Pharmaceutics,
Год журнала:
2023,
Номер
15(4), С. 1184 - 1184
Опубликована: Апрель 7, 2023
Lipid
nanoparticles
(LNP)
have
gained
much
attention
after
the
approval
of
mRNA
COVID-19
vaccines.
The
considerable
number
currently
ongoing
clinical
studies
are
testament
to
this
fact.
These
efforts
towards
development
LNPs
warrant
an
insight
into
fundamental
developmental
aspects
such
systems.
In
review,
we
discuss
key
design
that
confer
efficacy
a
LNP
delivery
system,
i.e.,
potency,
biodegradability,
and
immunogenicity.
We
also
cover
underlying
considerations
regarding
route
administration
targeting
hepatic
non-hepatic
targets.
Furthermore,
since
is
function
drug/nucleic
acid
release
within
endosomes,
take
holistic
view
charged-based
approaches
not
only
in
context
endosomal
escape
but
relation
other
comparable
target
cell
internalization
strategies.
Electrostatic
charge-based
interactions
been
used
past
as
potential
strategy
enhance
drug
from
pH-sensitive
liposomes.
strategies
around
low
pH
tumor
micro-environments.
Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Авг. 29, 2022
Tumor
acidity
is
one
of
the
cancer
hallmarks
and
associated
with
metabolic
reprogramming
use
glycolysis,
which
results
in
a
high
intracellular
lactic
acid
concentration.
Cancer
cells
avoid
stress
major
by
activation
expression
proton
lactate
transporters
exchangers
have
an
inverted
pH
gradient
(extracellular
pHs
are
alkaline,
respectively).
The
shift
tumor
acid-base
balance
promotes
proliferation,
apoptosis
avoidance,
invasiveness,
metastatic
potential,
aggressiveness,
immune
evasion,
treatment
resistance.
For
example,
weak-base
chemotherapeutic
agents
may
substantially
reduced
cellular
uptake
capacity
due
to
"ion
trapping".
Lactic
negatively
affects
functions
activated
effector
T
cells,
stimulates
regulatory
them
express
programmed
cell
death
receptor
1.
On
other
hand,
inversion
could
be
weakness
that
will
allow
development
new
promising
therapies,
such
as
tumor-targeted
pH-sensitive
antibodies
pH-responsible
nanoparticle
conjugates
anticancer
drugs.
regulation
levels
pharmacological
inhibition
proteins
(monocarboxylate
transporters,
H
Advanced Engineering Materials,
Год журнала:
2023,
Номер
25(21)
Опубликована: Авг. 29, 2023
Stimuli‐responsive
polymers
(SRPs)
are
special
types
of
soft
materials,
which
have
been
extensively
used
for
developing
flexible
actuators,
robots,
wearable
devices,
sensors,
self‐expanding
structures,
and
biomedical
thanks
to
their
ability
change
shapes
functional
properties
in
response
external
stimuli
including
light,
humidity,
heat,
pH,
electric
field,
solvent,
magnetic
field
or
combinations
two
more
these
stimuli.
In
recent
years,
additive
manufacturing
(AM)
aka
3D
printing
technology
SRPs,
also
known
as
4D
printing,
has
gained
phenomenal
attention
different
engineering
fields,
its
unique
develop
complex,
personalized,
innovative
undergo
twisting,
elongating,
swelling,
rolling,
shrinking,
bending,
spiraling,
other
complex
morphological
transformations.
Herein,
an
effort
made
provide
insightful
information
about
the
AM
techniques,
type
applications
including,
but
not
limited
tissue
engineering,
bionics,
construction,
smart
textiles.
This
article
incorporates
current
challenges
prospects,
hoping
basis
utilization
this
fields.
It
is
expected
that
amalgamation
with
SRPs
would
unparalleled
advantages
arenas.
Polymers,
Год журнала:
2024,
Номер
16(6), С. 843 - 843
Опубликована: Март 19, 2024
Chemotherapy
together
with
surgery
and/or
radiotherapy
are
the
most
common
therapeutic
methods
for
treating
cancer.
However,
off-target
effects
of
chemotherapy
known
to
produce
side
and
dose-limiting
toxicities.
Novel
delivery
platforms
based
on
natural
synthetic
polymers
enhanced
pharmacokinetic
potential
treatment
cancer
have
grown
tremendously
over
past
10
years.
Polymers
can
facilitate
selective
targeting,
enhance
prolong
circulation,
improve
delivery,
provide
controlled
release
cargos
through
various
mechanisms,
including
physical
adsorption,
chemical
conjugation,
internal
loading.
Notably,
that
biodegradable,
biocompatible,
physicochemically
stable
considered
be
ideal
carriers.
This
biomimetic
bio-inspired
system
offers
a
bright
future
effective
drug
overcome
obstacles
encountered.
review
focuses
barriers
impact
success
as
well
recent
developments
improving
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
8, С. 100265 - 100265
Опубликована: Июнь 26, 2024
Cancer
remains
a
major
global
health
challenge,
and
despite
available
treatments,
its
prognosis
poor.
Recently,
researchers
have
turned
their
attention
to
intelligent
nanofibers
for
cancer
drug
delivery.
These
exhibit
remarkable
capabilities
in
targeted
controlled
release.
Their
inherent
characteristics,
such
as
high
surface
area-to-volume
ratio,
make
them
attractive
candidates
delivery
applications.
Smart
can
release
drugs
response
specific
stimuli,
including
pH,
temperature,
magnetic
fields,
light.
This
unique
feature
not
only
reduces
side
effects
but
also
enhances
the
overall
efficiency
of
systems.
Electrospinning,
widely
used
method,
allows
precision
fabrication
smart
nanofibers.
Its
advantages
include
efficiency,
user-friendliness,
ability
control
various
manufacturing
parameters.
In
this
review,
we
explore
latest
developments
producing
electrospun
treatment.
Additionally,
discuss
materials
these
critical
parameters
involved
electrospinning
process.
Bioactive Materials,
Год журнала:
2023,
Номер
31, С. 440 - 462
Опубликована: Сен. 6, 2023
Cancer
immunotherapy
has
gained
momentum
for
treating
malignant
tumors
over
the
past
decade.
Checkpoint
blockade
and
chimeric
antigen
receptor
cell
therapy
(CAR-T)
have
shown
considerable
potency
against
liquid
solid
cancers.
However,
tumor
microenvironment
(TME)
is
highly
immunosuppressive
hampers
effect
of
currently
available
cancer
immunotherapies
on
overall
treatment
outcomes.
Advancements
in
design
engineering
nanomaterials
opened
new
avenues
to
modulate
TME.
Progress
current
nanocomposite
technology
can
overcome
immunosuppression
trigger
robust
immunotherapeutic
responses
by
integrating
synergistic
functions
different
molecules.
We
will
review
recent
advancements
nanomedical
applications
discuss
specifically
designed
nanocomposites
modulating
TME
immunotherapy.
In
addition,
we
provide
information
landscape
clinical-stage
Biomaterials Science,
Год журнала:
2023,
Номер
11(6), С. 1948 - 1961
Опубликована: Янв. 1, 2023
"Smart"
biomaterials
that
are
responsive
to
pathological
abnormalities
an
appealing
class
of
therapeutic
platforms
for
the
development
personalized
medications.
The
such
requires
novel
techniques
could
precisely
deliver
agents
diseased
tissues,
resulting
in
enhanced
effects
without
harming
normal
tissues.
Among
various
platforms,
injectable
pH-responsive
promising
respond
change
environmental
pH.
Aqueous
solutions
exhibit
a
phase
transition
from
sol-to-gel
response
pH
changes.
hydrogel
depot
can
provide
spatially
and
temporally
controlled
release
bioactive
including
chemotherapeutic
drugs,
peptides,
proteins.
Therapeutic
imbibed
into
hydrogels
by
simple
mixing
use
toxic
solvents
used
long-term
storage
or
situ
injection
using
syringe
catheter
form
stable
gel
acts
as
minimally
invasive
manner.
Tunable
physicochemical
properties
hydrogels,
biodegradability,
ability
interact
with
drugs
mechanical
properties,
control
agent.
This
review
highlights
advances
design
biodegradable
forming
physiological
conditions.
Special
attention
has
been
paid
amphoteric
their
utilization
biomedical
applications.
We
also
highlight
key
challenges
future
directions
clinical
translation.
