Cited by Advancements in pH-responsive nanocarriers: enhancing drug delivery for tumor therapy

Chitosan-Based pH-Sensitive Semi-Interpenetrating Network Nanoparticles as a Sustained Release Matrix for Anticancer Drug delivery DOI

Raymond Shikuku,

Mohammed Abul Hasnat,

Salman Bin Aziz Mashrur

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 7, P. 100515 - 100515

Published: May 21, 2024

Chitosan-based nanoparticles have demonstrated a growing potential for use in drug delivery systems due to their remarkable versatility. To enhance the effectiveness of chitosan-based stimulus-responsive cancer delivery, novel pH-sensitive semi-interpenetrating networks (semi-IPN) chitosan-poly(1-vinyl imidazole) (CS-PVIm) and Chitosan-poly(methacrylic-acid) (CS-PMAA) were synthesized through free radical polymerization. The semi-IPN analyzed evaluate suitability as carriers. SEM analysis revealed that spherical within nanoscale size range. average particle measured by DLS CS-PMAA was 107.9 nm without 175.2 after encapsulation. CS-PVIm-nanoparticles had an 138.32 which increased 165.84 loading. ATR-FTIR confirmed formation CS-PVIm nanoparticles. Cytotoxicity showed are biocompatibility demonstrating over 95% cell survival HeLa lines. Further, Doxorubicin-hydrochloride (Dox) loaded exhibited sustained release caused protonation deprotonation functional groups based on pH change. encapsulation efficiency (EE) 57 % whereas EE CS-PMAA-nanoparticles 52% respectively. This research presents straightforward method producing intelligent pH-responsive semi-IPN-nanoparticles tailored anticancer delivery.

Language: Английский

Citations

The utilization of nanotechnology in the female reproductive system and related disorders DOI

Xin Luo,

Keran Jia,

Jinshan Xing

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e25477 - e25477

Published: Feb. 1, 2024

The health of the reproductive system is intricately linked to female fertility and quality life. There has been a growing prevalence disorders among women, particularly in younger age groups, resulting significant adverse effects on their health. Consequently, there an urgent need for effective treatment modalities. Nanotechnology, as advanced discipline, provides innovative avenues managing treating diseases by enabling precise manipulation regulation biological molecules cells. By utilizing nanodelivery systems, drugs can be administered with pinpoint accuracy, leading reduced side improved therapeutic efficacy. Moreover, nanomaterial imaging techniques enhance diagnostic precision sensitivity, aiding assessment disease severity progression. Furthermore, implementation nanobiosensors facilitates early detection prevention ailments. This comprehensive review aims summarize recent applications nanotechnology diseases. latest advancements drug delivery, diagnosis, approaches will discussed, emphasis potential improve outcomes overall

Language: Английский

Citations

Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems DOI

Matteo Perra, Ines Castangia, Matteo Aroffu

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 21, 2025

Cancer remains the second leading cause of death globally, driving need for innovative therapies. Among natural compounds, maytansinoids have shown significant promise, contributing to nearly 25% recently approved anticancer drugs. Despite their potential, early clinical trials faced challenges due severe side effects, prompting advancements in delivery systems such as antibody-maytansinoid conjugates (AMCs). This review highlights activity maytansinoids, with a focus on AMCs designed target cancer cells specifically. Preclinical and studies show that AMCs, including FDA-approved drugs like Kadcyla Elahere, effectively inhibit tumor growth while reducing systemic toxicity. Key developments include improved synthesis methods, linker chemistry payload design. Ongoing research aims enhance safety efficacy integrate nanotechnology drug delivery, identify novel therapeutic targets. These hold potential transform maytansinoid-based treatments future.

Language: Английский

Citations

In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology DOI

Julie Schock Vaiani,

Mans Broekgaarden, Jean‐Luc Coll

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Gene and RNA-based therapeutics represent a promising frontier in oncology, enabling targeted modulation of tumor-associated genes proteins. This review explores the latest advances payload vectorization delivery systems developed for vivo cancer treatments. We discuss viral non-viral organic particles, including lipid based nanoparticles polymeric structures, effective transport plasmids, siRNA, self-amplifying RNA therapeutics. Their physicochemical properties, strategies to overcome intracellular barriers, innovations cell-based carriers engineered extracellular vesicles are highlighted. Moreover, we consider oncolytic viruses, novel capsid modifications, approaches that refine tumor targeting immunomodulation. Ongoing clinical trials regulatory frameworks guide future directions emphasize need safe, scalable production. The potential convergence these with combination therapies paves way toward personalized medicine.

Language: Английский

Citations

Ultra-sensitive pH responsive hydrogels with injectable and self-healing performance for controlled drug delivery DOI

Yang Yu, Yili Zhao,

Yujiao Zou

et al.

International Journal of Pharmaceutics X, Journal Year: 2025, Volume and Issue: unknown, P. 100334 - 100334

Published: April 1, 2025

Language: Английский

Citations

Ferrocene and glucose oxidase-installed multifunctional hydrogel reactors for local cancer therapy DOI

Song Yi Lee, Jihye Park,

Da In Jeong

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 349, P. 617 - 633

Published: July 26, 2022

Language: Английский

Citations

pH-triggered cancer-targeting polymers: From extracellular accumulation to intracellular release DOI

Rizwan Ullah Khan,

Jinning Shao,

Jia‐Yu Liao

et al.

Nano Research, Journal Year: 2023, Volume and Issue: 16(4), P. 5155 - 5168

Published: Jan. 3, 2023

Language: Английский

Citations

Use of stimulatory responsive soft nanoparticles for intracellular drug delivery DOI

Krystal A. Hughes, Bishal Misra,

Maryam Maghareh

et al.

Nano Research, Journal Year: 2023, Volume and Issue: 16(5), P. 6974 - 6990

Published: Jan. 14, 2023

Language: Английский

Citations

Recent Advances in the Application of ATRP in the Synthesis of Drug Delivery Systems DOI

Matylda Szewczyk‐Łagodzińska, Andrzej Plichta, Maciej Dębowski

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(5), P. 1234 - 1234

Published: Feb. 28, 2023

Advances in atom transfer radical polymerization (ATRP) have enabled the precise design and preparation of nanostructured polymeric materials for a variety biomedical applications. This paper briefly summarizes recent developments synthesis bio-therapeutics drug delivery based on linear branched block copolymers bioconjugates using ATRP, which been tested systems (DDSs) over past decade. An important trend is rapid development number smart DDSs that can release bioactive response to certain external stimuli, either physical (e.g., light, ultrasound, or temperature) chemical factors changes pH values and/or environmental redox potential). The use ATRPs containing drugs, proteins, nucleic acids, as well applied combination therapies, has also received considerable attention.

Language: Английский

Citations

Pharmacokinetics and tumor delivery of nanoparticles DOI

Long Yuan, Qiran Chen, Jim E. Riviere

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 83, P. 104404 - 104404

Published: April 5, 2023

Language: Английский

Citations