since
Albert
Szent-Györgyi
discovered
it
and
became
used
in
treating
scurvy,
vitamin
C
has
attracted
interest
many
studies
due
to
its
unique
properties.
It
is
an
important
cofactor
the
synthesis
of
collagen
hormones,
involved
immunity,
iron
absorption,
processes
requiring
antioxidants.
Thus,
this
review
aims
emphasize
importance
usefulness
improving
quality
life
preventing
various
diseases
(e.g.,
chronic
diseases,
cardiovascular
cancer)
but
also
for
use
treatments
against
infections,
neurodegenerative
cancer.
Although
presented
provide
essential
information
about
properties
VIC
beneficial
effect
on
health,
some
contradict
these
theories.
In
respect,
further
larger
samples
over
a
longer
period
are
needed
demonstrate
therapeutic
potential
nutrient.
However,
remains
necessary
that
should
be
consumed
daily
maintain
optimal
health
prevent
deficiencies
can
lead
scurvy
associated
complications.
Journal of Alzheimer s Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
that
primarily
affects
the
elderly,
leading
to
severe
cognitive
decline
and
loss
of
autonomy.
The
accumulation
amyloid-β
peptides
tau
proteins
in
brain
considered
central
pathogenic
mechanism,
which
results
neuronal
dysfunction
cell
death.
Various
metabolic
disruptions,
such
as
chronic
oxidative
stress
inflammatory
processes,
further
exacerbate
progression
AD.
This
review,
based
on
literature
from
PubMed,
SciELO,
MDPI,
ScienceDirect,
evaluates
role
bioactive
compounds
dietary
patterns,
specifically
Mediterranean
MIND
diets,
mitigating
These
rich
vitamins,
flavonoids,
carotenoids,
omega-3
fatty
acids,
have
shown
potential
reducing
damage
inflammation
brain,
offering
neuroprotective
benefits.
findings
suggest
vitamin
E
isomers
polyphenols
may
delay
decline,
presenting
promising
avenue
for
future
interventions
aimed
at
optimizing
consumption
these
prevent
or
slow
onset
Further
research
needed
determine
optimal
doses
combinations
maximize
their
protective
effects.
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1672 - 1672
Опубликована: Май 29, 2024
The
relation
of
vitamin
C
with
Alzheimer’s
disease
(AD)
is
equivocal.
aim
this
study
was
to
assess
the
serum
levels
AD-related
mortality,
and
evaluate
threshold
beyond
which
potential
benefits
higher
concentrations
for
AD
mortality
ceases.
cohort
consisted
4504
adults
aged
≥60
years
enrolled
in
National
Health
Nutrition
Examination
Survey
who
had
measures
no
cognitive
impairment
at
baseline
(1988–1994)
were
followed-up
until
2019.
Vitamin
assayed
from
fasting
blood
samples
using
isocratic
high-performance
liquid
chromatography.
At
baseline,
mean
age
participants
70
years,
42.7%
being
men.
end
follow-up
(median:
15
years),
rate
2.4
per
1000
person-years.
In
Cox
regression
models,
compared
lowest
tertile
(<0.56
mg/dL),
those
highest
(>0.98
mg/dL)
a
lower
risk
(hazard
ratio:
0.44,
95%
confidence
intervals:
0.25–0.77)
after
adjusting
sociodemographic
factors,
behavior/lifestyle
prevalent
health
conditions,
dietary
intake.
dose–response
analysis
restricted
cubic
splines,
2.3
mg/dL
associated
elevated
mortality.
findings
national
sample
community-dwelling
elderly
suggest
that
are
slower
progression,
although
normal
reference
values
Alzheimer's
disease
is
a
neurodegenerative
involving
memory
impairment,
confusion,
and
behavioural
changes.
The
characterised
by
the
accumulation
of
amyloid
beta
plaques
neurofibrillary
tangles
in
brain,
which
disrupt
normal
neuronal
function.
There
no
known
cure
for
due
to
increasing
life
expectancy,
occurrence
projected
rise
over
coming
decades.
causes
are
multifactorial
with
inflammation,
oxidative
stress,
genetic
epigenetic
variation,
cerebrovascular
abnormalities
among
strongest
contributors.
We
review
current
literature
surrounding
inflammation
epigenetics
disease,
focus
on
how
oxidants
from
infiltrating
immune
cells
have
potential
alter
DNA
methylation
profiles
ageing
brain.
Molecules,
Год журнала:
2024,
Номер
29(24), С. 5936 - 5936
Опубликована: Дек. 16, 2024
Alzheimer’s
disease
(AD)
is
a
progressive
neurodegenerative
disorder
with
cognitive
dysfunction,
memory
decline,
and
behavioral
disturbance,
it
pathologically
characterized
by
the
accumulation
of
amyloid
plaques
neurofibrillary
tangles
in
brain.
Although
various
hypotheses
have
been
proposed
to
explain
pathogenesis
AD,
including
beta
hypothesis,
oxidative
stress
abnormal
phosphorylation
tau
proteins,
exact
pathogenic
mechanisms
underlying
AD
remain
largely
undefined.
Furthermore,
effective
curative
treatments
are
very
limited.
Epidemiologic
studies
provide
convincing
evidence
for
significant
association
between
type
2
diabetes
AD.
Here,
we
showed
energy
metabolism
using
glucose,
lactate,
ketone
bodies,
lipids
as
substrates
normal
brain,
changes
such
due
diabetes.
We
also
influences
altered
on
pathology
comprehensively
searched
risk
factors
related
possible
therapeutic
interventions
based
considering
brain
development
