Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Март 4, 2024
Breast
cancer
(BC)
is
a
heterogenous
disease,
with
prognosis
and
treatment
options
depending
on
Estrogen,
Progesterone
receptor,
Human
Epidermal
Growth
Factor
Receptor-2
(HER-2)
status.
HER-2
negative,
endocrine-independent
BC
presents
significant
clinical
challenge
limited
options.
To
date,
promising
strategies
like
immune
checkpoint
inhibitors
have
not
yielded
breakthroughs
in
patient
prognosis.
Despite
being
considered
archaic,
agents
derived
from
natural
sources,
mainly
plants,
remain
backbone
of
current
treatment.
In
this
context,
we
critically
analyze
novel
naturally-derived
drug
candidates,
elucidate
their
intricate
mechanisms
action,
evaluate
pre-clinical
vitro
vivo
activity
negative
BC.
Since
research
success
often
does
directly
correlate
approval,
focus
ongoing
trials
to
uncover
trends.
Finally,
demonstrate
the
potential
combining
cutting-edge
technologies,
such
as
antibody-drug
conjugates
or
nanomedicine,
agents,
offering
new
opportunities
that
utilize
both
traditional
cytotoxic
metabolites.
Journal of Hematology & Oncology,
Год журнала:
2022,
Номер
15(1)
Опубликована: Апрель 12, 2022
Abstract
Triple-negative
breast
cancer
(TNBC)
is
a
subtype
of
human
with
one
the
worst
prognoses,
no
targeted
therapeutic
strategies
currently
available.
Regulated
cell
death
(RCD),
also
known
as
programmed
(PCD),
has
been
widely
reported
to
have
numerous
links
progression
and
therapy
many
types
cancer.
Of
note,
RCD
can
be
divided
into
different
subroutines,
including
autophagy-dependent
death,
apoptosis,
mitotic
catastrophe,
necroptosis,
ferroptosis,
pyroptosis
anoikis.
More
recently,
targeting
subroutines
small-molecule
compounds
emerging
promising
strategy,
which
rapidly
progressed
in
treatment
TNBC.
Therefore,
this
review,
we
focus
on
summarizing
molecular
mechanisms
above-mentioned
seven
major
related
TNBC
latest
progress
subroutines.
Moreover,
further
discuss
combined
drug
(e.g.,
narciclasine)
or
more
drugs
torin-1
chloroquine)
achieve
potential
by
regulating
importantly,
demonstrate
several
ONC201
NCT03733119)
clinical
trials.
Taken
together,
these
findings
will
provide
clue
illuminating
actionable
low-hanging-fruit
druggable
targets
candidate
for
RCD-related
therapies.
Graphical
abstract
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115170 - 115170
Опубликована: Июль 21, 2023
Breast
cancer
is
a
leadingcause
of
cancer-related
deaths
in
women
globally,
with
triple-negative
breast
(TNBC)
being
an
aggressive
subtype
that
lacks
targeted
therapies
and
associated
poor
prognosis.
Polyphenols,
naturally
occurring
compounds
plants,
have
been
investigated
as
potential
therapeutic
strategy
for
TNBC.
This
review
provides
overview
the
anticancer
effects
polyphenols
TNBC
their
mechanisms
action.
Several
polyphenols,
including
resveratrol,
quercetin,
kaempferol,
genistein,
epigallocatechin-3-gallate,
apigenin,
fisetin,
hesperetin
luteolin,
shown
to
inhibit
cell
proliferation,
induce
cycle
arrest,
promote
apoptosis,
suppress
migration/invasion
preclinical
models.
The
molecular
underlying
involve
modulation
several
signalling
pathways,
such
PI3K/Akt,
MAPK,
STATT,
NF-κB
pathways.
Polyphenols
also
exhibit
synergistic
chemotherapy
drugs,
making
them
promising
candidates
combination
therapy.
highlights
clinical
trials
investigating
use
individually
or
therapy,
against
cancer.
deepens
under-standing
mechanism
action
respective
valuable
insights
into
TNBC,
lays
groundwork
future
research
this
area.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3370 - 3370
Опубликована: Март 16, 2024
Natural
products
have
been
a
long-standing
source
for
exploring
health-beneficial
components
from
time
immemorial.
Modern
science
has
had
renewed
interest
in
natural-products-based
drug
discovery.
The
quest
new
potential
secondary
metabolites
or
enhanced
activities
existing
molecules
remains
pertinent
topic
research.
Resveratrol
belongs
to
the
stilbenoid
polyphenols
group
that
encompasses
two
phenol
rings
linked
by
ethylene
bonds.
Several
plant
species
and
foods,
including
grape
skin
seeds,
are
primary
of
this
compound.
is
known
possess
potent
anti-inflammatory,
antiproliferative,
immunoregulatory
properties.
Among
notable
bioactivities
associated
with
resveratrol,
its
pivotal
role
safeguarding
intestinal
barrier
highlighted
capacity
prevent
inflammation
regulate
gut
microbiome.
A
better
understanding
how
oxidative
stress
can
be
controlled
using
resveratrol
capability
protect
microbiome
perspective
shed
more
light
on
physiological
conditions.
Additionally,
exhibits
antitumor
activity,
proving
cancer
treatment
prevention.
Moreover,
cardioprotective,
vasorelaxant,
phytoestrogenic,
neuroprotective
benefits
also
reported.
pharmaceutical
industry
continues
encounter
difficulties
administering
owing
inadequate
bioavailability
poor
solubility,
which
must
addressed
simultaneously.
This
report
summarizes
currently
available
literature
unveiling
pharmacological
effects
resveratrol.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
12
Опубликована: Янв. 28, 2022
Breast
cancer
is
one
of
the
top-ranked
malignant
carcinomas
associated
with
morbidity
and
mortality
in
women
worldwide.
Chemotherapy
main
approaches
to
breast
treatment.
initially
responds
traditional
first-
second-line
drugs
(aromatase
inhibitor,
tamoxifen,
carboplatin),
but
eventually
acquires
resistance,
certain
patients
relapse
within
5
years.
Chemotherapeutic
also
have
obvious
toxic
effects.
In
recent
years,
natural
products
been
widely
used
research
because
their
low
side
effects,
toxicity,
good
efficacy
based
on
multitarget
therapy.
Apoptosis,
a
programmed
cell
death,
occurs
as
normal
controlled
process
that
promotes
growth
death.
Inducing
apoptosis
an
important
strategy
control
excessive
proliferation.
Accumulating
evidence
has
revealed
become
increasingly
treatment
by
suppressing
apoptosis.
this
study,
we
reviewed
current
studies
product-induced
summarized
proapoptosis
mechanisms
including
mitochondrial,
FasL/Fas,
PI3K/AKT,
reactive
oxygen
species,
mitogen-activated
protein
kinase-mediated
pathway.
We
hope
our
review
can
provide
direction
search
for
candidate
derived
from
treat
promoting
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
63(33), С. 12422 - 12440
Опубликована: Июль 19, 2022
Cancer
is
a
severe
public
health
problem.
Resveratrol
famous
natural
compound
that
has
various
bioactivities,
such
as
antioxidant,
anti-inflammatory,
antidiabetic
and
antiaging
activities.
Especially,
resveratrol
could
prevent
treat
cancers,
oral,
thyroid,
breast,
lung,
liver,
pancreatic,
gastric,
colorectal,
bladder,
prostate
ovarian
cancers.
The
underlying
mechanisms
have
been
widely
studied,
inhibiting
cell
proliferation,
suppressing
metastasis,
inducing
apoptosis,
stimulating
autophagy,
modulating
immune
system,
attenuating
inflammation,
regulating
gut
microbiota
enhancing
effects
of
other
anticancer
drugs.
In
this
review,
we
summarize
on
different
This
paper
helpful
to
develop
resveratrol,
crude
extract
containing
or
foods
into
functional
food,
dietary
supplements
auxiliary
agents
for
prevention
management
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(4), С. 2240 - 2258
Опубликована: Янв. 28, 2024
Abstract
Resveratrol,
a
natural
polyphenol
in
various
plants,
has
gained
significant
attention
for
its
potential
health‐promoting
properties.
It
been
demonstrated,
after
reviewing
clinical
and
vitro
studies,
that
resveratrol
possesses
potent
antioxidant
potential.
Resveratrol
demonstrates
cellular
component
protection
by
directly
neutralizing
free
radicals
(FRs)
enhancing
the
expression
of
enzymes,
thereby
mitigating
oxidative
damage
to
proteins,
lipids,
nucleic
acids.
Clinical
trials
have
shown
promising
results,
indicating
supplementation
can
enhance
defenses
reduce
markers
populations.
In
addition
effects,
exhibits
anti‐inflammatory
modulate
key
inflammatory
pathways,
such
as
nuclear
factor‐kappa
B
(NF‐κB)
mitogen‐activated
protein
kinases
(MAPKs),
suppressing
production
pro‐inflammatory
cytokines
chemokines.
Furthermore,
resveratrol's
multimodal
effects
extend
beyond
discovered
exert
regulatory
on
processes,
including
apoptosis,
cell
cycle
progression,
angiogenesis,
immunological
responses.
The
primary
aim
this
review
paper
is
provide
thorough
overview
current
knowledge
resveratrol,
chemical
composition,
bioaccessibility,
effectiveness,
utilization
nanotechnology
bioavailability.
From
future
perspectives,
revising
administration
methods
certain
contexts
understanding
underlying
systems
responsible
will
require
further
inquiry.
For
highest
health
advanced
trial‐based
research
necessary
combinational
nano‐delivery
resveratrol.
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(2), С. 229 - 244
Опубликована: Фев. 1, 2024
Introduction
Triple-negative
breast
cancer
(TNBC)
presents
unique
challenges
indiagnosis
and
treatment.Resveratrolexhibits
potential
as
a
therapeutic
intervention
for
TNBC
byregulating
various
pathways
such
the
PI3K/AKT,
RAS/RAF/ERK,
PKCδ,and
AMPK,
leading
to
apoptosis
through
ROS-mediated
CHOP
activationand
expression
of
DR4
DR5.
However,
clinical
efficacy
resveratrol
is
limited
due
itspoor
biopharmaceutical
characteristics
low
bioavailability
at
thetumor
site.
Nanotechnology
offers
promising
approach
improvingthe
achieveclinical
in
different
cancers.
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(1), С. 30 - 30
Опубликована: Янв. 6, 2025
Extensive
investigation
has
been
conducted
on
plant-based
resources
for
their
pharmacological
usefulness,
including
various
cancer
types.
The
scope
of
this
review
is
wider
than
several
studies
with
a
particular
focus
breast
cancer,
which
an
international
health
concern
while
studying
sources
flavonoids,
carotenoids,
polyphenols,
saponins,
phenolic
compounds,
terpenoids,
and
glycosides
apart
from
focusing
nursing.
Important
findings
prior
are
synthesized
to
explore
these
compounds'
sources,
mechanisms
action,
complementary
synergistic
effects,
associated
side
effects.
It
was
reviewed
that
the
exposure
certain
doses
catechins,
piperlongumine,
lycopene,
isoflavones
cucurbitacinfor
sufficient
period
can
provide
profound
anticancer
benefits
through
biological
events
such
as
cell
cycle
arrest,
cells
undergoing
apoptosis
disruption
signaling
pathways
including,
but
not
limited
JAK-STAT3,
HER2-integrin,
MAPK.
Besides,
study
also
covers
potential
adverse
effects
phytochemicals.
Regarding
mechanisms,
widest
attention
paid
Complementary
strategies
discussed
indicate
it
would
be
realistic
alter
dosage
delivery
systems
liposomes,
nanoparticles,
nanoemulsions,
films
enhance
efficacy.
Future
research
directions
include
refining
approaches,
further
elucidating
molecular
conducting
clinical
trials
validate
findings.
These
efforts
could
significantly
advance
role
phytocompounds
in
management.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
153, С. 113274 - 113274
Опубликована: Июнь 17, 2022
Natural
product
compounds
have
lately
attracted
interest
in
the
scientific
community
as
a
possible
treatment
for
gastrointestinal
(GI)
cancer,
due
to
their
anti-inflammatory
and
anticancer
properties.
There
are
many
preclinical,
clinical,
epidemiological
studies,
suggesting
that
consumption
of
polyphenol
compounds,
which
abundant
vegetables,
grains,
fruits,
pulses,
may
help
prevent
various
illnesses
disorders
from
developing,
including
several
GI
cancers.
The
development
malignancies
follows
well-known
path,
normal
cells
acquire
abnormalities
genetic
composition,
causing
continuously
proliferate,
metastasize
other
sites,
especially
brain
liver.
with
ability
affect
oncogenic
pathways
might
be
treatments
malignancies,
could
easily
tested
clinical
trials.
Resveratrol
is
non-flavonoid
natural
stilbene,
acting
phytoestrogen
anti-cancer,
cardioprotective,
anti-oxidant,
has
been
shown
overcome
resistance
mechanisms
cancer
cells,
when
combined
conventional
drugs,
sensitize
chemotherapy.
Several
new
resveratrol
analogs
nanostructured
delivery
vehicles
improved
anti-GI
efficacy,
absorption,
pharmacokinetic
profiles
already
developed.
This
present
review
focuses
on
vitro
vivo
effects
cancers,
well
underlying
molecular
action.
