Pharmaceutics,
Год журнала:
2023,
Номер
15(4), С. 1184 - 1184
Опубликована: Апрель 7, 2023
Lipid
nanoparticles
(LNP)
have
gained
much
attention
after
the
approval
of
mRNA
COVID-19
vaccines.
The
considerable
number
currently
ongoing
clinical
studies
are
testament
to
this
fact.
These
efforts
towards
development
LNPs
warrant
an
insight
into
fundamental
developmental
aspects
such
systems.
In
review,
we
discuss
key
design
that
confer
efficacy
a
LNP
delivery
system,
i.e.,
potency,
biodegradability,
and
immunogenicity.
We
also
cover
underlying
considerations
regarding
route
administration
targeting
hepatic
non-hepatic
targets.
Furthermore,
since
is
function
drug/nucleic
acid
release
within
endosomes,
take
holistic
view
charged-based
approaches
not
only
in
context
endosomal
escape
but
relation
other
comparable
target
cell
internalization
strategies.
Electrostatic
charge-based
interactions
been
used
past
as
potential
strategy
enhance
drug
from
pH-sensitive
liposomes.
strategies
around
low
pH
tumor
micro-environments.
Carbohydrate Polymer Technologies and Applications,
Год журнала:
2024,
Номер
7, С. 100515 - 100515
Опубликована: Май 21, 2024
Chitosan-based
nanoparticles
have
demonstrated
a
growing
potential
for
use
in
drug
delivery
systems
due
to
their
remarkable
versatility.
To
enhance
the
effectiveness
of
chitosan-based
stimulus-responsive
cancer
delivery,
novel
pH-sensitive
semi-interpenetrating
networks
(semi-IPN)
chitosan-poly(1-vinyl
imidazole)
(CS-PVIm)
and
Chitosan-poly(methacrylic-acid)
(CS-PMAA)
were
synthesized
through
free
radical
polymerization.
The
semi-IPN
analyzed
evaluate
suitability
as
carriers.
SEM
analysis
revealed
that
spherical
within
nanoscale
size
range.
average
particle
measured
by
DLS
CS-PMAA
was
107.9
nm
without
175.2
after
encapsulation.
CS-PVIm-nanoparticles
had
an
138.32
which
increased
165.84
loading.
ATR-FTIR
confirmed
formation
CS-PVIm
nanoparticles.
Cytotoxicity
showed
are
biocompatibility
demonstrating
over
95%
cell
survival
HeLa
lines.
Further,
Doxorubicin-hydrochloride
(Dox)
loaded
exhibited
sustained
release
caused
protonation
deprotonation
functional
groups
based
on
pH
change.
encapsulation
efficiency
(EE)
57
%
whereas
EE
CS-PMAA-nanoparticles
52%
respectively.
This
research
presents
straightforward
method
producing
intelligent
pH-responsive
semi-IPN-nanoparticles
tailored
anticancer
delivery.
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e25477 - e25477
Опубликована: Фев. 1, 2024
The
health
of
the
reproductive
system
is
intricately
linked
to
female
fertility
and
quality
life.
There
has
been
a
growing
prevalence
disorders
among
women,
particularly
in
younger
age
groups,
resulting
significant
adverse
effects
on
their
health.
Consequently,
there
an
urgent
need
for
effective
treatment
modalities.
Nanotechnology,
as
advanced
discipline,
provides
innovative
avenues
managing
treating
diseases
by
enabling
precise
manipulation
regulation
biological
molecules
cells.
By
utilizing
nanodelivery
systems,
drugs
can
be
administered
with
pinpoint
accuracy,
leading
reduced
side
improved
therapeutic
efficacy.
Moreover,
nanomaterial
imaging
techniques
enhance
diagnostic
precision
sensitivity,
aiding
assessment
disease
severity
progression.
Furthermore,
implementation
nanobiosensors
facilitates
early
detection
prevention
ailments.
This
comprehensive
review
aims
summarize
recent
applications
nanotechnology
diseases.
latest
advancements
drug
delivery,
diagnosis,
approaches
will
discussed,
emphasis
potential
improve
outcomes
overall
Cancer
remains
the
second
leading
cause
of
death
globally,
driving
need
for
innovative
therapies.
Among
natural
compounds,
maytansinoids
have
shown
significant
promise,
contributing
to
nearly
25%
recently
approved
anticancer
drugs.
Despite
their
potential,
early
clinical
trials
faced
challenges
due
severe
side
effects,
prompting
advancements
in
delivery
systems
such
as
antibody-maytansinoid
conjugates
(AMCs).
This
review
highlights
activity
maytansinoids,
with
a
focus
on
AMCs
designed
target
cancer
cells
specifically.
Preclinical
and
studies
show
that
AMCs,
including
FDA-approved
drugs
like
Kadcyla
Elahere,
effectively
inhibit
tumor
growth
while
reducing
systemic
toxicity.
Key
developments
include
improved
synthesis
methods,
linker
chemistry
payload
design.
Ongoing
research
aims
enhance
safety
efficacy
integrate
nanotechnology
drug
delivery,
identify
novel
therapeutic
targets.
These
hold
potential
transform
maytansinoid-based
treatments
future.
Gene
and
RNA-based
therapeutics
represent
a
promising
frontier
in
oncology,
enabling
targeted
modulation
of
tumor-associated
genes
proteins.
This
review
explores
the
latest
advances
payload
vectorization
delivery
systems
developed
for
vivo
cancer
treatments.
We
discuss
viral
non-viral
organic
particles,
including
lipid
based
nanoparticles
polymeric
structures,
effective
transport
plasmids,
siRNA,
self-amplifying
RNA
therapeutics.
Their
physicochemical
properties,
strategies
to
overcome
intracellular
barriers,
innovations
cell-based
carriers
engineered
extracellular
vesicles
are
highlighted.
Moreover,
we
consider
oncolytic
viruses,
novel
capsid
modifications,
approaches
that
refine
tumor
targeting
immunomodulation.
Ongoing
clinical
trials
regulatory
frameworks
guide
future
directions
emphasize
need
safe,
scalable
production.
The
potential
convergence
these
with
combination
therapies
paves
way
toward
personalized
medicine.
Polymers,
Год журнала:
2023,
Номер
15(5), С. 1234 - 1234
Опубликована: Фев. 28, 2023
Advances
in
atom
transfer
radical
polymerization
(ATRP)
have
enabled
the
precise
design
and
preparation
of
nanostructured
polymeric
materials
for
a
variety
biomedical
applications.
This
paper
briefly
summarizes
recent
developments
synthesis
bio-therapeutics
drug
delivery
based
on
linear
branched
block
copolymers
bioconjugates
using
ATRP,
which
been
tested
systems
(DDSs)
over
past
decade.
An
important
trend
is
rapid
development
number
smart
DDSs
that
can
release
bioactive
response
to
certain
external
stimuli,
either
physical
(e.g.,
light,
ultrasound,
or
temperature)
chemical
factors
changes
pH
values
and/or
environmental
redox
potential).
The
use
ATRPs
containing
drugs,
proteins,
nucleic
acids,
as
well
applied
combination
therapies,
has
also
received
considerable
attention.
