Factors Affecting Resilience and Prevention of Alzheimer's Disease and Related Dementias
Annals of Neurology,
Год журнала:
2024,
Номер
96(4), С. 633 - 649
Опубликована: Авг. 17, 2024
Alzheimer's
disease
(AD)
is
a
devastating,
age‐associated
neurodegenerative
disorder
and
the
most
common
cause
of
dementia.
The
clinical
continuum
AD
spans
from
preclinical
to
subjective
cognitive
decline,
mild
impairment,
dementia
stages
(mild,
moderate,
severe).
Neuropathologically,
defined
by
accumulation
amyloid
β
(Aβ)
into
extracellular
plaques
in
brain
parenchyma
cerebral
vasculature,
abnormally
phosphorylated
tau
that
accumulates
intraneuronally
forming
neurofibrillary
tangles
(NFTs).
Development
treatment
approaches
prevent
or
even
reduce
decline
because
has
been
slow
compared
other
major
causes
death.
Recently,
United
States
Food
Drug
Administration
gave
full
approval
2
different
Aβ‐targeting
monoclonal
antibodies.
However,
this
breakthrough
modifying
approach
only
applies
limited
subset
patients
there
are
stringent
eligibility
criteria.
Furthermore,
these
do
not
progression
disease,
AD‐related
pathologies,
such
as
NFTs,
directly
targeted.
A
non‐mutually
exclusive
alternative
address
lifestyle
interventions
can
help
risk
dementias
(ADRD).
It
estimated
addressing
modifiable
factors
could
potentially
delay
up
40%
AD/ADRD
cases.
In
review,
we
discuss
some
many
may
be
associated
with
prevention
and/or
increasing
resilience,
well
interact
influence
progression.
[Color
figure
viewed
at
www.annalsofneurology.org
]
ANN
NEUROL
2024;96:633–649
Язык: Английский
Prior infections are associated with smaller hippocampal volume in older women
Frontiers in Dementia,
Год журнала:
2024,
Номер
3
Опубликована: Фев. 7, 2024
Accumulating
evidence
suggests
that
infections
may
play
a
major
role
in
Alzheimer's
disease
(AD),
however,
mechanism
is
unclear,
as
multiple
pathways
be
involved.
One
possibility
could
contribute
to
neurodegeneration
directly
by
promoting
neuronal
death.
We
explored
relationships
between
history
of
and
brain
hippocampal
volume
(HV),
biomarker
neurodegeneration,
subsample
the
UK
Biobank
(UKB)
participants.
Infectious
diagnoses
were
based
on
ICD10
codes.
The
left/right
HV
was
measured
magnetic
resonance
imaging
(MRI)
cubic
millimeters
normalized.
Analysis
variance
(ANOVA),
Welch
test,
regression
used
examine
statistical
significance.
found
significantly
lower
women
aged
60–75,
well
65–80,
years,
with
infections,
compared
same
age
without
such
history.
effect
size
increased
faster
for
left
vs.
right
HV.
Results
males
didn't
reach
our
study
support
adult
women.
detrimental
became
stronger
age,
line
declining
resilience
increasing
vulnerability
stressors
due
aging.
increase
observed
indicate
female
verbal
memory
degrades
over
time
than
visual-spatial
memory.
sex
difference
reflect
higher
infection-related
factors,
which
turn
risk
AD
men.
Язык: Английский
Charting Alzheimer’s Disease and Dementia: Epidemiological Insights, Risk Factors and Prevention Pathways
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(14), С. 4100 - 4100
Опубликована: Июль 13, 2024
Alzheimer’s
disease
(AD),
the
most
common
cause
of
dementia,
is
a
complex
and
multifactorial
condition
without
cure
at
present.
The
latest
treatments,
based
on
anti-amyloid
monoclonal
antibodies,
have
only
modest
effect
in
reducing
progression
cognitive
decline
AD,
whereas
possibility
preventing
AD
has
become
crucial
area
research.
In
fact,
recent
studies
observed
decrease
dementia
incidence
developed
regions
such
as
US
Europe.
However,
these
trends
not
been
mirrored
non-Western
countries
(Japan
or
China),
contributing
factors
this
reduction
remain
unclear.
Lancet
Commission
delineated
constrained
classification
12
risk
across
different
life
stages.
Nevertheless,
scientific
literature
pointed
to
over
200
factors—including
sociodemographic,
medical,
psychological,
sociocultural
conditions—related
development
dementia/AD.
This
narrative
review
aims
synthesize
risk/protective
Essentially,
we
found
that
vary
between
individuals
populations,
complicating
creation
unified
prevention
strategy.
Moreover,
dementia/AD
explanatory
mechanisms
involve
diverse
array
genetic
environmental
interact
from
early
stages
life.
future,
population-based
cohorts
are
essential
validate
dementia.
evidence
would
help
develop
public
health
policies
Язык: Английский
Long-Term Exposure to PM2.5 Constituents, Genetic Susceptibility, and Incident Dementia: A Prospective Cohort Study among 0.2 Million Older Adults
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Fine
particulate
matter,
known
as
PM2.5,
is
recognized
a
risk
factor
for
dementia.
However,
the
specific
linkage
between
PM2.5
constituents
and
dementia
not
well
understood.
We
conducted
cohort
of
217,336
participants
UK
Biobank
to
explore
association
long-term
exposure
with
all-cause
dementia,
Alzheimer's
disease
(AD),
vascular
estimated
based
on
residential
addresses
by
an
evaluation
model
used
time-varying
Cox
models
Quantile
g-computation
assess
effects
individual
their
mixtures.
Genetic
susceptibility
was
assessed
using
polygenic
score,
its
multiplicative
additive
interactions
were
analyzed.
Our
results
showed
that
black
carbon
(BC),
ammonium
(NH4+),
organic
matter
(OM),
sulfate
(SO42-)
positively
associated
while
BC
OM
linked
AD,
being
most
influential.
The
combined
effect
genetic
stronger
than
effect.
This
study
offers
new
insights
into
especially
those
from
fuel
combustion
automobile
exhaust,
highlights
need
effective
prevention
strategies.
Язык: Английский
Association between air quality and neurodegenerative diseases in River Sacco Valley: A retrospective cohort study in Latium, central Italy
International Journal of Hygiene and Environmental Health,
Год журнала:
2025,
Номер
267, С. 114578 - 114578
Опубликована: Апрель 16, 2025
Язык: Английский
Traffic-related air pollution and APOE4 can synergistically affect hippocampal volume in older women: new findings from UK Biobank
Frontiers in Dementia,
Год журнала:
2024,
Номер
3
Опубликована: Июль 29, 2024
A
growing
research
body
supports
the
connection
between
neurodegenerative
disorders,
including
Alzheimer's
disease
(AD),
and
traffic-related
air
pollution
(TRAP).
However,
underlying
mechanisms
are
not
well
understood.
deeper
investigation
of
TRAP
effects
on
hippocampal
volume
(HV),
a
major
biomarker
neurodegeneration,
may
help
clarify
these
mechanisms.
Here,
we
explored
associations
with
HV
in
older
participants
UK
Biobank
(UKB),
taking
into
account
presence
APOE
e4
allele
(
APOE4
),
strongest
genetic
risk
factor
for
AD.
Exposure
to
was
approximated
by
distance
participant's
main
residence
nearest
road
(DNMR).
The
left/right
measured
magnetic
resonance
imaging
(MRI)
cubic
millimeters
(mm
3
).
Analysis
variance
(ANOVA),
Welch
test,
regression
were
used
examine
statistical
significance.
We
found
significant
interactions
DNMR
that
influenced
HV.
Specifically,
<50m
(equivalent
chronically
high
exposure
TRAP),
carrying
synergistically
associated
P
=
0.01)
reduction
right
about
2.5%
women
aged
60–75
years
(results
men
didn't
reach
significance).
Results
our
study
suggest
jointly
promote
neurodegeneration
women.
Living
farther
from
roads
reduce
risks
AD,
female
carriers.
Язык: Английский
Seasonal anomaly of particulate matter concentration in an equatorial climate: Evaluating the transboundary impact from neighboring provinces on Padang City, Indonesia
Environmental Monitoring and Assessment,
Год журнала:
2024,
Номер
196(11)
Опубликована: Окт. 4, 2024
Язык: Английский
Causal associations of ambient particulate matter 10 and Alzheimer’s disease: result from a two-sample multivariable Mendelian randomization study
Archives of Medical Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 18, 2024
Introduction
Alzheimer’s
disease
(AD)
and
ambient
particulate
matter
10
(PM10)
have
been
associated
in
epidemiological
studies.
However,
the
relationship
between
PM10
risk
of
AD
has
not
proven
to
be
causal.
Thus
we
used
two-sample
multivariable
Mendelian
randomization
(MR)
examine
this
relationship.
Material
methods
Genome-wide
association
studies
(GWAS)
for
from
UK
Biobank,
EBI
GWAS
IEU
OpenGWAS
were
discovery
replication,
respectively.
Pooled
meta-analysis
inverse
variance
weighted
(IVW)
method
was
main
method.
Sensitivity
analyses
included
MR-Egger
regression,
median,
mode
leave-one-out
methods.
The
MR
model
adjusted
education.
estimates
causality
expressed
as
odds
ratios
(OR)
corresponding
95%
confidence
intervals
(CI).
Results
There
total
17
19
genetic
variants
with
replication
steps,
In
univariate
MR,
pooled
genetically
predicted
a
99%
increased
(95%
CI:
1.25,
3.15,
p
=
0.004)
per
1
standard
deviation
(SD)
increment
by
IVW,
meta-analysis,
found
that
each
SD
increase
127%
1.33,
3.86,
0.002)
after
accounting
education
levels.
Conclusions
Increased
levels
significantly
related
an
AD.
This
study
provided
evidence
prediction
causal
AD,
suggesting
air
pollution
control
may
significant
implications
prevention
Язык: Английский
Zebrafish Experimental Animal Models for AD: A Comprehensive Review
Current Reviews in Clinical and Experimental Pharmacology,
Год журнала:
2024,
Номер
19(4), С. 295 - 311
Опубликована: Янв. 29, 2024
AD
disease
(AD)
is
a
multifaceted
and
intricate
neurodegenerative
disorder
characterized
by
intracellular
neurofibrillary
tangle
(NFT)
formation
the
excessive
production
deposition
of
Aβ
senile
plaques.
While
transgenic
models
have
been
found
instrumental
in
unravelling
pathogenesis,
they
involve
cost
time
constraints
during
preclinical
phase.
Zebrafish,
owing
to
their
simplicity,
well-defined
behavioural
patterns,
relevance
research,
emerged
as
promising
complementary
model.
Zebrafish
possess
glutaminergic
cholinergic
pathways
implicated
learning
memory,
actively
contributing
our
understanding
neural
transmission
processes.
This
review
sheds
light
on
molecular
mechanisms
which
various
neurotoxic
agents,
including
okadaic
acid
(OKA),
cigarette
smoke
extract,
metals,
zebrafish
with
genetic
similarities
patients,
induce
cognitive
impairments
neuronal
degeneration
mammalian
systems.
These
insights
may
facilitate
identification
effective
agents
for
replicating
pathogenesis
brain.
In
this
comprehensive
review,
pivotal
role
advancing
comprehension
emphasized.
hold
immense
potential
shaping
future
research
directions
clinical
interventions,
ultimately
development
novel
therapies.
Язык: Английский