International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(11), С. 6215 - 6215
Опубликована: Июнь 1, 2022
Ovarian
cancer
(OC)
is
one
of
the
most
common
gynecological
cancers,
with
worst
prognosis
and
highest
mortality
rate.
Peritoneal
dissemination
(or
carcinomatosis)
accompanied
by
ascites
formation
unfavorable
factor
in
progression
recurrence
OC.
Tumor
cells
are
present
as
either
separate
or,
more
often,
cell
aggregates,
i.e.,
spheroids
which
promote
implantation
on
surface
nearby
organs
and,
at
later
stages,
metastases
to
distant
organs.
Malignant
comprises
a
unique
tumor
microenvironment;
this
fact
may
be
relevance
search
for
new
prognostic
predictive
factors
that
would
make
it
possible
personalize
treatment
patients
However,
precise
mechanisms
spheroid
carcinomatosis
still
under
investigation.
Here,
we
summarize
data
composition
well
activity
fibroblasts
macrophages,
key
stromal
immune
components,
OC
ascites.
We
describe
current
knowledge
about
role
macrophages
formation,
discuss
specific
functions
fibroblasts,
T
peritoneal
implantation.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(21)
Опубликована: Янв. 15, 2024
Microfluidic
chips
are
valuable
tools
for
studying
intricate
cellular
and
cell-microenvironment
interactions.
Traditional
in
vitro
cancer
models
lack
accuracy
mimicking
the
complexities
of
vivo
tumor
microenvironment.
However,
cancer-metastasis-on-a-chip
(CMoC)
combine
advantages
3D
cultures
microfluidic
technology,
serving
as
powerful
platforms
exploring
mechanisms
facilitating
drug
screening.
These
able
to
compartmentalize
metastatic
cascade,
deepening
understanding
its
underlying
mechanisms.
This
article
provides
an
overview
current
CMoC
models,
focusing
on
distinctive
that
simulate
invasion,
intravasation,
circulation,
extravasation,
colonization,
their
applications
Furthermore,
challenges
faced
by
technologies
discussed,
while
promising
future
directions
research.
The
ongoing
development
integration
these
into
studies
expected
drive
transformative
advancements
field.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5569 - 5569
Опубликована: Май 20, 2024
Due
to
its
propensity
metastasize,
cancer
remains
one
of
the
leading
causes
death
worldwide.
Thanks
in
part
their
intrinsic
low
cytotoxicity,
effects
flavonoid
family
prevention
and
treatment
various
human
cancers,
both
vitro
vivo,
have
received
increasing
attention
recent
years.
It
is
well
documented
that
Apigenin
(4′,5,7-trihydroxyflavone),
among
other
flavonoids,
able
modulate
key
signaling
molecules
involved
initiation
cell
proliferation,
invasion,
metastasis,
including
JAK/STAT,
PI3K/Akt/mTOR,
MAPK/ERK,
NF-κB,
Wnt/β-catenin
pathways,
as
oncogenic
non-coding
RNA
network.
Based
on
these
premises,
aim
this
review
emphasize
some
events
through
which
suppresses
focusing
specifically
ability
target
molecular
pathways
angiogenesis,
epithelial-to-mesenchymal
transition
(EMT),
maintenance
stem
cells
(CSCs),
cycle
arrest,
death.
Molecules,
Год журнала:
2022,
Номер
27(19), С. 6401 - 6401
Опубликована: Сен. 28, 2022
Most
anticancer
treatments
trigger
tumor
cell
death
through
apoptosis,
where
initiation
of
proteolytic
action
caspase
protein
is
a
basic
need.
But
under
certain
circumstances,
apoptosis
prevented
by
the
inhibitor
proteins,
survivin
and
Hsp70.
Several
drugs
focusing
on
classical
programmed
have
been
reported
to
low
anti-tumorogenic
potency
due
mutations
in
proteins
involved
caspase-dependent
with
intrinsic
extrinsic
pathways.
This
review
concentrates
role
anti-cancer
drug
molecules
targeting
alternative
pathways
cancer
for
treatment,
providing
molecular
basis
new
strategies
novel
treatment.
Under
these
conditions,
active
agents
can
be
considered
as
potent
chemotherapeutic
drugs.
Many
natural
compounds
other
small
molecules,
such
inorganic
synthetic
compounds,
including
several
repurposing
drugs,
are
cause
caspase-independent
system.
However,
few
indicated
both
well
caspase-free
specific
lines.
Cancer
cells
methods
which
equally
promising
being
targeted
molecules.
These
may
useful
leads
rational
therapeutic
design,
potential
interest
future
cancer-preventive
strategies.
Neurospine,
Год журнала:
2023,
Номер
20(2), С. 430 - 448
Опубликована: Март 2, 2023
Cell
death
is
a
systematic/nonsystematic
process
of
cessation
normal
morphology
and
functional
properties
the
cell
to
replace
recycle
old
cells
with
new
also
promoting
inflammation
in
some
cases.
It
complicated
comprising
multiple
pathways.
Some
are
well-explored,
others
have
just
begun
be.
The
research
on
appropriate
control
pathways
after
acute
chronic
damage
neuronal
being
widely
researched
today
due
lack
regeneration
recovering
potential
sustaining
inability
direction
growth.
In
progression
onset
various
neurological
diseases,
impairments
programmed
signaling
processes,
like
necroptosis,
apoptosis,
ferroptosis,
pyroptosis,
directly
or
indirectly
linked,
autophagy
as
nonprogrammed
necrosis,
observed.
Spinal
cord
injury
(SCI)
involves
temporary
permanent
disruption
motor
activities
glial
spinal
accompanied
by
axonal
degeneration.
Recent
years
seen
significant
increase
intricate
biochemical
interactions
that
occur
SCI.
Different
may
significantly
impact
subsequent
processes
lead
eventual
deficiency
an
cord.
A
better
knowledge
molecular
basis
involved
might
help
enhance
survival
deficits,
curative
path
for
Mini-Reviews in Medicinal Chemistry,
Год журнала:
2023,
Номер
23(14), С. 1461 - 1478
Опубликована: Янв. 20, 2023
Induction
of
cell
death
and
inhibition
proliferation
in
cancer
have
been
set
as
some
the
main
goals
anti-tumor
therapy.
Cancer
resistance
leads
to
less
efficient
therapy,
consequently,
higher
doses
anticancer
drugs,
which
may
eventually
increase
risk
serious
side
effects
normal
tissues.
Apigenin,
a
nature-derived
herbal
agent,
has
shown
properties
several
types
cancer,
can
induce
directly
and/or
amplify
induction
through
other
modalities.
Although
mechanism
apigenin
order
is
apoptosis,
pathways,
such
autophagic
death,
senescence,
anoikis,
necroptosis,
ferroptosis,
reported
be
induced
by
apigenin.
It
seems
that
enhances
apoptosis
inducing
immunity
tumor
suppressor
genes,
like
p53
PTEN,
also
inhibiting
STAT3
NF-κB
signaling
pathways.
Furthermore,
it
ferroptosis
endogenous
ROS
generation.
Stimulation
production
well
downregulation
drug-resistance
mediators,
mechanisms
necroptosis.
each
type
highly
dependent
on
cancer.
These
modulatory
actions
enhance
agents,
ionizing
radiation
chemotherapy
drugs.
This
review
explains
how
at
cellular
molecular
levels.
Abstract
Background
Oncogenic
transformation
alters
intracellular
metabolism
and
contributes
to
the
growth
of
malignant
cells.
Metabolomics,
or
study
small
molecules,
can
reveal
insight
about
cancer
progression
that
other
biomarker
studies
cannot.
Number
metabolites
involved
in
this
process
have
been
spotlight
for
detection,
monitoring,
therapy.
Recent
Findings
In
review,
“Metabolomics”
is
defined
terms
current
technology
having
both
clinical
translational
applications.
Researchers
shown
metabolomics
be
used
discern
metabolic
indicators
non‐invasively
using
different
analytical
methods
like
positron
emission
tomography,
magnetic
resonance
spectroscopic
imaging
etc.
Metabolomic
profiling
a
powerful
technically
feasible
way
track
changes
tumor
gauge
treatment
response
across
time.
also
predict
individual
treatment,
measure
medication
efficacy,
monitor
drug
resistance.
Its
significance
development
summarized
review.
Conclusion
Although
infancy,
identify
options
and/or
responsiveness
treatments.
Technical
challenges
database
management,
cost
methodical
knowhow
still
persist.
Overcoming
these
near
further
help
designing
new
régimes
with
increased
sensitivity
specificity.
