Innovation at the Intersection: Emerging Translational Research in Neurology and Psychiatry

Cells, Год журнала: 2024, Номер 13(10), С. 790 - 790

Опубликована: Май 7, 2024

Translational research in neurological and psychiatric diseases is a rapidly advancing field that promises to redefine our approach these complex conditions [...]

Язык: Английский

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Evidence of Neuroplastic Changes after Transcranial Magnetic, Electric, and Deep Brain Stimulation

Brain Sciences, Год журнала: 2022, Номер 12(7), С. 929 - 929

Опубликована: Июль 15, 2022

Electric and magnetic stimulation of the human brain can be used to excite or inhibit neurons. Numerous methods have been designed over years for this purpose with various advantages disadvantages that are topic review. Deep (DBS) is most direct focal application electric impulses tissue. Electrodes placed in order modulate neural activity correct parameters pathological oscillation circuits such as their amplitude frequency. Transcranial (TMS) a non-invasive alternative stimulator generating field coil scalp induces an which, turn, interacts ongoing activity. Depending upon parameters, excitation inhibition achieved. (tES) applies fields spread along skull reach brain, thus, limiting current strength avoid skin sensations cranial muscle pain. Therefore, tES only considered subthreshold, i.e., it does not directly elicit neuronal action potentials. In review, we collect hints neuroplastic changes modulation behavior, evolution clinical signs symptoms response stimulation. Possible mechanisms discussed, future paradigms suggested.

Язык: Английский

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Alpha and Theta Oscillations Are Causally Linked to Interference Inhibition: Evidence from High-Definition Transcranial Alternating Current Stimulation

Brain Sciences, Год журнала: 2023, Номер 13(7), С. 1026 - 1026

Опубликована: Июль 4, 2023

(1) Background: The Go/NoGo task and color-word Stroop were used to investigate the effect of applying different frequency bands neural oscillations lDLPFC on inhibitory control modulation. (2) Methods: Participants randomly categorized into four groups received HD-tACS at 6, 10, 20 Hz or sham stimulation 1.5 mA for min. All participants performed a before immediately after stimulation; closed-eye resting-state EEG signals acquired 3 min tasks. (3) Results: There no significant differences in behavioral indices across groups. In task, response time was significantly reduced by 6 10 stimulations compared stimulation, accuracy stimulation. range-specific (delta, theta, alpha, beta, gamma) resting power (4) Conclusions: effectively improved participants' performance demonstrating importance interference inhibition supporting causal relationship between theta alpha inhibition.

Язык: Английский

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Shared oscillatory mechanisms of alpha-band activity in prefrontal regions in eyes open and closed state using a portable EEG acquisition device

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 4, 2024

Alpha oscillations are associated with various psychiatric disorders, many studies focusing on the prefrontal cortex, where transcranial alternating current stimulation (TACS) is applied in alpha frequency band. This approach often involves selecting individualized frequencies to resonate their endogenous oscillations. While strong (8–13 Hz) typically induced when eyes closed, they can also occur during resting state open. However, it remains unclear whether these share a common neural generation mechanism. Exploring which of more suitable as stable peak question significant interest. Therefore, systematically study this issue, we specifically collected resting-state electroencephalographic (EEG) data from region 40 individuals, under both eyes-open and closed- eye conditions, multiple follow-ups extending up nine months. Through spectral analysis each person's entire dataset averaging results, observed positive correlation between alpha-band power eyes-closed states, terms absolute relative power. Further revealed that was primarily contributed by periodic activity within Upon modelling oscillatory components, discovered distinct differences characteristics-such number sub-oscillations state. Our first explored relationship cortex identifying shared part mechanism some mechanisms unique

Язык: Английский

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Alpha rhythm transcranial electrical stimulation to inferior parietal cortex increases alpha power and phase synchrony while attending to mind–body self-states

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Visual Working Memory Recruits Two Functionally Distinct Alpha Rhythms in Posterior Cortex

eNeuro, Год журнала: 2022, Номер 9(5), С. ENEURO.0159 - 22.2022

Опубликована: Сен. 1, 2022

Oscillatory activity in the human brain is dominated by posterior alpha oscillations (8-14 Hz), which have been shown to be functionally relevant a wide variety of cognitive tasks. Although are commonly considered single oscillator anchored at an individual frequency (IAF; ∼10 previous work suggests that IAF reflects spatial mixture different rhythms. In this study, we assess whether Independent Component Analysis (ICA) can disentangle distinct rhythms context visual short-term memory retention. Magnetoencephalography (MEG) was recorded 33 subjects while performing working task. Group analysis sensor level suggested existence increases power and decreases during Conversely, single-subject independent components revealed two dissociable rhythms: one retention (Alpha1) another (Alpha2). Alpha1 Alpha2 were differentially modulated presence distractors (Alpha1 increased decreased) had opposite relationship with accuracy (positive for negative Alpha2). addition, showed lower peak frequency, narrower width, greater relative amplitude more central source than Together, our results demonstrate modulations reflect dynamics least functions spatiospectral characteristics.Significance statementAlpha most prominent feature brain's electrical activity, consist rhythmic neuronal parts cortex. Alpha usually rhythm changes support operations. We here show entails characteristics. These findings could solve inconsistencies literature regarding direction task-related power/frequency their relation performance. important consequences design neurostimulation protocols aimed modulating subsequently cognition.

Язык: Английский

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Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Май 8, 2023

Individuals with multi-domain amnestic mild cognitive impairment (md-aMCI) have an elevated risk of dementia and need interventions that may retain or remediate function. In a feasibility pilot study, 30 older adults aged 60-80 years md-aMCI were randomized to 8 sessions transcranial alternating current stimulation (tACS) simultaneous control training (CCT). The intervention took place within the participant's home without direct researcher assistance. Half participants received prefrontal theta tACS during CCT other half tACS. We observed high tolerability adherence for at-home + CCT. Within 1-week, only those who exhibited improved attentional abilities. Neuromodulation is feasible in-home settings, which can be conducted by patient, thereby enabling treatment in difficult reach populations. TACS facilitate abilities md-aMCI, but research larger population needed validate efficacy.

Язык: Английский

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Mental strategies and resting state EEG: Effect on high alpha amplitude modulation by neurofeedback in healthy young adults

Biological Psychology, Год журнала: 2023, Номер 178, С. 108521 - 108521

Опубликована: Фев. 17, 2023

Язык: Английский

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Probing the Promises of Noninvasive Transcranial Electrical Stimulation for Boosting Mental Performance in Sports

Brain Sciences, Год журнала: 2023, Номер 13(2), С. 282 - 282

Опубликована: Фев. 8, 2023

While the importance of physical abilities is noncontested to perform in elite sport, more focus has recently been turned toward cognitive processes involved sport performance. Practicing any requires a high demand functioning including, but not limited to, decision-making, processing speed, working memory, perceptual processing, motor functioning, and attention. Noninvasive transcranial electrical stimulation (tES) attracted considerable scientific interest due its ability modulate brain functioning. Neuromodulation apparently improves functions engaged sports This opinion manuscript aimed reveal that tES likely an adjunct ergogenic resource for improving processes, counteracting mental fatigue, managing anxiety athletes. Nevertheless, first evidence insufficient guarantee real effectiveness benefits. All techniques could be add-ons make performance-related efficient obtain better results. Modulating inhibitory control through over frontal cortex might largely contribute improvement studies athletes are required assess long-term effects application as aid conjunction with other training methods (e.g., neurofeedback, imagery) where trainable.

Язык: Английский

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Neurofeedback training for children with ADHD using individual beta rhythm

Cognitive Neurodynamics, Год журнала: 2022, Номер 16(6), С. 1323 - 1333

Опубликована: Апрель 1, 2022

Язык: Английский

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