Effects of the neonatal intensive care environment on circadian health and development of preterm infants

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Авг. 31, 2023

The circadian system in mammals ensures adaptation to the light-dark cycle on Earth and imposes 24-h rhythmicity metabolic, physiological behavioral processes. central pacemaker is located brain entrained by environmental signals called Zeitgebers. From here, neural, humoral systemic drive rhythms peripheral clocks nearly every mammalian tissue. During pregnancy, disruption of complex interplay between mother’s rhythmic fetal developing can lead long-term health consequences offspring. When an infant born very preterm, it loses temporal received from mother prematurely becomes totally dependent 24/7 care Neonatal Intensive Care Unit (NICU), where day/night usually blurred. In this literature review, we provide overview neonatal development system, short-term process as occurs NICU environment. Moreover, a theoretical molecular framework how could later-life disease. Finally, discuss studies that aim improve outcomes after preterm birth studying effects enhancing light noise exposure.

Язык: Английский

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A subclass of evening cells promotes the switch from arousal to sleep at dusk

Current Biology, Год журнала: 2024, Номер 34(10), С. 2186 - 2199.e3

Опубликована: Май 1, 2024

Язык: Английский

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Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Сен. 24, 2021

Abstract There is only one known portal system in the mammalian brain - that of pituitary gland, first identified 1933 by Popa and Fielding. Here we describe a second pathway mouse linking capillary vessels brain’s clock suprachiasmatic nucleus (SCN) to those organum vasculosum lamina terminalis (OVLT), circumventricular organ. The localized blood pathways enable small amounts important secretions reach their specialized targets high concentrations without dilution general circulatory system. These point an entirely new route for secreted SCN signals, potentially restructures our understanding communication pathways.

Язык: Английский

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Rhythms in barriers and fluids: Circadian clock regulation in the aging neurovascular unit

Neurobiology of Disease, Год журнала: 2023, Номер 181, С. 106120 - 106120

Опубликована: Апрель 10, 2023

The neurovascular unit is where two very distinct physiological systems meet: central nervous system (CNS) and the blood. permeability of barriers separating these regulated by time, including both 24 h circadian clock longer processes aging. An endogenous rhythm regulates transport molecules across blood-brain barrier circulation cerebrospinal fluid glymphatic system. These dynamics change with time day, age, especially in context neurodegeneration. Factors may differ depending on brain region, as can be highlighted consideration regulation niche white matter. As an example a potential target for clinical applications, we highlight chaperone-mediated autophagy one mechanism at intersection dysregulation, aging neurodegenerative disease. In this review emphasize key areas future research.

Язык: Английский

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Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models

Molecular Neurodegeneration, Год журнала: 2024, Номер 19(1)

Опубликована: Янв. 10, 2024

Tauopathies, a group of neurodegenerative diseases that includes Alzheimer's disease, commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The rhythm, recurring 24-hour cycle governing human biological activity, is regulated by the hypothalamic suprachiasmatic nucleus (SCN) endogenous transcriptional-translational feedback loops. Surprisingly, little attention has been given investigating tauopathy-driven neuropathology SCN repercussions gene dysfunction brain affected tauopathies. This review aims provide an overview current literature on vulnerability tauopathies humans. Emphasis placed elucidating neuronal glial changes contributing widespread disruption molecular clock. Furthermore, this identifies areas knowledge requiring further investigation.

Язык: Английский

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Neuromodulation of Cardiac Ischemic Pain: Role of the Autonomic Nervous System and Vasopressin

Journal of Integrative Neuroscience, Год журнала: 2024, Номер 23(3)

Опубликована: Март 1, 2024

Cardiac pain is an index of cardiac ischemia that helps the detection hypoxia and adjustment activity in sufferer. Drivers thresholds markedly differ different subjects can oscillate same individual, showing a distinct circadian rhythmicity clinical picture. In patients with syndrome X or silent ischemia, intensity may cause neurogenic stress potentiates work intensifies discomfort patient. The reasons for individual differences sensation are not fully understood. Thus far, most attention has been focused on inappropriate regulation heart by autonomic nervous system, autacoids, cardiovascular hormones. Herein, we summarize evidence system regulates cooperation vasopressin (AVP). AVP essential analgesic compound it exerts its antinociceptive function through actions brain (the periaqueductal gray, caudate nucleus, nucleus raphe magnus), spinal cord, coronary vessels. Vasopressin acts directly means V1 V2 receptors as well multiple interactions hormones, particular, angiotensin II endothelin. regulatory effects significantly impaired diseases.

Язык: Английский

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Crosstalk Between Aging, Circadian Rhythm, and Melatonin

Rejuvenation Research, Год журнала: 2023, Номер 26(6), С. 229 - 241

Опубликована: Окт. 17, 2023

Circadian rhythms (CRs) are 24-hour periodic oscillations governed by an endogenous circadian pacemaker located in the suprachiasmatic nucleus (SCN), which organizes physiology and behavior of organisms. rhythm disruption (CRD) is also indicative aging process. In mammals, melatonin primarily synthesized pineal gland participates a variety multifaceted intracellular signaling networks has been shown to synchronize CRs. Endogenous synthesis its release tend decrease progressively with advancing age. Older individuals experience frequent CR disruption, hastens process aging. A profound understanding relationship between CRs potential improve existing treatments facilitate development novel chronotherapies that target age-related disorders. This review article aims examine regulatory mechanisms plays key role signaling. We describe basic architecture molecular clock functional decline age detail. Furthermore, we discuss regulation redox homeostasis during Moreover, protective effect exogenous supplementation age-dependent sheds light on this pleiotropic molecule how it can be used as effective chronotherapeutic medicine.

Язык: Английский

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Estrogen‐mediated coupling via gap junctions in the suprachiasmatic nucleus

European Journal of Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Фев. 7, 2024

Abstract The circadian clock orchestrates many physiological and behavioural rhythms in mammals with 24‐h periodicity, through a hierarchical organisation, the central located suprachiasmatic nucleus (SCN) hypothalamus. circuits of SCN generate precision, relying on intrinsic coupling mechanisms, for example, neurotransmitters like arginine vasopressin (AVP), vasoactive intestinal peptide (VIP), neuronal gamma‐aminobutyric acid (GABA) signalling astrocytes connected by gap junctions composed connexins (Cx). In female rodents, presence estrogen receptors (ERs) dorsal suggests an influence (E2) circuit timekeeping that could regulate rhythm coupling. To investigate this, we used explants together hypothalamic neurons astrocytes. First, showed E2 stabilised amplitude when rAVPs (receptor‐associated peptides) were inhibited. However, phase delay induced VIPAC2 (VIP receptors) inhibition remained unaffected E2. We then exerted its effects via ERβ (estrogen receptor beta), resulting increased expression Cx36 Cx43 . Notably, specific both resulted significant reduction within SCN. Remarkably, restored period inhibited but not inhibition. This implies network between neurons, responsible SCN, can be reinforced conclusion, these findings provide new insights into how regulates ex vivo ERβ‐dependent manner, underscoring crucial role fortifying SCN's rhythm.

Язык: Английский

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Circadian disruptions and brain clock dysregulation in mood disorders

Nature Mental Health, Год журнала: 2024, Номер 2(7), С. 749 - 763

Опубликована: Июль 11, 2024

Язык: Английский

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Chronobiology of Parkinson's disease: Past, present and future

European Journal of Neuroscience, Год журнала: 2022, Номер 57(1), С. 178 - 200

Опубликована: Ноя. 7, 2022

Parkinson's disease is a neurodegenerative disorder predominately affecting midbrain dopaminergic neurons that results in broad range of motor and non-motor symptoms. Sleep complaints are among the most common symptoms, even prodromal period. alterations patients may be associated with dysregulation circadian rhythms, intrinsic 24-h cycles control essential physiological functions, or side effects from levodopa medication physical mental health challenges. The impact on sleep disturbances not fully understood; as such, we review systems, cellular molecular mechanisms underlie perturbations disease. We also discuss potential benefits chronobiology-based personalized medicine management both terms behavioural pharmacological interventions. propose fuller understanding clock function shed important new light aetiology symptomatology allow for improvements quality life millions people

Язык: Английский

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