Perspectives on adaptive dynamical systems

Chaos An Interdisciplinary Journal of Nonlinear Science, Год журнала: 2023, Номер 33(7)

Опубликована: Июль 1, 2023

Adaptivity is a dynamical feature that omnipresent in nature, socio-economics, and technology. For example, adaptive couplings appear various real-world systems, such as the power grid, social, neural networks, they form backbone of closed-loop control strategies machine learning algorithms. In this article, we provide an interdisciplinary perspective on systems. We reflect notion terminology adaptivity different disciplines discuss which role plays for fields. highlight common open challenges give perspectives future research directions, looking to inspire approaches.

Язык: Английский

---

Decoupling of interacting neuronal populations by time-shifted stimulation through spike-timing-dependent plasticity

PLoS Computational Biology, Год журнала: 2023, Номер 19(2), С. e1010853 - e1010853

Опубликована: Фев. 1, 2023

The synaptic organization of the brain is constantly modified by activity-dependent plasticity. In several neurological disorders, abnormal neuronal activity and pathological connectivity may significantly impair normal function. Reorganization circuits therapeutic stimulation has potential to restore dynamics. Increasing evidence suggests that temporal pattern crucially determines long-lasting effects stimulation. Here, we tested whether a specific can enable suppression pathologically strong inter-population through spike-timing-dependent plasticity (STDP). More specifically, how introducing time shift between stimuli delivered two interacting populations neurons effectively decouple them. To end, first used tractable model, i.e., bidirectionally coupled leaky integrate-and-fire (LIF) neurons, theoretically analyze optimal range frequency for decoupling. We then extended our results reciprocally connected (modules) where delayed connections were STDP. As predicted theoretical results, appropriately time-shifted causes decoupling two-module system STDP, unlearning interactions populations. Based on overall topology connections, modules, in turn, desynchronization outlasts cessation Decoupling be realized burst as well continuous simulation. Our provide insight into further optimization variety multichannel protocols aiming at reshaping diseased networks.

Язык: Английский

---

Neuroplasticity in Parkinson’s disease

Journal of Neural Transmission, Год журнала: 2024, Номер 131(11), С. 1329 - 1339

Опубликована: Авг. 5, 2024

Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, affecting millions of people and rapidly increasing over last decades. Even though there no intervention yet to stop pathology, many efficient treatment methods are available, including for patients with advanced PD. Neuroplasticity a fundamental property human brain adapt both external changes internal insults pathological processes. In this paper we examine current knowledge concepts concerning at network level, cellular level molecular as parts neuroplastic response protein aggregation synapse loss neuronal in We analyse beneficial, compensatory effects, such augmentation nigral neurons efficacy, well negative, maladaptive levodopa-induced dyskinesia. Effects physical activity different treatments on neuroplasticity considered opportunity biomarkers identification use discussed.

Язык: Английский

---

Inhibitory Spike-Timing-Dependent Plasticity Can Account for Pathological Strengthening of Pallido-Subthalamic Synapses in Parkinson’s Disease

Frontiers in Physiology, Год журнала: 2022, Номер 13

Опубликована: Май 19, 2022

Parkinson’s disease (PD) is a neurodegenerative brain disorder associated with dysfunction of the basal ganglia (BG) circuitry. Dopamine (DA) depletion in experimental PD models leads to pathological strengthening pallido-subthalamic synaptic connections, contributing emergence abnormally synchronized neuronal activity external segment globus pallidus (GPe) and subthalamic nucleus (STN). Augmented GPe-STN transmission following loss DA was attributed heterosynaptic plasticity mechanisms induced by cortico-subthalamic inputs. However, may play role this process. Here, employing computational modeling we show that assuming inhibitory spike-timing-dependent (iSTDP) at synapses can account for further promoting correlated network. In addition, delays shape bistable activity-connectivity states due iSTDP, characterized strong connectivity (pathological states) as opposed weak desynchronized (physiological states). Our results shed light on how abnormal reshaping during parkinsonism related pathophysiology contribute development therapeutic stimulation techniques targeting plasticity-induced rewiring network connectivity.

Язык: Английский

---

Mean-Field Approximations With Adaptive Coupling for Networks With Spike-Timing-Dependent Plasticity

Neural Computation, Год журнала: 2023, Номер 35(9), С. 1481 - 1528

Опубликована: Июль 12, 2023

Understanding the effect of spike-timing-dependent plasticity (STDP) is key to elucidating how neural networks change over long timescales and design interventions aimed at modulating such in neurological disorders. However, progress restricted by significant computational cost associated with simulating network models STDP lack low-dimensional description that could provide analytical insights. Phase-difference-dependent (PDDP) rules approximate phase oscillator networks, which prescribe synaptic changes based on differences neuron pairs rather than spike timing. Here we construct mean-field approximations for describe part space this very high-dimensional system. We first show single-harmonic PDDP can a simple form symmetric STDP, while multiharmonic are required accurately causal STDP. then derive exact expressions evolution average coupling weight terms synchrony. For adaptive Kuramoto oscillators clusters, formulate family descriptions dynamics each cluster weights between within clusters. Finally, two-cluster model be fitted synthetic data approximation full Our framework represents step toward example inform development new therapies maximizing long-lasting effects brain stimulation.

Язык: Английский

---

Neural underpinnings of fine motor skills under stress and anxiety: A review

Physiology & Behavior, Год журнала: 2024, Номер 282, С. 114593 - 114593

Опубликована: Май 22, 2024

Язык: Английский

---

Delay-dependent transitions of phase synchronization and coupling symmetry between neurons shaped by spike-timing-dependent plasticity

Cognitive Neurodynamics, Год журнала: 2022, Номер 17(2), С. 523 - 536

Опубликована: Июль 23, 2022

Язык: Английский

---

Dopamine depletion alters neuroplasticity-related signaling in the rat hippocampus

Animal Cells and Systems, Год журнала: 2023, Номер 27(1), С. 436 - 446

Опубликована: Дек. 11, 2023

Dopamine (DA) plays a significant role in regulating hippocampal function, particularly modulating synaptic plasticity. Despite this, comprehensive understanding of the molecular mechanisms involved neuroplasticity-related signaling influenced by DA remains incomplete. This study aimed to elucidate changes expression key molecules related neuroplasticity following depletion rats. To induce depletion, unilateral striatal infusions 6-hydroxydopamine (6-OHDA) were administered adult Sprague-Dawley The subsequent loss nigrostriatal DAergic these 6-OHDA-lesioned rats was confirmed using an apomorphine-induced rotation test at 4 weeks post-infusion and assessing levels tyrosine hydroxylase (TH) through immunohistochemistry western blotting 7 post-infusion. A decrease signaling, evidenced reduced TH-positive immunoreactivity, also noted ipsilateral hippocampus lesioned Interestingly, 6-OHDA infusion led increased phosphorylation pivotal plasticity-related proteins, including extracellular signal-regulated kinase (ERK), protein B (Akt), glycogen synthase 3β (GSK3β), cAMP response element-binding (CREB), infusion. extend findings, vitro experiments conducted on primary neurons exposed and/or active D1/D2 receptor antagonist, flupentixol (Flux). inhibited constitutive ERK, Akt, GSK3, CREB, while Flux restored levels. Taken together, findings indicate that triggers increase hippocampus, suggesting possible compensatory mechanism promotes activity-independent depletion.

Язык: Английский

---

Device Engineering of Dual Metal Gate-Based Artificial Synapse for Enhanced Plasticity Utilizing Al₂O₃-Based Ion Conducting Electrolyte

IEEE Transactions on Electron Devices, Год журнала: 2024, Номер 71(4), С. 2749 - 2754

Опубликована: Фев. 26, 2024

An energy-efficient artificial neuron can be developed with synaptic transistors using the electric double-layer (EDL) effect in transistor's oxide layer. This work proposes a dual metal gate (DMG) engineered indium-gallium-zinc-oxide (IGZO) transistor utilizing novel Al2O3-based ion conducting electrolyte for tunable performance based on drift-diffusion model. The simulation has been carried out at an ultralow voltage of 0.5 V employing two connection schemes. results show accurate simulations activities like paired-pulse facilitation, excitatory postsynaptic current (EPSC), memory transition from short-term to long-term, depression, and dynamic filtering characteristics. To validate device's performance, voltage, frequency, pulse interval modulation have determine strength device. assists higher ON/OFF ratio, leading more robust potentiation depression imply that DMG-based EDL device proposed provides physical understanding helps relate biological neuron.

Язык: Английский

---

Dynamics of parkinsonian oscillations mediated by transmission delays in a mean-field model of the basal ganglia

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Март 14, 2024

Neural interactions in the brain are affected by transmission delays which may critically alter signal propagation across different regions both normal and pathological conditions. The effect of interaction on dynamics generic neural networks has been extensively studied theoretical computational models. However, role development oscillatory basal ganglia (BG) Parkinson's disease (PD) is overlooked.

Язык: Английский

---