International review of neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(6), С. 789 - 789
Опубликована: Март 10, 2024
Recent research exploring the relationship between gut and brain suggests that condition of microbiota can influence cognitive health. A well-balanced may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, symbiotics are nutritional supplements functional food components associated with gastrointestinal well-being. The bidirectional communication gut–brain axis essential for maintaining homeostasis, pre-, pro-, potentially affecting various functions such as attention, perception, memory. Numerous studies have consistently shown incorporating into a healthy diet lead improvements in mood. Maintaining support optimal function, crucial disease prevention our fast-paced, Westernized society. Our results indicate benefits older individuals probiotic supplementation but not who good adequate levels physical activity. Additionally, it appears there patients mild impairment Alzheimer’s disease, while mixed seem arise younger healthier individuals. However, important acknowledge individual responses vary, use these dietary should be tailored each individual’s unique health circumstances needs.
Язык: Английский
Процитировано
22
ACS Chemical Neuroscience, Год журнала: 2023, Номер 14(6), С. 1045 - 1062
Опубликована: Март 3, 2023
The gut-brain axis (GBA) is the umbrella term to include all bidirectional communication between brain and gastrointestinal (GI) tract in mammalian body. Evidence from over two centuries describes a significant role of GI microbiome health disease states host organism. Short-chain fatty acids (SCFAs), mainly acetate, butyrate, propionate that are physiological forms acetic acid, butyric propionic acid respectively, bacteria derived metabolites. SCFAs have been reported influence cellular function multiple neurodegenerative diseases (NDDs). In addition, inflammation modulating properties make them suitable therapeutic candidates neuroinflammatory conditions. This review provides historical background GBA current knowledge individual central nervous system (CNS) disorders. Recently, few reports also identified effects metabolites case viral infections. Among these viruses, flaviviridae family associated with neuroinflammation deterioration CNS functions. this context, we additionally introduce SCFA based mechanisms different pathogenesis understand former's potential as agents against flaviviral disease.
Язык: Английский
Процитировано
33
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Фев. 12, 2024
Background Intermittent fasting (IF) has gained popularity in interventions targeting overweight, obesity and metabolic syndrome. IF may affect the gut microbiome composition therefore have various effects on mediated functions humans. Research of human is limited. Therefore, objective this systematic review was to determine how different types microbiome. Methods A literature search conducted for studies investigating association microbiota richness, alpha beta diversity, subjects. Databases included Cochrane Library (RRID:SCR_013000), PubMed (RRID:SCR_004846), Scopus (RRID:SCR_022559) Web Science (RRID:SCR_022706). total 1,332 were retrieved, which 940 remained after removing duplicates. Ultimately, a 8 review. The randomized controlled trials, quasi-experimental pilot implementing an intervention (time-restricted eating, alternate day or 5:2 diet) healthy subjects with any disease. Results Most found between diversity compositional changes. There heterogeneity results, bacteria be statistically significantly affected by varied widely depending study. Conclusion findings suggest that influences microbiota. It seems possible can improve richness diversity. Due substantial more research required validate these clarify whether changes might beneficial health. Systematic Review Registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42021241619.
Язык: Английский
Процитировано
11
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Апрель 19, 2024
All microorganisms like bacteria, viruses and fungi that reside within a host environment are considered microbiome. The number of bacteria almost equal human cells, however, the genome these may be 100 times larger than genome. Every aspect physiology health can influenced by microbiome living in various parts our body. Any imbalance composition or function is seen as dysbiosis. Different types dysbiosis corresponding symptoms depend on site microbial imbalance. contribution intestinal extra-intestinal microbiota to influence systemic activities through interplay between different axes. Whole body complex process involving gut non-gut related It still at stage infancy has not yet been fully understood. Dysbiosis genetic factors, lifestyle habits, diet including ultra-processed foods food additives, well medications. associated with many diseases cannot diagnosed standard blood tests investigations. Microbiota derived metabolites analyzed useful management addressed altering proper modulation. effect interventions humans depends beneficial alteration mostly based animal studies evolving evidence from studies. There tremendous potential for diagnosis, treatment, prognosis diseases, as, monitoring disease humans. system-based approach diagnosis better pure taxonomic approach. could new therapeutic target conditions.
Язык: Английский
Процитировано
11
Carbohydrate Polymers, Год журнала: 2025, Номер 353, С. 123271 - 123271
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
1
Aquaculture Reports, Год журнала: 2025, Номер 40, С. 102651 - 102651
Опубликована: Янв. 25, 2025
Язык: Английский
Процитировано
1
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Март 1, 2024
Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous disorder with elusive causes, but most likely because of clinical and other biological factors. As vital environmental factor, the gut microbiome increasingly emphasized in various refractory diseases including ME/CFS. The present study aimed to enhance our understanding relationship between ME/CFS through data analysis studies. We conducted literature search four databases (PubMed, Cochrane Library, Web Science, Google Scholar) until May 31, 2023. Our encompassed 11 studies 553 patients 480 healthy controls. A comparative meta revealed significant decrease α-diversity noticeable change β-diversity compared notable ratio Firmicutes Bacteroides was 2.3 times decreased, also, there reduction production microbial metabolites such as acetate, butyrate, isobutyrate, some amino acids (alanine, serine, hypoxanthine) observed patients. lack comparison under similar conditions standardized analytical methods has impeded optimal calculation results This review provides comprehensive overview recent advancements role Additionally, we have also discussed potentials using microbiome-related interventions associated challenges alleviate
Язык: Английский
Процитировано
7
Psychiatry Research, Год журнала: 2024, Номер 336, С. 115914 - 115914
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
7
The Science of The Total Environment, Год журнала: 2024, Номер 916, С. 170060 - 170060
Опубликована: Янв. 19, 2024
Язык: Английский
Процитировано
6
Experimental Gerontology, Год журнала: 2023, Номер 176, С. 112164 - 112164
Опубликована: Апрель 7, 2023
Due to the increasing human life expectancy and limited supply of healthcare resources, strategies promote healthy aging reduce associated functional deficits are public health importance. The gut microbiota, which remodels with age, has been identified as a significant contributor process that is modifiable by diet. Since prebiotic dietary components such inulin have shown impart positive benefits regards aging, this study used C57Bl6 mice investigate whether 8 weeks on 2.5 % enhanced AIN-93M 1 cellulose diet could offset age-associated changes in microbiome composition markers colon systemic inflammation comparison AIN 93M 0 inulin. Our results demonstrated that, both age groups, significantly increased production butyrate cecum induced community structure but did not affect or other gastrointestinal health. Aged had different less diverse microbiomes when compared adult were sensitive inulin-induced shifts, evidenced longitudinal differences differentially abundant taxa beta diversity. In aged mice, restored potentially beneficial including Bifidobacterium key producing genera (e.g. Faecalibaculum). Despite inducing notable taxonomic changes, however, reduced alpha diversity groups failed overall compositional between groups. conclusion, altered α β diversity, composition, more potent effects greater number mice. However, intestinal outcomes detected.
Язык: Английский
Процитировано
13