Curcumin effects on glycaemic indices, lipid profile, blood pressure, inflammatory markers and anthropometric measurements of non-alcoholic fatty liver disease patients: A systematic review and meta-analysis of randomized clinical trials

Complementary Therapies in Medicine, Год журнала: 2024, Номер 80, С. 103025 - 103025

Опубликована: Янв. 16, 2024

Curcumin has antioxidant properties and been proposed as a potential treatment for NAFLD. The aim of current systematic review meta-analysis was to evaluate previous findings the effect curcumin supplementation on glycaemic indices, lipid profile, blood pressure, inflammatory markers, anthropometric measurements NAFLD patients. Relevant studies published up January 2024 were searched systematically using following databases: PubMed, SCOPUS, WOS, Science Direct, Ovid Cochrane. conducted according 2020 PRISMA guidelines. quality papers assessed Joanna Briggs Institute (JBI) Critical Appraisal Checklist. Pooled sizes calculated random-effects model reported WMD 95% CI. Also, subgroup analyses done find probable sources heterogeneity among studies. Out 21010 records initially identified, 21 eligible RCTs selected inclusion in meta-analysis. Overall, 1191 participants both genders, 600 intervention 591 control group with included. There are several limitations that included, instance, results weakened substantially by bias or failure account adulteration (with pharmaceuticals) contamination other herbs) supplements tested. However, have be safe complementary therapy conditions. Our study indicated doses 50−3000 mg/day associated significant change FBG [WMD: −2.83; CI: −4.61, −1.06), I2 = 51.3%], HOMA-IR −0.52; −0.84, −0.20), I2= 82.8%], TG −10.31; −20.00, −0.61), 84.5%], TC −11.81; −19.65, −3.96), 94.6%], LDL −8.01; −15.79, −0.24), 96.1%], weight −0.81; −1.28, −0.35), 0.0%] BMI −0.35; −0.57, −0.13), adults no HbA1C, plasma insulin, QUICKI, HDL, SBP, DBP, CRP, TNF-α WC after therapy. Subgroup analysis suggested changes serum FBG, TG, durations ≥ 8 weeks, LDL, BMI, sample size > 55 participants. over 8–12 weeks reductions levels HOMA-IR, TC, patients Previous diseases. We would suggest should used clinically specific conditions, it caution. difference grades may evaluated outcomes, so is future an subgroups their grade. Furthermore, because conduct independent biochemical assessment turmeric/curcumin product most well bias, interpreted

Язык: Английский

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Exploring the Contribution of Curcumin to Cancer Therapy: A Systematic Review of Randomized Controlled Trials

Pharmaceutics, Год журнала: 2023, Номер 15(4), С. 1275 - 1275

Опубликована: Апрель 19, 2023

Although the anticancer role of curcumin has been extensively addressed in preclinical research, only a few studies were carried out humans, with conflicting results. The aim this systematic review is to collate together results therapeutic effect cancer patients. A literature search was Pubmed, Scopus, and Cochrane Central Register Controlled Trials up 29 January 2023. Only randomized controlled trials (RCTs) designed evaluate effects on progression, patient survival, or surgical/histological response included. Seven 114 articles, published between 2016 2022, analyzed. They evaluated patients locally advanced and/or metastatic prostate, colorectal, breast cancers, as well multiple myeloma oral leucoplakia. Curcumin given an add-on therapy five studies. Cancer most investigated primary endpoint issued some positive On contrary, ineffective improving overall progression-free survival. safety profile favorable. In conclusion, available clinical evidence not strong enough support use cancer. New RCTs exploring different formulations early-stage cancers would be welcome.

Язык: Английский

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Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies

Antioxidants, Год журнала: 2023, Номер 12(6), С. 1163 - 1163

Опубликована: Май 27, 2023

Mitochondrial fission is a crucial process in maintaining metabolic homeostasis normal physiology and under conditions of stress. Its dysregulation has been associated with several diseases, including, but not limited to, obesity, type 2 diabetes (T2DM), cardiovascular diseases. Reactive oxygen species (ROS) serve vital role the genesis these conditions, mitochondria are both main sites ROS production primary targets ROS. In this review, we explore physiological pathological roles mitochondrial fission, its regulation by dynamin-related protein 1 (Drp1), interplay between health We also discuss potential therapeutic strategies targeting through antioxidant treatments for ROS-induced including effects lifestyle interventions, dietary supplements, chemicals, such as division inhibitor-1 (Mdivi-1) other inhibitors, well certain commonly used drugs This review highlights importance understanding approach to protecting against conditions.

Язык: Английский

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Effects of dietary polyphenol curcumin supplementation on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Июль 14, 2023

Objective The aim was to conduct a systematic review and meta-analysis for assessing the effectiveness safety of dietary polyphenol curcumin supplement on metabolic, inflammatory, oxidative stress indices in patients with metabolic syndrome (MetS). Methods A comprehensive search clinical trials conducted following scientific databases: PubMed, SCOPUS, Cochrane Library, EMBASE, Web Science, China Biological Medicine. Randomized controlled (RCTs) evaluating efficacy MetS were identified. random-effects performed using inverse variance, expressed as mean difference (MD) 95% confidence interval (CI). markers that evaluated present study included waist circumference (WC), fasting blood sugar (FBS), systolic pressure (SBP), diastolic (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor-a (TNF-a), interleukin 6 (IL-6), C-reactive protein (CRP), ultrasensitive c-reactive (hsCRP), malondialdehyde (MDA). By employing tool, RCTs assessed bias risk. Results total 785 participants from 13 included, intervention durations ranging 4 12 weeks. Compared control group, group had positive effects WC (MD = -2.16, CI: -3.78 -0.54, p 0.009, seven studies), FBS -8.6, -15.45 -1.75, 0.01, nine DBP -2.8, -4.53 - 1.06, 0.002, five HDL-C 4.98, 2.58 7.38, < 0.0001, eight TNF-a -12.97, -18.37 -7.57, 0.00001, two CRP 1.24, -1.71 -0.77, MDA -2.35, -4.47 -0.24, 0.03, three studies). These improvements statistically significant. Meanwhile, there no significant improvement SBP -4.82, -9.98 0.35, 0.07, six TG 1.28, -3.75 6.30, 0.62, IL-6 -1.5, -3.97 0.97, 0.23, or hsCRP -1.10, -4.35 2.16, 0.51, FBS, SBP, HDL-C, IL-6, CRP, hsCRP, relatively high heterogeneity. Conclusion Curcumin exhibited promising potential enhancing associated syndrome, including inflammation. However, additional studies are required confirm such findings since evidence is limited has Systematic registration https://www.crd.york.ac.uk/prospero , identifier CRD42022362553.

Язык: Английский

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The effect of curcumin supplementation on weight loss and anthropometric indices: an umbrella review and updated meta-analyses of randomized controlled trials

American Journal of Clinical Nutrition, Год журнала: 2023, Номер 117(5), С. 1005 - 1016

Опубликована: Март 9, 2023

Curcumin supplementation may promote weight loss and ameliorate obesity-related complications through its antioxidative anti-inflammatory properties.

Язык: Английский

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Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

Nutrients, Год журнала: 2023, Номер 15(2), С. 411 - 411

Опубликована: Янв. 13, 2023

Nutraceuticals act as cellular and functional modulators, contributing to the homeostasis of physiological processes. In an inflammatory microenvironment, these foods can interact with immune system by modulating or balancing exacerbated proinflammatory response. this process, cells, such antigen-presenting cells (APCs), identify danger signals and, after interacting T lymphocytes, induce a specific effector Moreover, conditions their change state phenotypical modifications from resting activated state, supposing increase in energy requirements that affect intracellular metabolism, each cell showing unique metabolic signature. Thus, nutraceuticals, polyphenols, vitamins, fatty acids, sulforaphane, represent active option use therapeutically for health prevention different pathologies, including obesity, syndrome, diabetes. To regulate inflammation associated intervention pathways through modulation nutraceuticals is attractive strategy allows inducing important changes properties. we provide overview link between function, chronic processes obesity diabetes, paying particular attention nutritional effects on APC immunometabolism, well mechanisms required energetic involved activation.

Язык: Английский

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Effect of dietary anthocyanins on the risk factors related to metabolic syndrome: A systematic review and meta-analysis

PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0315504 - e0315504

Опубликована: Фев. 10, 2025

This meta-analysis aims to systematically investigate whether dietary anthocyanin supplementation can reduce metabolic syndrome (MetS)-related risk factors: abdominal obesity, dyslipidemia (low high-density lipoprotein cholesterol (HDL-C) and hypertriglyceridemia), hypertension, hyperglycemia by conducting a of randomized controlled trials (RCTs). A systematic search 5 electronic databases (PubMed, Web Science, Scopus, Cochrane Library, Embase) was conducted from inception until April 25, 2024. total 1213 studies were identified, which involving subjects with MetS-related factors, comparing placebo, reporting results on anthropometric, physiological, markers relevant this study selected. Depending the heterogeneity included studies, fixed-effect model applied for low (I2 < 50%), whereas random-effects employed when substantial present ≥ 50%). The weighted mean difference (WMD) 95% confidence intervals (CI) calculated. 29 2006 participants. showed that anthocyanins significantly improved various lipid glycemic markers: HDL-C: increased 0.05 mmol/L (95% CI: 0.01 0.10, p = 0.026), LDL-C: decreased 0.18 -0.28 -0.08, 0.000), Triglycerides (TGs): reduced 0.11 -0.20 -0.02, 0.021), Total (TC): lowered 0.34 -0.49 -0.18, Fasting blood glucose (FBG): 0.29 -0.46 -0.12, 0.001), Glycated hemoglobin (HbA1c): 0.43% -0.74 -0.13, 0.005). Weight: (WMD: -0.12 kg, -0.45 0.21, 0.473), Body mass index (BMI): kg/m2, -0.26 0.03, 0.12), Overall WC: cm, -0.51 0.87, 0.613), Systolic pressure (SBP): mmHg, -1.06 0.82, 0.801), Diastolic (DBP): 0.61 -0.03 1.25, 0.061), Insulin levels: -0.02 mU/L, -0.44 0.40, 0.932), HOMA-IR: -0.11, 0.28, 0.573). Additionally, 100 mg/day dosage reduced: Waist circumference (WC): 0.55 cm -1.09 -0.01, 0.047). Subgroup analyses based intervention duration, dosage, health status, formulation, frequency, physical activity levels, baseline levels corresponding revealed varying significances, particularly in relation pressure. Dietary effectively improve HDL cholesterol, hypertriglyceridemia, hyperglycemia, making them promising adjunct managing MetS. However, it is important note interventions may raise systolic (SBP) diastolic (DBP) depending dose, participant formulation. Clinicians should fully consider these effects recommending supplementation. Further long-term, well-designed, large-scale clinical are needed draw definitive conclusions.

Язык: Английский

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Bioactive compounds in childhood obesity and associated metabolic complications: Current evidence, controversies and perspectives

Pharmacological Research, Год журнала: 2022, Номер 187, С. 106599 - 106599

Опубликована: Дек. 9, 2022

Obesity represents the most frequent chronic disease among children worldwide, with a significant global burden on society. Metabolically unhealthy obesity (MUO) can affect since their first years of life, and novel therapeutic strategies to tackle metabolic complications are under investigation. This review focuses bioactive compounds possible beneficial effects obesity, particularly omega-3, docosahexaenoic acid, vitamin D, biotics, polysaccharide macromolecules, polyphenols, inositols, alpha lipoic bromelaine. Our aim is summarize current evidence about in treatment highlighting recent findings use adolescents. Most studied molecules omega-3 despite heterogeneity between studies. Moreover, given emerging interest gut-brain axis link health microbiota, various studies prebiotics, probiotics, synbiotics, postbiotics macromolecules have been considered. Some preclinical seem highlight role even if clinical still discussed. Lastly, we describe inositols alpha-lipoic acid. Despite some dietary supplements be promising overweight subjects, only few them dose/response efficacy has found pediatric age. Innovative, well-designed targeted trials then needed prove these that could support standard behavioral therapy for obesity.

Язык: Английский

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Empowering mitochondrial metabolism: Exploring L-lactate supplementation as a promising therapeutic approach for metabolic syndrome

Metabolism, Год журнала: 2024, Номер 152, С. 155787 - 155787

Опубликована: Янв. 11, 2024

Язык: Английский

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Potential use of seaweed polysaccharides as prebiotics for management of metabolic syndrome: a review

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 64(22), С. 7707 - 7727

Опубликована: Март 27, 2023

Seaweed polysaccharides (SPs) obtained from seaweeds are a class of functional prebiotics. SPs can regulate glucose and lipid anomalies, affect appetite, reduce inflammation oxidative stress, therefore have great potential for managing metabolic syndrome (MetS). poorly digested by the human gastrointestinal tract but available to gut microbiota produce metabolites exert series positive effects, which may be mechanism render their anti-MetS effects. This article reviews as prebiotics in management MetS-related disturbances. The structure studies related process degradation bacteria therapeutic effects on MetS highlighted. In summary, this review provides new perspectives prevent treat MetS.

Язык: Английский

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