Association of composite dietary antioxidant index with prevalence of stroke: insights from NHANES 1999-2018

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Март 8, 2024

Background There is a growing acknowledgment of the potential influence antioxidative effects resulting from dietary decisions on occurrence stroke. The objective this study was to elucidate correlation between composite antioxidant index (CDAI) and incidence stroke in general population United States. Methods We gathered cross-sectional data encompassing 40,320 participants National Health Nutrition Examination Survey (NHANES) spanning years 1999 2018. Employing weighted multivariate logistic regression, we assessed CDAI stroke, while also investigating nonlinear relationships through restricted cubic spline (RCS) regression. Further, intake components were then incorporated into predictive nomogram model, subsequently evaluated for its discriminatory prowess risk assessment using receiver operating characteristic (ROC) curve. Results Post-adjustment confounding variables, found that higher score associated with decreased odds ratio (OR) [95% CI] associating prevalence 0.96 [0.94-0.98] (P< 0.001). Moreover, adjusted OR across ascending quartiles stood at 0.90 [0.74-1.09], 0.74 [0.60-0.91], 0.61 [0.50-0.76] compared reference quartile, respectively. RCS analysis indicated yet negative constructed based antioxidants, exhibited significant capacity risk, boasting an area under curve (AUC) 77.4% (76.3%–78.5%). Conclusion Our investigation ascertained relationship within broader American population. However, given inherent limitations design, further comprehensive research imperative establish causative nature association.

Язык: Английский

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Composite dietary antioxidant index is inversely and nonlinearly associated with cardiovascular disease, atherosclerotic cardiovascular disease, and cardiovascular mortality in people with dyslipidemia: evidence from NHANES 2001–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 7, 2025

Dyslipidemia is a major risk factor for cardiovascular disease (CVD) and atherosclerotic CVD (ASCVD). The composite dietary antioxidant index (CDAI), an emerging measure of combined exposure, may provide insights into the relationship between diet CVD/ASCVD outcomes. We aimed to explore association CDAI prevalence CVD/ASCVD, as well mortality in individuals with dyslipidemia. was assessed by integrating vitamins A, C, E, zinc, selenium, carotenoids. diagnosed according widely established criteria. Data on were obtained through self-reports, while prospective matching participant records National Death Index database. Multivariate logistic regression analysis Cox proportional hazards used these associations calculate odds ratios [OR], hazard [HR], 95% confidence intervals [CI], respectively. A total 23,126 participants dyslipidemia from NHANES 2001-2018 included. After adjusting potential confounders, inversely associated both ASCVD populations (OR CI 0.979 (0.964, 0.995) 0.977 (0.961, 0.993), respectively). Similar observed specific types CVD. also (HR = 0.957, 0.939-0.976, p < 0.0001). Restricted cubic spline threshold effects analyses indicated that nonlinearly significant occurring only when CDAI≤0; however, > -2. Furthermore, age, sex, drinking found modify body mass influenced mortality. events dyslipidemic populations. These findings highlight patterns alleviate burden underscore importance personalized strategies.

Язык: Английский

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Linear association of compound dietary antioxidant index with hyperlipidemia: a cross-sectional study

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Фев. 29, 2024

Background There is growing evidence that antioxidant-rich diets may prevent hyperlipidemia. However, the relationship between Composite Dietary Antioxidant Index (CDAI) and hyperlipidemia unclear. The CDAI a composite score reflecting antioxidant content of an individual’s diet, this study aimed to investigate Methods used 2003–2018 National Health Nutrition Examination Survey (NHANES) database for cross-sectional analyses included 27,626 participants aged 20 years older. CDAI, which includes vitamins A, C, E, zinc, selenium, carotenoids, was calculated based on dietary intake reported in 24-h recall interview. Hyperlipidemia defined by Cholesterol Education Program (NCEP). Covariates age, sex, race, education, marriage, household poverty-to-income ratio (PIR), glomerular filtration rate (eGFR), body mass index (BMI), energy, carbohydrates, total fat, cholesterol, smoking, alcohol consumption, hypertension, diabetes mellitus, coronary heart disease, lipid-lowering medications. association explored through multiple logistic regression smoothed curve fitting. We also performed subgroup interaction tests verify relationship’s stability. Results After adjusting potential confounders, negatively associated with risk developing (OR 0.98, 95% CI 0.96–0.99, p &lt; 0.01). results weighted models stratified quartiles (−8.664 ≤ Q1 −2.209, −2.209 Q2 −0.002, −0.002 Q3 2.774, 2.774 Q4 124.284), fully adjusted confounding variables, indicated compared bottom quartile (Q1) Q2, Q3, had lower advantage (Q2: OR 0.91, 0.78–1.06, 0.21; Q3: 0.85, 0.73–1.00, 0.05; Q4: 0.77, 0.64–0.94, 0.01), confirmed test trend ( 0.05). Smoothed fit analysis showed linearity (p non-linear = 0.0912). In summary, there linear negative Subgroup ethnicity, education level, tobacco status, alcoholic drinking, did not indicate strong interactions. Conclusion large study, among US adults. Therefore increase rich foods your life as prevention

Язык: Английский

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Association between oxidative balance score and sarcopenia in US adults: NHANES 2011–2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Апрель 24, 2024

Sarcopenia, a condition characterized by diminished skeletal muscle mass, strength, and function, accompanied inflammation oxidative stress, remains an area of limited exploration concerning its correlation with the Oxidative Balance Score (OBS).

Язык: Английский

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Composite dietary antioxidant index is associated with reduced prevalence of metabolic syndrome but not mortality in metabolic syndrome: Results from NHANES 2001–2018

Preventive Medicine Reports, Год журнала: 2024, Номер 41, С. 102704 - 102704

Опубликована: Март 26, 2024

The relationship between the composite dietary antioxidant index (CDAI), a comprehensive measure of individual antioxidants, and prevalence mortality metabolic syndrome (MetS) remains unknown. We aimed to explore these relationships in National Health Nutrition Examination Survey (NHANES). explored using two independent cohorts. First, we addressed CDAI MetS general population; second, association patients with by following NHANES 2001-2018 participants through December 31, 2019. In addition, restricted cubic spline (RCS), stratified analysis, sensitivity analysis were used for further interpretation. included 24,514 aged 20-85 years, which was 27.61 %. negatively dose-responsively associated MetS, however it not MetS. reduced certain components including dyslipidemia central obesity. RCS showed linear correlation above components. Stratified analyses indicated that alcohol consumption significant influence CDAI-MetS socioeconomic status lifestyle specificity existed. Sensitivity confirmed stability results. protective against development population, but Clinicians need develop individualized prevention strategies reduce modifying CDAI.

Язык: Английский

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Association between different composite dietary antioxidant indexes and low back pain in American women adults: a cross-sectional study from NHANES

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Янв. 10, 2024

Abstract Background Low back pain is the leading cause of productivity loss, imposes a significant economic burden on patients and society. Oxidative stress considered critical factor in complex pathophysiological process pathogenic mechanism low pain. Adjustment dietary pattern can effectively increase antioxidant biomarkers levels within body to reduce oxidative stress. The composite index (CDAI) serves reliable scoring system for quantifying potential capacity daily diets. Objective We aim investigate association between CDAI pain, order enhance management through guidance. Methods This study included 17,682 participants from National Health Nutrition Examination Survey (NHANES) 1999–2000, 2001–2002, 2003–2004 2009–2010. weighted logistic regression model was used while restricted cubic spline (RCS) employed examine non-linear trend cutoffs. Results After adjusting all confounders, results showed that there no However, individuals highest quartile exhibited an 11.7% less likelihood experiencing than those lowest (OR = 0.883; 95% CI [0.787,0.991], P 0.034), test also (P < 0.001). RCS indicated linear relationship 0.876). Gender subgroup analysis this negative female population 0.983; [0.968, 0.998], 0.027), females were 19.7% likely suffer 0.803; [0.682,0.945], 0.008). Additionally, changes zinc 1.009; [1.002, 1.016], 0.015) selenium 0.379; [0.164, 0.875], 0.023) per milligram independently associated with Conclusion fully adjusted but it quartiles. Meanwhile, by gender revealed population. findings suggested diets should be studied context.

Язык: Английский

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Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 24, 2024

Objective Selenium is an essential micronutrient and a type of dietary antioxidant. This study aimed to investigate the associations selenium intake with risk human chronic disease [cardiovascular (CVD), diabetes mellitus (DM), cancer] mortality among US general adults. Methods The demographic data in this were collected from National Health Nutrition Examination Survey (NHANES) 2007 2018. Death outcomes determined by associating Index (NDI) records as December 31, 2019. Logistic regression analyses used relationship CVD, DM, cancer. effect on all-cause disease-specific was estimated restricted cubic spline (RCS) curves based univariate multivariate Cox proportional hazard models. Results Among 25,801 participants, divided into quintiles (Q1–Q5). After covariate adjustment, results showed that participants higher (Q4 Q5) tended have low CVD (OR = 0.97, 95% CI: 0.96, 0.99; OR 0.98, 1.00, respectively). Moreover, RCS significant nonlinear association between (with HR 0.82, 0.68, 0.99) DM-specific lowest 0.30; CI, 0.12–0.75). Furthermore, we conducted subgroup analysis found negative correlation highest quartile aged 50 above (HR 0.75, 0.60–0.93, p 0.009). Conclusion Our indicated moderate supplement decreased displayed trend In addition, older may benefit intake. However, these findings still need be confirmed through further mechanism exploration.

Язык: Английский

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Association between composite dietary antioxidant index and hyperlipidemia: a cross-sectional study from NHANES (2005–2020)

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 10, 2024

Abstract The association between the composite dietary antioxidant index (CDAI) and hyperlipidemia remains unclear. Therefore, this study aimed to investigate relationship CDAI hyperlipidemia. data used in were obtained from National Health Nutrition Examination Survey (NHANES) dataset spanning 2005 2020. Based on 24-h recall interviews, was calculated using intake of six antioxidants. Univariate multivariate logistic regression models employed occurrence Additionally, restricted cubic spline (RCS) analysis utilized potential non-linear relationships risk final included 30,788 adults United States, among whom 25,525 (82.91%) diagnosed with A significant negative correlation observed unadjusted (Odds ratio [OR] 0.97 [95% CI 0.96, 0.98]) multi-variable adjusted (OR 0.98 0.97, 0.99]) models. When values analyzed as a categorical variable, individuals highest quartile 0.82 0.73, 0.92]) exhibited nearly one fifth decreased compared those lowest quartile. RCS revealed linear ( P for nonlinearity = 0.124). results remained consistent across subgroups except under age 60 or diabetes mellitus. There hyperlipidemia, indicating that maintaining an optimal level could effectively reduce incidence

Язык: Английский

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Associations of micronutrient dietary patterns with sarcopenia among US adults: a population-based study

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Фев. 12, 2024

Current epidemiological evidence points to an association between micronutrient (MN) intake and sarcopenia, but studies have focused on single MN, no combined effects MNs been reported. The aim of this study was investigate the relationship different MN patterns sarcopenia skeletal muscle mass.

Язык: Английский

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Association between the composite dietary antioxidant index and non-alcoholic fatty liver disease: evidence from National Health and Nutrition Examination Survey 2005–2016

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 23, 2025

Importance Oxidative stress contributes to the progression of non-alcoholic fatty liver disease (NAFLD). Antioxidants from food can reduce NAFLD incidence, and Composite Dietary Antioxidant Index (CDAI) measures total antioxidant capacity (TAC). However, relationship between CDAI in US adult population remains unclear. Objective To assess whether is associated with adults. Design, setting, participants This population-based cross-sectional study used data on adults National Health Nutrition Examination Survey (NHANES) 2005–2016 cycles. Data were analyzed January February 2024. Exposures obtained dietary intake questionnaire. Main outcomes The main outcome was which defined by score (USFLI) ≥30. Sampling weights calculated according NHANES guidelines. Results Among 9,746 included this [mean age, 48.3 years; 4,662 (47.6%) males], 3,324 (33.0%) classified as having using USFLI. In fully adjusted multivariable logistic regression, negatively (odds ratio [OR], 0.95; 95% CI, 0.93–0.98). Furthermore, individuals highest quartile 34% less likely have compared those lowest (OR, 0.66; 0.52–0.85). subgroup analyses, inversely among a BMI &lt;25 0.89; 0.83–0.95) without metabolic syndrome 0.93; 0.91–0.96). interaction tests revealed significant differences these subgroups ( P for = 0.04 0.003 syndrome). Sensitivity analyses confirmed association hepatic steatosis index (HSI) define NAFLD, applying unweighted adjusting physical activity or after excluding non-Hispanic Black participants, medications known their potential hepatotoxic effects. Conclusions relevance based six cycles (2005–2016) NHANES, population. highlights interventions incidence underscores need future research, including clinical trials mechanistic studies, further explore role antioxidants prevention management.

Язык: Английский

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