Therapeutic potential of cannabidiol polypharmacology in neuropsychiatric disorders

Trends in Pharmacological Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Cannabidiol (CBD), the primary non-intoxicating compound in cannabis, is currently approved for treating rare, treatment-resistant seizures. Recent preclinical research suggests that CBD's multifaceted mechanisms of action brain, which involve multiple molecular targets, underlie its neuroprotective, anti-inflammatory, anxiolytic, and antipsychotic effects. Clinical trials are also exploring therapeutic potential beyond current uses. This review focuses on polypharmacological profile discusses latest clinical findings regarding efficacy neuropsychiatric disorders. Existing evidence ability to modulate signaling pathways may benefit disorders, we propose further areas clarify mechanisms, address data gaps, refine indications.

Язык: Английский

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Nanoemulsions with cannabidiol reduced autistic-like behaviors and reversed decreased hippocampus viable cells and cerebral cortex neuronal death in a prenatal valproic acid rat model

Anais da Academia Brasileira de Ciências, Год журнала: 2025, Номер 97(1)

Опубликована: Янв. 1, 2025

Abstract The highly lipophilic nature and low aqueous solubility of cannabidiol (CBD) limit its oral bioavailability, resulting in poor intestinal absorption. To overcome these limitations, we proposed the production a nanoemulsion with CBD to be included therapeutic treatment autism spectrum disorder. current study aimed evaluate effect CBD-rich corn oil male rats born females exposed valproic acid (VPA) during pregnancy on autistic-like behaviors hippocampal histology. Offspring were treated orally twice daily nanoemulsions at different doses (1 2 mg/animal). endpoints evaluated anxiety, grooming time, exploratory activity, sociability, social preference index, cerebral cortex All formulations characterized as showed reduced vesicle size (107.6 - 72.6 nm), PDI (0.290-0.432), negative zeta potential (-40.6 mv), good stability. Prenatal exposure VPA increased anxiety index animals. Furthermore, VPA-exposed animals exhibited elevated neuronal death reduction viable cells hippocampus. In conclusion, reversed behaviors, potentially by protecting against death.

Язык: Английский

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Cannabinoid treatment for the symptoms of autism spectrum disorder

Expert Opinion on Emerging Drugs, Год журнала: 2024, Номер 29(1), С. 65 - 79

Опубликована: Янв. 2, 2024

Introduction Autism spectrum disorder (ASD) is a neurodevelopmental affecting approximately 3% of school-age children. The core symptoms are deficits in social communication and restricted repetitive patterns behavior. Associated problems cognition, language, behavior, sleep mood prevalent. Currently, no established pharmacological treatment exists for ASD symptoms. Risperidone aripiprazole used to manage associated irritability, but their effectiveness limited adverse events common.

Язык: Английский

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Endocannabinoid System Changes throughout Life: Implications and Therapeutic Potential for Autism, ADHD, and Alzheimer’s Disease

Brain Sciences, Год журнала: 2024, Номер 14(6), С. 592 - 592

Опубликована: Июнь 10, 2024

The endocannabinoid system has been linked to various physiological and pathological processes, because it plays a neuromodulator role in the central nervous system. In this sense, cannabinoids have used off-label for neurodevelopmental disorders, such as autism spectrum disorder (ASD) attention-deficit/hyperactivity (ADHA), well Alzheimer's disease (AD), more prevalent neurodegenerative disease. Thus, study aims, through comprehensive literature review, arrive at better understanding of impact therapeutic treatment patients with ASD, ADHD, (AD). Overall, cannabis products rich CBD displayed higher potential ASD children, while THC tested AD therapy. For clinical studies are incipient inconclusive, but promising. general, main limitations lack standardization cannabis-based consumed by participants, scientific rigor, small number participants.

Язык: Английский

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Therapeutic potential of CBD in Autism Spectrum Disorder

International review of neurobiology, Год журнала: 2024, Номер unknown, С. 149 - 203

Опубликована: Янв. 1, 2024

Язык: Английский

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Simultaneous quantification of terpenes and cannabinoids by reversed-phase LC-APCI-MS/MS in Cannabis sativa L. samples combined with a subsequent chemometric analysis

Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер 416(18), С. 4193 - 4206

Опубликована: Май 25, 2024

Cannabis sativa L. has been the most discussed medicinal plant in recent years. In particular, dynamic shift from a formerly illicit and tightly controlled substance to recognized for both recreational purposes brought C. into global spotlight. Due ongoing international legalization processes, fast convenient analytical methods quality control of flowers are tremendous interest. this study, we report development validation liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method applying atmospheric pressure chemical ionization (APCI) fully quantify 16 terpenes 7 cannabinoids including their acidic forms by single chromatographic method. The presented here is unique simple, as it eliminates need derivatization reactions includes unconventional analysis volatile compounds chromatography. Samples were prepared simple ethanolic extraction. Separation was accomplished within 25 min on reversed-phase C18 column. Method conducted according guidelines regarding selectivity, accuracy, precision, robustness, linearity. Detection done multiple reaction monitoring, which allowed simultaneous quantification co-eluting analytes two selective transitions. addition, due reproducible in-source decarboxylation, reliably quantified using transitions neutral forms. accuracy given bias below 15% all analytes. Matrix effects studied spiking Humulus lupulus extracts with at varying concentrations. APCI did not show susceptibility toward ion suppression or enhancement. recovery effect after between 80 120% terpenes. Further, 55 authentic quantified, obtained results terpene profiles compared state-of-the-art gas chromatography coupled flame detection. Comparable achieved, emphasizing method's applicability acquired metabolite patterns samples studied, identifying relationship cannabinoid patterns, well abundance myrcene CBD-dominant strains.

Язык: Английский

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Investigating the phytochemical diversity and anti-inflammatory activity of a non-psychoactive genotype of Cannabis sativa L. from India

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113111 - 113111

Опубликована: Фев. 1, 2025

Язык: Английский

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Persistent behavioural consequences of chronic adolescent cannabidiol (CBD) in a mouse model with increased susceptibility to Δ9-tetrahydrocannabinol and schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111306 - 111306

Опубликована: Март 1, 2025

Язык: Английский

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Cannabis Sativa Oil Promotes Social Interaction and Ultrasonic Communication by Acting on Oxytocin Pathway

Cannabis and Cannabinoid Research, Год журнала: 2024, Номер 9(6), С. 1514 - 1523

Опубликована: Май 27, 2024

Cannabis sativa is the most used recreational drug worldwide. In recent years, there has been a growing interest in potential therapeutic benefits of medicinal cannabis to treat variety psychiatric and neurological conditions. particular, cannabidiol (CBD), nonpsychoactive constituent, investigated for its prosocial effects on behavior, although molecular mechanisms underlying this effect are still largely unknown. The aim study was investigate C. oil CBD rich (CS oil) social interaction ultrasonic communication mice.

Язык: Английский

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Behavioral effects of two cannabidiol and cannabigerol-rich formulas on mice

Heliyon, Год журнала: 2024, Номер 10(21), С. e39938 - e39938

Опубликована: Ноя. 1, 2024

L. produces more than 100 specific bioactive compounds, known as cannabinoids. The major non-psychotropic

Язык: Английский

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