Pharmacogenomics,
Год журнала:
2023,
Номер
24(10), С. 523 - 527
Опубликована: Июль 1, 2023
The
field
of
psychiatry
is
facing
an
important
paradigm
shift
in
the
provision
clinical
care
and
mental
health
service
organization
toward
personalization
integration
multimodal
data
science.
This
approach,
termed
precision
psychiatry,
aims
at
identifying
subgroups
patients
more
prone
to
development
a
certain
phenotype,
such
as
symptoms
or
severe
disorders
(risk
detection),
and/or
guide
treatment
selection.
Pharmacogenomics
computational
are
two
fundamental
tools
which
have
seen
increasing
levels
settings.
Here
we
present
brief
overview
these
applications
Journal of Medical Internet Research,
Год журнала:
2023,
Номер
25, С. e44502 - e44502
Опубликована: Авг. 21, 2023
The
term
"digital
phenotype"
refers
to
the
digital
footprint
left
by
patient-environment
interactions.
It
has
potential
for
both
research
and
clinical
applications
but
challenges
our
conception
of
health
care
opposing
2
distinct
approaches
medicine:
one
centered
on
illness
with
aim
classifying
curing
disease,
other
patients,
their
personal
distress,
lived
experiences.
In
context
mental
psychiatry,
benefits
phenotyping
include
creating
new
avenues
treatment
enabling
patients
take
control
own
well-being.
However,
this
comes
at
cost
sacrificing
fundamental
human
element
psychotherapy,
which
is
crucial
addressing
patients'
distress.
viewpoint
paper,
we
discuss
advances
rendered
possible
highlight
risk
that
technology
may
pose
partially
excluding
professionals
from
diagnosis
therapeutic
process,
thereby
foregoing
an
essential
dimension
care.
We
conclude
setting
out
concrete
recommendations
how
improve
current
so
it
can
be
harnessed
redefine
empowering
without
alienating
them.
Frontiers in Psychiatry,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 13, 2023
While
contemporary
psychiatry
seeks
the
mechanisms
of
mental
disorders
in
neurobiology,
health
problems
clearly
depend
on
developmental
processes
learning
and
adaptation
through
ongoing
interactions
with
social
environment.
Symptoms
or
emerge
specific
contexts
involve
predicaments
that
cannot
be
fully
characterized
terms
brain
function
but
require
a
larger
social-ecological
view.
Causal
result
can
begin
anywhere
within
extended
system
body-person-environment.
In
particular,
individuals'
narrative
self-construal,
culturally
mediated
interpretations
symptoms
coping
strategies
as
well
responses
others
world
contribute
to
disorders,
illness
experience,
recovery.
this
paper,
we
outline
conceptual
basis
practical
implications
hierarchical
ecosocial
systems
view
for
an
integrative
approach
psychiatric
theory
practice.
The
cultural-ecosocial
propose
understands
mind,
person
situated
constituted
by
cultural
self-reflexive
processes.
This
incorporated
into
pragmatic
clinical
assessment
case
formulation
characterizes
pathology
identifies
targets
intervention.
Current Medical Research and Opinion,
Год журнала:
2024,
Номер
40(11), С. 1943 - 1961
Опубликована: Окт. 16, 2024
The
development
of
therapies
followed
a
generalized
approach
for
long
time,
assuming
that
single
treatment
could
effectively
address
various
patient
populations.
However,
recent
breakthroughs
have
revealed
the
limitations
this
one-size-fits-all
paradigm.
More
recently,
field
therapeutics
has
witnessed
shift
toward
other
modules,
including
cell
therapies,
high
molecular
weight
remedies,
personalized
medicines,
and
gene
therapies.
Such
advancements
in
therapeutic
modules
potential
to
revolutionize
healthcare
pave
way
medicines
are
more
efficient
with
minimal
side
effects.
Cell
gained
considerable
attention
regenerative
medicine.
Stem
cell-based
instance,
hold
promise
tissue
repair
regeneration,
ongoing
research
focusing
on
enhancing
their
efficacy
safety.
High
drugs
like
peptides
proteins
emerged
as
promising
because
specificity
diverse
biological
functions.
Engineered
developed
targeted
drug
delivery,
immunotherapy,
disease-modulation.
In
medicine,
tailored
treatments
individuals
based
specific
genetic
profiling,
lifestyle,
biomarkers,
disease
characteristics
all
implemented.
Clinicians
optimize
outcomes
minimize
adverse
effects,
using
mutations,
yielding
remarkable
results.
Gene
revolutionized
disorders
by
directly
targeting
underlying
abnormalities.
Innovative
techniques,
such
CRISPR-Cas9
allowed
precise
editing,
opening
up
possibilities
curing
previously
incurable
conditions.
conclusion,
World Psychiatry,
Год журнала:
2025,
Номер
24(1), С. 4 - 31
Опубликована: Янв. 15, 2025
Feeding
and
eating
disorders
(FEDs)
are
a
heterogeneous
grouping
of
at
the
mind-body
interface,
with
typical
onset
from
childhood
into
emerging
adulthood.
They
occur
along
spectrum
disordered
compensatory
weight
management
behaviors,
low
to
high
body
weight.
Psychiatric
comorbidities
norm.
In
contrast
other
major
psychiatric
disorders,
first-line
treatments
for
FEDs
mainly
psychological
and/or
nutrition-focused,
medications
playing
minor
adjunctive
role.
Patients,
carers
clinicians
all
have
identified
personalization
treatment
as
priority.
Yet,
FEDs,
evidence
base
supporting
this
is
limited.
Importantly,
related
behaviors
can
serious
physical
consequences
may
put
patient's
life
risk.
these
cases,
immediate
safety
risk
considerations
least
period
need
be
prioritized
over
efforts
care.
This
paper
systematically
reviews
several
key
domains
that
relevant
characterization
individual
patient
FED
aimed
management.
These
include
symptom
profile,
clinical
subtypes,
severity,
staging,
complications
consequences,
antecedent
concomitant
conditions,
social
functioning
quality
life,
neurocognition,
cognition
emotion,
dysfunctional
cognitive
schemata,
personality
traits,
family
history,
early
environmental
exposures,
recent
stigma,
protective
factors.
Where
possible,
validated
assessment
measures
use
in
practice
identified.
The
limitations
current
pointed
out,
possible
directions
future
research
highlighted.
also
novel
approaches
providing
more
fine-grained
sophisticated
ways
personalize
such
those
utilize
neurobiological
markers.
We
additionally
outline
remote
measurement
technologies
designed
delineate
patients'
illness
recovery
trajectories
facilitate
development
intervention
approaches.
Cell Stress,
Год журнала:
2024,
Номер
8, С. 21 - 50
Опубликована: Янв. 1, 2024
The
eight
biological
hallmarks
of
health
that
we
initially
postulated
(Cell.
2021
Jan
7;184(1):33-63)
include
features
spatial
compartmentalization
(integrity
barriers,
containment
local
perturbations),
maintenance
homeostasis
over
time
(recycling
&
turnover,
integration
circuitries,
rhythmic
oscillations)
and
an
array
adequate
responses
to
stress
(homeostatic
resilience,
hormetic
regulation,
repair
regeneration).
These
affect
all
somatic
strata
the
human
body
(molecules,
organelles,
cells,
supracellular
units,
organs,
organ
systems,
systemic
circuitries
meta-organism).
Here
postulate
mental
socioeconomic
factors
must
be
added
this
8×8
matrix
as
additional
hallmark
(“psychosocial
adaptation”)
stratum
interactions”),
hence
building
a
9×9
matrix.
Potentially,
perturbation
each
affects
psychosocial
vice
versa.
Finally,
discuss
(patho)physiological
bases
these
interactions
their
implications
for
improvement.
The World Journal of Biological Psychiatry,
Год журнала:
2024,
Номер
25(6), С. 342 - 351
Опубликована: Июнь 21, 2024
Objectives
This
survey
assessed
psychiatry
residents'/early-career
psychiatrists'
attitudes
towards
the
utility
of
therapeutic
drug
monitoring
(TDM)
antipsychotics.
PLoS ONE,
Год журнала:
2024,
Номер
19(6), С. e0304461 - e0304461
Опубликована: Июнь 13, 2024
Insomnia
symptoms
are
negatively
related
to
opioid
use
disorder
(OUD)
treatment
outcomes,
possibly
reflecting
the
influence
of
sleep
on
neurofunctional
domains
implicated
in
addiction.
Moreover,
intersection
between
OUD
recovery
and
represents
an
area
well-suited
for
development
novel,
personalized
strategies.
This
study
assessed
prevalence
clinically
significant
insomnia
characterized
its
correlates
among
a
clinical
sample
adults
with
receiving
buprenorphine.
