Advances in neurobiology, Год журнала: 2024, Номер unknown, С. 163 - 193
Опубликована: Янв. 1, 2024
Язык: Английский
Frontiers in Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Июнь 11, 2024
Hippocampal neurogenesis is critical for improving learning, memory, and spatial navigation. Inhabiting navigating complexity key to stimulating adult hippocampal (AHN) in rodents because they share similar neuroplasticity characteristics with humans. AHN humans has recently been found persist until the tenth decade of life, but it declines aging influenced by environmental enrichment. This systematic review investigated impact on plasticity rodents, discussed translatability these findings human interventions.
Язык: Английский
Процитировано
12
Molecular Psychiatry, Год журнала: 2024, Номер 29(8), С. 2527 - 2542
Опубликована: Март 18, 2024
In most mammals, new neurons are not only produced during embryogenesis but also after birth. Soon adult neurogenesis was discovered, the influence of recruiting on cognitive functions, especially memory, documented. Likewise, late process neuronal production contributes to affective this outcome recognized with more difficulty. This review covers hypes and hopes discovering newly-generated brain circuits devoted functions. If possibility integrating into is a commonly accepted faculty in realm reluctance strong when it comes translating concept humans. Compiling data suggest now that derived from stem cells, population neuroblasts displaying protracted maturation ready be engaged circuits, under specific signals. Here, we discuss significance specifically context outcomes. We fact could ultimate cellular integrates elements both internal external environment adjust While must critical beware unreal promises Science generate sometimes, important continue exploring potential neural recruitment primates. Reporting humankind vision humans as mammals whose continues develop throughout life. peculiar one day become target treatment for mental health, disorders, elderly-associated diseases. The an which never stops real game changer designing therapeutic interventions treat disorders associated substantial morbidity, mortality, social costs.
Язык: Английский
Процитировано
11
The Neuroscientist, Год журнала: 2024, Номер unknown
Опубликована: Май 17, 2024
The existence of neurogenesis in the adult human hippocampus has been under considerable debate within past three decades due to diverging conclusions originating mostly from immunohistochemistry studies. While some these reports conclude that hippocampal humans occurs throughout physiologic aging, others indicate this phenomenon ends by early childhood. More recently, groups have adopted next-generation sequencing technologies characterize with more acuity extent humans. Here, we review current state research on brain an emphasis challenges and limitations using for its study.
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3543 - 3543
Опубликована: Фев. 10, 2023
The brain-derived neurotrophic factor (BDNF) is an extensively studied neurotrophin es sential for both developing the brain and maintaining adult function. In hippocampus, BDNF critical neurogenesis. Adult hippocampal neurogenesis involved not only in memory formation learning ability, but also mood regulation stress responses. Accordingly, decreased levels of BDNF, accompanied by low neurogenesis, occurs brains older adults with impaired cognitive function those patients major depression disorder. Therefore, elucidating mechanisms that maintain biologically clinically important. It has been revealed signalling from peripheral tissues contribute to expression across blood-brain barrier. Moreover, recent studies indicated evidence neuronal pathways can be a mechanism which signal expression. this review, we give overview current status central signalling, special interest signals via vagus nerve. Finally, discuss relationship between age-associated control
Язык: Английский
Процитировано
16
Hippocampus, Год журнала: 2023, Номер 33(4), С. 373 - 390
Опубликована: Март 9, 2023
Abstract Adult hippocampal neurogenesis is important for preserving learning and memory‐related cognitive functions. Physical exercise, especially voluntary running, one of the strongest stimuli to promote has beneficial effects on Voluntary running promotes exit neural stem cells (NSCs) from quiescent stage, proliferation NSCs progenitors, survival newborn cells, morphological development immature neuron, integration new neurons into circuitry. However, detailed mechanisms driving these changes remain unclear. In this review, we will summarize current knowledge with respect molecular underlying running‐induced neurogenesis, highlighting recent genome‐wide gene expression analyses. addition, discuss approaches future directions dissecting complex cellular change in adult‐born response physical exercise.
Язык: Английский
Процитировано
16
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12924 - 12924
Опубликована: Дек. 1, 2024
This paper bridges critical gaps through proposing a novel, environmentally mediated brain-derived neurotrophic factor (BDNF)-interactive model that promises to sustain adult hippocampal neurogenesis in humans. It explains how three environmental enrichment mechanisms (physical activity, cognitive stimulation, and mindfulness) can integratively regulate BDNF other growth factors neurotransmitters support at various stages, those be promoted by the physical environment. The approach enables isolation of specific their molecular effects promote sustainable regulation testing environment's ability increase immediately or shortly before it is consumed for muscle repair brain update. offers feasible method research environment dynamics real-world human contexts immediate level, overcoming confounds complex settings challenges long-term exposure structural plasticity changes. advance understanding influences on hippocampus enhance health cognition. work fundamental methodology knowledge facilitate more enrichment-neuroplasticity interplay humans without methodological limitations.
Язык: Английский
Процитировано
6
Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 149, С. 105147 - 105147
Опубликована: Март 27, 2023
Язык: Английский
Процитировано
13
Life Sciences, Год журнала: 2024, Номер 350, С. 122750 - 122750
Опубликована: Май 25, 2024
C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase family, are significantly linked with neurological and neurodegenerative pathologies cancer progression. However, JNKs serve key roles under physiological conditions, particularly within central-nervous-system (CNS), where they critical in governing neural proliferation differentiation during both embryogenesis adult stages. These processes control development CNS, avoiding neurodevelopment disorders. JNK to maintain proper activity neural-stem-cells (NSC) neural-progenitors (NPC) that exist adults, which keep convenient brain plasticity homeostasis. This review underscores how interaction upstream downstream molecules acts as a regulatory mechanism manage self-renewal capacity NSC/NPC CNS neurogenic niches. Evidence suggests is reliant on non-canonical Wnt components, Fbw7-ubiquitin-ligase, WDR62-scaffold-protein, regulating substrates such transcription factors cytoskeletal proteins. Therefore, understanding pathways interact will bring knowledge activation orchestrates neuronal occur
Язык: Английский
Процитировано
5
Pharmacology & Therapeutics, Год журнала: 2025, Номер unknown, С. 108831 - 108831
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7122 - 7122
Опубликована: Июнь 28, 2024
The notion of notable anatomical, biochemical, and behavioral distinctions within male female brains has been a contentious topic interest the scientific community over several decades. Advancements in neuroimaging molecular biological techniques have increasingly elucidated common mechanisms characterizing brain aging while also revealing disparities between sexes these processes. Variations cognitive functions; susceptibility to progression neurodegenerative conditions, notably Alzheimer’s Parkinson’s diseases; life expectancy sexes, underscore significance evaluating framework gender differences. This comprehensive review surveys contemporary literature on restructuring structures fundamental processes unfolding at cellular levels, with focus distinctions. Additionally, delves into age-related alterations, exploring factors influencing acceleration or deceleration aging, particular attention estrogen’s hormonal support central nervous system.
Язык: Английский
Процитировано
4