Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 419 - 443
Опубликована: Сен. 13, 2024
Язык: Английский
Cancers, Год журнала: 2022, Номер 14(4), С. 885 - 885
Опубликована: Фев. 10, 2022
The plant Cannabis sativa has been in use medicinally for several thousand years. It over 540 metabolites thought to be responsible its therapeutic effects. Two of the key phytocannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC). Unlike THC, CBD does not have potentially intoxicating Preclinical clinical research indicates that a wide range effects, many them relevant management cancer. In this article, we explore some potential mechanisms action cancer, evidence efficacy integrative cancer including side effects associated with treatment, demonstrating integration orthodox care.
Язык: Английский
Процитировано
49
Pharmaceuticals, Год журнала: 2023, Номер 16(2), С. 148 - 148
Опубликована: Янв. 19, 2023
The endocannabinoid system (eCB) has been studied to identify the molecular structures present in Cannabis sativa. eCB consists of cannabinoid receptors, endogenous ligands, and associated enzymatic apparatus responsible for maintaining energy homeostasis cognitive processes. Several physiological effects cannabinoids are exerted through interactions with various such as CB1 CB2 vanilloid recently discovered G-protein-coupled receptors (GPR55, GPR3, GPR6, GPR12, GPR19). Anandamide (AEA) 2-arachidoylglycerol (2-AG), two small lipids derived from arachidonic acid, showed high-affinity binding both receptors. plays a critical role chronic pain mood disorders extensively because its wide therapeutic potential it is promising target development new drugs. Phytocannabinoids synthetic have shown varied affinities relevant treatment several neurological diseases. This review provides description components discusses how phytocannabinoids other exogenous compounds may regulate balance. Furthermore, we show hypo- or hyperfunctionality body related disorders, even integrative complementary health practices (ICHP) harmonizing eCB.
Язык: Английский
Процитировано
39
Experimental and Clinical Medicine, Год журнала: 2024, Номер unknown, С. 87 - 93
Опубликована: Янв. 1, 2024
One of the ways to solve problem pain relief for palliative patients in Ukraine is expand arsenal painkillers through use medical cannabis. In many diseases, cannabis able alleviate other symptoms that accompany with incurable diseases at end their lives: nausea, lack appetite, seizures, anxiety, depression. The procedure legalization coming an end, which a timely decision legislators and government. Before full-scale war, 2.3 million were needed. Since its inception, this need has increased 5.5–6 million. Ukrainian agricultural market pharmaceutical industry will eventually be not only provide country necessary amount plant raw materials production medicines products, but also earn profits from exports, providing part growing demand Europe countries world. But require good conditions investors consistent state policy adoption by-laws practical implementation already adopted laws. effects herbal preparations containing it depend on content narcotic TetraHydroCannabiol (THC) non-narcotic CanaBiDiol (CBD). Consumer preferences recreational are gradually flooding high-THC, low-CBD cannabis, increases risk faster addiction, frequency severity side such as psychotic disorders cardiovascular crises. needs prepared increase illicit along including among children adolescents, counter these phenomena. even despite risks, significant positive social consequences can expected war victims post-traumatic stress disorders. Keywords: chronic pain, hospices, painkillers, PTSD.
Язык: Английский
Процитировано
6
Lipids in Health and Disease, Год журнала: 2022, Номер 21(1)
Опубликована: Янв. 13, 2022
Abstract The discovery of the endocannabinoidome (eCBome) is evolving gradually with yet to be elucidated functional lipid mediators and receptors. diet modulates these bioactive lipids gut microbiome, both working in an entwined alliance. Mounting evidence suggests that, different ways a certain specialisation, signalling such as N -acylethanolamines (NAEs), 2-monoacylglycerols (2-MAGs), -acyl-amino acids (NAAs), along endocannabinoids (eCBs), can modulate physiological mechanisms underpinning appetite, food intake, macronutrient metabolism, pain sensation, blood pressure, mood, cognition, immunity. This knowledge has been primarily utilised pharmacology medicine develop many drugs targeting fine specific molecular pathways orchestrating eCB eCBome activity. Conversely, contribution dietary NAEs, 2-MAGs eCBs biological functions molecules little studied. In this review, we discuss importance (Wh) olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N) utrition (WHEN), management obesity related disorders.
Язык: Английский
Процитировано
24
Frontiers in Cellular Neuroscience, Год журнала: 2022, Номер 16
Опубликована: Май 30, 2022
Historically, Cannabis is one of the first plants to be domesticated and used in medicine, though only last years amount Cannabis-based products or medicines has increased worldwide. Previous preclinical studies few published clinical trials have demonstrated efficacy safety humans. Indeed, Cannabis-related are treat multiple pathological conditions, including neurodegenerative disorders. In practice, already been introduced treatment regimens Alzheimer’s disease, Parkinson’s disease Multiple Sclerosis’s patients, mechanisms action behind reported improvement outcome progression associated with their anti-inflammatory, immunosuppressive, antioxidant, neuroprotective properties, due modulation endocannabinoid system. this review, we describe role played by system physiopathology Alzheimer, Parkinson, Sclerosis, mainly at neuroimmunological level. We also discuss evidence for correlation between phytocannabinoids therapeutic effects these disorders, thus describing main carried out so far on performance medicines.
Язык: Английский
Процитировано
20
Advances in Nutrition, Год журнала: 2024, Номер 15(4), С. 100196 - 100196
Опубликована: Март 1, 2024
Cannabis use has increased sharply in the last 20 years among adults, including reproductive-aged women. Its recent widespread legalization is associated with a decrease risk perception of cannabis during breastfeeding. However, effect (if any) on milk production and composition not known. This narrative review summarizes current knowledge related to maternal breastfeeding provides an overview possible pathways whereby might affect production. Several studies have demonstrated that cannabinoids their metabolites are detectable human produced by mothers who cannabis. Due physicochemical properties, stored adipose tissue, can easily reach mammary gland, be secreted milk. Moreover, cannabinoid receptors present adipocytes epithelial cells. The activation these directly modulates fatty acid metabolism, potentially causing changes profiles. Additionally, endocannabinoid system (ECS) intimately connected endocrine system. As such, it probable interactions exogenous ECS modify release critical hormones (e.g., prolactin dopamine) regulate secretion. Nonetheless, few investigated effects (including composition) lactating Additional research utilizing robust methodologies needed elucidate whether how affects composition. To our knowledge, no focused potential evidence provided herein supports possibility that, through several well documented pathways, alter lipid metabolism as Considering increase women, this highlights need for designed, address question.
Язык: Английский
Процитировано
4
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111278 - 111278
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Muscle & Nerve, Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
ABSTRACT A unifying mechanistic cause for amyotrophic lateral sclerosis (ALS) remains uncertain. Multiple pathophysiological processes appear to occur simultaneously. Cannabinoids, including delta‐9‐tetrahydrocannabinol (THC), cannabidiol (CBD), cannabigerol (CBG), and others found in cannabis, cannabis extracts (CEs), have activity these pathogenic pathways, which led increasing interest cannabinoids as therapeutic agents ALS. The use of a treatment strategy is substantiated by preclinical evidence suggesting role the endocannabinoid system (ECS) ALS other neurodegenerative disorders. Preclinical data indicate that CEs powerful antioxidative, anti‐inflammatory, neuroprotective effects SOD1 G93A mouse model murine models has been shown prolong neuronal cell survival, leads delayed onset disease state, slows progression disease. Although research humans limited, few studies suggest CBD, humans, provide benefits both motor symptoms, rigidity, cramps, fasciculations, non‐motor symptoms sleep quality, pain, emotional quality life, depression. There need further, well‐designed clinical trials validate further an individual cannabinoid, or combination cannabinoids, disease‐modifying therapy
Язык: Английский
Процитировано
0
The Annual Review of Pharmacology and Toxicology, Год журнала: 2022, Номер 63(1), С. 1 - 13
Опубликована: Июль 18, 2022
After a traumatic childhood in Europe during the Second World War, I found that scientific research Israel was pleasure beyond my expectations. Over last 65 year, have worked on chemistry and pharmacology of natural products. During few decades, most has been plant cannabinoids, endogenous cannabinoids arachidonoyl ethanolamide (anandamide) 2-arachidonoyl glycerol, anandamide-like compounds, all which are involved wide spectrum physiological reactions. Two Δ9-tetrahydrocannabinol cannabidiol, approved drugs. However, constituents not yet well investigated humans. For me, intellectual freedom-the ability to do based own interests-has satisfying part working life. Looking back over 91 years long life, conclude lucky, very both personally scientifically.
Язык: Английский
Процитировано
13
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Март 3, 2023
Objective: Over the last decade, researchers have sought to develop novel medications against dementia. One potential agent under investigation is cannabinoids. This review systematically appraised and meta-analyzed published pre-clinical research on mechanism of endocannabinoid system modulation in glial cells their effects cognitive function animal models Alzheimer's disease (AD). Methods: A systematic complying with PRISMA guidelines was conducted. Six databases were searched: EBSCOHost, Scopus, PubMed, CINAHL, Cochrane, Web Science, using keywords AD, cannabinoid, cells, cognition. The methodological quality each selected study evaluated SYRCLE risk bias tool. random-effects model applied analyze data calculate effect size, while I2 p-values used assess heterogeneity. Results: analysis included 26 original articles describing (1050 rodents) AD-like symptoms. Rodents treated cannabinoid agonists showed significant reductions escape latency (standard mean difference [SMD] = -1.26; 95% confidence interval [CI]: -1.77 -0.76, p < 0.00001) ability discriminate objects (SMD 1.40; CI: 1.04 1.76, compared control group. Furthermore, a decrease Aβ plaques -0.91; -1.55 -0.27, 0.006) observed endocannabinoid-treated group Trends toward neuroprotection, as represented by decreased levels cell markers including fibrillary acid protein -1.47; -2.56 -0.38, 0.008) Iba1 -1.67; -0.79, 0.0002). Studies wild-type mice demonstrated significantly pro-inflammatory TNF-α, IL-1, IL-6 -2.28; -3.15 -1.41, 0.00001). Despite non-significant marker transgenic -0.47; -1.03 0.08, 0.09), result favored over Conclusion: revised suggested that stimulation promotes via decreasing rodent models. Thus, agents may be required modulate downstream chain enhance stability concurrent neuroinflammation AD. Population-based studies well-designed clinical trials are characterize acceptability real-world effectiveness agents. Systematic Review Registration: [https://inplasy.com/inplasy-2022-8-0094/], identifier [Inplasy Protocol 3770].
Язык: Английский
Процитировано
7