Biotin Mitigates Alcohol Withdrawal‐Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats
Neuropsychopharmacology Reports,
Год журнала:
2025,
Номер
45(1)
Опубликована: Янв. 4, 2025
ABSTRACT
Introduction
Substance
use
disorders,
particularly
alcohol
represent
a
significant
public
health
problem,
with
adolescents
vulnerable
to
their
adverse
effects.
This
study
examined
the
possible
anxiolytic
and
antidepressant
effects
of
biotin,
crucial
vitamin
for
brain
function,
in
attenuating
behavioral
neurobiological
changes
associated
withdrawal
adolescent
rats.
Materials
Methods
Sixty
male
Sprague–Dawley
rats
were
exposed
20%
ethanol
solution
21
days,
followed
by
21‐day
drug‐free
period
assess
long‐term
physiological
changes.
Behavioral
assessments
included
Open
Field
Test,
Elevated
Plus
Maze,
Forced
Swimming
administered
post‐withdrawal
evaluate
anxiety
depression
behaviors.
Additionally,
biochemical
analyses
performed
measure
serotonin
levels,
monoamine
oxidase‐A
(MAO‐A)
activity,
BDNF
concentrations.
Results
The
results
indicate
that
significantly
induced
anxiety‐
depression‐like
behavior
However,
treatment
at
higher
doses,
effectively
attenuated
these
withdrawal‐related
Mechanistically,
biotin
administration
was
found
regulate
oxidase
brain‐derived
neurotrophic
factor,
glial
fibrillary
acidic
protein,
alleviate
oxidative
stress
markers
cortical
tissue.
Discussion
this
suggest
may
have
therapeutic
potential
alleviating
negative
withdrawal,
those
related
depression.
Further
research
is
needed
elucidate
underlying
mechanisms
examine
clinical
supplementation
individuals
undergoing
withdrawal.
Язык: Английский
Voluntary adolescent alcohol exposure does not increase adulthood consumption of alcohol in multiple mouse and rat models
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
Adolescence
is
a
period
of
increased
risk
taking,
including
alcohol
and
drug
use.
Multiple
clinical
studies
report
positive
relationship
between
adolescent
consumption
developing
an
use
disorder
(AUD)
in
adulthood.
However,
few
preclinical
have
attempted
to
tease
apart
the
biological
contributions
exposure,
independent
other
social,
environmental,
stress
factors,
that
been
conducted
show
mixed
results.
Here
we
several
voluntary
models,
across
four
labs
three
institutes
with
two
rodent
species,
investigate
ramifications
on
adulthood
controlled,
pre-clinical
environments.
We
consistently
demonstrate
lack
robust
increases
consumption.
This
work
highlights
risks
seen
both
human
datasets
murine
drinking
models
may
be
due
unique
social
environmental
factors
-
some
which
humans.
Язык: Английский
Sexually dimorphic effects of a modified adolescent social isolation paradigm on behavioral risk factors of alcohol use disorder in Long Evans Rats
Addiction Neuroscience,
Год журнала:
2023,
Номер
9, С. 100134 - 100134
Опубликована: Ноя. 4, 2023
Early
life
stress
(ELS)
is
a
major
risk
factor
for
alcohol
use
disorder
(AUD)
and
comorbid
neuropsychiatric
conditions.
We
previously
demonstrated
that
an
adolescent
social
isolation
(aSI)
model
of
ELS
significantly
increased
behavioral
factors
these
disorders
(e.g.
anxiety-like
behaviors,
drinking)
in
male,
but
not
female
rats.
Since
many
neurodevelopmental
milestones
are
accelerated
females,
we
investigated
whether
earlier/shorter
window
(PND
21-38)
would
yield
comparable
phenotypes
both
sexes.
In
two
experiments,
Long
Evans
rats
were
socially
isolated
(SI)
or
group-housed
(GH)
on
postnatal
day
(PND)
21
locomotion
was
assessed
the
open
field
test
(OFT;
PND
30).
Experiment
1
also
behavior
elevated
plus-maze
(EPM)
32).
2,
all
single
housed
38
to
assess
home
cage
drinking.
revealed
SI
females
had
locomotor
activity
OFT
did
differ
from
GH
subjects
EPM.
The
results
replicated
sexes
2
male
greater
ethanol
consumption
during
eight
continuous
access
paradigm.
contrast,
subsequent
intermittent
two-bottle
choice
drinking,
only
displayed
intake
preference
quinine-adulterated
solution.
These
findings
demonstrate
early
can
promote
AUD
vulnerability-related
there
profound
sex
differences
vulnerability
this
stressor.
Uncovering
neural
mechanisms
responsible
sexually
dimorphic
sensitivity
may
shed
light
biological
substrates
associated
with
negative
emotion
men
women.
Язык: Английский
Adolescent Alcohol Exposure Dysregulates Developing Cortical GABA Circuits
Advances in experimental medicine and biology,
Год журнала:
2025,
Номер
unknown, С. 159 - 177
Опубликована: Янв. 1, 2025
Язык: Английский
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood
Pharmacological Reviews,
Год журнала:
2022,
Номер
75(2), С. 380 - 396
Опубликована: Дек. 12, 2022
Studies
universally
find
early
age
of
drinking
onset
is
linked
to
lifelong
risks
alcohol
problems
and
use
disorder
(AUD).
Assessment
the
lasting
effect
during
adolescent
development
in
humans
confounded
by
diversity
environmental
genetic
factors
that
affect
development,
including
emerging
personality
disorders
progressive
increases
trajectories
into
adulthood.
Preclinical
studies
using
an
intermittent
ethanol
(AIE)
exposure
rat
model
underage
binge
avoid
human
confounds
support
changes
increase
risks.
AIE
adult
drinking,
risky
decision-making,
reward-seeking,
anxiety
as
well
reductions
executive
function
all
for
AUD.
causes
persistent
brain
neuroimmune
signaling
high-mobility
group
box
1
(HMGB1),
Toll-like
receptor,
receptor
advanced
glycation
end
products,
innate
immune
genes
are
also
found
be
increased
AUD
brain.
HMGB1
released
from
cells
ethanol,
both
free
within
extracellular
vesicles,
act
on
neurons
glia,
shifting
transcription
cellular
phenotype.
AIE-induced
decreases
hippocampal
neurogenesis
loss
basal
forebrain
cholinergic
reviewed
examples
pathology.
Both
prevented
reversed
anti-inflammatory
epigenetic
drugs.
Findings
suggest
AIE-increased
induces
RE-1
silencing
transcript
blunting
gene
expression,
neuronal
Inhibition
signaling,
histone
methylation
enzymes,
galantamine,
cholinesterase
inhibitor,
prevent
reverse
These
findings
provide
new
targets
may
neuropathology
other
diseases
signaling.
Significance
Statement
Adolescent
earlier
associated
with
high
levels
lifetime
adults
developing
problems.
Loss
how
novel
therapeutic
Язык: Английский
Voluntary adolescent alcohol exposure does not robustly increase adulthood consumption of alcohol in multiple mouse and rat models
Addiction Neuroscience,
Год журнала:
2024,
Номер
12, С. 100171 - 100171
Опубликована: Авг. 3, 2024
Adolescence
is
a
period
of
increased
risk
taking,
including
alcohol
and
drug
use.
Multiple
clinical
studies
report
positive
relationship
between
adolescent
consumption
developing
an
use
disorder
(AUD)
in
adulthood.
However,
few
preclinical
have
attempted
to
tease
apart
the
biological
contributions
exposure,
independent
other
social,
environmental,
stress
factors,
that
been
conducted
show
mixed
results.
Here
we
several
voluntary
models,
across
four
labs
three
institutes
with
two
rodent
species,
investigate
ramifications
on
adulthood
controlled,
pre-clinical
environments.
We
consistently
demonstrate
lack
robust
increases
consumption.
This
work
highlights
risks
seen
both
human
datasets
murine
drinking
models
may
be
due
unique
social
environmental
factors
-
some
which
humans.
Язык: Английский
Adolescent social isolation increases binge-like alcohol drinking in male but not female high-alcohol-preferring mice
Alcohol and Alcoholism,
Год журнала:
2024,
Номер
59(2)
Опубликована: Янв. 17, 2024
Abstract
Aims
This
study
examined
how
adolescent
social
isolation
affects
adult
binge-like
alcohol
drinking
and
stress–axis
function,
via
basal
levels
of
circulating
corticosterone
(CORT),
in
male
female
mice
with
a
genetic
predisposition
toward
high
preference
(HAP).
Methods
Male
HAP2
were
randomly
assigned
to
group-housed
or
(ISO)
group.
Social
began
at
postnatal
Days
40–42
lasted
for
21
days
prior
assessment
using
4-day
drinking-in-the-dark
(DID)
procedure.
Blood
samples
assess
CORT
taken
6
after
ended
24
h
before
DID
started,
again
60
ended,
during
the
light
portion
cycle.
Results
Adolescent
increased
but
not
mice.
All
groups
showed
significantly
lower
compared
DID.
Pearson
bivariate
correlation
coefficients
between
first
2
grams-per-kilogram
intake
on
Day
4
indicated
significant
positive
ISO
males
only
negative
correlations
females
Conclusions
These
findings
demonstrate
that
Stress–axis
adaptations
may
be
associated
social-isolation-induced
increase
drinking.
Язык: Английский
Associations between binge drinking experience, depressive mood, and suicidality in adolescents: Based on the 2021 Korea Youth Risk Behavior Web-based Survey
Journal of Affective Disorders,
Год журнала:
2022,
Номер
323, С. 386 - 391
Опубликована: Ноя. 30, 2022
This
study
aimed
to
investigate
the
associations
between
binge
drinking
experience
(BDE),
depressive
mood,
and
suicidality
among
Korean
adolescents.
We
analyzed
17th
population-based
cross-sectional
data
from
Youth
Risk
Behavior
Web-based
Survey.
Multiple
logistic
regression
analysis
was
performed
compare
BDE,
by
sex.
In
54,848
adolescents,
prevalence
of
BDE
5.3
%
in
boys
4.4
girls.
The
suicidal
ideation,
plans,
attempts
girls
7.8
%,
2.4
1.4
respectively.
suicide
with
both
moods
higher
than
that
boys.
Boys
mood
had
12.60
times
14.50
adjusted
odds
ratio
(aOR)
ideation
plan,
respectively,
compared
non-drinking/non-depressed
group.
Girls
22.06
aOR
has
few
limitations
including
use
self-report
questionnaires,
participants'
response
bias,
lack
diagnosis
mental
health
professionals.
These
findings
represent
South
adolescents
or
mood.
Since
showed
particularly
high
suicidality,
it
is
necessary
establish
services,
such
as
proper
prevention
strategies
targeted
interventions.
Язык: Английский
Adolescent social housing protects against adult emotional and cognitive deficits and alters the PFC and NAc transcriptome in male and female C57BL/6J mice
Frontiers in Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Дек. 7, 2023
Introduction
Adolescence
is
a
critical
period
in
cognitive
and
emotional
development,
characterized
by
high
levels
of
social
interaction
increases
risk-taking
behavior
including
binge
drinking.
Adolescent
exposure
to
stress
ethanol
have
individually
been
associated
with
the
development
social,
emotional,
deficits,
as
well
increased
risk
for
alcohol
use
disorder.
Disruption
cortical
early
life
and/or
drinking
may
partly
underlie
these
enduring
cognitive,
behavioral
effects.
The
study
goal
implement
novel
neighbor
housing
environment
identify
effects
adolescent
on
(1)
battery
tasks
(2)
adult
behavior,
(3)
nucleus
accumbens
prefrontal
cortex
transcriptome.
Methods
male
female
C57BL/6J
mice
were
single
or
housed
without
access
intermittent
ethanol.
One
cohort
underwent
testing
during
adulthood
determine
preference,
expression
anxiety-like
performance,
patterns
intake.
second
was
sacrificed
late
adolescence
brain
tissue
used
transcriptomics
analysis.
Results
As
adults,
displayed
decreased
interaction,
deficits
object
recognition
task,
relative
neighbor-housed
mice.
There
no
effect
condition
consumption.
did
not
alter
Transcriptomics
analysis
revealed
that
resulted
differential
genes
related
synaptic
plasticity
methylation,
extracellular
matrix
inflammation
cortex.
Discussion
results
indicate
via
model
protect
against
deficits.
In
addition,
suggest
alterations
be
mediated
part
dysregulation
transcription
frontal
accumbens.
Язык: Английский