BMC Public Health, Год журнала: 2024, Номер 24(1)
Опубликована: Авг. 8, 2024
The impact of obesity on cognitive function has engendered considerable interest. Weight-adjusted waist index (WWI) emerged as a novel and innovative marker that reflects weight-independent abdominal obesity. However, the association between WWI remains unclear. To address this gap, present study aims to explore relationship weight-adjusted performance in older adults.
Язык: Английский
Metabolites, Год журнала: 2023, Номер 13(1), С. 86 - 86
Опубликована: Янв. 5, 2023
Obesity is defined as abnormal and excessive fat accumulation, it a risk factor for developing metabolic neurodegenerative diseases cognitive deficits. caused by an imbalance in energy homeostasis resulting from increased caloric intake associated with sedentary lifestyle. However, the entire physiopathology linking obesity neurodegeneration decline has not yet been elucidated. During progression of obesity, adipose tissue undergoes immune, metabolic, functional changes that induce chronic low-grade inflammation. It proposed inflammatory processes may participate both peripheral disorders brain including development In addition, mitochondrial dysfunction related to inflammation oxidative stress, causing cellular damage. Preclinical clinical studies have demonstrated dysfunction. Since neuronal cells high demand mitochondria play important role maintaining constant supply, impairments activity lead damage and, consequently, neurotoxicity. this review, we highlight effect high-fat diet consumption on neuroinflammation link between decline.
Язык: Английский
Процитировано
47
Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)
Опубликована: Апрель 29, 2024
Abstract Obesity increases the morbidity and mortality of traumatic brain injury (TBI). Detailed analyses transcriptomic changes in adipose tissue were performed to elucidate interactive effects between high-fat diet-induced obesity (DIO) TBI. Adult male mice fed a diet (HFD) for 12 weeks prior experimental TBI continuing after injury. High-throughput analysis using Nanostring panels total visceral (VAT) cellular components brain, followed by unsupervised clustering, principal component analysis, IPA pathway used determine shifts gene expression patterns molecular activity. Cellular populations cortex hippocampus, as well VAT, during chronic phase combined TBI-HFD showed amplification central peripheral microglia/macrophage responses, including superadditive selected signatures pathways. Furthermore, HFD caused additive dysfunction Y-Maze, Novel Object Recognition (NOR), Morris water maze (MWM) cognitive function tests. These novel data suggest that HFD-induced can independently prime support development altered states microglia disease-associated (DAM) phenotype observed neurodegenerative disorders. The interaction promotes shift toward reactive associated pro-inflammatory disease-altered may, part, underlie exacerbation deficits. Thus, targeting phenotypes, immune cell populations, may serve reduce microglial maladaptive TBI, attenuating post-traumatic neurodegeneration neurological dysfunction.
Язык: Английский
Процитировано
11
Reviews in Endocrine and Metabolic Disorders, Год журнала: 2023, Номер 24(5), С. 795 - 807
Опубликована: Май 10, 2023
Abstract Obesity is a complex disease that relapses frequently and associates with multiple complications comprise worldwide health priority because of its rising prevalence association numerous complications, including metabolic disorders, mechanic pathologies, cancer, among others. Noteworthy, excess adiposity accompanied by chronic inflammation, oxidative stress, insulin resistance, subsequent organ dysfunction. This dysfunctional adipose tissue initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity ectopic depots like liver, heart, muscle, pancreas, People living obesity need diagnostic approach considers an exhaustive pathophysiology assessment. Thus, it essential warrant holistic diagnosis management guarantees adequate status, quality life. The present review summarizes different associated obesity, at same time, we aim fostering novel framework enhances patient-centered precision medicine era.
Язык: Английский
Процитировано
22
Advanced Materials, Год журнала: 2024, Номер 36(21)
Опубликована: Апрель 9, 2024
Obesity is a significant health concern that often leads to metabolic dysfunction and chronic diseases. This study introduces novel approach combat obesity using orally ingested self-powered electrostimulators. These electrostimulators consist of piezoelectric BaTiO
Язык: Английский
Процитировано
6
Molecular Neurobiology, Год журнала: 2024, Номер 61(10), С. 8069 - 8085
Опубликована: Март 9, 2024
Язык: Английский
Процитировано
5
Biomedicines, Год журнала: 2024, Номер 12(9), С. 1994 - 1994
Опубликована: Сен. 2, 2024
Depression affects several aspects of life, including socioeconomic status, relationships, behavior, emotions, and overall health. The etiology depression is complex influenced by various factors, with obesity emerging as a significant contributor. This narrative review aims to investigate the factors associated development depression, particular focus on role obesity. literature search was conducted PubMed, Embase, PsycINFO from May July 2024. highlights impact environmental conditions; lifestyle choices, physical activity dietary habits; stress; traumatic experiences; neurotransmitter imbalances; medical psychological hormone fluctuations; epigenetic depression. A key emphasis placed inflammatory processes linked obesity, which may drive bidirectional relationship between findings suggest that an increased risk potentially due chronic inflammation, neurochemical dysregulation, emotional social challenges related weight stigma management. Understanding these interconnected important for developing targeted interventions address both leading improved quality life those affected.
Язык: Английский
Процитировано
5
The Innovation Medicine, Год журнала: 2024, Номер 2(3), С. 100090 - 100090
Опубликована: Янв. 1, 2024
<p>Obesity, a growing global health crisis, is driven by complex interplay of genetic, biological, environmental, behavioral, socio-cultural, and economic factors. This comprehensive review encapsulates the epidemiology, pathophysiological mechanism, myriad complications it triggers, such as cardiovascular diseases (CVDs), cancer, neurological disorders, respiratory ailments, digestive diseases, mobility impairments, psychological stress. The etiology obesity multifaceted, involving genetic predispositions, environmental influences, behavioral tendencies, socio-economic elements. underpinnings encompass multifaceted aspects energy metabolism, including regulation appetite, glucose, lipid, amino acid metabolism. also addresses seemingly contradictory roles in various offering insights into these phenomena. management multi-pronged, lifestyle modifications, pharmacological interventions, metabolic surgeries. Lifestyle changes are foundational, but advancements molecular techniques, digital technology, wearable devices, artificial intelligence opening new avenues for personalized treatment early intervention. Pharmacological surgery effective should be judiciously tailored to individual patient needs. underscores importance approach management, aiming curb escalating trend enhance future interventions treatments. ultimate goal synthesize current evidence innovative strategies combat effectively.</p>
Язык: Английский
Процитировано
5
Food & Function, Год журнала: 2024, Номер 15(15), С. 8070 - 8086
Опубликована: Янв. 1, 2024
Aloe polysaccharides (APs) display cognition-improving properties, but the underlying mechanisms remain unclear. Herein, AP supplementation for 24 weeks significantly improved cognitive behavioral disturbances caused by a high-fat diet. Moreover, APs notably reshaped structure of gut microbiota, which was manifested increasing relative abundance
Язык: Английский
Процитировано
4
Annals of Surgery Open, Год журнала: 2025, Номер 6(1), С. e541 - e541
Опубликована: Янв. 10, 2025
To evaluate the association of bariatric surgery with reduced incidence and delayed development mild cognitive impairment (MCI) Alzheimer disease related dementias (ADRD) in patients obesity. This retrospective longitudinal study utilized Electronic Health Records from Vanderbilt University Medical Center, covering 5303 who underwent 10,606 propensity score-matched obese did not, 2000 to 2023. Patients prior MCI, ADRD, schizophrenia, alcoholism, gastric cancer, ulcers, inflammatory bowel disease, coagulopathy, stroke, Parkinson or brain cancer were excluded both groups. Differences time MCI/ADRD between surgical control groups analyzed using linear regression, adjusted for confounders: demographics, medical history, socioeconomic status. Survival probability differences MCI ADRD 2 over assessed Kaplan-Meier curves log-rank tests. Incidence evaluated Fine-Gray subdistribution hazard models, accounting competing risk death confounders. Bariatric was associated a significantly evidenced by ratio (SHR) 0.37 (95% confidence interval [CI]: 0.15-0.89; P = 0.03). Similarly, lower group, an SHR 0.57 CI: 0.39-0.85; 0.01). Additionally, experienced delay 2.01 years before developing compared group 0.70-3.50; 0.004). These findings suggest that may serve as effective strategy onset reduce
Язык: Английский
Процитировано
0
European Stroke Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 15, 2025
Introduction: While adiposity is an established risk factor for incident ischemic stroke, its influence on functional recovery after stroke uncertain. We leveraged Mendelian randomization (MR) to examine the causal effects of body mass index (BMI) and waist-to-hip ratio (WHR) post-stroke motor, cognitive, global recovery. Materials methods: Genetic proxies BMI WHR were obtained from a genome-wide association study (GWAS) meta-analysis GIANT consortium UK Biobank ( n = 806,834). The primary outcomes longitudinal trajectories three National Institutes Health Stroke Scale (NIHSS) measures assessed over 2-year period: motor function subscores, cognitive performance total NIHSS scores (as measure recovery). associations with these GWAS conducted within VISP trial mild 1270). MR estimated using inverse-variance weighted method. Results: A 1-standard deviation (SD) increase (~4.8 kg/m 2 ) in genetically predicted associated lower odds improvement (OR 0.37, 95% CI 0.19-0.72; p 0.003). Similarly, was worse (β −0.12, −0.21, −0.03; 0.009) −0.36, −0.59, −0.13; 0.002). Associations between directionally concordant but not statistically significant > 0.05). Discussions conclusions: Human genetic evidence suggests that elevated negatively impacts multiple outcomes, including function, cognition, overall biological pathways underlying warrant further investigation.
Язык: Английский
Процитировано
0