Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer’s disease

Neurobiology of Aging, Год журнала: 2023, Номер 126, С. 113 - 122

Опубликована: Март 2, 2023

Язык: Английский

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Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 149, С. 112925 - 112925

Опубликована: Апрель 9, 2022

Anxiety and stress disorders are often characterized by an inability to extinguish learned fear responses. Orexins/hypocretins involved in the modulation of aversive memories, dysregulation this system may contribute aetiology anxiety pathological fear. The mechanisms which orexins regulate unknown. Here we investigated role endogenous cannabinoid impaired extinction induced orexin-A (OXA) male mice. selective inhibitor 2-arachidonoylglycerol (2-AG) biosynthesis O7460 abolished deficits OXA. Accordingly, increased 2-AG levels were observed amygdala hippocampus mice treated with OXA that do not fear, suggesting high endocannabinoid related poor extinction. Impairment was associated expression CB2 receptor (CB2R) microglial cells basolateral amygdala. Consistently, intra-amygdala infusion CB2R antagonist AM630 completely blocked promoted Microglial depletion PLX5622 chow also prevented these deficits. These results show overactivation orexin leads through amygdalar CB2R. This novel mechanism could be relevance for development potential approaches treat diseases inappropriate retention such as post-traumatic disorder, panic phobias.

Язык: Английский

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Brain disorders: Impact of mild SARS-CoV-2 may shrink several parts of the brain

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 149, С. 105150 - 105150

Опубликована: Март 31, 2023

Язык: Английский

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Videogame training increases clinical well-being, attention and hippocampal-prefrontal functional connectivity in patients with schizophrenia

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Май 28, 2024

Abstract Recent research shows that videogame training enhances neuronal plasticity and cognitive improvements in healthy individuals. As patients with schizophrenia exhibit reduced linked to deficits symptoms, we investigated whether videogame-related changes extend this population. In a study, controls were randomly assigned 3D or 2D platformer E-book reading (active control) for 8 weeks, 30 min daily. After training, both conditions showed significant increases sustained attention compared the control condition, correlated increased functional connectivity hippocampal-prefrontal network. Notably, trained videogames mostly improved negative general psychopathology, perceived mental health recovery. Videogames, incorporating initiative, goal setting gratification, offer approach closer real life than current psychiatric treatments. Our results provide initial evidence they may represent possible adjunct therapeutic intervention complex disorders.

Язык: Английский

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Serotonergic neuromodulation of synaptic plasticity

Neuropharmacology, Год журнала: 2024, Номер 257, С. 110036 - 110036

Опубликована: Июнь 12, 2024

Язык: Английский

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Maternal fluoxetine impairs synaptic transmission and plasticity in the medial prefrontal cortex and alters the structure and function of dorsal raphe nucleus neurons in offspring mice

Pharmacology Biochemistry and Behavior, Год журнала: 2024, Номер 244, С. 173849 - 173849

Опубликована: Авг. 13, 2024

Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are commonly prescribed to women during pregnancy and breastfeeding despite posing a risk of adverse cognitive outcomes affective disorders for the child. The consequences SSRI-induced excess 5-HT development brain neuromodulatory system remain largely unexplored. In this study, an SSRI - fluoxetine (FLX) was administered C57BL/6 J mouse dams lactation assess its effects on offspring. We found that maternal FLX decreased field potentials, impaired long-term potentiation, facilitated depression tended increase density 5-HTergic fibers in medial prefrontal cortex (mPFC) female but not male adolescent These were accompanied by deteriorated performance temporal order memory task reduced sucrose preference with no change marble burying behavior FLX-exposed also axodendritic tree complexity dorsal raphe nucleus (DRN) neurons offspring, changes excitability DRN either sex. While inhibitory postsynaptic currents (sIPSCs) found, we observed significant influence exposure kinetics spontaneous excitatory (sEPSCs) neurons. Finally, report potentials synaptic plasticity evident mPFC offspring after new antidepressant, vortioxetine. findings show contrast mPFC, structure function mild suggest sex-dependent, distinct sensitivity cortical brainstem early life. Vortioxetine appears exert fewer side regards when compared FLX. Created BioRender.com • Maternal alters cortex. increases innervation reduces more pronounced females than males. vortioxetine does alter plasticity.

Язык: Английский

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A Comparative Study of Koizumi and Longa Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Rats: Early Corticosterone and Inflammatory Response in the Hippocampus and Frontal Cortex

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(24), С. 13544 - 13544

Опубликована: Дек. 17, 2021

Two classical surgical approaches for intraluminal filament middle cerebral artery occlusion (MCAO), the Longa et al. (LM) and Koizumi methods (KM), are used as alternatives in preclinical studies to induce stroke rodents. Comparisons of these MCAO models mice showed critical differences between them along with similarities (Smith 2015; Morris 2016). In this study, a direct comparison MCAO-KM MCAO-LM rats was performed. Three days after MCAO, infarct volume, mortality rate, neurological deficit, weight loss were similar models. an increase ACTH levels, while demonstrated elevated corticosterone interleukin-1β blood serum. Corticosterone accumulation detected frontal cortex (FC) hippocampus group. IL1β beta increased ipsilateral group decreased contralateral FC rats. Differences revealed suggest that release well hippocampal is more expressed rats, predisposing corticosterone-dependent distant neuroinflammatory damage. The two models, particularly, malfunction hypothalamic-pituitary-adrenal axis, should be considered interpretation, comparison, translation pre-clinical experimental results.

Язык: Английский

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Shedding light on subiculum’s role in human brain disorders

Brain Research Bulletin, Год журнала: 2024, Номер 214, С. 110993 - 110993

Опубликована: Май 31, 2024

Subiculum is a pivotal output component of the hippocampal formation, structure often overlooked in neuroscientific research. Here, this review aims to explore role subiculum various brain disorders, shedding light on its significance within functional-neuroanatomical perspective neurological diseases. The subiculum's involvement multiple disorders was thoroughly examined. In Alzheimer's disease, alterations precede cognitive decline, while epilepsy, plays critical seizure initiation. Stress involves impact hypothalamic-pituitary-adrenocortical axis. Moreover, exhibits structural and functional changes anxiety, schizophrenia, Parkinson's contributing deficits. Bipolar disorder linked abnormalities, autism spectrum reveals an alteration inward deformation subiculum. Lastly, frontotemporal dementia shows volumetric differences subiculum, emphasizing contribution disorder's complexity. Taken together, consolidates existing knowledge may facilitate future research, diagnostic strategies, therapeutic interventions for conditions.

Язык: Английский

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Memory’s gatekeeper: The role of PFC in the encoding of congruent events

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(30)

Опубликована: Июль 17, 2024

Theoretical models conventionally portray the consolidation of memories as a slow process that unfolds during sleep. According to classical Complementary Learning Systems theory, hippocampus (HPC) rapidly changes its connectivity wakefulness encode ongoing events and create memory ensembles are later transferred prefrontal cortex (PFC) However, recent experimental studies challenge this notion by showing new information consistent with prior knowledge can be consolidated in PFC lesions disrupt encoding congruent HPC. The contributions have therefore largely been overlooked. Moreover, most theoretical frameworks assume random uncorrelated patterns representing memories, disregarding correlations between our experiences. To address these shortcomings, we developed HPC-PFC network model simulates interactions HPC (awake stage), subsequent (sleeping stage) examine each region novel memories. Our results show uses stored "schemas" previous experiences identify inputs evoke activity, quickly integrate it into network, gate which components encoded More specifically, GABAergic long-range projections inhibit neurons input correlated previously "schema," eliciting sparse hippocampal activity exposure events, has experimentally observed.

Язык: Английский

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Managing malice in negative environments: the mediating effect of coping styles on the relationship between negative sense of place and malevolent creativity among Chinese high school students

BMC Psychology, Год журнала: 2025, Номер 13(1)

Опубликована: Янв. 14, 2025

Creativity motivated by negative intentions can be referred to as malevolent creativity. While existing findings have largely focused on environmental or individual factors influencing creativity, less attention has been directed towards understanding how the sense of place—derived from individual-environment interaction—affects Additionally, role coping styles mediating mechanisms in environments insufficiently explored. This study aims investigate relationship between place and while examining styles. To this end, a paper-based survey was conducted among 1310 Chinese high school students, utilizing Negative Sense Place Scale, Coping Styles Malevolent Scale. Data were analyzed using SPSS 26.0 Mplus 8.3. The revealed that environment significantly positively predicted also associated with negatively positive Furthermore, mediated enriches literature elucidating links place, styles, These provide valuable insights for strategies aimed at reducing creativity preventing harmful creative behaviors educational contexts.

Язык: Английский

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