Sarcopenia and Cardiogeriatrics: The Links Between Skeletal Muscle Decline and Cardiovascular Aging

Nutrients, Год журнала: 2025, Номер 17(2), С. 282 - 282

Опубликована: Янв. 14, 2025

Sarcopenia, an age-related decline in skeletal muscle mass, strength, and function, is increasingly recognized as a significant condition the aging population, particularly among those with cardiovascular diseases (CVD). This review provides comprehensive synthesis of interplay between sarcopenia cardiogeriatrics, emphasizing shared mechanisms such chronic low-grade inflammation (inflammaging), hormonal dysregulation, oxidative stress, physical inactivity. Despite advancements diagnostic frameworks, EWGSOP2 AWGS definitions, variability criteria assessment methods continues to challenge standardization. Key tools include dual-energy X-ray absorptiometry (DXA) bioimpedance analysis (BIA) for alongside functional measures grip strength gait speed. The highlights bidirectional relationship conditions heart failure, aortic stenosis, atherosclerotic disease, which exacerbate each other through complex pathophysiological mechanisms. Emerging therapeutic strategies targeting mTOR pathway, NAD+ metabolism, senescence-related processes offer promise mitigating sarcopenia’s progression. Additionally, integrated interventions combining resistance training, nutritional optimization, novel anti-aging therapies hold potential improving outcomes. paper underscores critical gaps evidence, including need longitudinal studies establish causality validation advanced approaches clinical settings. Future research should leverage multi-omics technologies machine learning identify biomarkers personalize interventions. Addressing these challenges essential reducing burden enhancing quality life elderly individuals comorbid conditions. aims guide future promote effective, individualized management strategies.

Язык: Английский

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Evidence that tirzepatide protects against diabetes-related cardiac damages

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Март 30, 2024

Язык: Английский

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Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102267 - 102267

Опубликована: Март 9, 2024

Язык: Английский

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Emerging Targets and Treatments for Sarcopenia: A Narrative Review

Nutrients, Год журнала: 2024, Номер 16(19), С. 3271 - 3271

Опубликована: Сен. 27, 2024

Sarcopenia is characterized by the progressive loss of skeletal muscle mass, strength, and function, significantly impacting overall health quality life in older adults. This narrative review explores emerging targets potential treatments for sarcopenia, aiming to provide a comprehensive overview current prospective interventions.

Язык: Английский

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2096 - 2096

Опубликована: Сен. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Язык: Английский

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Sarcopenia as a Prognostic Factor for the Outcomes of Surgical Treatment of Colorectal Carcinoma

Healthcare, Год журнала: 2025, Номер 13(7), С. 726 - 726

Опубликована: Март 25, 2025

Background/Objectives: Sarcopenia, defined as the progressive loss of muscle mass and function, is increasingly associated with worse outcomes in surgical treatment colorectal cancer (CRC). This paper focuses on analyzing impact sarcopenia a prognostic factor postoperative CRC patients. The aim study to identify main factors influencing results. will be accomplished via bibliometric analysis highlighting significance condition preoperative assessment Methods: methodological approach involves bibliographic data from relevant scientific databases focused oncological surgery. employs quantitative citations collaborations among authors institutions. focus research publications 2013, when we first identified references examined context. Results: results show that significantly increases risk morbidity mortality Network keyword mapping reveal dominant topics such condition, mortality, complications. Meanwhile, need for standardized diagnostic methods their integration into clinical practice improve predictive models approaches. Conclusions: These findings underscore importance interdisciplinary collaboration, implementation approaches

Язык: Английский

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HucMSCs Delay Muscle Atrophy After Peripheral Nerve Injury Through Exosomes by Repressing Muscle-Specific Ubiquitin Ligases

Stem Cells, Год журнала: 2024, Номер 42(5), С. 460 - 474

Опубликована: Фев. 20, 2024

Cell therapy based on mesenchymal stem cells (MSCs) alleviate muscle atrophy caused by diabetes and aging; however, the impact of human umbilical cord following nerve injury underlying mechanisms remain unclear. In this study, we evaluated therapeutic efficacy MSCs (hucMSCs) hucMSC-derived exosomes (hucMSC-EXOs) for identified molecular mechanisms. Sciatic crush in rats induction myotubes L6 were used to determine ameliorating effect hucMSCs hucMSC-EXOs atrophy. Q-PCR Western blot analyses measure expression muscle-specific ubiquitin ligases Fbxo32 (Atrogin1, MAFbx) Trim63 (MuRF-1). Dual-luciferase reporter gene experiments conducted validate direct binding miRNAs their target genes. Local injection mitigated rat gastrocnemius sciatic injury. vitro, alleviated myotubes. Mechanistic analysis indicated upregulation miR-23b-3p levels treatment. MiR-23b-3p significantly inhibited its genes, Trim63, suppressed myotube Notably, an inhibitor reversed inhibitory vitro. These results suggest that secreted contributes mechanism inhibiting ubiquitination Trim63.

Язык: Английский

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Changes in the gut microbiota of patients with sarcopenia based on 16S rRNA gene sequencing: a systematic review and meta-analysis

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 28, 2024

Sarcopenia, an age-related disease, has become a major public health concern, threatening muscle and daily functioning in older adults around the world. Changes gut microbiota can affect skeletal metabolism, but exact association is unclear. The richness of refers to number different species sample, while diversity not only considers also evenness their abundances. Alpha comprehensive metric that measures both (richness) abundances, thereby providing thorough understanding composition structure community.

Язык: Английский

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Baseline (modified) Glasgow prognostic score as a predictor of therapeutic response to immune checkpoint inhibitors in solid tumors: A systematic review and meta‑analysis

Oncology Letters, Год журнала: 2025, Номер 29(4)

Опубликована: Фев. 13, 2025

A systemic analysis was performed to evaluate the prognostic utility of Glasgow score (GPS) and modified (m)GPS in cancer patients treated with immune checkpoint inhibitors (ICI). The PubMed, Cochrane Library, EMBASE Google Scholar databases were searched for entries added until May 1st, 2023, obtain relevant articles this study. examined several clinical outcomes, including overall survival (OS), progression‑free (PFS), objective response rate disease control (DCR). In analysis, a total 38 3,772 included. pooled results indicated that high GPS levels had shorter OS [GPS 2 vs. 0, hazard ratio (HR): 4.35, P<0.001; 1 HR: 2.00, 1/0, 2.62, 2/1 2.60, P<0.001) PFS (GPS 2.11, P=0.001; 1.33, 1.62, P<0.001], as well lower DCR odds (OR): 0.53, P<0.001, OR: 0.51, P<0.001]. It also found mGPS poorer (mGPS 3.15, 1.70, 1.95, P=0.049; 3.14, P=0.041; continuous variables, 1.52, 2.70, 1.74, P=0.016; 1.91, P=0.044; 1.29, P<0.001), 0.46, P<0.001). conclusion, reliable predictors outcomes ICIs.

Язык: Английский

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Preoperative sarcopenia and postoperative accelerated muscle loss negatively impact survival after resection of locally advanced gastric cancer

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 14, 2025

Abstract Background Gastric cancer remains a major health concern worldwide, with locally advanced gastric (LAGC) posing significant challenges due to frequent lymph node metastasis and poor prognosis. While curative gastrectomy D2 dissection is the standard treatment, sarcopenia perioperative skeletal muscle loss (SML) have emerged as critical prognostic factors. Methods We retrospectively analyzed 198 LAGC patients who underwent gastrectomy. Preoperative postoperative were assessed via computed tomography (CT)-derived index (SMI) at L3 level. SML was defined based on sex-specific thresholds of SMI changes (%/30 days). Prognostic significance for overall survival (OS) disease-free (DFS) evaluated using Kaplan-Meier Cox regression analyses. Results The prevalence increased from 23.7% preoperatively 33.3% postoperatively. Patients showed worse OS DFS compared non-SML ( P < 0.05). also associated higher incidence Clavien-Dindo grade ≥ 3a complications Multivariate analysis identified preoperative (HR = 2.332, 0.001), 3.189, 0.011), 11.231, 0.002) independent risk factors OS. Adjuvant chemotherapy significantly improved both 0.532, 0.015) 0.587, 0.041). Conclusions Both may negatively impact prognosis in patients, suggesting that evaluation mass help identify high-risk surgical candidates targeted interventions.

Язык: Английский

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