The Role of Physical Activity in Adjunctive Nursing Management of Neuro-Degenerative Diseases among Older Adults: A Systematic Review of Interventional Studies DOI Creative Commons
Majed Alanazi

Life, Год журнала: 2024, Номер 14(5), С. 597 - 597

Опубликована: Май 7, 2024

Neurodegenerative diseases such as dementia and Parkinson’s disease pose significant challenges to older adults globally. While pharmacological treatments remain primary, increasing evidence supports the role of non-pharmacological strategies like physical activity in managing these conditions. This systematic review critically evaluates effectiveness Nursing based interventions improving cognitive function, functioning, mobility, overall quality life among with neurodegenerative diseases. We conducted a comprehensive search across PubMed, EMBASE, Web Science, CENTRAL, other relevant databases, focusing on randomized controlled trials observational studies that examined impact structured activity. Our findings from nineteen involving 1673 participants indicate ranging aerobic exercises, resistance training, mind-body exercises Tai Chi yoga have beneficial effects. Specifically, was consistently found enhance performance, increase improve balance daily living activities, contributing better life. However, benefits vary depending type, intensity, duration performed. Despite promising results, limitations small sample sizes, study heterogeneity, short-term follow-up periods call for more robust, long-term solidify findings. underscores potential tailored programs adjunctive therapy management elderly population.

Язык: Английский

Understanding the mechanisms of disease modifying effects of aerobic exercise in people with Alzheimer’s disease DOI
Auwal Abdullahi, Thomson W. L. Wong, Shamay S. M. Ng

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 94, С. 102202 - 102202

Опубликована: Янв. 23, 2024

Язык: Английский

Процитировано

8
The protective role of ginsenoside Rg3 in heart diseases and mental disorders DOI Creative Commons
Lili Shi,

Jinlan Luo,

Xiupan Wei

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 26, 2024

Ginsenoside Rg3, a compound derived from

Язык: Английский

Процитировано

8
Comparing the Impact of Various Exercise Modalities on Old Adults with Alzheimer's Disease: A Bayesian Network Meta-Analysis DOI

Fengting Hu,

Jinrong Peng,

Weiran Wang

и другие.

Complementary Therapies in Clinical Practice, Год журнала: 2025, Номер 59, С. 101968 - 101968

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

1
Bridging the gap: glucose transporters, Alzheimer’s, and future therapeutic prospects DOI Creative Commons
Mai Albaik,

Dalaa Sheikh Saleh,

Dana Kauther

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Янв. 16, 2024

Glucose is the major source of chemical energy for cell functions in living organisms. The aim this mini-review to provide a clearer and simpler picture fundamentals glucose transporters as well relationship these Alzheimer’s disease. This study was conducted accordance with Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA). Electronic databases ( PubMed ScienceDirect ) were used search relevant studies mainly published during period 2018–2023. covers two main types transporters, facilitated (GLUTs) sodium-glucose linked (SGLTs). difference between that first type works through passive transport across concentration gradient. second active co-transportation against its Fluctuation translates into disturbance normal functioning, such disease, which may be caused by significant downregulation GLUTs most closely associated insulin resistance brain. sign lack GLUT4 translocation. tau hyperphosphorylation, GLUT1 3 being strongly upregulated. current focuses on use treating diseases because their proven therapeutic potential. Despite this, remain insufficient inconclusive due complex intertwined nature processes. recommends further understanding mechanisms related vectors promising future therapies.

Язык: Английский

Процитировано

7
The VEGFs/VEGFRs system in Alzheimer’s and Parkinson’s diseases: Pathophysiological roles and therapeutic implications DOI Creative Commons
Claudia Ceci, Pedro Miguel Lacal, Maria Luisa Barbaccia

и другие.

Pharmacological Research, Год журнала: 2024, Номер 201, С. 107101 - 107101

Опубликована: Фев. 7, 2024

The vascular endothelial growth factors (VEGFs) and their cognate receptors (VEGFRs), besides well-known involvement in physiological angiogenesis/lymphangiogenesis diseases associated to pathological vessel formation, play multifaceted functions the central nervous system (CNS). In addition shaping brain development, by controlling cerebral vasculogenesis regulating neurogenesis as well astrocyte differentiation, VEGFs/VEGFRs axis exerts essential adult both contexts. this article, after describing CNS, we focus on neurodegenerative reviewing current literature rather complex contribution pathogenic mechanisms of Alzheimer's (AD) Parkinson's (PD) diseases. Thereafter, based outcome targeting animal models AD PD, discuss factual relevance pharmacological modulation a novel potential disease-modifying approach for these pathologies. Specific VEGFRs targeting, aimed at selective VEGFR-1 inhibition, while preserving VEGFR-2 signal transduction, appears promising strategy hit molecular underlying pathology. Moreover, therapeutic VEGFs-based approaches can be proposed PD treatment, with aim fine-tuning levels amplify neurotrophic/neuroprotective effects limiting an excessive impact permeability.

Язык: Английский

Процитировано

7
Irisin Levels in Cerebrospinal Fluid Correlate with Biomarkers and Clinical Dementia Scores in Alzheimer Disease DOI Creative Commons

Manuela Dicarlo,

Patrizia Pignataro,

Chiara Zecca

и другие.

Annals of Neurology, Год журнала: 2024, Номер 96(1), С. 61 - 73

Опубликована: Май 23, 2024

Objective Irisin, released by muscles during exercise, was recently identified as a neuroprotective factor in mouse models of Alzheimer disease (AD). In cohort AD patients, we studied cerebrospinal fluid (CSF) and plasma irisin levels, sex interactions, correlations with biomarkers. Methods Correlations between CSF levels biomarkers (amyloid β 1‐42, hyperphosphorylated tau, total tau [t‐tau]) Clinical Dementia Rating Scale Sum Boxes (CDR‐SOB) were analyzed patients dementia (n = 82), mild cognitive impairment 44), subjective memory complaint 20) biologically characterized according to the recent amyloid/tau/neurodegeneration classification. Results reduced ( p < 0.0001), lower female patients. Moreover, correlated positively Aβ42 both r 0.379, 0.001) male 0.262, 0.05) negatively CDR‐SOB −0.234, only A negative trend also observed t‐tau all −0.144, 0.082) subgroup −0.189, 0.084). Interpretation The results highlight relationship pathology, especially females. Our findings offer perspectives toward use marker continuum. ANN NEUROL 2024;96:61–73

Язык: Английский

Процитировано

6
The impact of physical exercise on neuroinflammation mechanism in Alzheimer’s disease DOI Creative Commons
Junhui Hu,

Baiqing Huang,

Kang Chen

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Авг. 21, 2024

Introduction Alzheimer’s disease (AD), a major cause of dementia globally, imposes significant societal and personal costs. This review explores the efficacy physical exercise as non-pharmacological intervention to mitigate impacts AD. Methods draws on recent studies that investigate effects neuroinflammation neuronal enhancement in individuals with Results Consistent alters neuroinflammatory pathways, enhances cognitive functions, bolsters brain health among AD patients. It favorably influences activation states microglia astrocytes, fortifies integrity blood-brain barrier, attenuates gut inflammation associated These changes are substantial improvements performance indicators. Discussion The findings underscore potential integrating into comprehensive management strategies. Emphasizing necessity for further research, this advocates refinement regimens maximize their enduring benefits decelerating progression

Язык: Английский

Процитировано

5
Low‐grade systemic inflammation biomarkers in sedentary young healthy adults are not significantly affected by a 24‐week concurrent training intervention DOI
Héctor Vázquez‐Lorente, Lourdes Herrera‐Quintana, Francisco M. Acosta

и другие.

Annals of the New York Academy of Sciences, Год журнала: 2025, Номер unknown

Опубликована: Апрель 12, 2025

In this study, we measured the dose-response effect of a 24-week concurrent training (CT) intervention on low-grade systemic inflammation biomarkers in sedentary young healthy adults. A total 100 untrained participants were randomized to (1) no exercise (control group, n = 35), (2) aerobic + resistance at moderate intensity (exercise-moderate group; 33), or (3) CT vigorous (exercise-vigorous 32). Serum concentrations C-reactive protein (CRP), interleukin-6 (IL-6), IL-7, IL-8, and IL-10, interferon-gamma (IFN-γ), tumor necrosis factor-α, leptin, adiponectin determined compared among three groups. The exercise-vigorous group members had lower differences IL-7 levels them, exercise-moderate (Δ ‒7.97% vs. 1.90%; p 0.030; 95% CI [‒0.90, ‒0.04]). showed higher CRP values 20.1%; F 3.339; 0.046) both control ‒1.91%) ‒23.3%) members, whereas exhibited IFN-γ 15.3% 2.62%; 0.048; [‒0.68, ‒0.01]). For individuals groups, body composition physical fitness correlated overall with leptin. data show, concluded, that significant biomarkers.

Язык: Английский

Процитировано

0
A review of the application of exercise intervention on improving cognition in patients with Alzheimer’s disease: mechanisms and clinical studies DOI
Man Wang, Hua Yan, Yulong Bai

и другие.

Reviews in the Neurosciences, Год журнала: 2024, Номер unknown

Опубликована: Июль 19, 2024

Alzheimer's disease (AD) is the most common form of dementia, leading to sustained cognitive decline. An increasing number studies suggest that exercise an effective strategy promote improvement cognition in AD. Mechanisms benefits intervention on function may include modulation vascular factors by affecting cardiovascular risk factors, regulating cardiorespiratory health, and enhancing cerebral blood flow. Exercise also promotes neurogenesis stimulating neurotrophic neuroplasticity brain. Additionally, regular improves neuropathological characteristics AD improving mitochondrial function, brain redox status. More more attention has been paid effect Aβ tau pathology as well sleep disorders persons diagnosed with Besides, there are various forms patients AD, including aerobic exercise, resistance multi-component exercise. Consequently, purpose this review summarize findings mechanisms discuss application different interventions impairment provide a theoretical basis reference for selection rehabilitation

Язык: Английский

Процитировано

4
Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance DOI Open Access
Kinga Humińska‐Lisowska

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11602 - 11602

Опубликована: Окт. 29, 2024

This narrative review examines the relationship between dopamine-related genetic polymorphisms, personality traits, and athletic success. Advances in sports genetics have identified specific single nucleotide polymorphisms (SNPs) genes linked to traits crucial for performance, such as motivation, cognitive function, emotional resilience. clarifies how variations can influence predisposition through dopaminergic pathways environmental interactions. Key findings reveal associations SNPs enhanced performance various sports. For example, COMT Val158Met rs4680 BDNF Val66Met rs6265 are associated with that could benefit increased focus, stress resilience conscientiousness, especially martial arts. DRD3 rs167771 is higher agreeableness, benefiting teamwork like football. synthesis underscores multidimensional role of shaping ability advocates integrating profiling into personalized training optimize well-being. However, research gaps remain, including need standardized protocols exploring gene–environment interactions diverse populations. Future studies should focus on epigenetic factors inform tailored interventions enhance both physical psychological aspects performance. By bridging genetics, psychology, exercise science, this paves way innovative optimization strategies.

Язык: Английский

Процитировано

4