Medicinal Cannabis for Paediatric Developmental, Behavioural and Mental Health Disorders

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(8), P. 5430 - 5430

Published: April 7, 2023

Parents of children with developmental, behavioural and mental health disorders are increasingly asking whether medicinal cannabis might be a therapeutic option for their child. This paper presents the current evidence in this population. Preliminary from open-label studies suggests potential to ameliorate some symptoms autism spectrum disorder. However, only one double-blind placebo-controlled trial has been completed, inconclusive findings. Synthetic, transdermal cannabidiol gel demonstrated efficacy reducing social avoidance sub-group Fragile X syndrome. Studies planned or underway and/or adolescents autism, intellectual disability, Tourette’s syndrome, anxiety, psychosis, anorexia nervosa number specific neurodevelopmental syndromes. High quality trials is needed guide clinical practice.

Language: Английский

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Endocannabinoid signaling in stress, nausea, and vomiting

Neurogastroenterology & Motility, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Background Classical antiemetics that target the serotonin system may not be effective in treating certain nausea and vomiting conditions like cyclic syndrome (CVS) cannabinoid hyperemesis (CHS). As a result, there is need for better therapies to manage symptoms of these disorders, including nausea, vomiting, anxiety. Cannabis often used its purported antiemetic anxiolytic effects, given regulation processes by endocannabinoid (ECS). However, considerable evidence cannabinoids can also produce increase anxiety instances, especially at higher doses. This paradoxical effect on due dysregulation ECS, altering how it maintains contributing pathophysiology CVS or CHS. Purpose The purpose this review highlight involvement ECS stress, vomiting. We discuss prolonged cannabis use, such as case CHS heightened dysregulate affect modulation functions. examines roles stress systems' dysfunction understand underlying mechanisms conditions.

Language: Английский

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The marijuana-schizophrenia multifaceted nexus: Connections and conundrums towards neurophysiology

Computational Biology and Chemistry, Journal Year: 2023, Volume and Issue: 107, P. 107957 - 107957

Published: Sept. 13, 2023

Language: Английский

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Effects of prenatal cannabinoid use on the monoamine system in the fetoplacental unit: a systematic review of animal and human studies

Drug and Alcohol Dependence, Journal Year: 2025, Volume and Issue: unknown, P. 112579 - 112579

Published: Jan. 1, 2025

Language: Английский

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Age- and sex-dependent participation of the endocannabinoid system in locomotion and risk assessment of an ADHD rat model

Pharmacology Biochemistry and Behavior, Journal Year: 2025, Volume and Issue: 248, P. 173969 - 173969

Published: Feb. 6, 2025

Language: Английский

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Modern perspectives on psychoses: dissociation, automatism, and temporality across exogenous and endogenous dimensions

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

Substance use and the emergence of Novel Psychoactive Substances (NPS) present a significant public health challenge diagnostic dilemma, particularly in context psychosis. The increasing availability psychoactive substances among youth has led to rise Use Disorders (SUDs), with profound implications for mental health. This paper explores psychopathological distinctions between substance-induced psychoses (SIPs) endogenous psychoses, such as schizophrenia, from phenomenological perspective. We emphasize three key aspects: dissociation, automatism, temporality, elucidate underlying mechanisms these conditions. Dissociation, organizer, is central exogenous those triggered by NPS. phenomenon leads fragmentation consciousness, detachment reality, disintegration identity, distinct spaltung observed psychoses. concept theorized De Clerambault, also explored, highlighting its role early stages where cognitive disruptions precede delusions hallucinations. Furthermore, temporal experience SIPs characterized disconnection past future, trapping individuals an “eternal present.” contrasts fragmented temporality patients struggle maintain coherent narrative their lives. approach provides critical insights into clinical differentiation Primary Psychotic (PPDs), emphasizing need targeted interventions that address specific In conclusion, this underscores importance integrating psychopathology practice, face evolving landscape substance Understanding can inform more accurate diagnoses effective treatments, ultimately improving patient outcomes growing issue.

Language: Английский

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Crosstalk Between Signaling Stroke Cascade and Therapeutic Receptors PPAR-γ, ROCK, CB1R, and CB2R: From Mechanism to Therapies

Translational Stroke Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

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Rethinking Mental Automatism: De Clérambault’s Theory in the Age of Novel Psychoactive Drugs: Psychotropic Effects and Synthetic Psychosis

Healthcare, Journal Year: 2024, Volume and Issue: 12(12), P. 1172 - 1172

Published: June 10, 2024

The widespread use of novel psychoactive substances (NPSs)-defined as new narcotic or psychotropic agents not classified under the Single Convention on Narcotic Drugs 1961 Psychotropic Substances 1971-poses a significant challenge to contemporary mental health paradigms due their impact psychiatric disorders. This study revisits and expands upon theory automatism proposed by Gaëtan Gatian de Clérambault, aiming elucidate psychopathological mechanisms underlying substance-induced psychoses (SIP) distinction from non-induced (schizophrenia related disorders). Through phenomenological clinical investigation, we explore relevance in development toxic psychoses, drawing historical literature. research highlights distinctions between induced transition acute chronic psychosis states. De Clérambault's theory, supplemented Janet, Jackson, Bonhoeffer's contributions, provides foundational framework for understanding genesis SIP. Our findings suggest that NPS consumption, particularly among adolescents patients, significantly correlates with increased risks SIP, marked chronicity influenced biological lesions triggered substance use. Furthermore, propose comprehensive integrating automatism, distinctions, mechanisms. aims refine diagnostic criteria therapeutic approaches, addressing gaps practice research. underscores need nuanced advocating paradigm shift assessment treatment approaches better address complexities

Language: Английский

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Unraveling the Endocannabinoid System: Exploring Its Therapeutic Potential in Autism Spectrum Disorder

NeuroMolecular Medicine, Journal Year: 2024, Volume and Issue: 26(1)

Published: May 14, 2024

Abstract The salient features of autism spectrum disorder (ASD) encompass persistent difficulties in social communication, as well the presence restricted and repetitive facets behavior, hobbies, or pursuits, which are often accompanied with cognitive limitations. Over past few decades, a sizable number studies have been conducted to enhance our understanding pathophysiology ASD. Preclinical rat models proven be extremely valuable simulating analyzing roles wide range established environmental genetic factors. Recent research has also demonstrated significant involvement endocannabinoid system (ECS) pathogenesis several neuropsychiatric diseases, including In fact, ECS potential regulate multitude metabolic cellular pathways associated autism, immune system. Moreover, emerged promising target for intervention high predictive validity. Particularly noteworthy resent preclinical rodents, describe onset ASD-like symptoms after various pharmacological interventions targeting ECS, providing encouraging evidence further exploration this area.

Language: Английский

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Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review

Veterinary Research Communications, Journal Year: 2024, Volume and Issue: 48(5), P. 2915 - 2941

Published: Aug. 20, 2024

Since the discovery of endocannabinoid system and due to empirical evidence therapeutic effects on several illnesses both in humans animals that follow administration exogenous cannabinoids (i.e., phytocannabinoids), numerous studies have been conducted. These investigations aimed identify expression distribution cannabinoid receptors healthy pathologic organs tissues different animal species define interactions phytocannabinoids with these receptors. In last decade, pharmacokinetics, efficacy tolerability many Cannabis derivatives formulations, mainly containing cannabidiol, main veterinary interest, also investigated. This manuscript summarizes findings reported by scientific published so far molecular mode action phytocannabinoids, localization tissues, as well dogs, cats, horses other interest. A deep knowledge issues is crucial for use purposes species.

Language: Английский

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