Intermittent Fasting: Myths, Fakes and Truth on This Dietary Regimen Approach

Foods, Год журнала: 2024, Номер 13(13), С. 1960 - 1960

Опубликована: Июнь 21, 2024

Intermittent fasting (IF) has been indicated as a valuable alternative to the classical caloric restriction dietary regimen for lowering body weight and preventing obesity-related complications, such metabolic syndrome type II diabetes. However, is it effective? In this review article, we analyzed over 50 clinical studies in which IF, conducted by alternate day (ADF) or time-restricted feeding (TRF), was compared with approach. We evaluated different roles of IF treating human disorders syndrome, diabetes, some types cancer, well usefulness reducing cardiovascular risk factors hypertension. Furthermore, explored cellular pathways targeted exert their beneficial effects activating effector proteins that modulate cell functions resistance oxidative stress. contrast, investigated concerns regarding health related adoption regimens, highlighting profound debate surrounding loss regimens. examined several trials formulate an updated concept its therapeutic potential.

Язык: Английский

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Metabolic changes with intermittent fasting

Journal of Human Nutrition and Dietetics, Год журнала: 2023, Номер 37(1), С. 256 - 269

Опубликована: Окт. 3, 2023

Abstract Background The prevalence of obesity is rising globally and effective strategies to treat are needed. Intermittent fasting, a dietary intervention for weight management, has received growing interest from the general public, as well healthcare professionals, form lifestyle intervention. Methods We executed rapid review using PUBMED database identify systematic reviews that examined impact intermittent fasting on metabolic indices, published between 2011 2022. Results leads loss similar magnitude continuous energy restriction. Most evidence shows greater fat measured by mass (kg) or body percentage compared an ad libitum diet, but attained during not significantly different restriction, although recent be superior. There mixed insulin resistance, glucose lipid profile. Some studies focused populations Muslim people, which showed Ramadan may lead improvement parameters effects reversed when finished. Conclusions more than intake, equally management. However, there inconclusive whether clinically beneficial effect metabolism.

Язык: Английский

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Effect of Intermittent Fasting on Lipid Profile, Anthropometric and Hepatic Markers in Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review

Current Vascular Pharmacology, Год журнала: 2024, Номер 22(3), С. 187 - 202

Опубликована: Фев. 4, 2024

The first-line treatment for non-alcoholic fatty liver disease (NAFLD) is lifestyle modification; this should accompany any pharmacological intervention. Intermittent fasting (IF) has shown benefits over metabolic and cardiovascular parameters. Non-religious IF includes Time-Restricted Feeding (TRF), Alternate-Day Fasting (ADF), 5:2 interventions.

Язык: Английский

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Effects of different types of intermittent fasting on metabolic outcomes: an umbrella review and network meta-analysis

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 12, 2024

Intermittent fasting (IF) holds promise for enhancing metabolic health. However, the optimum IF forms and their superiority over continuous energy restriction (CER) remain unclear due to disconnected findings.

Язык: Английский

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Efficacy of intermittent fasting on improving liver function in individuals with metabolic disorders: a systematic review and meta-analysis

Nutrition & Metabolism, Год журнала: 2025, Номер 22(1)

Опубликована: Янв. 6, 2025

Intermittent fasting (IF) can be an effective dietary therapy for weight loss and improving cardiometabolic health. However, there is scant evidence regarding the role of IF on indicators liver function, particularly in adults with metabolic disorders. Therefore, we performed a systematic review meta-analysis to investigate effects function Three primary electronic databases including PubMed, Web Science, Scopus, were searched from inception September 2024 identify original studies that used interventions or without control groups Inclusion criteria (1) human participants diseases, (2) evaluated IF, (3) group, (4) measured fat, steatosis, fibrosis, enzymes, alanine aminotransferase (ALT) aspartate (AST) as outcomes. Standardized mean differences (SMD) 95% confidence intervals calculated using random models. Heterogeneity was assessed Cochran's Q statistic I-squared (I2). Publication bias visual inspection funnel plots Egger's tests. The risk PEDro scale NIH quality assessment tool. A total 21 involving 1,226 disorders included meta-analysis. Overall, effectively decreased fat large effect size [SMD: -1.22 (95% CI: -1.63 -0.80), p = 0.001], steatosis medium -0.73 -1.12 -0.35), ALT small -0.44 -0.58 -0.30), AST -0.30 -0.49 -0.11), but not fibrosis -0.28 -0.59 0.02), 0.07]. Subgroup analyses showed significantly, independent mode, participant age, health status, intervention duration. significantly those obesity; following 5:2 diets, middle-aged adults, obesity, regardless status seems disorders, many function-related benefits occur duration, status. Significant heterogeneity, numbers inclusion non-randomized trials single-group pre-post main limitation our Further randomized clinical are needed elucidate

Язык: Английский

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The research progress and prospects of circadian rhythm in obesity: a bibliometric analysis

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 7, 2025

Numerous studies have shown a link between circadian rhythms disruptions and higher risk of obesity. This article aims to conduct an extensive bibliometric analysis deepen our understanding the relationship The literature related rhythm obesity, published from inception Web Science Core Collection (WoSCC) until June 30, 2024, was extracted WoSCC databases (SCIE, SSCI, ESCI). Using CiteSpace, Vosviewer, WPS, other software, this paper examines publication trends, including number papers, countries/regions, institutions, authors, journals, references, keywords. A total 2,870 articles were included in analysis, revealing consistent year by increase research on These publications originate 460 institutions 88 countries. Among authors Garaulet, Marta most prolific, Turek FW co-cited. Proceedings National Academy Sciences United States America emerged as journal with highest publications, American Journal Physiology had centrality. frequently used keywords "obesity," "circadian rhythm," clock," "metabolic syndrome," "metabolism." Additionally, areas involving intermittent fasting, restricted feeding, gut microbiota rapidly developing represented forefront Our study demonstrates that obesity has been expanding, increasingly in-depth exploration topic. It is recommended strengthen cooperation countries jointly promote field. gene expression early hotspot emerging such endothelial nitric oxide synthase will become significant hotspots trends field findings provide researchers critical directions for future may implications clinical practice public health policy.

Язык: Английский

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Exploring the Connection: How Does Fluid Restrictive Intermittent Fasting Affect Benign Anorectal Diseases?

Journal of Coloproctology, Год журнала: 2025, Номер 45(01), С. e1 - e6

Опубликована: Март 1, 2025

Abstract Introduction Intermittent fasting (IF) has gained popularity in recent years as a potential tool for promoting health and reducing disease risk. However, little research been done on the impact of fluid restrictive IF benign anorectal diseases. In this study, we aim to explore effects long periods conditions such hemorrhoids anal fissures, focusing role other influencing factors. Materials Methods This study utilized cohort design examine changes admissions hemorrhoidal fissure during Ramadan, period intermittent with restriction, compared remainder year. Patients admitted these between January 1, 2010, December 31, 2019, were divided into two groups: Ramadan group control (non-Ramadan) group. The primary endpoint was determine any significant differences groups. Results results showed that total 49,046 patients (0.68% all admissions) disease, 33,480 (0.45%) fissures reviewed. Admissions significantly higher at 0.9%, 0.7% (p < 0.001). no increase observed admittance rate Conclusion explores connection incidence, shedding light under-researched area. Findings suggest extended may risk highlighting need clinicians individuals adopting regimes consider related

Язык: Английский

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Comorbid patient with obesity:comparative assessment of the effect of intermittent or continuous calorie restriction on body weight and cardiometabolic risk markers

Experimental and Clinical Gastroenterology, Год журнала: 2025, Номер 9, С. 26 - 35

Опубликована: Март 6, 2025

The purpose of this study is to present the results a comparative assessment effect intermittent restricted diet (ICR) with constant (CCR) on weight loss, fat mass, cardiometabolic risk markers, glucose and insulin levels in obese adults. Materials methods: works cited were selected using keywords “obesity”, “comorbidity”, “weight loss”, “intermittent calorie restriction”, “constant search engines PubMed, Scopus. Publications had meet following criteria: randomized clinical trials, published last decade (2014-2024), access full text publication, primary endpoint or continuous restriction as main intervention, adult population, subjects obesity comorbid pathology. Results: Obesity has acquired pandemic proportions worldwide. In some countries, prevalence rates range from 20 40%. Prevalence incidence continue increase. It estimated that by 2030, almost 50% world’s population will be overweight obese. increases number chronic noncommunicable diseases (T2DM, CVD, CKD, CLD, types cancer). Weight loss intervention for people obesity. Conservative non-drug therapy form nutritional modification mainstay treatment recommended first, mandatory permanent component treatment. Daily caloric feeding are two forms dietary can help reduce body weight. Conclusion: Based analysis, we concluded ICR CCR alternative energy regimens comparable improvements obesity-related markers. Both well tolerated most studies may equivalent approaches loss. Further needed examine efficacy, feasibility safety patients such type 2 diabetes, cardiovascular disease cancer.

Язык: Английский

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Debunking the myths of intermittent fasting

Nature Reviews Endocrinology, Год журнала: 2024, Номер 20(9), С. 503 - 504

Опубликована: Июнь 19, 2024

Язык: Английский

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Does Timing Matter? A Narrative Review of Intermittent Fasting Variants and Their Effects on Bodyweight and Body Composition

Nutrients, Год журнала: 2022, Номер 14(23), С. 5022 - 5022

Опубликована: Ноя. 25, 2022

The practice of fasting recently has been purported to have clinical benefits, particularly as an intervention against obesity and its related pathologies. Although a number different temporal dietary restriction strategies employed in practice, they are generally classified under the umbrella term “intermittent fasting” (IF). IF can be stratified into two main categories: (1) intra-weekly (alternate-day fasting/ADF, twice-weekly fasting/TWF) (2) intra-daily (early time-restricted eating/eTRE delayed eating/dTRE). A growing body evidence indicates that is viable alternative daily caloric (DCR), showing effectiveness weight loss intervention. This paper narratively reviews literature on effects various commonly used composition when compared traditional DCR approaches, draws conclusions for their practical application. specific focus provided use combination with regimented exercise programs associated fat mass lean mass.

Язык: Английский

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