Therapeutic potential of cannabidiol polypharmacology in neuropsychiatric disorders

Trends in Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cannabidiol (CBD), the primary non-intoxicating compound in cannabis, is currently approved for treating rare, treatment-resistant seizures. Recent preclinical research suggests that CBD's multifaceted mechanisms of action brain, which involve multiple molecular targets, underlie its neuroprotective, anti-inflammatory, anxiolytic, and antipsychotic effects. Clinical trials are also exploring therapeutic potential beyond current uses. This review focuses on polypharmacological profile discusses latest clinical findings regarding efficacy neuropsychiatric disorders. Existing evidence ability to modulate signaling pathways may benefit disorders, we propose further areas clarify mechanisms, address data gaps, refine indications.

Language: Английский

---

Nanoemulsions with cannabidiol reduced autistic-like behaviors and reversed decreased hippocampus viable cells and cerebral cortex neuronal death in a prenatal valproic acid rat model

Anais da Academia Brasileira de Ciências, Journal Year: 2025, Volume and Issue: 97(1)

Published: Jan. 1, 2025

Abstract The highly lipophilic nature and low aqueous solubility of cannabidiol (CBD) limit its oral bioavailability, resulting in poor intestinal absorption. To overcome these limitations, we proposed the production a nanoemulsion with CBD to be included therapeutic treatment autism spectrum disorder. current study aimed evaluate effect CBD-rich corn oil male rats born females exposed valproic acid (VPA) during pregnancy on autistic-like behaviors hippocampal histology. Offspring were treated orally twice daily nanoemulsions at different doses (1 2 mg/animal). endpoints evaluated anxiety, grooming time, exploratory activity, sociability, social preference index, cerebral cortex All formulations characterized as showed reduced vesicle size (107.6 - 72.6 nm), PDI (0.290-0.432), negative zeta potential (-40.6 mv), good stability. Prenatal exposure VPA increased anxiety index animals. Furthermore, VPA-exposed animals exhibited elevated neuronal death reduction viable cells hippocampus. In conclusion, reversed behaviors, potentially by protecting against death.

Language: Английский

---

Cannabinoid treatment for the symptoms of autism spectrum disorder

Expert Opinion on Emerging Drugs, Journal Year: 2024, Volume and Issue: 29(1), P. 65 - 79

Published: Jan. 2, 2024

Introduction Autism spectrum disorder (ASD) is a neurodevelopmental affecting approximately 3% of school-age children. The core symptoms are deficits in social communication and restricted repetitive patterns behavior. Associated problems cognition, language, behavior, sleep mood prevalent. Currently, no established pharmacological treatment exists for ASD symptoms. Risperidone aripiprazole used to manage associated irritability, but their effectiveness limited adverse events common.

Language: Английский

---

Endocannabinoid System Changes throughout Life: Implications and Therapeutic Potential for Autism, ADHD, and Alzheimer’s Disease

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 592 - 592

Published: June 10, 2024

The endocannabinoid system has been linked to various physiological and pathological processes, because it plays a neuromodulator role in the central nervous system. In this sense, cannabinoids have used off-label for neurodevelopmental disorders, such as autism spectrum disorder (ASD) attention-deficit/hyperactivity (ADHA), well Alzheimer's disease (AD), more prevalent neurodegenerative disease. Thus, study aims, through comprehensive literature review, arrive at better understanding of impact therapeutic treatment patients with ASD, ADHD, (AD). Overall, cannabis products rich CBD displayed higher potential ASD children, while THC tested AD therapy. For clinical studies are incipient inconclusive, but promising. general, main limitations lack standardization cannabis-based consumed by participants, scientific rigor, small number participants.

Language: Английский

---

Therapeutic potential of CBD in Autism Spectrum Disorder

International review of neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 149 - 203

Published: Jan. 1, 2024

Language: Английский

---

Investigating the phytochemical diversity and anti-inflammatory activity of a non-psychoactive genotype of Cannabis sativa L. from India

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113111 - 113111

Published: Feb. 1, 2025

Language: Английский

---

Persistent behavioural consequences of chronic adolescent cannabidiol (CBD) in a mouse model with increased susceptibility to Δ9-tetrahydrocannabinol and schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111306 - 111306

Published: March 1, 2025

Language: Английский

---

Simultaneous quantification of terpenes and cannabinoids by reversed-phase LC-APCI-MS/MS in Cannabis sativa L. samples combined with a subsequent chemometric analysis

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(18), P. 4193 - 4206

Published: May 25, 2024

Cannabis sativa L. has been the most discussed medicinal plant in recent years. In particular, dynamic shift from a formerly illicit and tightly controlled substance to recognized for both recreational purposes brought C. into global spotlight. Due ongoing international legalization processes, fast convenient analytical methods quality control of flowers are tremendous interest. this study, we report development validation liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method applying atmospheric pressure chemical ionization (APCI) fully quantify 16 terpenes 7 cannabinoids including their acidic forms by single chromatographic method. The presented here is unique simple, as it eliminates need derivatization reactions includes unconventional analysis volatile compounds chromatography. Samples were prepared simple ethanolic extraction. Separation was accomplished within 25 min on reversed-phase C18 column. Method conducted according guidelines regarding selectivity, accuracy, precision, robustness, linearity. Detection done multiple reaction monitoring, which allowed simultaneous quantification co-eluting analytes two selective transitions. addition, due reproducible in-source decarboxylation, reliably quantified using transitions neutral forms. accuracy given bias below 15% all analytes. Matrix effects studied spiking Humulus lupulus extracts with at varying concentrations. APCI did not show susceptibility toward ion suppression or enhancement. recovery effect after between 80 120% terpenes. Further, 55 authentic quantified, obtained results terpene profiles compared state-of-the-art gas chromatography coupled flame detection. Comparable achieved, emphasizing method's applicability acquired metabolite patterns samples studied, identifying relationship cannabinoid patterns, well abundance myrcene CBD-dominant strains.

Language: Английский

---

Cannabis Sativa Oil Promotes Social Interaction and Ultrasonic Communication by Acting on Oxytocin Pathway

Cannabis and Cannabinoid Research, Journal Year: 2024, Volume and Issue: 9(6), P. 1514 - 1523

Published: May 27, 2024

Cannabis sativa is the most used recreational drug worldwide. In recent years, there has been a growing interest in potential therapeutic benefits of medicinal cannabis to treat variety psychiatric and neurological conditions. particular, cannabidiol (CBD), nonpsychoactive constituent, investigated for its prosocial effects on behavior, although molecular mechanisms underlying this effect are still largely unknown. The aim study was investigate C. oil CBD rich (CS oil) social interaction ultrasonic communication mice.

Language: Английский

---

Behavioral effects of two cannabidiol and cannabigerol-rich formulas on mice

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e39938 - e39938

Published: Nov. 1, 2024

L. produces more than 100 specific bioactive compounds, known as cannabinoids. The major non-psychotropic

Language: Английский

---