Antioxidants,
Год журнала:
2023,
Номер
12(8), С. 1525 - 1525
Опубликована: Июль 29, 2023
Cellular
redox
status
has
a
crucial
role
in
brain
physiology,
as
well
pathologic
conditions.
Physiologic
senescence,
by
dysregulating
cellular
homeostasis
and
decreasing
antioxidant
defenses,
enhances
the
central
nervous
system’s
susceptibility
to
diseases.
The
reduction
of
free
radical
accumulation
through
lifestyle
changes,
supplementation
antioxidants
prophylactic
therapeutic
approach
increase
health,
are
strongly
suggested.
Bilirubin
is
powerful
endogenous
antioxidant,
with
more
recognized
roles
biomarker
disease
resistance,
predictor
all-cause
mortality,
molecule
that
may
promote
health
adults.
alteration
expression
activity
enzymes
involved
bilirubin
production,
an
altered
blood
level,
often
reported
neurologic
conditions
neurodegenerative
diseases
(together
denoted
NCDs)
aging.
These
changes
predict
or
contribute
both
positively
negatively
Understanding
onset
progression
NCDs
will
be
functional
consider
benefits
vs.
drawbacks
hypothesize
best
strategies
for
its
manipulation
purposes.
Molecules,
Год журнала:
2023,
Номер
28(15), С. 5623 - 5623
Опубликована: Июль 25, 2023
This
review
describes
the
various
innovative
approaches
implemented
for
naringin
extraction
as
well
recent
developments
in
field.
Naringin
was
assessed
terms
of
its
structure,
chemical
composition,
and
potential
food
sources.
How
works
pharmacologically
discussed,
including
an
anti-diabetic,
anti-inflammatory,
hepatoprotective
substance.
Citrus
flavonoids
are
crucial
herbal
additives
that
have
a
huge
spectrum
organic
activities.
is
nutritional
flavanone
glycoside
has
been
shown
to
be
effective
treatment
few
chronic
disorders
associated
with
ageing.
fruits
contain
common
flavone
specific
pharmacological
biological
properties.
Naringin,
range
intriguing
characteristics,
abundant
citrus
fruits.
variety
biological,
medicinal,
effects.
hydrolyzed
into
rhamnose
prunin
by
naringinase,
which
also
possesses
l-rhamnosidase
activity.
D-glucosidase
subsequently
catalyzes
hydrolysis
glucose
naringenin.
known
having
antioxidant,
tumor-fighting
Numerous
test
animals
cell
lines
used
correlate
exposure
asthma,
hyperlipidemia,
diabetes,
cancer,
hyperthyroidism,
osteoporosis.
study
focused
on
many
documented
actions
in-vitro
in-vivo
experimental
preclinical
investigations,
prospective
therapeutic
advantages,
utilizing
information
presently
accessible
literature.
In
addition
pharmacokinetic
naringin’s
distribution,
different
methods,
use
cosmetic,
food,
pharmaceutical,
animal
feed
sectors
were
discussed.
Biomolecules,
Год журнала:
2024,
Номер
14(6), С. 697 - 697
Опубликована: Июнь 14, 2024
The
antioxidant
defense
mechanisms
play
a
critical
role
in
mitigating
the
deleterious
effects
of
reactive
oxygen
species
(ROS).
Catalase
stands
out
as
paramount
enzymatic
antioxidant.
It
efficiently
catalyzes
decomposition
hydrogen
peroxide
(H
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2476 - 2476
Опубликована: Июль 31, 2024
Glutathione
(GSH),
a
tripeptide
synthesized
intracellularly,
serves
as
pivotal
antioxidant,
neutralizing
reactive
oxygen
species
(ROS)
and
nitrogen
(RNS)
while
maintaining
redox
homeostasis
detoxifying
xenobiotics.
Its
potent
antioxidant
properties,
particularly
attributed
to
the
sulfhydryl
group
(-SH)
in
cysteine,
are
crucial
for
cellular
health
across
various
organelles.
The
glutathione-glutathione
disulfide
(GSH-GSSG)
cycle
is
facilitated
by
enzymes
like
glutathione
peroxidase
(GPx)
reductase
(GR),
thus
aiding
detoxification
processes
mitigating
oxidative
damage
inflammation.
Mitochondria,
being
primary
sources
of
species,
benefit
significantly
from
GSH,
which
regulates
metal
supports
autophagy,
apoptosis,
ferroptosis,
playing
fundamental
role
neuroprotection.
vulnerability
brain
stress
underscores
importance
GSH
neurological
disorders
regenerative
medicine.
Nebulization
presents
novel
promising
approach
delivering
this
directly
central
nervous
system
(CNS),
potentially
enhancing
its
bioavailability
therapeutic
efficacy.
This
method
may
offer
significant
advantages
neurodegeneration
nuclear
factor
erythroid
2-related
2
(NRF2)
pathway
signaling
mitochondrial
function,
thereby
providing
direct
By
addressing
detrimental
effects
on
neuronal
health,
nebulized
could
play
managing
ameliorating
conditions
such
Parkinson's
Disease
(PD)
Alzheimer's
(AD).
Further
clinical
research
warranted
elucidate
potential
preserving
CNS
combating
neurodegenerative
conditions,
aiming
improve
outcomes
individuals
affected
diseases
characterized
neuroinflammation.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(2), С. 386 - 386
Опубликована: Янв. 9, 2025
The
blood-brain
barrier
(BBB)
is
a
crucial
structure
that
maintains
brain
homeostasis
by
regulating
the
entry
of
molecules
and
cells
from
bloodstream
into
central
nervous
system
(CNS).
Neurodegenerative
diseases
such
as
Alzheimer's
Parkinson's
disease,
well
ischemic
stroke,
compromise
integrity
BBB.
This
leads
to
increased
permeability
infiltration
harmful
substances,
thereby
accelerating
neurodegeneration.
In
this
review,
we
explore
mechanisms
underlying
BBB
disruption,
including
oxidative
stress,
neuroinflammation,
vascular
dysfunction,
loss
tight
junction
integrity,
in
patients
with
neurodegenerative
diseases.
We
discuss
how
breakdown
contributes
neurotoxicity,
abnormal
accumulation
pathological
proteins,
all
which
exacerbate
neuronal
damage
facilitate
disease
progression.
Furthermore,
potential
therapeutic
strategies
aimed
at
preserving
or
restoring
function,
anti-inflammatory
treatments,
antioxidant
therapies,
approaches
enhance
integrity.
Given
role
neurodegeneration,
maintaining
its
represents
promising
approach
slow
prevent
progression
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 791 - 791
Опубликована: Фев. 25, 2025
Background/Objectives:
Chronic
treatment
with
dapsone
(DDS)
has
been
linked
to
adverse
reactions
involving
all
organ
systems,
such
as
hypersensitivity
syndrome,
methemoglobinemia
and
hemolytic
anemia,
besides
neuroinflammation
neurodegeneration
due
iron
accumulation
oxidative
stress.
These
effects
probably
occur
the
presence
of
its
toxic
metabolite
DDS-NOH,
which
can
generate
reactive
oxygen
species
(ROS)
overload.
In
this
sense,
antioxidant
compounds
chelating
properties,
alpha-lipoic
acid
(ALA),
may
be
an
interesting
adjuvant
therapy
strategy
in
treating
or
preventing
these
effects.
Thus,
aim
study
was
evaluate
ALA
on
neuroinflammatory
changes
caused
by
DDS
prefrontal
cortex
hippocampus
mice.
Materials
Methods:Mus
musculus
male
mice
that
were
pre-treated
(40
mg/kg)
post-treated
(25
underwent
analyses
for
stress,
capacity,
cytokine
expression
microglial/astrocytic
activity.
Results:
did
not
activate
macrophages/microglia
astrocytes
but
induced
their
activation
hippocampus.
stimulated
a
protective
microglial
profile
reduced
astrocyte
reactivity,
especially
increased
pro-inflammatory
IL-1β
brain-derived
neurotrophic
factor
(BDNF),
reversed
ALA.
also
capacity
(TEAC,
GSH,
SOD,
CAT)
damage
(lipid
peroxidation,
accumulation),
while
restored
levels
Conclusions:
able
reduce
DDS,
reducing
astrocytic
activation,
well
decrease
cytokines
increase
BDNF,
addition
increasing
accumulation.
Therefore,
is
considered
useful
promising
therapeutic
alternative
diseases
related
stress
neuroinflammation.
Cellular and Molecular Life Sciences,
Год журнала:
2023,
Номер
80(7)
Опубликована: Июнь 24, 2023
Abstract
Ageing
is
characterized
by
the
progressive
loss
of
cellular
homeostasis,
leading
to
an
overall
decline
organism’s
fitness.
In
brain,
ageing
highly
associated
with
cognitive
and
neurodegenerative
diseases.
With
rise
in
life
expectancy,
characterizing
brain
process
becomes
fundamental
for
developing
therapeutic
interventions
against
increased
incidence
age-related
diseases
aim
increase
human
span
and,
more
importantly,
health
span.
this
review,
we
start
introducing
molecular/cellular
hallmarks
their
impact
on
cell
populations.
Subsequently,
assess
emerging
evidence
how
systemic
translates
into
ageing.
Finally,
revisit
mainstream
novel
rejuvenating
strategies,
discussing
most
successful
ones
delaying
related
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1462 - 1462
Опубликована: Ноя. 28, 2024
Upregulation
of
reactive
oxygen
species
(ROS)
levels
is
a
principal
feature
observed
in
the
brains
neurodegenerative
diseases
such
as
Parkinson’s
disease
(PD)
and
Alzheimer’s
(AD).
In
these
diseases,
oxidative
stress
can
disrupt
blood–brain
barrier
(BBB).
This
disruption
allows
neurotoxic
plasma
components,
blood
cells,
pathogens
to
enter
brain,
leading
increased
ROS
production,
mitochondrial
dysfunction,
inflammation.
Collectively,
factors
result
protein
modification,
lipid
peroxidation,
DNA
damage,
and,
ultimately,
neural
cell
damage.
this
review
article,
we
present
mechanisms
by
which
damage
leads
BBB
breakdown
brain
diseases.
Additionally,
summarize
potential
therapeutic
approaches
aimed
at
reducing
that
contributes
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Апрель 3, 2024
Oxidative
stress
is
caused
by
an
imbalance
between
the
production
of
reactive
oxygen
species
(ROS)
and
body’s
ability
to
counteract
their
harmful
effects,
playing
a
key
role
in
pathogenesis
brain
lung-related
diseases.
This
review
comprehensively
examines
intricate
mechanisms
which
oxidative
influences
cellular
molecular
pathways,
contributing
neurodegenerative,
cardiovascular,
respiratory
disorders.
Emphasizing
detrimental
effects
on
both
lung
health,
we
discuss
innovative
diagnostic
biomarkers,
such
as
8-hydroxy-2′-deoxyguanosine
(8-OHdG),
potential
antioxidant
therapies.
For
these
topics,
provide
insights
into
future
research
directions
field
treatment,
including
development
personalized
treatment
approaches,
discovery
validation
novel
new
drug
delivery
systems.
not
only
provides
perspective
understanding
diseases
but
also
offers
for
clinical
treatments.
