The immunomodulatory mechanisms for acupuncture practice

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Апрель 6, 2023

The system physiology approaches that emerge in western countries recent years echo the holistic view of ancient Traditional Chinese Medicine (TCM) practices deal with root, rather than only symptoms diseases. Particularly, TCM practices, including acupuncture, emphasize mobilization self-healing mechanisms to bring back body homeostasis. Acupuncture has been practiced for over two thousand modulate via stimulation at specific regions (acupoints). With development various research on acupuncture therapy, its regulatory effect immune gradually recognized, especially immunological diseases, infectious and allergic In this study, we reviewed immunomodulatory mechanism systematically integrates existing respectively elucidate modulatory innate system, adaptive well-known neuroanatomical mechanisms, intact somatosensory-autonomic reflex pathway. advances made systems studies, now have a great opportunity gain insight into how modulates immunity, subsequently improves efficacy.

Язык: Английский

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Effects of TCM on polycystic ovary syndrome and its cellular endocrine mechanism

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Май 16, 2023

Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease characterized by menstrual disorders, infertility, and obesity, often accompanied insulin resistance metabolic disorders. The pathogenesis of PCOS relatively complex has certain relationship with increase androgen luteinizing hormone (LH) the main cause series symptoms. Traditional Chinese medicine (TCM) obvious advantages significant curative effects in treatment this disease. It can effectively reduce level patients, regulate lipid metabolism, ovulation rate pregnancy fewer side effects. This article reviews efficacy safety herbs other TCM (such as acupuncture) its complications recent years, well effect mechanism on cellular endocrine, order to provide new clinical idea for PCOS.

Язык: Английский

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Objectivization study of acupuncture Deqi and brain modulation mechanisms: a review

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Май 3, 2024

Deqi is an important prerequisite for acupuncture to achieve optimal efficacy. Chinese medicine has long been concerned with the relationship between and clinical efficacy of acupuncture. However, underlying mechanisms are complex there a lack systematic summaries objective quantitative studies . Acupuncture can purpose treating diseases by regulating interaction local neighboring acupoints, brain centers, target organs. At change their tissue structure, temperature, blood perfusion, energy metabolism, electrophysiological indicators. central level, activate regions thalamus, parahippocampal gyrus, postcentral insular, middle temporal cingulate etc. It also extensive effects on limbic-paralimbic-neocortical-network default mode network. The vary depending techniques points chosen. In addition, 's mechanism action involves correcting abnormalities in multi-targeted multi-layered. biological closely related centers. This study will help explore from local-central-target-organ perspective provide information future decision-making.

Язык: Английский

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Acupuncture modulates emotional network resting-state functional connectivity in patients with insomnia disorder: a randomized controlled trial and fMRI study

BMC Complementary Medicine and Therapies, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 21, 2024

Insomnia disorder (ID) is one of the most common sleep problems, usually accompanied by anxiety and depression symptoms. Functional magnetic resonance imaging (fMRI) study suggests that both poor quality negative emotion are linked to dysregulation brain network related processing in ID patients. Acupuncture therapy has been proven effective improving mood patients, but involved neurobiological mechanism remains unclear. We aimed investigate modulation effect acupuncture on resting-state functional connectivity (rsFC) emotional (EN) patients experiencing insomnia. A total 30 healthy controls (HCs) 60 were enrolled this study. Sixty randomly assigned real sham groups attended fMRI scans before after 4 weeks treatment. HCs completed an MRI/fMRI scan at baseline. The rsFC values within EN calculated, Hamilton Anxiety Scale (HAMA), Depression (HAMD), Pittsburgh Sleep Quality Index (PSQI), Hyperarousal (HAS), actigraphy data collected for clinical efficacy evaluation. Resting-state FC analysis showed abnormalities centered thalamus dorsolateral prefrontal cortex compared HCs. After treatment, anterior cingulate cortex, hippocampus, amygdala increased with group (p < 0.05, FDR corrected). In group, value was decreased between left treatment trend correlation found right hippocampus positively correlated HAMA scores across all negatively efficiency group. Our findings could produce a positive modulating which may illustrate central underlying insomnia regulation. http://www.chictr.org.cn ., ChiCTR1800015282, 20/03/2018.

Язык: Английский

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Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons‐Vagus‐Macrophage Axis in 70% Partial Hepatectomy of Mice

Advanced Science, Год журнала: 2024, Номер 11(32)

Опубликована: Июнь 25, 2024

Abstract Lack of liver regenerative capacity is the primary cause hepatic failure and even mortality in patients undergoing hepatectomy, with no effective intervention strategies currently available. Therefore, identifying efficacious interventions to enhance regeneration pivotal for optimizing clinical outcomes. Recent studies have demonstrated that vagotomy exerts an inhibitory effect on following partial thereby substantiating role played by vagus nerve process regeneration. In recent years, electroacupuncture (EA) has emerged as a non‐invasive technique stimulating nerve. However, EA remains uncertain. this study, 70% hepatectomy (PH) mouse model utilized investigate effects acute elucidate its underlying molecular mechanisms. It observed at ST36 acutely activated cholinergic neurons dorsal motor nucleus (DMV), resulting increased release acetylcholine from vagal endings subsequent activation IL‐6 signaling macrophages. Ultimately, these events promoted hepatocyte proliferation facilitated These findings provide insights into fundamental brain‐liver axis mechanism through which promotes regeneration, offering novel therapeutic approach post‐hepatectomy disorders.

Язык: Английский

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Advances in acupuncture treatment for tinnitus

American Journal of Otolaryngology, Год журнала: 2024, Номер 45(3), С. 104215 - 104215

Опубликована: Янв. 5, 2024

Tinnitus is the abnormal perception of sound in absence a corresponding external acoustic stimulus, which seriously affects patients' quality life, physical and mental health, safety life. There almost no effective cure for tinnitus, primarily due to its complicated etiopathogenesis unclear mechanisms. As major ancient therapy Traditional Chinese Medicine, acupuncture has been widely used tinnitus because simple operation, rapid effect, low cost. This paper reviews relevant literature on treatment different kinds by acupuncture, summarizes therapeutic efficacy mechanism expected provide new ideas research directions study acupuncture.

Язык: Английский

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Comparative efficacy of seven nonpharmacological interventions on global cognition in older adults with and without mild cognitive impairment: a network meta-analysis of randomized controlled trials

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 10, 2024

Abstract To maintain current cognitive function and access greater reserves, nonpharmacological interventions may be a viable alternative for older adults with or without impairment. This study aimed to compare different enhancing global cognition, including mind–body exercise, physical non-invasive brain stimulation, training intervention (CTI), acutherapy (ACU), meditation, music therapy, by applying network meta-analysis (NMA). Sixty-one randomized controlled trials evaluating the efficacy of on cognition in mild decline were selected. An NMA was conducted interventions. The revealed that exercise (standardized mean difference, 1.384; 95% confidence interval, 0.777–1.992); ACU (1.283; 0.478–2.088); meditation (0.910; 0.097–1.724); stimulation (1.242; 0.254–2.230); CTI (1.269; 0.736–1.802); (0.977; 0.212–1.742), showed positive effects compared passive controls. There no significant differences between efficacies other Nonpharmacological potentially enhance through various pathways, such as memorizing movements plasticity reducing stress adult population. Additional studies are needed clarify impact variables, methods psychological variables.

Язык: Английский

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Acupuncture in Traditional Chinese Medicine: A Complementary Approach for Cardiovascular Health

Journal of Multidisciplinary Healthcare, Год журнала: 2024, Номер Volume 17, С. 3459 - 3473

Опубликована: Июль 1, 2024

Abstract: Cardiovascular diseases (CVDs) are increasingly prevalent in clinical settings. With the continuous improvement of people's living standards, gradual acceleration pace life, and deterioration environment recent years, incidence CVDs is increasing annually. The prevalence among individuals aged 50 above notably elevated, posing a significant risk to patients' well-being lives. At this juncture, numerous treatment choices available for managing CVDs, with traditional Chinese medicine (TCM) therapy standing out as practical, safe, reliable option. Over there has been growing acknowledgement both medical professionals patients. expanding integration TCM various conditions, use gained attention within community, potentially emerging an efficacious approach addressing cardiovascular diseases. This article conducts comprehensive review approach, particularly acupuncture, supplementary highlighting its ability effectively lower blood pressure, decrease coronary artery events, mitigate arrhythmias, enhance cardiac function when used alongside conventional medication. underscores promise acupuncture enhancing health, although variations research methodologies necessitate standardized applications. Keywords: diseases, medicine,

Язык: Английский

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Electroacupuncture Relieves Neuropathic Pain via Adenosine 3 Receptor Activation in the Spinal Cord Dorsal Horn of Mice

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10242 - 10242

Опубликована: Сен. 24, 2024

Neuropathic pain (NPP) is a devastating and unbearable painful condition. As prevailing treatment strategies have failed to mitigate its complications, there remains demand for effective therapies. Electroacupuncture (EA) has proved potent remedial strategy in NPP management humans mammals. However, past studies investigated the underlying mechanism of analgesic effects EA on NPP, focusing primarily adenosine receptors peripheral tissues. Herein, we elucidate role (Adora-3) signaling pathway mediating relief through central nervous system, which obscure literature needs exploration. Specific pathogen-free (SPF) male adult mice (C57BL/6 J) were utilized investigate effect metabolism (CD73, ADA) receptor activation (Adora-3), as potential mechanisms system. was induced via spared nerve injury (SNI). administered seven times post-SNI surgery, lumber (L4–L6) spinal cord collected determine molecular expression mRNA protein levels. In mice, following application, results revealed that upregulated (p < 0.05) Adora-3 CD73 by inhibiting ADA expression. addition, triggered release (ADO), modulated nociceptive responses enhanced neuronal activation. Meanwhile, interplay between ADO levels EA-induced antinociception, using an agonist antagonist, showed IB-MECA significantly increased thresholds contrast, antagonist MRS1523 exacerbated neuropathic pain. Furthermore, inferred when administered, fluorescent intensity cord. Taken together, effectively modulates regulating under conditions. These findings enhance our understanding offer avenues innovative therapeutic interventions.

Язык: Английский

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Does perioperative electroacupuncture reduce postoperative pain in dogs undergoing ovariohysterectomy?

Frontiers in Veterinary Science, Год журнала: 2025, Номер 11

Опубликована: Янв. 7, 2025

This study aimed to investigate the analgesic efficacy of perioperative electroacupuncture in fifty-six healthy female dogs undergoing ovariohysterectomy as part a catch-neuter-release project. Ten minutes after sedation with 20 μg/kg medetomidine combined 0.3 mg/kg butorphanol intramuscularly, were randomly allocated into two groups and received either (EA, n = 27) or sham acupuncture (C, 29) treatment for 10 min (after until end surgery) at 6 different points LI-4 (Large intestine 4), LIV-3 (Liver 3), ST-36 (Stomach 36), SP-6 (Spleen 6) bilateral. After administration 0.2 meloxicam anesthesia induction 2 ketamine intravenously, was performed by same experienced surgeon using midline surgical approach dorsal recumbency. Pain evaluated blinded independent anesthetists Short Form Multimodal Glasgow Composite Scale (mCMPS-SF) before (T0), three (T3), six (T6), 24 h (T24) induction. Postoperative pain scores did not differ significantly between (p 0.36), but increased (T3) 0.001) (T6) hours surgery compared postoperative both groups. Three 89.4% postoperatively 71.4% exceeded intervention threshold mCMPS-SF, indicating need rescue analgesia. The results indicate that improve ovariohysterectomy. Therefore, 10-min may be insufficient provide effective assessment feral notably impacted anxious behavior, which have influenced final outcome ¾ early phase (T3, T6), suggesting widely used protocol consisting butorphanol, combination long-lasting sufficient relief.

Язык: Английский

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