The therapeutic potential of natural metabolites in targeting endocrine-independent HER-2-negative breast cancer DOI Creative Commons
Mirosława Püsküllüoğlu, Izabela Michalak

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 4, 2024

Breast cancer (BC) is a heterogenous disease, with prognosis and treatment options depending on Estrogen, Progesterone receptor, Human Epidermal Growth Factor Receptor-2 (HER-2) status. HER-2 negative, endocrine-independent BC presents significant clinical challenge limited options. To date, promising strategies like immune checkpoint inhibitors have not yielded breakthroughs in patient prognosis. Despite being considered archaic, agents derived from natural sources, mainly plants, remain backbone of current treatment. In this context, we critically analyze novel naturally-derived drug candidates, elucidate their intricate mechanisms action, evaluate pre-clinical vitro vivo activity negative BC. Since research success often does directly correlate approval, focus ongoing trials to uncover trends. Finally, demonstrate the potential combining cutting-edge technologies, such as antibody-drug conjugates or nanomedicine, agents, offering new opportunities that utilize both traditional cytotoxic metabolites.

Language: Английский

Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies DOI Creative Commons

Minru Liao,

Rui Qin, Wei Huang

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: April 12, 2022

Abstract Triple-negative breast cancer (TNBC) is a subtype of human with one the worst prognoses, no targeted therapeutic strategies currently available. Regulated cell death (RCD), also known as programmed (PCD), has been widely reported to have numerous links progression and therapy many types cancer. Of note, RCD can be divided into different subroutines, including autophagy-dependent death, apoptosis, mitotic catastrophe, necroptosis, ferroptosis, pyroptosis anoikis. More recently, targeting subroutines small-molecule compounds emerging promising strategy, which rapidly progressed in treatment TNBC. Therefore, this review, we focus on summarizing molecular mechanisms above-mentioned seven major related TNBC latest progress subroutines. Moreover, further discuss combined drug (e.g., narciclasine) or more drugs torin-1 chloroquine) achieve potential by regulating importantly, demonstrate several ONC201 NCT03733119) clinical trials. Taken together, these findings will provide clue illuminating actionable low-hanging-fruit druggable targets candidate for RCD-related therapies. Graphical abstract

Language: Английский

Citations

93
The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC) DOI Open Access
Reyhaneh Farghadani, Rakesh Naidu

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115170 - 115170

Published: July 21, 2023

Breast cancer is a leadingcause of cancer-related deaths in women globally, with triple-negative breast (TNBC) being an aggressive subtype that lacks targeted therapies and associated poor prognosis. Polyphenols, naturally occurring compounds plants, have been investigated as potential therapeutic strategy for TNBC. This review provides overview the anticancer effects polyphenols TNBC their mechanisms action. Several polyphenols, including resveratrol, quercetin, kaempferol, genistein, epigallocatechin-3-gallate, apigenin, fisetin, hesperetin luteolin, shown to inhibit cell proliferation, induce cycle arrest, promote apoptosis, suppress migration/invasion preclinical models. The molecular underlying involve modulation several signalling pathways, such PI3K/Akt, MAPK, STATT, NF-κB pathways. Polyphenols also exhibit synergistic chemotherapy drugs, making them promising candidates combination therapy. highlights clinical trials investigating use individually or therapy, against cancer. deepens under-standing mechanism action respective valuable insights into TNBC, lays groundwork future research this area.

Language: Английский

Citations

44
Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer DOI Open Access
Vidhya Prakash, Chinchu Bose, Damu Sunilkumar

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3370 - 3370

Published: March 16, 2024

Natural products have been a long-standing source for exploring health-beneficial components from time immemorial. Modern science has had renewed interest in natural-products-based drug discovery. The quest new potential secondary metabolites or enhanced activities existing molecules remains pertinent topic research. Resveratrol belongs to the stilbenoid polyphenols group that encompasses two phenol rings linked by ethylene bonds. Several plant species and foods, including grape skin seeds, are primary of this compound. is known possess potent anti-inflammatory, antiproliferative, immunoregulatory properties. Among notable bioactivities associated with resveratrol, its pivotal role safeguarding intestinal barrier highlighted capacity prevent inflammation regulate gut microbiome. A better understanding how oxidative stress can be controlled using resveratrol capability protect microbiome perspective shed more light on physiological conditions. Additionally, exhibits antitumor activity, proving cancer treatment prevention. Moreover, cardioprotective, vasorelaxant, phytoestrogenic, neuroprotective benefits also reported. pharmaceutical industry continues encounter difficulties administering owing inadequate bioavailability poor solubility, which must addressed simultaneously. This report summarizes currently available literature unveiling pharmacological effects resveratrol.

Language: Английский

Citations

26
Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review DOI Creative Commons

Lie Yuan,

Yongqing Cai, Liang Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 28, 2022

Breast cancer is one of the top-ranked malignant carcinomas associated with morbidity and mortality in women worldwide. Chemotherapy main approaches to breast treatment. initially responds traditional first- second-line drugs (aromatase inhibitor, tamoxifen, carboplatin), but eventually acquires resistance, certain patients relapse within 5 years. Chemotherapeutic also have obvious toxic effects. In recent years, natural products been widely used research because their low side effects, toxicity, good efficacy based on multitarget therapy. Apoptosis, a programmed cell death, occurs as normal controlled process that promotes growth death. Inducing apoptosis an important strategy control excessive proliferation. Accumulating evidence has revealed become increasingly treatment by suppressing apoptosis. this study, we reviewed current studies product-induced summarized proapoptosis mechanisms including mitochondrial, FasL/Fas, PI3K/AKT, reactive oxygen species, mitogen-activated protein kinase-mediated pathway. We hope our review can provide direction search for candidate derived from treat promoting

Language: Английский

Citations

63
Effects and mechanisms of resveratrol for prevention and management of cancers: An updated review DOI
Si-Xia Wu, Ruo-Gu Xiong, Siyu Huang

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(33), P. 12422 - 12440

Published: July 19, 2022

Cancer is a severe public health problem. Resveratrol famous natural compound that has various bioactivities, such as antioxidant, anti-inflammatory, antidiabetic and antiaging activities. Especially, resveratrol could prevent treat cancers, oral, thyroid, breast, lung, liver, pancreatic, gastric, colorectal, bladder, prostate ovarian cancers. The underlying mechanisms have been widely studied, inhibiting cell proliferation, suppressing metastasis, inducing apoptosis, stimulating autophagy, modulating immune system, attenuating inflammation, regulating gut microbiota enhancing effects of other anticancer drugs. In this review, we summarize on different This paper helpful to develop resveratrol, crude extract containing or foods into functional food, dietary supplements auxiliary agents for prevention management

Language: Английский

Citations

55
Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action DOI

Mitra Behroozaghdam,

Maryam Dehghani,

Amirhossein Zabolian

et al.

Cellular and Molecular Life Sciences, Journal Year: 2022, Volume and Issue: 79(11)

Published: Oct. 4, 2022

Language: Английский

Citations

40
Exploring the multimodal health‐promoting properties of resveratrol: A comprehensive review DOI Creative Commons
Zargham Faisal,

Aimen Mazhar,

Syeda Ayesha Batool

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(4), P. 2240 - 2258

Published: Jan. 28, 2024

Abstract Resveratrol, a natural polyphenol in various plants, has gained significant attention for its potential health‐promoting properties. It been demonstrated, after reviewing clinical and vitro studies, that resveratrol possesses potent antioxidant potential. Resveratrol demonstrates cellular component protection by directly neutralizing free radicals (FRs) enhancing the expression of enzymes, thereby mitigating oxidative damage to proteins, lipids, nucleic acids. Clinical trials have shown promising results, indicating supplementation can enhance defenses reduce markers populations. In addition effects, exhibits anti‐inflammatory modulate key inflammatory pathways, such as nuclear factor‐kappa B (NF‐κB) mitogen‐activated protein kinases (MAPKs), suppressing production pro‐inflammatory cytokines chemokines. Furthermore, resveratrol's multimodal effects extend beyond discovered exert regulatory on processes, including apoptosis, cell cycle progression, angiogenesis, immunological responses. The primary aim this review paper is provide thorough overview current knowledge resveratrol, chemical composition, bioaccessibility, effectiveness, utilization nanotechnology bioavailability. From future perspectives, revising administration methods certain contexts understanding underlying systems responsible will require further inquiry. For highest health advanced trial‐based research necessary combinational nano‐delivery resveratrol.

Language: Английский

Citations

14
Nanotechnology-mediated delivery of resveratrol as promising strategy to improve therapeutic efficacy in triple negative breast cancer (TNBC): progress and promises DOI
Javed Ahmad, Javed Ahamad, Mohammed S. Algahtani

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(2), P. 229 - 244

Published: Feb. 1, 2024

Introduction Triple-negative breast cancer (TNBC) presents unique challenges indiagnosis and treatment.Resveratrolexhibits potential as a therapeutic intervention for TNBC byregulating various pathways such the PI3K/AKT, RAS/RAF/ERK, PKCδ,and AMPK, leading to apoptosis through ROS-mediated CHOP activationand expression of DR4 DR5. However, clinical efficacy resveratrol is limited due itspoor biopharmaceutical characteristics low bioavailability at thetumor site. Nanotechnology offers promising approach improvingthe achieveclinical in different cancers.

Language: Английский

Citations

9
Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review DOI Creative Commons
Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Sirajunisa Talath

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(1), P. 30 - 30

Published: Jan. 6, 2025

Extensive investigation has been conducted on plant-based resources for their pharmacological usefulness, including various cancer types. The scope of this review is wider than several studies with a particular focus breast cancer, which an international health concern while studying sources flavonoids, carotenoids, polyphenols, saponins, phenolic compounds, terpenoids, and glycosides apart from focusing nursing. Important findings prior are synthesized to explore these compounds' sources, mechanisms action, complementary synergistic effects, associated side effects. It was reviewed that the exposure certain doses catechins, piperlongumine, lycopene, isoflavones cucurbitacinfor sufficient period can provide profound anticancer benefits through biological events such as cell cycle arrest, cells undergoing apoptosis disruption signaling pathways including, but not limited JAK-STAT3, HER2-integrin, MAPK. Besides, study also covers potential adverse effects phytochemicals. Regarding mechanisms, widest attention paid Complementary strategies discussed indicate it would be realistic alter dosage delivery systems liposomes, nanoparticles, nanoemulsions, films enhance efficacy. Future research directions include refining approaches, further elucidating molecular conducting clinical trials validate findings. These efforts could significantly advance role phytocompounds in management.

Language: Английский

Citations

1
Applications of resveratrol in the treatment of gastrointestinal cancer DOI Creative Commons

Mohammad Roshani,

Ameneh Jafari, Amir Hossein Loghman

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 153, P. 113274 - 113274

Published: June 17, 2022

Natural product compounds have lately attracted interest in the scientific community as a possible treatment for gastrointestinal (GI) cancer, due to their anti-inflammatory and anticancer properties. There are many preclinical, clinical, epidemiological studies, suggesting that consumption of polyphenol compounds, which abundant vegetables, grains, fruits, pulses, may help prevent various illnesses disorders from developing, including several GI cancers. The development malignancies follows well-known path, normal cells acquire abnormalities genetic composition, causing continuously proliferate, metastasize other sites, especially brain liver. with ability affect oncogenic pathways might be treatments malignancies, could easily tested clinical trials. Resveratrol is non-flavonoid natural stilbene, acting phytoestrogen anti-cancer, cardioprotective, anti-oxidant, has been shown overcome resistance mechanisms cancer cells, when combined conventional drugs, sensitize chemotherapy. Several new resveratrol analogs nanostructured delivery vehicles improved anti-GI efficacy, absorption, pharmacokinetic profiles already developed. This present review focuses on vitro vivo effects cancers, well underlying molecular action.

Language: Английский

Citations

30