Zebrafish Experimental Animal Models for AD: A Comprehensive Review DOI

Ruksar Sande,

Angel Godad, Gaurav Doshi

et al.

Current Reviews in Clinical and Experimental Pharmacology, Journal Year: 2024, Volume and Issue: 19(4), P. 295 - 311

Published: Jan. 29, 2024

AD disease (AD) is a multifaceted and intricate neurodegenerative disorder characterized by intracellular neurofibrillary tangle (NFT) formation the excessive production deposition of Aβ senile plaques. While transgenic models have been found instrumental in unravelling pathogenesis, they involve cost time constraints during preclinical phase. Zebrafish, owing to their simplicity, well-defined behavioural patterns, relevance research, emerged as promising complementary model. Zebrafish possess glutaminergic cholinergic pathways implicated learning memory, actively contributing our understanding neural transmission processes. This review sheds light on molecular mechanisms which various neurotoxic agents, including okadaic acid (OKA), cigarette smoke extract, metals, zebrafish with genetic similarities patients, induce cognitive impairments neuronal degeneration mammalian systems. These insights may facilitate identification effective agents for replicating pathogenesis brain. In this comprehensive review, pivotal role advancing comprehension emphasized. hold immense potential shaping future research directions clinical interventions, ultimately development novel therapies.

Language: Английский

Factors Affecting Resilience and Prevention of Alzheimer's Disease and Related Dementias DOI Creative Commons
Arjun V. Masurkar, Karyn Marsh, Brianna Morgan

et al.

Annals of Neurology, Journal Year: 2024, Volume and Issue: 96(4), P. 633 - 649

Published: Aug. 17, 2024

Alzheimer's disease (AD) is a devastating, age‐associated neurodegenerative disorder and the most common cause of dementia. The clinical continuum AD spans from preclinical to subjective cognitive decline, mild impairment, dementia stages (mild, moderate, severe). Neuropathologically, defined by accumulation amyloid β (Aβ) into extracellular plaques in brain parenchyma cerebral vasculature, abnormally phosphorylated tau that accumulates intraneuronally forming neurofibrillary tangles (NFTs). Development treatment approaches prevent or even reduce decline because has been slow compared other major causes death. Recently, United States Food Drug Administration gave full approval 2 different Aβ‐targeting monoclonal antibodies. However, this breakthrough modifying approach only applies limited subset patients there are stringent eligibility criteria. Furthermore, these do not progression disease, AD‐related pathologies, such as NFTs, directly targeted. A non‐mutually exclusive alternative address lifestyle interventions can help risk dementias (ADRD). It estimated addressing modifiable factors could potentially delay up 40% AD/ADRD cases. In review, we discuss some many may be associated with prevention and/or increasing resilience, well interact influence progression. [Color figure viewed at www.annalsofneurology.org ] ANN NEUROL 2024;96:633–649

Language: Английский

Citations

8
Prior infections are associated with smaller hippocampal volume in older women DOI Creative Commons

Vladimir A. Popov,

Svetlana Ukraintseva,

Hongzhe Duan

et al.

Frontiers in Dementia, Journal Year: 2024, Volume and Issue: 3

Published: Feb. 7, 2024

Accumulating evidence suggests that infections may play a major role in Alzheimer's disease (AD), however, mechanism is unclear, as multiple pathways be involved. One possibility could contribute to neurodegeneration directly by promoting neuronal death. We explored relationships between history of and brain hippocampal volume (HV), biomarker neurodegeneration, subsample the UK Biobank (UKB) participants. Infectious diagnoses were based on ICD10 codes. The left/right HV was measured magnetic resonance imaging (MRI) cubic millimeters normalized. Analysis variance (ANOVA), Welch test, regression used examine statistical significance. found significantly lower women aged 60–75, well 65–80, years, with infections, compared same age without such history. effect size increased faster for left vs. right HV. Results males didn't reach our study support adult women. detrimental became stronger age, line declining resilience increasing vulnerability stressors due aging. increase observed indicate female verbal memory degrades over time than visual-spatial memory. sex difference reflect higher infection-related factors, which turn risk AD men.

Language: Английский

Citations

4
Charting Alzheimer’s Disease and Dementia: Epidemiological Insights, Risk Factors and Prevention Pathways DOI Open Access
Israel Contador, Bárbara Buch-Vicente,

Teodoro del Ser

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4100 - 4100

Published: July 13, 2024

Alzheimer’s disease (AD), the most common cause of dementia, is a complex and multifactorial condition without cure at present. The latest treatments, based on anti-amyloid monoclonal antibodies, have only modest effect in reducing progression cognitive decline AD, whereas possibility preventing AD has become crucial area research. In fact, recent studies observed decrease dementia incidence developed regions such as US Europe. However, these trends not been mirrored non-Western countries (Japan or China), contributing factors this reduction remain unclear. Lancet Commission delineated constrained classification 12 risk across different life stages. Nevertheless, scientific literature pointed to over 200 factors—including sociodemographic, medical, psychological, sociocultural conditions—related development dementia/AD. This narrative review aims synthesize risk/protective Essentially, we found that vary between individuals populations, complicating creation unified prevention strategy. Moreover, dementia/AD explanatory mechanisms involve diverse array genetic environmental interact from early stages life. future, population-based cohorts are essential validate dementia. evidence would help develop public health policies

Language: Английский

Citations

4
Long-Term Exposure to PM2.5 Constituents, Genetic Susceptibility, and Incident Dementia: A Prospective Cohort Study among 0.2 Million Older Adults DOI

Lei Zheng,

Binbin Su, Fei-Peng Cui

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Fine particulate matter, known as PM2.5, is recognized a risk factor for dementia. However, the specific linkage between PM2.5 constituents and dementia not well understood. We conducted cohort of 217,336 participants UK Biobank to explore association long-term exposure with all-cause dementia, Alzheimer's disease (AD), vascular estimated based on residential addresses by an evaluation model used time-varying Cox models Quantile g-computation assess effects individual their mixtures. Genetic susceptibility was assessed using polygenic score, its multiplicative additive interactions were analyzed. Our results showed that black carbon (BC), ammonium (NH4+), organic matter (OM), sulfate (SO42-) positively associated while BC OM linked AD, being most influential. The combined effect genetic stronger than effect. This study offers new insights into especially those from fuel combustion automobile exhaust, highlights need effective prevention strategies.

Language: Английский

Citations

0
Association between air quality and neurodegenerative diseases in River Sacco Valley: A retrospective cohort study in Latium, central Italy DOI

Alessandro Trentalange,

Chiara Badaloní, Daniela Porta

et al.

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 267, P. 114578 - 114578

Published: April 16, 2025

Language: Английский

Citations

0
Traffic-related air pollution and APOE4 can synergistically affect hippocampal volume in older women: new findings from UK Biobank DOI Creative Commons

Vladimir A. Popov,

Svetlana Ukraintseva,

Hongzhe Duan

et al.

Frontiers in Dementia, Journal Year: 2024, Volume and Issue: 3

Published: July 29, 2024

A growing research body supports the connection between neurodegenerative disorders, including Alzheimer's disease (AD), and traffic-related air pollution (TRAP). However, underlying mechanisms are not well understood. deeper investigation of TRAP effects on hippocampal volume (HV), a major biomarker neurodegeneration, may help clarify these mechanisms. Here, we explored associations with HV in older participants UK Biobank (UKB), taking into account presence APOE e4 allele ( APOE4 ), strongest genetic risk factor for AD. Exposure to was approximated by distance participant's main residence nearest road (DNMR). The left/right measured magnetic resonance imaging (MRI) cubic millimeters (mm 3 ). Analysis variance (ANOVA), Welch test, regression were used examine statistical significance. We found significant interactions DNMR that influenced HV. Specifically, <50m (equivalent chronically high exposure TRAP), carrying synergistically associated P = 0.01) reduction right about 2.5% women aged 60–75 years (results men didn't reach significance). Results our study suggest jointly promote neurodegeneration women. Living farther from roads reduce risks AD, female carriers.

Language: Английский

Citations

1
Seasonal anomaly of particulate matter concentration in an equatorial climate: Evaluating the transboundary impact from neighboring provinces on Padang City, Indonesia DOI
Muhammad Amin,

Teguh Ariefianto,

Dikarama Kaula

et al.

Environmental Monitoring and Assessment, Journal Year: 2024, Volume and Issue: 196(11)

Published: Oct. 4, 2024

Language: Английский

Citations

1
Causal associations of ambient particulate matter 10 and Alzheimer’s disease: result from a two-sample multivariable Mendelian randomization study DOI
Zehan Huang, Guodong He,

Shuo Sun

et al.

Archives of Medical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Introduction Alzheimer’s disease (AD) and ambient particulate matter 10 (PM10) have been associated in epidemiological studies. However, the relationship between PM10 risk of AD has not proven to be causal. Thus we used two-sample multivariable Mendelian randomization (MR) examine this relationship. Material methods Genome-wide association studies (GWAS) for from UK Biobank, EBI GWAS IEU OpenGWAS were discovery replication, respectively. Pooled meta-analysis inverse variance weighted (IVW) method was main method. Sensitivity analyses included MR-Egger regression, median, mode leave-one-out methods. The MR model adjusted education. estimates causality expressed as odds ratios (OR) corresponding 95% confidence intervals (CI). Results There total 17 19 genetic variants with replication steps, In univariate MR, pooled genetically predicted a 99% increased (95% CI: 1.25, 3.15, p = 0.004) per 1 standard deviation (SD) increment by IVW, meta-analysis, found that each SD increase 127% 1.33, 3.86, 0.002) after accounting education levels. Conclusions Increased levels significantly related an AD. This study provided evidence prediction causal AD, suggesting air pollution control may significant implications prevention

Language: Английский

Citations

1
Zebrafish Experimental Animal Models for AD: A Comprehensive Review DOI

Ruksar Sande,

Angel Godad, Gaurav Doshi

et al.

Current Reviews in Clinical and Experimental Pharmacology, Journal Year: 2024, Volume and Issue: 19(4), P. 295 - 311

Published: Jan. 29, 2024

AD disease (AD) is a multifaceted and intricate neurodegenerative disorder characterized by intracellular neurofibrillary tangle (NFT) formation the excessive production deposition of Aβ senile plaques. While transgenic models have been found instrumental in unravelling pathogenesis, they involve cost time constraints during preclinical phase. Zebrafish, owing to their simplicity, well-defined behavioural patterns, relevance research, emerged as promising complementary model. Zebrafish possess glutaminergic cholinergic pathways implicated learning memory, actively contributing our understanding neural transmission processes. This review sheds light on molecular mechanisms which various neurotoxic agents, including okadaic acid (OKA), cigarette smoke extract, metals, zebrafish with genetic similarities patients, induce cognitive impairments neuronal degeneration mammalian systems. These insights may facilitate identification effective agents for replicating pathogenesis brain. In this comprehensive review, pivotal role advancing comprehension emphasized. hold immense potential shaping future research directions clinical interventions, ultimately development novel therapies.

Language: Английский

Citations

0