Enrichable consortia of microbial symbionts degrade macroalgal polysaccharides in Kyphosus fish DOI Creative Commons
Aaron Oliver, Sheila Podell, Linda Wegley Kelly

и другие.

mBio, Год журнала: 2024, Номер 15(5)

Опубликована: Март 27, 2024

ABSTRACT Coastal herbivorous fishes consume macroalgae, which is then degraded by microbes along their digestive tract. However, there scarce genomic information about the microbiota that perform this degradation. This study explores potential of Kyphosus gastrointestinal microbial symbionts to collaboratively degrade and ferment polysaccharides from red, green, brown macroalgae through in silico carbohydrate-active enzyme sulfatase sequences. Recovery metagenome-assembled genomes (MAGs) previously described gut metagenomes newly sequenced bioreactor enrichments reveals differences enzymatic capabilities between major taxa guts. The most versatile recovered MAGs were Bacteroidota phylum, whose house collections able decompose a variety algal polysaccharides. Unique enzymes predicted degradative capacities Bacillota (genus Vallitalea ) Verrucomicrobiota (order Kiritimatiellales highlight importance metabolic contributions multiple phyla broaden polysaccharide degradation capabilities. Few contain required fully any complex sulfated alone. distribution suitable originating different taxa, with widespread detection signal peptides candidate enzymes, consistent cooperative extracellular these carbohydrates. leverages evidence reveal an untapped diversity at strain level among decomposition. Bioreactor provide foundation for fermentative processes central translating knowledge gained system aquaculture bioenergy sectors. IMPORTANCE Seaweed has long been considered promising source sustainable biomass feed, but scalable industrial methods decomposing terrestrial compounds can struggle break down seaweed efficiently due unique structures. Fish genus feed on leveraging bacteria into simple sugars. reconstructs enhance our understanding fish digestion fermentation Investigations gene identify guts as seaweed-degrading ripe further characterization. These discoveries set stage future work incorporating marine communities

Язык: Английский

Epidemiology of small intestinal bacterial overgrowth DOI Creative Commons

Irina Efremova,

Roman Maslennikov, Elena Poluektova

и другие.

World Journal of Gastroenterology, Год журнала: 2023, Номер 29(22), С. 3400 - 3421

Опубликована: Июнь 6, 2023

Small intestinal bacterial overgrowth (SIBO) is defined as an increase in the content of small intestine above normal values. The presence SIBO detected 33.8% patients with gastroenterological complaints who underwent a breath test, and significantly associated smoking, bloating, abdominal pain, anemia. Proton pump inhibitor therapy significant risk factor for SIBO. increases age does not depend on gender or race. complicates course number diseases may be pathogenetic significance development their symptoms. functional dyspepsia, irritable bowel syndrome, constipation, diarrhea, short chronic pseudo-obstruction, lactase deficiency, diverticular celiac diseases, ulcerative colitis, Crohn's disease, cirrhosis, metabolic-associated fatty liver disease (MAFLD), primary biliary cholangitis, gastroparesis, pancreatitis, cystic fibrosis, gallstone diabetes, hypothyroidism, hyperlipidemia, acromegaly, multiple sclerosis, autism, Parkinson's systemic spondylarthropathy, fibromyalgia, asthma, heart failure, other diseases. often slowdown orocecal transit time that decreases clearance bacteria from intestine. this due to motor dysfunction gut, autonomic diabetic polyneuropathy, portal hypertension, decrease motor-stimulating influence thyroid hormones. In including MAFLD, association was found between severity Further work effect eradication condition prognosis various required.

Язык: Английский

Процитировано

44
Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications DOI Creative Commons
Balaraman Kalyanaraman, Gang Cheng, Micaël Hardy

и другие.

Redox Biology, Год журнала: 2024, Номер 71, С. 103092 - 103092

Опубликована: Фев. 16, 2024

In this review, we explore how short-chain fatty acids (SCFAs) produced by the gut microbiome affect Parkinson's disease (PD) through their modulatory interactions with alpha-synuclein, neuroinflammation, and oxidative stress mediated reactive oxygen nitrogen species (ROS/RNS). particular, SCFAs-such as acetate, propionate, butyrate-are involved in gut-brain communication can modulate alpha-synuclein aggregation, a hallmark of PD. The patients PD has lower levels SCFAs than healthy individuals. Probiotics may be potential strategy to restore alleviate symptoms, but underlying mechanisms are not fully understood. Also discuss present guts brains PD, induce neuroinflammation via ROS/RNS. Alpha-synuclein is considered an early biomarker for link axis pathogenesis. Therefore, elucidating role impact on alpha-synuclein-induced microglia ROS/RNS crucial pathogenesis treatment.

Язык: Английский

Процитировано

30
Critical Review of the Cross-Links Between Dietary Components, the Gut Microbiome, and Depression DOI Open Access
Nidesha Randeni, Baojun Xu

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 614 - 614

Опубликована: Янв. 13, 2025

The complex relationship between diet, the gut microbiota, and mental health, particularly depression, has become a focal point of contemporary research. This critical review examines how specific dietary components, such as fiber, proteins, fats, vitamins, minerals, bioactive compounds, shape microbiome influence microbial metabolism in order to regulate depressive outcomes. These dietary-induced changes microbiota can modulate production metabolites, which play vital roles gut–brain communication. axis facilitates this communication through neural, immune, endocrine pathways. Alterations metabolites central nervous system (CNS) functions by impacting neuroplasticity, inflammatory responses, neurotransmitter levels—all are linked onset course depression. highlights recent findings linking components with beneficial composition reduced symptoms. We also explore challenges individual variability responses interventions long-term sustainability these strategies. underscores necessity for further longitudinal mechanistic studies elucidate precise mechanisms diet interactions be leveraged mitigate paving way personalized nutritional therapies.

Язык: Английский

Процитировано

3
Circulating B vitamins metabolites in depressive disorders - connections with the microbiota-gut-brain axis DOI

Wiktor Śliwiński,

Oliwia Gawlik-Kotelnicka

Behavioural Brain Research, Год журнала: 2024, Номер 472, С. 115145 - 115145

Опубликована: Июль 9, 2024

Язык: Английский

Процитировано

9
Short-chain fatty acids reverses gut microbiota dysbiosis-promoted progression of glioblastoma by up-regulating M1 polarization in the tumor microenvironment DOI
Mengnan Zhou,

Jianqi Wu,

Yang Shao

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 141, С. 112881 - 112881

Опубликована: Авг. 18, 2024

Язык: Английский

Процитировано

8
Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies DOI Creative Commons
Aleksandra Hyży, Hanna Rozenek, Ewa Gondek

и другие.

Foods, Год журнала: 2025, Номер 14(2), С. 176 - 176

Опубликована: Янв. 8, 2025

Antioxidants are widely recognized for their potential health benefits, including impact on cognitive function and gut microbiome modulation. Understanding these effects is essential exploring broader clinical applications. This review aims to evaluate the of antioxidants function, with a focus findings from randomized controlled trials (RCTs). The studies involved human participants across range age groups, interventions encompassing natural antioxidant sources, such as berries, well specific vitamins. An extensive search PubMed, SCOPUS, Web Science databases identified six relevant RCTs, each evaluated bias. These focused variety antioxidant-rich products, both naturally derived sources supplemental forms. Antioxidants, vitamins C, B2, D, along polyphenols xanthohumol, fermented papaya, peanuts, berry extracts, demonstrate support promote through mechanisms that modulate diversity reduce inflammation. However, observed changes in were modest inconsistent studies. While preliminary evidence suggests may benefit heterogeneity existing limits immediate applicability. Additionally, more robust RCTs needed substantiate guide future interventions.

Язык: Английский

Процитировано

1
Update on the pathogenesis of endometriosis-related infertility based on contemporary evidence DOI Creative Commons
Qing Qi,

Yaonan Li,

Ziqin Chen

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Март 10, 2025

Endometriosis, the most prevalent cause of infertility, is associated with anatomical distortion leading to adhesions and fibrosis, as well endocrine abnormalities immune disorders. This review discusses mechanisms underlying endometriosis-related infertility. Firstly, alterations in hypothalamic-pituitary-ovarian axis lead secretion gonadotropins steroid hormones, adverse effects on ovulation implantation, fertility decline. Secondly, dysregulation hypothalamic-pituitary-adrenal induces elevated serum cortisol prolactin levels patients endometriosis, accounting for its regulation stress, depression, anxiety. Abnormal interactions between endometrial cells system change local microenvironment, resulting epithelial-mesenchymal transition inflammation. Activated epithelial cells, stromal immunocytes produce various chemokines, cytokines, or autoantibodies, creating an unfavorable environment embryo implantation. These findings suggest that spectrum play a crucial role Thirdly, oxidative stress has ovarian reserve subsequent embryonic development, predicting another promising strategy An unbalanced redox state, including impaired mitochondrial function, dysregulated lipid metabolism, iron-induced generates pro-oxidative which negatively impacts oocyte quality sperm viability. Thus, updated understanding involved this disease will help develop effective strategies manage

Язык: Английский

Процитировано

1
Alteration of shoaling behavior and dysbiosis in the gut of medaka (Oryzias latipes) exposed to 2-μm polystyrene microplastics DOI

Yui Tamura,

Yuki Takai, Hirokuni Miyamoto

и другие.

Chemosphere, Год журнала: 2024, Номер 353, С. 141643 - 141643

Опубликована: Март 4, 2024

Язык: Английский

Процитировано

7
High-quality identification of volatile organic compounds (VOCs) originating from breath DOI Creative Commons
Wisenave Arulvasan, Hsuan Chou,

Julia Greenwood

и другие.

Metabolomics, Год журнала: 2024, Номер 20(5)

Опубликована: Сен. 6, 2024

Язык: Английский

Процитировано

6
Microbiome–Gut–Brain Axis Modulation: New Approaches in Treatment of Neuropsychological and Gastrointestinal Functional Disorders DOI Open Access
Robert B. Kargbo

ACS Medicinal Chemistry Letters, Год журнала: 2023, Номер 14(6), С. 692 - 695

Опубликована: Май 11, 2023

The gut–brain axis (GBA) refers to the sophisticated bidirectional communication system connecting digestive with central nervous system. This interaction is enabled by a series of intricate signaling processes, encompassing various neuro-immune and hormonal pathways. association between gut microbiome mental health has garnered immense scientific public interest, driven an enhanced understanding microbiome's role in facilitating brain. Patent Highlight discloses methods for promoting colonization spore-forming bacteria gastrointestinal track. These include administering serotonin receptor agonist, such as psilocybin, psilocin, N,N-dimethyltryptamine, bufotenine, 5-methoxy-N,N-dimethyltryptamine, lysergic acid diethylamide, ergine, mescaline, 3,4-methylenedioxyamphetamine, 2,5-dimethoxy-4-methylamphetamine, others.

Язык: Английский

Процитировано

12