Опубликована: Янв. 1, 2024
Язык: Английский
Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16
Опубликована: Фев. 27, 2024
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the distributed over body surface. Studies suggest a correlation between brain-gut-microbiota (BGM) axis and pathogenesis Alzheimer’s disease (AD). The BGM represents complex bidirectional communication system, with being crucial component. Therefore, electrical might have potential modify—most time probably in non-physiological way—the signal transmission within axis, potentially influencing progression or symptoms AD. This review explores interaction percutaneous emphasizing its effects on It examines various aspects, such as specific brain regions, gut microbiota composition, maintenance intestinal environmental homeostasis, inflammatory responses, plasticity, hypothalamic–pituitary–adrenal (HPA) regulation. suggests that tVNS could serve effective strategy modulate intervene treatment future.
Язык: Английский
Процитировано
13
Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер unknown, С. 105990 - 105990
Опубликована: Дек. 1, 2024
The rising prevalence of treatment-resistant neuropsychiatric disorders underscores the need for innovative and effective treatment strategies. gut microbiota (GM) plays a pivotal role in progression these diseases, influencing brain mental health through gut-brain axis (GBA). vagus nerve significant GBA, making it key area focus potential novel therapeutic interventions. Vagus stimulation (VNS) was introduced approved as refractory forms some neuropsychological disorders, such depression epilepsy. Considering its impact on several regions that play vital part mood, motivation, affection, cognitive function, VNS has shown treating variety disorders. Harnessing to target bidirectional communication pathways linking GM VN could present an exciting approach Imbalances GM, dysbiosis, can impair between brain, contributing development shows modulating interconnected systems, helping restore balance. Interestingly, composition may also influence effectiveness VNS, modify brain's response this approach. This study provides comprehensive analysis relatively unexplored but noteworthy interaction In addition, we discussed mechanisms, potential, clinical implications GBA across
Язык: Английский
Процитировано
5
GeroScience, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
Attentional states reflect the changing behavioral relevance of stimuli in one's environment, having important consequences for learning and memory. Supporting well-established cortical contributions, attentional are hypothesized to originate from subcortical neuromodulatory nuclei, such as basal forebrain (BF) locus coeruleus (LC), which among first change with aging. Here, we characterized interplay between BF LC nuclei their relation two common afferent targets attention memory, posterior cingulate cortex hippocampus, across adult lifespan. Using an auditory target discrimination task during functional MRI, examined influence salience on task-dependent connectivity younger (19-45 years) older adults (66-86 years). In adults, was largely driven by processing, while associated distractor processing. These patterns reversed adults. This age-dependent pattern generalized nucleus basalis Meynert medial septal subnuclei. Preliminary data middle-aged indicates a transitional stage connectivity. Overall, these results reveal distinct roles systems related potential aging, consistent managing increased behaviorally irrelevant distraction Such prominent differences coupling lifespan suggests they may be drivers widespread changes neurocognitive middle age opportune time intervention.
Язык: Английский
Процитировано
0
Military Medicine, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
Transcutaneous auricular Vagus Nerve Stimulation (taVNS) is a noninvasive technique that activates vagal projections in the brain and brainstem by stimulating branch of vagus nerve. taVNS may be safer alternative to invasive nerve stimulation for treating treatment-resistant mood disorders, chronic pain, inflammation, cardiovascular dysfunction, inflammatory bowel disease, Crohn's disease. This study aims systematically review current evidence on efficacy safety depressive disorders its modulatory effects autonomic nervous system. Relevant primary secondary sources were identified through systematic search PubMed Google Scholar databases from 2008 2023. The used Scale Assessment Narrative Review Articles, resulting 0.77% intraclass correlation coefficient, 95% CI, 0.88 inter-rater reliability. taVNS, new neuromodulation method, stimulates regulates sympathetic parasympathetic branches ANS, increasing norepinephrine secretion, adaptability, heart rate variability. Future studies should clarify mechanisms address inconsistencies parameters. Standardizing treatment regimens can establish as viable, treatment. Our findings suggest However, further empirical research needed elucidate resolve parameters, larger are required confirm an effective
Язык: Английский
Процитировано
0
NeuroImage, Год журнала: 2025, Номер unknown, С. 121179 - 121179
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17
Опубликована: Апрель 28, 2025
This study aims to explore the central effects of acupuncture on vascular cognitive impairment (VCI) through peripheral nerve stimulation. scoping review followed methodological framework proposed by Arksey and O'Malley PRISMA-ScR guidelines. A comprehensive search databases, including PubMed, Web Science, MEDLINE, Embase, was conducted, 79 studies interventions for VCI. Acupoints their underlying anatomical structures related nerves were summarized, potential pathways via different explored. The results showed that acupuncture, stimulating specific acupoints head, face, torso, limbs, significantly affects networks, cervical, lumbar, sacral plexuses, thoracic nerves, vagus nerve, trigeminal its branches. stimulation can enhance regulation cerebral blood flow, modulate neuroimmune responses, improve brain function, promote neuroplasticity multiple nervous system pathways, ultimately improving function treating Acupuncture is a treatment modality influences treat deeper understanding induced acupuncture-triggered neural reflexes contribute improvement existing therapies help elucidate scientific principles acupuncture's therapeutic effects.
Язык: Английский
Процитировано
0
Frontiers in Neurology, Год журнала: 2024, Номер 14
Опубликована: Янв. 12, 2024
Transcutaneous auricular vagus nerve stimulation (taVNS) is becoming increasingly established in the treatment of various neurological and psychiatric diseases. However, only a few studies have focused on overall influence taVNS cortical excitability general. The planned study will investigate effect motor cortex young healthy subjects. aim to gain better understand physiological mechanism contribute new fields application areas such as stroke or multiple sclerosis. This protocol describes single-center, prospective, double blind, sham-controlled trial that evaluates with sample size 30 participants. investigated by neuronavigation electromyography (EMG) coupled transcranial magnetic (TMS) applied before after stimulation. following parameters are assessed: resting threshold (RMT), active (AMT), recruitment curve (RC), short intracortical inhibition (SICI), facilitation (ICF). All be assessed for basis perception tolerance threshold. investigations performed were reviewed approved local ethics committee University Medical Center Greifswald (study reference number: BB048/22).
Язык: Английский
Процитировано
3
European Psychiatry, Год журнала: 2024, Номер 67(1)
Опубликована: Янв. 1, 2024
Abstract Background Cognitive impairment (CI) is one of the most prevalent and burdensome consequences COVID-19 infection, which can persist up to months or even years after remission infection. Current guidelines on post-COVID CI are based available knowledge treatments used for improving in other conditions. The current review aims provide an updated overview existing evidence efficacy CI. Methods A systematic literature search was conducted studies published December 2023 using three databases (PubMed–Scopus–ProQuest). Controlled noncontrolled trials, cohort studies, case series, reports testing interventions subjects with following infection were included. Results After screening 7790 articles, 29 Multidisciplinary approaches, particularly those combining cognitive remediation interventions, physical exercise, dietary sleep support, may improve address different needs individuals post-COVID-19 condition. a safe, cost-effective option be tailored deficits specific domains. Noninvasive brain stimulation techniques hyperbaric oxygen therapy showed mixed preliminary results. Evidence including pharmacological ones, remains sparse. Challenges interpreting include heterogeneity study designs, assessment tools, recruitment criteria; lack long-term follow-up; under-characterization samples relation confounding factors. Conclusions Further research, grounded shared definitions condition accurate COVID-related CI, well-defined longer follow-ups, crucial this significant unmet need.
Язык: Английский
Процитировано
2
Journal of Neuropsychiatry, Год журнала: 2024, Номер 36(4), С. 278 - 282
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
2
Frontiers in Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Июль 18, 2024
Objective Recent studies have shown that transcutaneous vagal nerve stimulation (tVNS) holds promise as a treatment for neurological or psychiatric disease through the ability to modulate neural activity in some brain regions without an invasive procedure. The objective of this study was identify correlates underlying effects tVNS. Methods Twenty right-handed healthy subjects with normal hearing participated study. An auricle-applied tVNS device (Soricle, Neurive Co., Ltd., Gyeongsangnam-do, Republic Korea) used administer stimulation. A session consisted 14 blocks, including 7 blocks sham and rest, lasted approximately min (1 block = 30 s). Functional magnetic resonance imaging (fMRI) performed during Results No activated were observed fMRI scans following both after first session. After second session, two clusters right frontal gyrus. comparison each revealed exhibited four surviving clusters. Additionally, overall stimulated area sessions. When comparing results type stimulation, showed compared Conclusion could stimulate regions, fronto-parietal network. Stimulating these treating might require applying at least 3.5 min.
Язык: Английский
Процитировано
2