Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
As
a
key
member
of
the
neurotrophin
family
in
central
nervous
system,
brain-derived
neurotrophic
factor
(BDNF)
plays
critical
role
maintenance
and
plasticity
system.
Its
innate
neuroprotective
advantage
can
also
be
shared
with
brain
when
normal
aging-dependent
processes
challenge
neural
circuits.
The
intricate
relationship
between
BDNF
resilience
during
aging
process
signifies
molecular
mechanisms
that
underlie
protection
function,
such
as
cognition,
movement
psychological
well-being.
is
crucial
for
neuronal
growth
survival,
it
promote
against
age-related
functional
decline
frailty,
even
if
fails
to
entirely
prevent
aging-related
decline.
In
present
review,
we
discuss
function
from
perspective
how
may
aging.
We
emphasize
briefly
principal,
well-known
cellular
hallmarks
restrict
disabling
dynamics
enhance
overall
Insight
into
pathways
through
which
reduces
dysfunctions
and/or
improves
resilience,
provides
foundation
developing
targeted
interventions
mental
well-being
an
population.
Pharmaceutics,
Год журнала:
2023,
Номер
15(8), С. 2081 - 2081
Опубликована: Авг. 3, 2023
Brain-derived
neurotrophic
factor
(BDNF)
is
a
neurotrophin
that
plays
significant
role
in
the
survival
and
development
of
neurons,
being
involved
several
diseases
such
as
Alzheimer’s
disease
major
depression
disorder.
The
association
between
BDNF
depressive
disorder
subject
extensive
research.
Indeed,
numerous
studies
indicate
decreased
levels
are
linked
to
an
increased
occurrence
symptoms,
neuronal
loss,
cortical
atrophy.
Moreover,
it
has
been
observed
antidepressive
therapy
can
help
restore
levels.
In
this
review,
we
will
focus
on
serotonergic
imbalance
associated
stress
conditions,
particularly
hypothalamic–pituitary–adrenal
(HPA)
axis
dysregulation
oxidative
stress.
All
these
features
highly
connected
signaling
pathways
context
disease,
exploring
topic
aim
advance
our
understanding
disorder,
improve
diagnostic
treatment
approaches,
potentially
identify
new
therapeutic
targets
alleviate
heavy
burden
society.
Glia,
Год журнала:
2024,
Номер
72(4), С. 809 - 827
Опубликована: Янв. 11, 2024
Abstract
Recent
findings
highlight
myelin
breakdown
as
a
decisive
early
event
in
Alzheimer's
Disease
(AD)
acting
aggravating
factor
of
its
progression.
However,
it
is
still
unclear
whether
loss
attributed
to
increased
oligodendrocyte
vulnerability,
reduced
repairing
capacity
or
toxic
stimuli.
In
the
present
study,
we
sought
clarify
starting
point
disruption
accompanied
with
Oligodendrocyte
Progenitor
Cell
(OPC)
elimination
brain
5xFAD
mouse
model
AD
at
6
months
age
Dentate
Gyrus
hippocampus
relation
neurotrophin
system.
Prominent
inflammation
presence
was
detected
since
playing
key
role
disturbance
and
Expression
analysis
receptors
OPCs
performed
identify
new
targets
that
could
increase
myelination
health
disease.
both
control
mice
express
TrkB,
TrkC
p75
but
not
TrkA.
Brain‐derived
neurotrophic
(BDNF)
binds
TrkB
receptor
well‐known
about
pro‐myelination
effect,
promoting
oligodendrocytes
proliferation
differentiation,
so
focused
our
investigation
on
effects
under
neurodegenerative
conditions.
Our
vitro
results
showed
BDNF
rescues
from
death
promotes
their
differentiation
Amyloid‐β
1‐42.
Collectively,
indicate
possess
an
additional
neuroprotective
through
actions
oligodendrocytic
component
use
be
proposed
drug‐based
myelin‐enhancing
strategy,
complementary
amyloid
tau
centered
therapies
AD.
International Journal of Translational Medicine,
Год журнала:
2024,
Номер
4(1), С. 176 - 196
Опубликована: Март 5, 2024
Major
depressive
disorder
(MDD),
a
prevalent
mental
illness,
is
marked
by
complex
mixture
of
biological
factors.
This
review
focuses
on
the
roles
oxidative
stress,
tryptophan-serotonin
metabolism,
brain-derived
neurotrophic
factor
(BDNF),
and
hypothalamic–pituitary–adrenal
(HPA)
axis
in
MDD’s
pathophysiology.
Oxidative
defined
as
an
imbalance
between
pro-oxidants
antioxidants,
closely
linked
to
neurobiological
changes.
The
tryptophan
(TRP)-/serotonin
(5-HT)
metabolic
pathway
also
known
be
crucial
mood
regulation,
with
its
dysregulation
being
central
aspect
MDD.
Additionally,
BDNF,
key
for
neuronal
growth
plasticity,
often
shows
alterations
MDD
patients,
supporting
role
disorder’s
progression.
Furthermore,
HPA
axis,
which
manages
stress
response,
frequently
disrupted
MDD,
further
contributing
pathology.
In
addition
exploring
these
mechanisms,
this
explores
pharmacotherapy
including
new
advances.
These
advancements
treatment
strategies
are
managing
effectively.
Understanding
mechanisms
latest
pharmacological
interventions
essential
developing
more
effective
treatments
Brain Sciences,
Год журнала:
2023,
Номер
14(1), С. 19 - 19
Опубликована: Дек. 23, 2023
The
term
“neuroinflammation”
defines
the
typical
inflammatory
response
of
brain
closely
related
to
onset
many
neurodegenerative
diseases
(NDs).
Neuroinflammation
is
well
known,
but
its
mechanisms
and
pathways
are
not
entirely
comprehended.
Some
progresses
have
been
achieved
through
efforts
research.
Consequently,
new
cellular
molecular
mechanisms,
diverse
conventional,
emerging.
In
listing
some
those
that
will
be
subject
our
description
discussion,
essential
important
roles
peripheral
infiltrated
monocytes
clonotypic
cells,
alterations
in
gut–brain
axis,
dysregulation
apelinergic
system,
endothelial
glycocalyx
component
neuronal
vascular
units,
variations
expression
genes
levels
encoding
molecules
by
action
microRNAs
(miRNAs),
or
other
epigenetic
factors
distinctive
transcriptional
factors,
as
role
autophagy,
ferroptosis,
sex
differences,
modifications
circadian
cycle.
Such
can
add
significantly
understanding
complex
etiological
puzzle
neuroinflammation
ND.
addition,
they
could
represent
biomarkers
targets
ND,
which
increasing
elderly.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12924 - 12924
Опубликована: Дек. 1, 2024
This
paper
bridges
critical
gaps
through
proposing
a
novel,
environmentally
mediated
brain-derived
neurotrophic
factor
(BDNF)-interactive
model
that
promises
to
sustain
adult
hippocampal
neurogenesis
in
humans.
It
explains
how
three
environmental
enrichment
mechanisms
(physical
activity,
cognitive
stimulation,
and
mindfulness)
can
integratively
regulate
BDNF
other
growth
factors
neurotransmitters
support
at
various
stages,
those
be
promoted
by
the
physical
environment.
The
approach
enables
isolation
of
specific
their
molecular
effects
promote
sustainable
regulation
testing
environment's
ability
increase
immediately
or
shortly
before
it
is
consumed
for
muscle
repair
brain
update.
offers
feasible
method
research
environment
dynamics
real-world
human
contexts
immediate
level,
overcoming
confounds
complex
settings
challenges
long-term
exposure
structural
plasticity
changes.
advance
understanding
influences
on
hippocampus
enhance
health
cognition.
work
fundamental
methodology
knowledge
facilitate
more
enrichment-neuroplasticity
interplay
humans
without
methodological
limitations.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(8), С. 8170 - 8196
Опубликована: Июль 29, 2024
Estrogen
is
a
significant
hormone
that
involved
in
multitude
of
physiological
and
pathological
processes.
In
addition
to
its
pivotal
role
the
reproductive
system,
estrogen
also
implicated
pathogenesis
diseases.
Nevertheless,
previous
research
on
diseases,
including
Alzheimer’s
disease,
depression,
cardiovascular
diabetes,
osteoporosis,
gastrointestinal
estrogen-dependent
cancers,
has
concentrated
single
disease
area,
resulting
lack
comprehensive
understanding
cross-disease
mechanisms.
This
brought
some
challenges
current
treatment
methods
for
these
because
as
potential
therapeutic
tool
not
yet
fully
developed
potential.
Therefore,
this
review
aims
comprehensively
explore
mechanism
seven
types
The
objective
study
describe
relationship
between
each
estrogen,
ways
which
participates
regulating
mechanisms,
outline
efficacy
treating
diseases
clinical
practice.
By
studying
variety
it
hoped
more
accurate
theoretical
basis
guidance
future
strategies
will
be
provided,
thus
promoting
effective
management
