Antioxidants,
Год журнала:
2024,
Номер
14(1), С. 25 - 25
Опубликована: Дек. 28, 2024
Traumatic
brain
injury
(TBI)
is
a
disease
resulting
from
external
physical
forces
acting
against
the
head,
leading
to
transient
or
chronic
damage
tissue.
Primary
an
immediate
and,
therefore,
rather
irreversible
effect
of
trauma,
while
secondary
results
complex
cascade
pathological
processes,
among
which
oxidative
stress
and
neuroinflammation
are
most
prominent.
As
TBI
significant
cause
mortality
disability,
with
high
social
costs
all
over
world,
any
form
therapy
that
may
mitigate
trauma-evoked
desirable.
Melatonin,
sleep–wake-cycle-regulating
neurohormone,
exerts
strong
antioxidant
anti-inflammatory
effects
well
tolerated
when
used
as
drug.
Due
these
properties,
it
very
reasonable
consider
melatonin
potential
therapeutic
molecule
for
treatment.
This
review
summarizes
data
in
vitro
studies,
animal
models,
clinical
trials
focus
on
usage
TBI.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Дек. 10, 2023
Abstract
Ferroptosis,
a
unique
modality
of
cell
death
with
mechanistic
and
morphological
differences
from
other
modes,
plays
pivotal
role
in
regulating
tumorigenesis
offers
new
opportunity
for
modulating
anticancer
drug
resistance.
Aberrant
epigenetic
modifications
posttranslational
(PTMs)
promote
resistance,
cancer
progression,
metastasis.
Accumulating
studies
indicate
that
can
transcriptionally
translationally
determine
vulnerability
to
ferroptosis
functions
as
driver
nervous
system
diseases
(NSDs),
cardiovascular
(CVDs),
liver
diseases,
lung
kidney
diseases.
In
this
review,
we
first
summarize
the
core
molecular
mechanisms
ferroptosis.
Then,
roles
processes,
including
histone
PTMs,
DNA
methylation,
noncoding
RNA
regulation
such
phosphorylation,
ubiquitination,
SUMOylation,
acetylation,
ADP-ribosylation,
are
concisely
discussed.
The
PTMs
genesis
cancers,
NSD,
CVDs,
well
application
PTM
modulators
therapy
these
then
discussed
detail.
Elucidating
mediated
by
will
facilitate
development
promising
combination
therapeutic
regimens
containing
or
PTM-targeting
agents
inducers
be
used
overcome
chemotherapeutic
resistance
could
prevent
addition,
highlight
potential
approaches
chemoresistance
halt
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 6, 2025
Traumatic
brain
injury
(TBI)
represents
a
significant
global
public
health
issue,
with
effective
management
posing
numerous
challenges.
The
pathophysiology
of
TBI
is
typically
categorized
into
two
phases:
primary
and
secondary
injuries.
Secondary
involves
pathophysiological
mechanisms
such
as
blood-brain
barrier
(BBB)
disruption,
mitochondrial
dysfunction,
oxidative
stress,
inflammatory
responses.
Current
pharmacological
strategies
often
encounter
obstacles
in
treating
effectively,
primarily
due
to
challenges
BBB
penetration,
inadequate
target
site
accumulation,
off-target
toxicity.
Versatile
hydrogels
nanoparticles
offer
potential
solutions
these
limitations.
This
review
discusses
recent
progress
utilizing
for
treatment
over
the
past
5
years,
highlighting
their
relevance
underlying
pathophysiology.
Hydrogels
demonstrate
substantial
promise
addressing
injury,
providing
broad
spectrum
future
therapeutic
opportunities.
Cells,
Год журнала:
2024,
Номер
13(5), С. 385 - 385
Опубликована: Фев. 23, 2024
Traumatic
Brain
Injury
(TBI)
remains
a
significant
global
health
challenge,
lacking
effective
pharmacological
treatments.
This
shortcoming
is
attributed
to
TBI’s
heterogeneous
and
complex
pathophysiology,
which
includes
axonal
damage,
mitochondrial
dysfunction,
oxidative
stress,
persistent
neuroinflammation.
The
objective
of
this
study
analyze
transcranial
photobiomodulation
(PBM),
employs
specific
red
near-infrared
light
wavelengths
modulate
brain
functions,
as
promising
therapy
address
pathophysiology
in
single
intervention.
reviews
the
feasibility
therapy,
firstly
by
synthesizing
PBM’s
cellular
mechanisms
with
each
identified
pathophysiological
aspect.
outcomes
human
clinical
studies
are
then
reviewed.
findings
support
potential
for
treating
TBI,
notwithstanding
variations
parameters
such
wavelength,
power
density,
dose,
source
positioning,
pulse
frequencies.
Emerging
data
indicate
that
these
plays
role
outcomes.
Additionally,
new
research
into
effects
on
electrical
properties
polymerization
dynamics
neuronal
microstructures,
like
microtubules
tubulins,
provides
insights
future
parameter
optimization.
In
summary,
PBM
represents
multifaceted
therapeutic
intervention
TBI
vast
may
be
fulfilled
optimizing
parameters.
Future
should
investigate
parameters,
possible
incorporating
artificial
intelligence.
International Journal of Surgery,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 11, 2024
Background:
Traumatic
brain
injury
(TBI)
is
a
serious
public
health
burden
worldwide,
with
mortality
rate
of
20%-30%;
however,
reducing
the
incidence
and
rates
TBI
remains
major
challenge.
This
study
provides
multidimensional
analysis
to
explore
potential
breakthroughs
in
over
past
two
decades.
Materials
Methods:
We
used
bibliometric
Latent
Dirichlet
Allocation
(LDA)
analyses
analyze
publications
focusing
on
published
between
2003
2022
from
Web
Science
Core
Collection
(WOSCC)
database
identify
core
journals
collaborations
among
countries/regions,
institutions,
authors,
research
trends.
Results:
Over
20
years,
41,545
articles
3,043
were
included,
12,916
authors
20,449
institutions
across
145
countries/regions.
The
annual
number
has
increased
ten-fold
compared
previous
publications.
revealed
that
high-income
countries,
especially
United
States,
have
significant
influence.
Collaboration
was
limited
several
LDA
results
indicated
hotspots
included
four
main
areas:
“Clinical
finding”,
“Molecular
mechanism”,
“Epidemiology”,
“Prognosis”.
Epidemiological
consistently
recent
years.
Through
epidemiological
topic
analysis,
etiology
shifted
traffic
accidents
falls
demographically
aging
society.
Conclusion:
decades,
developed
rapidly,
its
epidemiology
received
increasing
attention.
Reducing
preventive
perspective
emerging
as
trend
alleviate
future
social
burden;
therefore,
might
bring
TBI.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 4, 2024
Traumatic
brain
injury
(TBI)
leads
to
damage,
comprising
both
immediate
primary
damage
and
a
subsequent
cascade
of
secondary
mechanisms.
The
results
in
localized
while
the
initiates
inflammatory
responses,
followed
by
disruption
blood-brain
barrier,
infiltration
peripheral
blood
cells,
edema,
release
various
immune
mediators,
including
chemotactic
factors
interleukins.
TBI
disrupts
molecular
signaling,
cell
structures,
functions.
In
addition
physical
tissue
such
as
axonal
injuries,
contusions,
haemorrhages,
interferes
with
functioning,
impacting
cognition,
decision-making,
memory,
attention,
speech
capabilities.
Despite
deep
understanding
pathophysiology
TBI,
an
intensive
effort
evaluate
underlying
mechanisms
effective
therapeutic
interventions
is
imperative
manage
repercussions
TBI.
Studies
have
commenced
explore
potential
employing
natural
compounds
for
These
are
characterized
their
low
toxicity
limited
interactions
conventional
drugs.
Moreover,
many
demonstrate
capacity
target
aspects
process.
While
our
there
urgent
need
mitigate
its
consequences.
Here,
we
aimed
summarize
mechanism
action
role
phytochemicals
against
progression.
This
review
discusses
implications
phytonutrients
addresses
consequences
addition,
highlighted
roles
emerging
promising
candidates
intervention
highlights
neuroprotective
mechanistic
approach.
Furthermore,
efforts
focused
on
mechanisms,
providing
better
therapeutics.
Neurology International,
Год журнала:
2024,
Номер
16(2), С. 406 - 418
Опубликована: Апрель 5, 2024
Traumatic
brain
injuries
(TBIs)
represent
a
significant
public
health
concern,
with
mild-to-moderate
cases
comprising
substantial
portion
of
incidents.
Understanding
the
predictors
mortality
among
adult
patients
TBIs
is
crucial
for
optimizing
clinical
management
and
improving
outcomes.
This
literature
review
examines
existing
research
to
identify
analyze
in
this
patient
population.
Through
comprehensive
peer-reviewed
articles
studies,
key
prognostic
factors,
such
as
age,
Glasgow
Coma
Scale
(GCS)
score,
presence
intracranial
hemorrhage,
pupillary
reactivity,
coexisting
medical
conditions,
are
explored.
Additionally,
investigates
role
advanced
imaging
modalities,
biomarkers,
scoring
systems
predicting
following
TBI.
By
synthesizing
findings
from
diverse
aims
provide
clinicians
researchers
valuable
insights
into
factors
influencing
outcomes
TBI,
thus
facilitating
more
informed
decision
making
targeted
interventions
practice.
Muscle & Nerve,
Год журнала:
2024,
Номер
69(4), С. 422 - 427
Опубликована: Фев. 9, 2024
Abstract
Introduction/Aims
The
clinical
presentation
of
multifocal
motor
neuropathy
(MMN)
may
mimic
early
amyotrophic
lateral
sclerosis
(ALS)
with
predominant
lower
neuron
(LMN)
involvement,
posing
a
diagnostic
challenge.
Both
diseases
have
specific
treatments
and
prognoses,
highlighting
the
importance
diagnosis.
aim
this
study
was
to
assess
value
serum
neurofilament
light
chain
(NfL)
in
differentiating
MMN
from
LMN
dominant
ALS.
Methods
NfL
measured
n
=
37
patients
age‐
sex‐matched
ALS,
determine
accuracy.
Clinical
demographic
data
were
obtained
at
time
sampling.
Results
Serum
concentration
significantly
compared
ALS
(mean
20.7
pg/mL
vs.
59.4
pg/mL,
p
<
.01).
demonstrated
good
discriminating
two
groups
(AUC
0.985
[95%
CI
0.963–1.000],
sensitivity
94.6%,
specificity
100%,
cut‐off
44.00
pg/mL).
Discussion
could
be
helpful
tool
those
whom
electrophysiological
examinations
remain
inconclusive
process.
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101335 - 101335
Опубликована: Ноя. 12, 2024
Traumatic
brain
injury
(TBI)
can
lead
to
severe
neurotrauma,
leading
long-term
cognitive
decline
and
even
death.
Massive
neuronal
loss
excessive
neuroinflammation
are
critical
issues
in
the
treatment
of
secondary
TBI.
To
tackle
these
challenges,
we
developed
a
GelMA
CSMA
hydrogel
loaded
with
Erythropoietin
(EPO)
Interleukin-4
(IL-4),
named
GC/I/E.
By
directly
loading
EPO,
rapid
neuroprotection
angiogenesis
were
achieved.
Meanwhile,
by
Mesoporous
silica
nanoparticles
(MSNs)
IL-4
(MSN@IL-4),
sustained
inflammation
modulation
during
was
attained.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(1), С. 115 - 115
Опубликована: Янв. 16, 2025
Traumatic
brain
injury
(TBI)
is
a
leading
cause
of
mortality
worldwide
and
often
results
in
substantial
cognitive,
motor,
psychological
impairments,
triggering
oxidative
stress,
neuroinflammation,
neurodegeneration.
This
study
examined
the
neuroprotective
effects
azithromycin
(AZI)
TBI.
TBI
was
induced
rats
using
weight-drop
method.
Subsequently,
received
daily
intraperitoneal
(I.P.)
dose
AZI
(150
mg/kg)
for
28
days.
Behavioral
tests
(Morris
water
maze,
rotarod,
open
field
tests)
were
performed
to
assess
cognitive
motor
functions.
Neurochemical
analyses
included
stress
markers
(GSH,
SOD,
MDA,
catalase),
inflammatory
cytokines
(TNF-α,
IL-1β),
apoptotic
(caspase-3,
Bax,
Bcl-2),
mitochondrial
complexes
(complex
I,
II,
III,
IV,
V),
transforming
growth
factor-
beta
(TGF-β)
as
neurofilament
marker.
Histological
evaluations
focused
on
neuronal
integrity
cortex,
hippocampus,
striatum.
Treatment
with
significantly
facilitated
function
recovery
TBI-affected
rats.
At
molecular
level,
effectively
reduced
markers,
ameliorated
neuroinflammation
by
decreasing
TNF-α,
IL-1β,
apoptosis,
differentially
modulated
complexes.
assessments
revealed
enhanced
fewer
pathological
changes
AZI-treated
compared
untreated
controls.
shown
interfere
several
pathways
involved
TBI's
pathophysiology.
While
preclinical
are
promising,
further
studies
necessary
establish
long-term
safety
efficacy
clinical
setting.
research
supports
potential
re-purposing
novel
treatment
strategy
related
neurodegenerative
disorders.