The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 167, С. 115511 - 115511

Опубликована: Сен. 18, 2023

Corydalis yanhusuo W. T. Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one of the herb components many Chinese Traditional Medicine prescriptions such Jin Ling Zi San Yuanhu-Zhitong priscription. C. was traditionally used to relieve pain motivate blood Qi circulation. Now there has been growing interest in pharmacological effects alkaloids, main bioactive yanhusuo. Eighty-four alkaloids isolated from are its important can be characterized into protoberberine aporphine opiate others proper extraction or co-administration methods modulate their contents efficacy. Alkaloids have various on nervous system, cardiovascular cancer through multiple molecular mechanisms modulating neurotransmitters, ion channels, gut microbiota, HPA axis signaling pathways potential treatments for diseases. Plenty novel drug delivery autologous red cells, self-microemulsifying systems, nanoparticles investigated better exert This review summarized alkaloid mechanisms, lay a foundation future investigations.

Язык: Английский

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Design and in vitro evaluation of curcumin-loaded PLGA nanoparticle-embedded sodium alginate/gelatin 3D printed scaffolds for Alzheimer's disease

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 268, С. 131841 - 131841

Опубликована: Апрель 26, 2024

Язык: Английский

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Liposome-Derived Nanosystems for the Treatment of Behavioral and Neurodegenerative Diseases: The Promise of Niosomes, Transfersomes, and Ethosomes for Increased Brain Drug Bioavailability

Pharmaceuticals, Год журнала: 2023, Номер 16(10), С. 1424 - 1424

Опубликована: Окт. 8, 2023

Psychiatric and neurodegenerative disorders are amongst the most prevalent debilitating diseases, but current treatments either have low success rates, greatly due to permeability of blood–brain barrier, and/or connected severe side effects. Hence, new strategies extremely important, here is where liposome-derived nanosystems come in. Niosomes, transfersomes, ethosomes nanometric vesicular structures that allow drug encapsulation, protecting them from degradation, increasing their solubility, permeability, brain targeting, bioavailability. This review highlighted great potential these for treatment Alzheimer’s disease, Parkinson’s schizophrenia, bipolar disorder, anxiety, depression. Studies regarding encapsulation synthetic natural-derived molecules in systems, intravenous, oral, transdermal, or intranasal administration, led an increased bioavailability when compared conventional pharmaceutical forms. Moreover, developed formulations proved neuroprotective, anti-inflammatory, antioxidant effects, including neurotransmitter level restoration oxidative status improvement, improved locomotor activity enhancement recognition working memories animal models. albeit being relatively technologies, niosomes, already proven increase psychoactive drugs, leading effectiveness decreased showing promise as future therapeutics.

Язык: Английский

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Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease

Pharmaceutics, Год журнала: 2023, Номер 15(8), С. 2052 - 2052

Опубликована: Июль 31, 2023

Alzheimer disease (AD) is the most prevalent form of dementia among elderly people. Owing to its varied and multicausal etiopathology, intervention strategies have been highly diverse. Despite ongoing advances in field, efficient therapies mitigate AD symptoms or delay their progression are still limited scope. Neuroplasticity, broad terms ability brain modify structure response external stimulation damage, has received growing attention as a possible therapeutic target, since disruption plastic mechanisms appear correlate with various forms cognitive impairment present patients. Several pre-clinical clinical studies attempted enhance neuroplasticity via different mechanisms, for example, regulating glucose lipid metabolism, targeting activity neurotransmitter systems, addressing neuroinflammation. In this review, we first describe several structural functional aspects neuroplasticity. We then focus on current status pharmacological approaches stemming from trials neuroplastic This followed by an analysis analogous interventions animal models, according action.

Язык: Английский

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Improving the Antimicrobial Potency of Berberine for Endodontic Canal Irrigation Using Polymeric Nanoparticles

Pharmaceutics, Год журнала: 2024, Номер 16(6), С. 786 - 786

Опубликована: Июнь 9, 2024

To address the challenges posed by biofilm presence and achieve a substantial reduction in bacterial load within root canals during endodontic treatment, various irrigants, including nanoparticle suspensions, have been recommended. Berberine (BBR), natural alkaloid derived from plants, has demonstrated potential applications dentistry treatments due to its prominent antimicrobial, anti-inflammatory, antioxidant properties. This study aimed produce characterize novel polymeric of poly (lactic-co-glycolic acid) (PLGA) loaded with berberine evaluate antimicrobial activity against relevant pathogens, Enterococcus faecalis, Candida albicans. Additionally, cytocompatibility using gingival fibroblasts was assessed. The prepared nanoprecipitation method. Physicochemical characterization revealed spheric nanoparticles around 140 nm ca, −6 mV surface charge, which unaffected BBR. successfully incorporated at an encapsulation efficiency 77% designed were stable upon 20 weeks storage 4 °C 25 °C. Free BBR reduced planktonic growth ≥125 μg/mL. Upon incorporation into PLGA nanoparticles, μg/mL [BBR]-loaded lead significant reduction, after 1 h contact, both bacteria yeast. Sessile cells biofilms also considered. At 30 40 μg/mL, viability sessile bacteria, 24 exposure. cytotoxicity BBR-loaded oral negligible. berberine-loaded hold as promising supplementary approach treatment infections.

Язык: Английский

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Decoding the neurotoxic effects of propofol: insights into the RARα-Snhg1-Bdnf regulatory cascade

AJP Cell Physiology, Год журнала: 2024, Номер 326(6), С. C1735 - C1752

Опубликована: Апрель 15, 2024

The potential neurotoxic effects of propofol, an extensively utilized anesthetic, underline the urgency to comprehend its influence on neuronal health. Insights into role retinoic acid receptor-α, small nucleolar RNA host gene 1, and brain-derived neurotrophic factor (RARα-Snhg1-Bdnf) network can offer significant advancements in minimizing these effects. study targets exploration RARα Snhg1 regulatory network's Bdnf expression realm propofol-induced neurotoxicity. Harnessing Gene Expression Omnibus (GEO) database utilizing JASPAR RNA-Protein Interaction Prediction (RPISeq) for projections, embarks in-depth analysis employing both vitro vivo models. findings draw a clear link between neurotoxicity amplification RAR signaling pathways, impacting hippocampal development apoptosis leading increased decreased Bdnf. Propofol is inferred accentuate by heightening interactions, culminating suppression.

Язык: Английский

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Silibinin alleviates intestinal inflammation via inhibiting JNK signaling in Drosophila

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Сен. 14, 2023

Inflammatory bowel diseases (IBDs) are characterized by chronic relapsing intestinal inflammation that causes digestive system dysfunction. For years, researchers have been working to find more effective and safer therapeutic strategies treat these diseases. Silibinin (SIL), a flavonoid compound extracted from the seeds of milk thistle plants, possesses multiple biological activities is traditionally applied liver SIL also widely used in treatment variety inflammatory attributed its excellent antioxidant anti-inflammatory effects. However, efficacy against IBDs mechanisms remain unclear. In this study, using Drosophila melanogaster as model organism, we found can effectively relieve caused dextran sulfate sodium (DSS). Our results suggested supplementation inhibit overproliferation stem cells (ISCs) induced DSS, protect barrier function, acid-base balance, excretion reduce reactive oxygen species (ROS) levels stress, extend lifespan Drosophila. Furthermore, our study demonstrated ameliorates via modulating c-Jun N-terminal kinase (JNK) signaling pathway research aims provide new insight into IBDs.

Язык: Английский

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Phytotherapy in Alzheimer’s Disease—A Narrative Review

Biomedicines, Год журнала: 2024, Номер 12(8), С. 1812 - 1812

Опубликована: Авг. 9, 2024

Alzheimer's disease (AD) affects 50-70% of patients with dementia, making it the leading cause dementia. The condition is classified as a neurodegenerative, progressive and incurable disease. affecting more people around world. AD has multifactorial nature, spreading from beta-amyloid deposition to inflammation in patients' brains. Patients experience cognitive impairment functional decline. Although that occurs mainly elderly, increasingly being diagnosed young between ages 30 40. It not only patient themself but also reduces quality life their closest caregivers. According WHO, treatment consumes USD 1.3 trillion globally, symptomatic, there are no drugs prevent onset or treat its onset. Due numerous side effects therapy lack proactive act on pathomechanism AD, alternative therapies sought. One possible option many studies confirming effect phytotherapy. Many herbs have pharmacological properties, such antioxidant, anti-inflammatory, neuroprotective effects, them future disorders treatment. This review focuses some most promising potentially potent properties therapy. These include

Язык: Английский

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Bioinformatic analysis of hippocampal histopathology in Alzheimer’s disease and the therapeutic effects of active components of traditional Chinese medicine

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Авг. 16, 2024

Background and aim Pathological changes in the central nervous system (CNS) begin before clinical symptoms of Alzheimer’s Disease (AD) manifest, with hippocampus being one first affected structures. Current treatments fail to alter AD progression. Traditional Chinese medicine (TCM) has shown potential improving pathology through multi-target mechanisms. This study investigates pathological hippocampal tissue explores TCM active components that may alleviate these changes. Methods GSE5281 GSE173955 datasets were downloaded from GEO normalized identify differentially expressed genes (DEGs). Key functional modules hub analyzed using Cytoscape R. Active identified literature Pharmacopoeia People’s Republic China. Enrichment analyses performed on target overlapping DEGs. Result From datasets, 76 upregulated 363 downregulated identified. Hub included SLAMF, CD34, ELN (upregulated) ATP5F1B, VDAC1, VDAC2, HSPA8, ATP5F1C, PDHA1, UBB, SNCA, YWHAZ, PGK1 (downregulated). Literature review 33 23 herbal medicines. Target gene enrichment analysis for six components: dihydroartemisinin, berberine, naringenin, calycosin, echinacoside, icariside II. Conclusion Mitochondrial synaptic vesicle dysfunction pathways enriched genes. Despite downregulation, UBB SNCA proteins accumulate brains. studies suggest curcumin echinacoside improve cognitive impairment AD. Further investigation into their mechanisms is needed.

Язык: Английский

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Comprehensive Analysis of Berberis aristata DC. Bark Extracts: In Vitro and In Silico Evaluation of Bioaccessibility and Safety

Nutrients, Год журнала: 2024, Номер 16(17), С. 2953 - 2953

Опубликована: Сен. 2, 2024

Berberine (BER) is an alkaloid found, together with other protoberberinoids (PROTBERs), in several species used medicines and food supplements. While some herbal preparations containing BER PROTBERs, such as Berberis aristata DC. bark extracts, have shown promising potential for human health, their safety has not been fully assessed. Recently, the EFSA issued a call data to deepen pharmacokinetic pharmacodynamic understanding of products PROTBERs comprehensively assess safety, especially when In this context, new were collected work by assessing: (i) phytochemical profile 16 different commercial B. dry which are among most widely Europe; (ii) Vitro Silico investigation properties PROTBERs; (iii) cytotoxicity selected extracts cell lines, including tests on hepatic cells presence CYP450 substrates; (iv) effects cancer migration; (v) molecular non-cancer cells. Results showed that contain main constituent, jatrorrhizine secondary PROTBER. found good bioaccessibility rate, but they interact P-gp. limited minimal interaction substrates. Furthermore, tested demonstrated inhibition migration devoid any pro-tumoral normal Overall, our provides valuable overview better elucidate important concerns regarding botanicals PROTBERs.

Язык: Английский

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