Managing malice in negative environments: the mediating effect of coping styles on the relationship between negative sense of place and malevolent creativity among Chinese high school students

BMC Psychology, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 14, 2025

Creativity motivated by negative intentions can be referred to as malevolent creativity. While existing findings have largely focused on environmental or individual factors influencing creativity, less attention has been directed towards understanding how the sense of place—derived from individual-environment interaction—affects Additionally, role coping styles mediating mechanisms in environments insufficiently explored. This study aims investigate relationship between place and while examining styles. To this end, a paper-based survey was conducted among 1310 Chinese high school students, utilizing Negative Sense Place Scale, Coping Styles Malevolent Scale. Data were analyzed using SPSS 26.0 Mplus 8.3. The revealed that environment significantly positively predicted also associated with negatively positive Furthermore, mediated enriches literature elucidating links place, styles, These provide valuable insights for strategies aimed at reducing creativity preventing harmful creative behaviors educational contexts.

Language: Английский

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Unlocking the Potential of Reactive EEG Biomarkers in Alzheimer’s Disease Diagnosis

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 273, P. 117181 - 117181

Published: Jan. 17, 2025

Language: Английский

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The Antidepressant Effect of Resveratrol Is Related to Neuroplasticity Mediated by the ELAVL4-Bdnf mRNA Pathway

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1113 - 1113

Published: Jan. 27, 2025

Resveratrol, a plant-derived polyphenol, exhibits significant antidepressant effects and notably enhances neuroplasticity in neurological diseases. However, whether the function of resveratrol is related to remains uncertain, underlying mechanisms poorly understood. This study aims investigate role mechanism depression. Here, we adopted chronic unpredictable mild stress (CUMS) model intervention by oral gavage. Thereafter, behavioral tests confirmed resveratrol’s effect, Nissl staining, Golgi Western blotting (WB) were employed assess neuronal plasticity. Moreover, proteomic analysis WB used screen identify key proteins. To downstream target ELAV-like RNA-binding protein 4 (ELAVL4) (one candidate genes), RNA Interactome Database National Center for Biotechnology Information databases utilized predict targets ELAVL4. Finally, Quantitative PCR, WB, Immunofluorescence verify prediction. Our results indicate that alleviates CUMS-induced depressive-like behaviors accompanied restoration impaired hippocampal neuroplasticity. Then, shows 351 differentially expressed proteins (DEPs) decrease after CUMS, while 24 DEPs increase remarkably with treatment. Among which, ELAVL4 downregulated simultaneously increasing intervention, which acts as protective this process. brain-derived neurotrophic factor (Bdnf) mRNA predicted be potential validated molecular technologies. In conclusion, our findings demonstrate efficacy closely associated ELAVL4, an protein, mediated pathway, potentially intersecting Bdnf mRNA. Overall, research sheds light on ELAVL4-Bdnf pathway through action, provides regulation perspective development novel antidepressants understanding depression pathology.

Language: Английский

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The neuroinflammatory effects of Nociceptin/Orphanin FQ receptor activation can be related to depressive-like behavior

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 183, P. 174 - 188

Published: Feb. 11, 2025

Language: Английский

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The lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 10, 2025

Fear can be induced either directly through self-experience of aversive events or vicariously by observing conspecifics experiencing such events. The locus coeruleus-norepinephrine (LC-NA) system is crucial in fear responses and cognitive processes. We investigated whether the LC-NA differentially processes these two types fear, direct vicarious male mice. results highlighted that right hemisphere LC→anterior cingulate cortex pathway uniquely for while inputs to LC—from bed nucleus stria terminalis (BNST) central amygdala (CeA)—differentially contribute processing. BNST plays a more targeted role CeA has broader influence on general. This underscores complexity specialization within fear-processing. arises vicariously, with involved both. Here, authors show LC → ACC key provide distinct LC, highlighting its complex fear.

Language: Английский

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Prefrontal-hippocampal pathways underlying adolescent resilience

European Child & Adolescent Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

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From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4271 - 4271

Published: April 30, 2025

The brain-derived neurotrophic factor (BDNF) has become one of the cornerstones neuropathology, influencing synaptic plasticity, cognitive resilience, and neuronal survival. Apart from its molecular biology, BDNF is a powerful target for transformative benefit in precision medicine, leading to innovative therapeutic approaches neurodegenerative psychiatric diseases like Alzheimer’s disease (AD), Parkinson’s (PD), major depressive disorder (MDD), post-traumatic stress (PTSD). Nevertheless, clinical applicability obstructed by hurdles delivery, patient-specific diversity, pleiotropic signaling. Here, we summarize findings research, including regulatory pathways diagnostic/prognostic biomarkers integrative approaches. We describe delivery systems, such as lipid nanoparticle-based mRNA therapies CRISPR-dCas9-based epigenetic editing that bypass obstacles BBB (blood–brain barrier) enzymatic degradation. recent implementation multiplex panels combining biodynamic indicators with tau amyloid-β signaling markers showcases novel levels specificity both early detection potential monitoring. Humanized preclinical models iPSC-derived neurons organoids point key role neurodeveloping processes, paralleling advances bridging observation environments. Moreover, tools delivering TrkB activators or AI-based dynamic care platforms enable tailored scalable treatments. This review also aims extend framework used understanding BDNF’s relevance traditional situating more work detailing actions ischemic tissues gut–brain axis context systemic health. Finally, outline roadmap incorporation BDNF-centered into worldwide healthcare, highlighting ethical issues, equity, interdisciplinary decomposition. heralds new era neuroscience revolutionizing brain health paving way advancement medicine.

Language: Английский

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Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 149, P. 112925 - 112925

Published: April 9, 2022

Anxiety and stress disorders are often characterized by an inability to extinguish learned fear responses. Orexins/hypocretins involved in the modulation of aversive memories, dysregulation this system may contribute aetiology anxiety pathological fear. The mechanisms which orexins regulate unknown. Here we investigated role endogenous cannabinoid impaired extinction induced orexin-A (OXA) male mice. selective inhibitor 2-arachidonoylglycerol (2-AG) biosynthesis O7460 abolished deficits OXA. Accordingly, increased 2-AG levels were observed amygdala hippocampus mice treated with OXA that do not fear, suggesting high endocannabinoid related poor extinction. Impairment was associated expression CB2 receptor (CB2R) microglial cells basolateral amygdala. Consistently, intra-amygdala infusion CB2R antagonist AM630 completely blocked promoted Microglial depletion PLX5622 chow also prevented these deficits. These results show overactivation orexin leads through amygdalar CB2R. This novel mechanism could be relevance for development potential approaches treat diseases inappropriate retention such as post-traumatic disorder, panic phobias.

Language: Английский

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Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 25, 2022

Increasing evidence indicates that the pathogenesis of depression is closely linked to impairments in neuronal synaptic plasticity. Honokiol, a biologically active substance extracted from Magnolia Officinalis, has been proven exert significant antidepressant effects. However, specific mechanism action remains unclear. In this study, PC12 cells and chronic unpredictable mild stress (CUMS) model rats were used explore effects potential mechanisms honokiol vitro rats. experiment, cell viability detection kit was screen concentration time administration. administered with hypoxia-inducible factor-1α (HIF-1α) blocker, 2-methoxyestradiol (2-ME), vascular endothelial growth factor receptor 2 (VEGFR-2) SU5416, detect expression HIF-1α, VEGF, protein 1 (SYN 1), postsynaptic density 95 (PSD 95) by western blotting. effect, we investigated whether plasticity dependent on HIF-1α-VEGF pathway. vivo, behavioral tests evaluate reproducibility CUMS depression-like behaviors. Molecular biology techniques examine mRNA signaling pathway plasticity-related regulators. Additionally, molecular docking study interaction between target proteins, predict their binding patterns affinities. Experimental results showed significantly reversed CUMS-induced Mechanically, exerted effect enhancing At level, can activate as well promote levels SYN PSD 95. Taken together, do not only provide an experimental basis for clinical treatment but also suggest may be depression.

Language: Английский

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Shedding light on subiculum’s role in human brain disorders

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 214, P. 110993 - 110993

Published: May 31, 2024

Subiculum is a pivotal output component of the hippocampal formation, structure often overlooked in neuroscientific research. Here, this review aims to explore role subiculum various brain disorders, shedding light on its significance within functional-neuroanatomical perspective neurological diseases. The subiculum's involvement multiple disorders was thoroughly examined. In Alzheimer's disease, alterations precede cognitive decline, while epilepsy, plays critical seizure initiation. Stress involves impact hypothalamic-pituitary-adrenocortical axis. Moreover, exhibits structural and functional changes anxiety, schizophrenia, Parkinson's contributing deficits. Bipolar disorder linked abnormalities, autism spectrum reveals an alteration inward deformation subiculum. Lastly, frontotemporal dementia shows volumetric differences subiculum, emphasizing contribution disorder's complexity. Taken together, consolidates existing knowledge may facilitate future research, diagnostic strategies, therapeutic interventions for conditions.

Language: Английский

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