Sarcopenia and Cardiogeriatrics: The Links Between Skeletal Muscle Decline and Cardiovascular Aging

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 282 - 282

Published: Jan. 14, 2025

Sarcopenia, an age-related decline in skeletal muscle mass, strength, and function, is increasingly recognized as a significant condition the aging population, particularly among those with cardiovascular diseases (CVD). This review provides comprehensive synthesis of interplay between sarcopenia cardiogeriatrics, emphasizing shared mechanisms such chronic low-grade inflammation (inflammaging), hormonal dysregulation, oxidative stress, physical inactivity. Despite advancements diagnostic frameworks, EWGSOP2 AWGS definitions, variability criteria assessment methods continues to challenge standardization. Key tools include dual-energy X-ray absorptiometry (DXA) bioimpedance analysis (BIA) for alongside functional measures grip strength gait speed. The highlights bidirectional relationship conditions heart failure, aortic stenosis, atherosclerotic disease, which exacerbate each other through complex pathophysiological mechanisms. Emerging therapeutic strategies targeting mTOR pathway, NAD+ metabolism, senescence-related processes offer promise mitigating sarcopenia’s progression. Additionally, integrated interventions combining resistance training, nutritional optimization, novel anti-aging therapies hold potential improving outcomes. paper underscores critical gaps evidence, including need longitudinal studies establish causality validation advanced approaches clinical settings. Future research should leverage multi-omics technologies machine learning identify biomarkers personalize interventions. Addressing these challenges essential reducing burden enhancing quality life elderly individuals comorbid conditions. aims guide future promote effective, individualized management strategies.

Language: Английский

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Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102267 - 102267

Published: March 9, 2024

Language: Английский

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Evidence that tirzepatide protects against diabetes-related cardiac damages

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: March 30, 2024

Language: Английский

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2096 - 2096

Published: Sept. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

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Emerging Targets and Treatments for Sarcopenia: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3271 - 3271

Published: Sept. 27, 2024

Sarcopenia is characterized by the progressive loss of skeletal muscle mass, strength, and function, significantly impacting overall health quality life in older adults. This narrative review explores emerging targets potential treatments for sarcopenia, aiming to provide a comprehensive overview current prospective interventions.

Language: Английский

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HucMSCs Delay Muscle Atrophy After Peripheral Nerve Injury Through Exosomes by Repressing Muscle-Specific Ubiquitin Ligases

Stem Cells, Journal Year: 2024, Volume and Issue: 42(5), P. 460 - 474

Published: Feb. 20, 2024

Cell therapy based on mesenchymal stem cells (MSCs) alleviate muscle atrophy caused by diabetes and aging; however, the impact of human umbilical cord following nerve injury underlying mechanisms remain unclear. In this study, we evaluated therapeutic efficacy MSCs (hucMSCs) hucMSC-derived exosomes (hucMSC-EXOs) for identified molecular mechanisms. Sciatic crush in rats induction myotubes L6 were used to determine ameliorating effect hucMSCs hucMSC-EXOs atrophy. Q-PCR Western blot analyses measure expression muscle-specific ubiquitin ligases Fbxo32 (Atrogin1, MAFbx) Trim63 (MuRF-1). Dual-luciferase reporter gene experiments conducted validate direct binding miRNAs their target genes. Local injection mitigated rat gastrocnemius sciatic injury. vitro, alleviated myotubes. Mechanistic analysis indicated upregulation miR-23b-3p levels treatment. MiR-23b-3p significantly inhibited its genes, Trim63, suppressed myotube Notably, an inhibitor reversed inhibitory vitro. These results suggest that secreted contributes mechanism inhibiting ubiquitination Trim63.

Language: Английский

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Changes in the gut microbiota of patients with sarcopenia based on 16S rRNA gene sequencing: a systematic review and meta-analysis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 28, 2024

Sarcopenia, an age-related disease, has become a major public health concern, threatening muscle and daily functioning in older adults around the world. Changes gut microbiota can affect skeletal metabolism, but exact association is unclear. The richness of refers to number different species sample, while diversity not only considers also evenness their abundances. Alpha comprehensive metric that measures both (richness) abundances, thereby providing thorough understanding composition structure community.

Language: Английский

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Baseline (modified) Glasgow prognostic score as a predictor of therapeutic response to immune checkpoint inhibitors in solid tumors: A systematic review and meta‑analysis

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(4)

Published: Feb. 13, 2025

A systemic analysis was performed to evaluate the prognostic utility of Glasgow score (GPS) and modified (m)GPS in cancer patients treated with immune checkpoint inhibitors (ICI). The PubMed, Cochrane Library, EMBASE Google Scholar databases were searched for entries added until May 1st, 2023, obtain relevant articles this study. examined several clinical outcomes, including overall survival (OS), progression‑free (PFS), objective response rate disease control (DCR). In analysis, a total 38 3,772 included. pooled results indicated that high GPS levels had shorter OS [GPS 2 vs. 0, hazard ratio (HR): 4.35, P<0.001; 1 HR: 2.00, 1/0, 2.62, 2/1 2.60, P<0.001) PFS (GPS 2.11, P=0.001; 1.33, 1.62, P<0.001], as well lower DCR odds (OR): 0.53, P<0.001, OR: 0.51, P<0.001]. It also found mGPS poorer (mGPS 3.15, 1.70, 1.95, P=0.049; 3.14, P=0.041; continuous variables, 1.52, 2.70, 1.74, P=0.016; 1.91, P=0.044; 1.29, P<0.001), 0.46, P<0.001). conclusion, reliable predictors outcomes ICIs.

Language: Английский

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Preoperative sarcopenia and postoperative accelerated muscle loss negatively impact survival after resection of locally advanced gastric cancer

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 14, 2025

Abstract Background Gastric cancer remains a major health concern worldwide, with locally advanced gastric (LAGC) posing significant challenges due to frequent lymph node metastasis and poor prognosis. While curative gastrectomy D2 dissection is the standard treatment, sarcopenia perioperative skeletal muscle loss (SML) have emerged as critical prognostic factors. Methods We retrospectively analyzed 198 LAGC patients who underwent gastrectomy. Preoperative postoperative were assessed via computed tomography (CT)-derived index (SMI) at L3 level. SML was defined based on sex-specific thresholds of SMI changes (%/30 days). Prognostic significance for overall survival (OS) disease-free (DFS) evaluated using Kaplan-Meier Cox regression analyses. Results The prevalence increased from 23.7% preoperatively 33.3% postoperatively. Patients showed worse OS DFS compared non-SML ( P < 0.05). also associated higher incidence Clavien-Dindo grade ≥ 3a complications Multivariate analysis identified preoperative (HR = 2.332, 0.001), 3.189, 0.011), 11.231, 0.002) independent risk factors OS. Adjuvant chemotherapy significantly improved both 0.532, 0.015) 0.587, 0.041). Conclusions Both may negatively impact prognosis in patients, suggesting that evaluation mass help identify high-risk surgical candidates targeted interventions.

Language: Английский

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The Improvement of Physical Function and Caregiver Burden by a Multimodal Intervention: A Case Study of Combined Exercise Therapy, Nutritional Guidance, and Hydrogen Gas Inhalation Therapy

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

The objective of this exploratory case study was to examine the impact a multifaceted intervention, which incorporated exercise therapy, nutritional guidance, and hydrogen gas inhalation, on physical function caregiver burden an older female patient suspected having sarcopenia. methods employed included three-month program group individualized sessions, three times per week, in addition guidance inhalation therapy. primary outcome measures grip strength, walking speed, inflammatory/oxidative stress markers (c-reactive protein (CRP), interleukin-6 (IL-6), 8-hydroxy-2' -deoxyguanosine (8-OHdG)), burden, assessed by Family Caregiver Burden Scale (FCS). results demonstrated that after period months, there improvement strength speed. Concurrently, decrease CRP, IL-6, 8-OHdG levels. FCS score shift from "severe" range "normal" range, suggesting reduction burden. findings suggest multidisciplinary, intervention combining support, may be effective enhancing reducing adults with However, further research is necessary clarify independent effects inhalation.

Language: Английский

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