Опубликована: Янв. 1, 2024
Язык: Английский
Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16
Опубликована: Фев. 27, 2024
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the distributed over body surface. Studies suggest a correlation between brain-gut-microbiota (BGM) axis and pathogenesis Alzheimer’s disease (AD). The BGM represents complex bidirectional communication system, with being crucial component. Therefore, electrical might have potential modify—most time probably in non-physiological way—the signal transmission within axis, potentially influencing progression or symptoms AD. This review explores interaction percutaneous emphasizing its effects on It examines various aspects, such as specific brain regions, gut microbiota composition, maintenance intestinal environmental homeostasis, inflammatory responses, plasticity, hypothalamic–pituitary–adrenal (HPA) regulation. suggests that tVNS could serve effective strategy modulate intervene treatment future.
Язык: Английский
Процитировано
13
Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер unknown, С. 105990 - 105990
Опубликована: Дек. 1, 2024
The rising prevalence of treatment-resistant neuropsychiatric disorders underscores the need for innovative and effective treatment strategies. gut microbiota (GM) plays a pivotal role in progression these diseases, influencing brain mental health through gut-brain axis (GBA). vagus nerve significant GBA, making it key area focus potential novel therapeutic interventions. Vagus stimulation (VNS) was introduced approved as refractory forms some neuropsychological disorders, such depression epilepsy. Considering its impact on several regions that play vital part mood, motivation, affection, cognitive function, VNS has shown treating variety disorders. Harnessing to target bidirectional communication pathways linking GM VN could present an exciting approach Imbalances GM, dysbiosis, can impair between brain, contributing development shows modulating interconnected systems, helping restore balance. Interestingly, composition may also influence effectiveness VNS, modify brain's response this approach. This study provides comprehensive analysis relatively unexplored but noteworthy interaction In addition, we discussed mechanisms, potential, clinical implications GBA across
Язык: Английский
Процитировано
6
Frontiers in Neurology, Год журнала: 2024, Номер 14
Опубликована: Янв. 12, 2024
Transcutaneous auricular vagus nerve stimulation (taVNS) is becoming increasingly established in the treatment of various neurological and psychiatric diseases. However, only a few studies have focused on overall influence taVNS cortical excitability general. The planned study will investigate effect motor cortex young healthy subjects. aim to gain better understand physiological mechanism contribute new fields application areas such as stroke or multiple sclerosis. This protocol describes single-center, prospective, double blind, sham-controlled trial that evaluates with sample size 30 participants. investigated by neuronavigation electromyography (EMG) coupled transcranial magnetic (TMS) applied before after stimulation. following parameters are assessed: resting threshold (RMT), active (AMT), recruitment curve (RC), short intracortical inhibition (SICI), facilitation (ICF). All be assessed for basis perception tolerance threshold. investigations performed were reviewed approved local ethics committee University Medical Center Greifswald (study reference number: BB048/22).
Язык: Английский
Процитировано
3
GeroScience, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
Attentional states reflect the changing behavioral relevance of stimuli in one's environment, having important consequences for learning and memory. Supporting well-established cortical contributions, attentional are hypothesized to originate from subcortical neuromodulatory nuclei, such as basal forebrain (BF) locus coeruleus (LC), which among first change with aging. Here, we characterized interplay between BF LC nuclei their relation two common afferent targets attention memory, posterior cingulate cortex hippocampus, across adult lifespan. Using an auditory target discrimination task during functional MRI, examined influence salience on task-dependent connectivity younger (19-45 years) older adults (66-86 years). In adults, was largely driven by processing, while associated distractor processing. These patterns reversed adults. This age-dependent pattern generalized nucleus basalis Meynert medial septal subnuclei. Preliminary data middle-aged indicates a transitional stage connectivity. Overall, these results reveal distinct roles systems related potential aging, consistent managing increased behaviorally irrelevant distraction Such prominent differences coupling lifespan suggests they may be drivers widespread changes neurocognitive middle age opportune time intervention.
Язык: Английский
Процитировано
0
Military Medicine, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
Transcutaneous auricular Vagus Nerve Stimulation (taVNS) is a noninvasive technique that activates vagal projections in the brain and brainstem by stimulating branch of vagus nerve. taVNS may be safer alternative to invasive nerve stimulation for treating treatment-resistant mood disorders, chronic pain, inflammation, cardiovascular dysfunction, inflammatory bowel disease, Crohn's disease. This study aims systematically review current evidence on efficacy safety depressive disorders its modulatory effects autonomic nervous system. Relevant primary secondary sources were identified through systematic search PubMed Google Scholar databases from 2008 2023. The used Scale Assessment Narrative Review Articles, resulting 0.77% intraclass correlation coefficient, 95% CI, 0.88 inter-rater reliability. taVNS, new neuromodulation method, stimulates regulates sympathetic parasympathetic branches ANS, increasing norepinephrine secretion, adaptability, heart rate variability. Future studies should clarify mechanisms address inconsistencies parameters. Standardizing treatment regimens can establish as viable, treatment. Our findings suggest However, further empirical research needed elucidate resolve parameters, larger are required confirm an effective
Язык: Английский
Процитировано
0
NeuroImage, Год журнала: 2025, Номер unknown, С. 121179 - 121179
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17
Опубликована: Апрель 28, 2025
This study aims to explore the central effects of acupuncture on vascular cognitive impairment (VCI) through peripheral nerve stimulation. scoping review followed methodological framework proposed by Arksey and O'Malley PRISMA-ScR guidelines. A comprehensive search databases, including PubMed, Web Science, MEDLINE, Embase, was conducted, 79 studies interventions for VCI. Acupoints their underlying anatomical structures related nerves were summarized, potential pathways via different explored. The results showed that acupuncture, stimulating specific acupoints head, face, torso, limbs, significantly affects networks, cervical, lumbar, sacral plexuses, thoracic nerves, vagus nerve, trigeminal its branches. stimulation can enhance regulation cerebral blood flow, modulate neuroimmune responses, improve brain function, promote neuroplasticity multiple nervous system pathways, ultimately improving function treating Acupuncture is a treatment modality influences treat deeper understanding induced acupuncture-triggered neural reflexes contribute improvement existing therapies help elucidate scientific principles acupuncture's therapeutic effects.
Язык: Английский
Процитировано
0
Frontiers in Robotics and AI, Год журнала: 2025, Номер 12
Опубликована: Май 23, 2025
Human operators of remote and semi-autonomous systems must have a high level executive function to safely efficiently conduct operations. These face unique cognitive challenges when monitoring controlling robotic machines, such as vehicles, drones, construction equipment. The development safe experienced human machines requires structured training credentialing programs. This review critically evaluates the potential for incorporating neurotechnology into operator work enhance human-machine interactions, performance, safety. Recent evidence demonstrating that different noninvasive neuromodulation neurofeedback methods can improve critical functions attention, learning, memory, control is reviewed. We further describe how these approaches be used outcomes, well teleoperator vigilance decision-making. also help during complex or high-risk tasks by mitigating impulsive decision-making errors. While our advocates programs, continued research required evaluate will impact industrial safety workforce readiness.
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 159, С. 114941 - 114941
Опубликована: Май 28, 2025
Язык: Английский
Процитировано
0
Neuroimage Reports, Год журнала: 2025, Номер 5(3), С. 100268 - 100268
Опубликована: Май 29, 2025
Язык: Английский
Процитировано
0