Novel Systemic Treatment Modalities Including Immunotherapy and Molecular Targeted Therapy for Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(14), С. 7889 - 7889

Опубликована: Июль 17, 2022

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers worldwide. More than half of patients with HNSCC eventually experience disease recurrence and/or metastasis, which can threaten their long-term survival. HNSCCs located in oral cavity larynx usually associated tobacco alcohol use, whereas human papillomavirus (HPV) infection, particularly HPV16 is increasingly recognized as a cause oropharyngeal HNSCC. Despite clinical, histologic, molecular differences between HPV-positive HPV-negative HNSCCs, current treatment approaches same. For recurrent disease, these strategies include chemotherapy, immunotherapy PD-1-inhibitors, or monoclonal antibody, cetuximab, that targets epidermal growth factor; therapies be administered either single agents combination. However, carry high risk toxic side effects; therefore, more effective less treatments needed. The landscape therapy changing significantly; numerous clinical trials underway to test novel therapeutic options like adaptive cellular therapy, antibody-drug conjugates, new targeted agents, combinations, vaccines. This review helps understanding various developments sheds light on path ahead terms further research this field.

Язык: Английский

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Artificial intelligence-assisted nursing interventions in psychiatry for oral cancer patients: A concise narrative review

Oral Oncology Reports, Год журнала: 2024, Номер 10, С. 100343 - 100343

Опубликована: Апрель 5, 2024

Oral cancer presents a significant global public health challenge, which is further complicated by the psychological distress experienced patients. The integration of artificial intelligence (AI) into psychiatric nursing offers an innovative approach to improving care for oral This paper explores multifaceted role nurses in addressing aspects cancer, highlighting transformative potential AI enhancing diagnostics, patient monitoring, treatment planning, and psychosocial support. AI-driven tools, such as predictive models, natural language processing, mobile applications, provide novel means early disease detection, risk assessment, personalized real-time By leveraging AI, can play crucial identifying cases, assessing risks, delivering targeted interventions, promoting engagement self-management. Furthermore, AI-powered telemedicine platforms wearable devices enable continuous support, particularly remote or underserved areas, ensuring timely intervention patients' quality life. collaboration between interdisciplinary teams aims utilize AI-generated insights comprehensive care. Challenges ethical considerations integrating healthcare include data privacy, algorithm validation, need professional training.

Язык: Английский

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Association of Social Vulnerability Index With Declining Recommended Surgical Treatment in Head and Neck Cancer Patients

The Laryngoscope, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Objective To investigate the impact of county‐level social vulnerability on patients' decision to refuse recommended surgical treatment. Methods Retrospective cohort analysis conducted HNSCC cases documented in latest available SEER databases from 2000 2020; various demographic, including county residence, and disease‐related variables were collected. CDC's Social Vulnerability Index (SVI) was assigned based patients subsequently categorized into four SVI quartiles. Pearson chi‐square tests binomial logistic regression determine refusal Results Among 83,184 patients, 2.6% (2,165) refused intervention by their physician as part (higher SVI), male sex, older age, more advanced disease stage, belonging non‐Hispanic Black or Native Hawaiian/Asian Pacific Islander Race Origin, single marital status associated with higher likelihood refusing surgery. Conclusion is a significant factor treatment patients. Advanced stages appear interplay, influencing decisions. Culturally competent care support for socially vulnerable may mitigate disparities acceptance, potentially improving survival outcomes. Level Evidence 3 Laryngoscope , 2025

Язык: Английский

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Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review

Quality of Life Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Язык: Английский

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Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results from a phase II study

Frontiers in Oncology, Год журнала: 2025, Номер 14

Опубликована: Янв. 7, 2025

Preventing malnutrition during chemoradiation (CRT) for head and neck cancer is critical maximizing quality of life (QOL). We sought to assess patient-reported QOL outcomes after integrating exclusive liquid meal replacement with Soylent, a novel agent, in patients undergoing CRT. Patients definitive or adjuvant concurrent CRT locally advanced enrolled on our single-institution, prospective phase II protocol evaluating nutritional Soylent. who reached 5% body weight loss were transitioned Soylent all needs. 10% recommended gastrostomy tube (G-tube) placement. UW-QOL FACT-H&N questionnaires assessed prior the receipt following conclusion Paired t-test Wilcoxon signed-rank test performed differences between scores at each follow-up time point baseline. Of 60 patients, 51/60 (85%) lost their pre-treatment weight. Among these 48/51 (94%) successfully 22/48 subsequently weight, 3/22 (14%) underwent G-tube placement remainder declining. This resulted an overall rate 5%. 41 evaluable data, nadirs health-related 1 month rebounded exceed baseline by 6 months. survey reduced from 32 20 (adjusted p<0.001) 26 3 months p<0.001), but increased 29, 30, 27 6, 12, 18 months, without significant as compared p>0.38 all). report high patient adherence cancers.

Язык: Английский

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Availability and Characteristics of Support Groups for People With Head and Neck Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Support groups are an effective way to improve quality of life (QoL) in cancer patients. Targeted support for head and neck (HNC) can also help patients address specific treatment survivorship challenges. The aim this study is understand the characteristics existing HNC Australian setting identify any gaps service provision. Existing were identified through online search their information was assessed by adopting perspective a person with HNC. considered eligible if they based Australia served patients, caregivers, friends, or family members. Of 26 search, more than half major cities (n = 16) three across inner regional areas outer areas. There no remote Australia. Most took place in-person 18) variety physical settings, including hospitals 10) community spaces 7). Topics frequently covered included: Education information, sharing experiences socializing, side effects, wellness well-being, carer support. need outside metropolitan areas, particularly We must therefore means supporting current future providing promoting valuable all locales.

Язык: Английский

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Changes in unmet needs after treatment for head and neck cancers – A prospective longitudinal cohort study

Oral Oncology, Год журнала: 2025, Номер 163, С. 107250 - 107250

Опубликована: Март 12, 2025

Язык: Английский

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Identification of molecular classification and gene signature for predicting prognosis and immunotherapy response in HNSCC using cell differentiation trajectories

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Ноя. 27, 2022

Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with poor prognosis. This article aims to explore the clinical significance of differentiation trajectory in HNSCC, identify different molecular subtypes by consensus clustering analysis, develop prognostic risk model on basis differentiation-related genes (DRGs) for predicting prognosis HNSCC patients. Firstly, analysis was performed single-cell RNA sequencing (scRNA-seq) data, four were identified from bulk RNA-seq predictive patient survival, features, immune infiltration status, expression checkpoint (ICGs)s. Secondly, we developed 10-DRG signature patients using weighted correlation network (WGCNA), differential univariate Cox regression multivariate analysis. Then, nomogram integrating assessment features can successfully predict favorable performance superior accuracy. We projected response immunotherapy sensitivity commonly used antitumor drugs between groups. Finally, quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) western blot verify signature. In conclusion, distinct constructed novel based differentially expressed DRGs, which could may provide valuable applications treatment HNSCC.

Язык: Английский

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Unmet supportive care needs and associated factors: Evidence from 4195 cancer survivors in Shanghai, China

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Ноя. 30, 2022

Cancer survivors at different stages of life often have needs that make it challenging for services to provide satisfactory care. Few studies considered whether are truly meeting the cancer patients by exploring and identifying their perspectives on unmet needs. The aim this study was identify further determine potential impact socio-demographic factors. A cross-sectional included 4195 conducted in Shanghai, China. Using Maslow's hierarchy theory as a conceptual framework, questionnaire five dimensions: information, finances, continuing care, emotions, self-actualization. Correlation analysis ordered logistic regression used explore relationship between demographic sociological factors supportive most common care include information (2.91 ± 1.32), self-actualization (2.69 1.32) (2.59 1.30). Unmet finances were more pronounced among participants 45-69 age group. After adjusting confounders, we found each 6-month increase time since diagnosis associated with 0.8% (OR: 0.992, 95% CI: 0.985-0.998) reduction high need 0.9% (OR:0.991, 0.983-0.999) self-actualization, respectively. Information important concern diverse survivors. Time is findings highlight large gap actual health patients' which will basis patient-centered system

Язык: Английский

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Mediating effects of rumination on insomnia in cancer survivors: Influences of cancer‐related fatigue, fear of recurrence, and psychological distress

Cancer Medicine, Год журнала: 2024, Номер 13(18)

Опубликована: Сен. 1, 2024

Abstract Background While advancements in cancer treatments have improved survival rates, they also lead to adverse effects such as insomnia, which significantly impacts survivors' sleep quality. Objective This study explores the influence of cancer‐related fatigue (CRF), Fear Cancer Recurrence (FCR), and psychological distress, with rumination serving a mediating factor, on insomnia experienced by survivors. Methods The involved 220 survivors attending Shohada‐e‐Tajrish Hospital's oncology center Tehran, Iran. Participants were selected through convenience sampling completed several questionnaires: Insomnia Severity Index, Inventory, Fatigue Scale, Kessler Psychological Distress Rumination Response Scale. Results results showed that tested model had good fit, correlation matrix demonstrated significant positive correlations between CRF (0.46), FCR (0.15), distress (0.55), (0.42) ( p < 0.05). Notably, (B = 0.356, 0.001) 0.339, affect both directly indirectly mediation rumination, while impact was 0.73, Conclusion findings suggest interventions focused managing could be potential targets alleviate improve quality

Язык: Английский

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