World Journal of Gastrointestinal Surgery,
Год журнала:
2025,
Номер
17(2)
Опубликована: Янв. 20, 2025
Restoring
the
balance
of
gut
microbiota
has
emerged
as
a
critical
strategy
in
treating
intestinal
disorders,
with
probiotics
playing
pivotal
role
maintaining
bacterial
equilibrium.
Surgical
preparations,
trauma,
and
digestive
tract
reconstruction
associated
surgeries
often
disrupt
flora,
prompting
interest
potential
postoperative
recovery.
Lan
et
al
conducted
prospective
randomized
study
on
60
patients
acute
appendicitis,
revealing
that
administration
Bacillus
licheniformis
capsules
facilitated
early
resolution
inflammation
restoration
gastrointestinal
motility,
offering
novel
therapeutic
avenue
for
accelerated
This
editorial
delves
into
effects
perioperative
probiotic
supplementation
physical
recovery
following
surgery.
Within
framework
enhanced
after
surgery,
exploration
new
strategies
to
mitigate
surgical
complications
reshape
is
particularly
intriguing.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Март 22, 2024
Background
Gut
microbiota
studies
in
the
field
of
endocrinology
metabolism
have
attracted
increasing
attention
recent
years.
To
comprehensively
assess
evolving
landscape
this
research
field,
we
conducted
a
thorough
bibliometric
analysis
gut
indexed
Web
Science
database.
Methods
We
collected
and
analyzed
3,339
original
articles
reviews
published
from
1972
to
2023.
Using
various
indicators,
investigated
publication
trends,
country
contributions,
international
collaborations,
prolific
authors,
top
journals,
influential
articles.
Results
Our
revealed
significant
upsurge
publications
after
2010,
indicating
growing
scientific
interest
metabolism.
Keyword
thematic
analyses
identified
microbiota,
obesity,
diabetes,
inflammation
as
core
themes.
Additionally,
roles
probiotics
prebiotics
are
increasingly
researched
for
their
therapeutic
effects
shaping
microbiota.
Conclusion
This
study
reveals
that
is
decoding
connection
between
diseases.
There’s
also
focus
on
manipulation,
which
points
shift
towards
personalized
medicine.
Future
should
integrating
these
findings
into
clinical
practice,
moving
lab-based
real-world
patient
care.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5377 - 5377
Опубликована: Май 15, 2024
In
recent
years,
there
has
been
a
growing
interest
in
the
concept
of
“gut–brain
axis”.
addition
to
well-studied
diseases
associated
with
an
imbalance
gut
microbiota,
such
as
cancer,
chronic
inflammation,
and
cardiovascular
diseases,
research
is
now
exploring
potential
role
microbial
dysbiosis
onset
development
brain-related
diseases.
When
function
intestinal
barrier
altered
by
dysbiosis,
aberrant
immune
system
response
interacts
nervous
system,
leading
state
“neuroinflammation”.
The
microbiota–brain
axis
mediated
inflammatory
immunological
mechanisms,
neurotransmitters,
neuroendocrine
pathways.
This
narrative
review
aims
illustrate
molecular
basis
neuroinflammation
elaborate
on
gut–brain
virtue
analyzing
various
metabolites
produced
microbiome
how
they
might
impact
system.
Additionally,
current
will
highlight
sex
influences
these
mechanisms.
fact,
hormones
brain–gut
microbiota
at
different
levels,
central
enteric
one,
enteroendocrine
cells.
A
deeper
understanding
human
health
disease
crucial
guide
diagnoses,
treatments,
preventive
interventions.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11629 - 11629
Опубликована: Окт. 29, 2024
Parkinson's
disease
(PD)
is
a
complex
neurodegenerative
disorder.
Recent
evidence
reveals
connections
between
neuroinflammatory
processes
and
intestinal
microbiota
alterations
in
the
progression
of
this
pathology.
This
comprehensive
review
explores
intricate
relationships
them,
highlighting
their
combined
impact
on
PD.
Neuroinflammation,
characterized
by
immune
activation
central
nervous
system,
increasingly
acknowledged
as
critical
factor
development
Concurrently,
gut
composition
have
been
linked
to
PD,
suggesting
potential
modulatory
role
progression.
Thus,
bidirectional
communication
along
gut-brain
axis
has
become
pivotal
comprehending
pathogenesis
Furthermore,
we
explore
emerging
therapeutic
strategies
that
target
these
interconnected
pathways,
providing
insights
into
avenues
for
PD
treatment.
The
elucidation
establishes
promising
foundation
innovative
aimed
at
altering
improving
quality
life
individuals
affected
Pharmaceuticals,
Год журнала:
2025,
Номер
18(1), С. 104 - 104
Опубликована: Янв. 15, 2025
Cytokine-mediated
inflammation
is
increasingly
recognized
for
playing
a
vital
role
in
the
pathophysiology
of
wide
range
brain
disorders,
including
neurodegenerative,
psychiatric,
and
neurodevelopmental
problems.
Pro-inflammatory
cytokines
such
as
interleukin-1
(IL-1),
tumor
necrosis
factor-alpha
(TNF-α),
interleukin-6
(IL-6)
cause
neuroinflammation,
alter
function,
accelerate
disease
development.
Despite
progress
understanding
these
pathways,
effective
medicines
targeting
are
still
limited.
Traditional
anti-inflammatory
immunomodulatory
drugs
peripheral
inflammatory
illnesses.
Still,
they
face
substantial
hurdles
when
applied
to
central
nervous
system
(CNS),
blood-brain
barrier
(BBB)
unwanted
systemic
effects.
This
review
highlights
developing
treatment
techniques
modifying
cytokine-driven
focusing
on
advances
that
selectively
target
critical
involved
pathology.
Novel
approaches,
cytokine-specific
inhibitors,
antibody-based
therapeutics,
gene-
RNA-based
interventions,
sophisticated
drug
delivery
systems
like
nanoparticles,
show
promise
with
respect
lowering
neuroinflammation
greater
specificity
safety.
Furthermore,
developments
biomarker
discoveries
neuroimaging
improving
our
ability
monitor
responses,
allowing
more
accurate
personalized
regimens.
Preclinical
clinical
trial
data
demonstrate
therapeutic
potential
tailored
techniques.
However,
significant
challenges
remain,
across
BBB
reducing
off-target
As
research
advances,
creation
personalized,
cytokine-centered
therapeutics
has
therapy
landscape
illnesses,
giving
patients
hope
better
results
higher
quality
life.
World Journal of Gastrointestinal Surgery,
Год журнала:
2025,
Номер
17(2)
Опубликована: Янв. 20, 2025
Restoring
the
balance
of
gut
microbiota
has
emerged
as
a
critical
strategy
in
treating
intestinal
disorders,
with
probiotics
playing
pivotal
role
maintaining
bacterial
equilibrium.
Surgical
preparations,
trauma,
and
digestive
tract
reconstruction
associated
surgeries
often
disrupt
flora,
prompting
interest
potential
postoperative
recovery.
Lan
et
al
conducted
prospective
randomized
study
on
60
patients
acute
appendicitis,
revealing
that
administration
Bacillus
licheniformis
capsules
facilitated
early
resolution
inflammation
restoration
gastrointestinal
motility,
offering
novel
therapeutic
avenue
for
accelerated
This
editorial
delves
into
effects
perioperative
probiotic
supplementation
physical
recovery
following
surgery.
Within
framework
enhanced
after
surgery,
exploration
new
strategies
to
mitigate
surgical
complications
reshape
is
particularly
intriguing.
