Cell and Tissue Biology, Год журнала: 2023, Номер 17(4), С. 339 - 352
Опубликована: Авг. 1, 2023
Язык: Английский
Frontiers in Oncology, Год журнала: 2022, Номер 12
Опубликована: Авг. 17, 2022
Cancer is one of the most frequently diagnosed malignant diseases worldwide, posing a serious, long-term threat to patients’ health and life. Systemic chemotherapy remains first-line therapeutic approach for recurrent or metastatic cancer patients after surgery, with potential effectively extend patient survival. However, development drug resistance seriously limits clinical efficiency ultimately results in treatment failure death. A large number studies have shown that non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular are widely involved regulation resistance. Their dysregulation contributes by modulating expression specific target genes cellular apoptosis, autophagy, efflux, epithelial-to-mesenchymal transition (EMT), stem cells (CSCs). Moreover, some ncRNAs also possess great as efficient, biomarkers diagnosis prognosis well targets patients. In this review, we summarize recent findings on emerging role underlying mechanisms focus their applications treatment. This information will be benefit early prognostic assessments ncRNA-based strategies
Язык: Английский
Процитировано
79
Cell & Bioscience, Год журнала: 2024, Номер 14(1)
Опубликована: Март 23, 2024
Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to vital roles physiological and pathological conditions by regulating gene expression through diverse mechanisms depending on their subcellular localization. Dysregulated angiogenesis is responsible various vascular oculopathies, including diabetic retinopathy, retinopathy prematurity, age-related macular degeneration, corneal neovascularization. While anti-VEGF treatment available, it curative, long-term outcomes suboptimal, some patients unresponsive. To better understand these diseases, researchers investigated the role models oculopathies. This review summarizes recent research ocular angiogenesis, pro-angiogenic ANRIL, HOTAIR, HOTTIP, H19, IPW, MALAT1, MIAT, NEAT1, TUG1, anti-angiogenic MEG3 PKNY, human/primate specific lncEGFL7OS, discussing functions action
Язык: Английский
Процитировано
5
Genes, Год журнала: 2025, Номер 16(2), С. 138 - 138
Опубликована: Янв. 24, 2025
Background/Objectives: Glioblastoma is the most common malignant primary brain tumor, characterized by necrosis, uncontrolled proliferation, infiltration, angiogenesis, apoptosis resistance, and genomic instability. Epigenetic modifiers hold promise as adjuvant therapies for gliomas, with synergistic combinations being explored to enhance efficacy reduce toxicity. This study aimed evaluate effects of single or combined treatments various anticancer drugs (Carboplatin, Paclitaxel, Avastin), natural compounds (Quercetin), epigenetic modulators (suberoylanilide hydroxamic acid 5-Azacytidine) on expression some long noncoding RNAs methylation drivers functional features in U87-MG cell line. Methods: Treated untreated cells were used evaluation drug-induced cytotoxicity, apoptotic events, distribution cycle phases, detection cytokine release, assessment gene global methylation. Results: Cytotoxicity assays led selection drug concentrations be further experiments. Expression analysis revealed distinct downregulation nearly all investigated genes following treatments. All resulted a higher percentage compared controls. effectively increased levels apoptosis, while exhibited lower proliferation profile, showing elevated values lysis. Conclusions: The results indicate link between Carboplatin Avastin DNA mechanisms involving EZH2, DNMT3A, DNMT3B, Avastin’s direct impact these enzymes warranting study. research underscores platinum-based reactivate silenced tumor suppressor optimize profiles.
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115187 - 115187
Опубликована: Июль 25, 2023
Brain tumors, which are highly malignant, pose a significant threat to health and often result in substantial rates of mortality morbidity worldwide. The brain cancer therapy has been challenging due obstacles such as the BBB, hinders effective delivery therapeutic agents. Additionally, emergence drug resistance further complicates management tumors. TMZ is utilized removal, but drawback. ncRNAs implicated various diseases, their involvement particularly noteworthy. focus current manuscript explore controlling resistance, specifically context chemotherapy TMZ. review emphasizes function ncRNAs, miRNAs, modulating growth invasion significantly influences response treatment. Through interactions with molecular pathways, miRNAs modulators response. Similarly, lncRNAs also associate pathways affecting efficacy chemotherapy. Given functional properties, can either induce or suppress Furthermore, circRNAs, controllers, regulate by acting sponges, thereby impacting explores correlation between chemotherapy, shedding light on underlying involved this process.
Язык: Английский
Процитировано
9
Immunological Investigations, Год журнала: 2022, Номер 51(7), С. 2086 - 2096
Опубликована: Авг. 3, 2022
Cardiac dysfunction is the most common clinical complication of sepsis. Herein, study explored importance long non-coding RNA (lncRNA) HOXA terminal transcript antisense (HOTTIP) in onset sepsis and development cardiac dysfunction.120 patients with were recruited divided into group non-cardiac group. Serum HOTTIP levels measured via RT-qPCR. AC16 cells treated lipopolysaccharide (LPS) for cell experiments detected viability apoptosis.High serum tested patients, which was associated procalcitonin (PCT) level. can identify cases from healthy people AUC 0.927. 72 developed dysfunction, accompanied by elevated HOTTIP. ROC curve displayed predictive ability After adjusting other parameters, independently affect dysfunction. In vitro, knockdown promoted recovery reversed LPS-induced apoptosis excessive interleukin-6 (IL-6) release.LncRNA closely related to condition possibly owing its function myocardial inflammation.
Язык: Английский
Процитировано
9
International Journal of Oncology, Год журнала: 2022, Номер 61(3)
Опубликована: Июль 5, 2022
Gliomas are a primary types of intracranial malignancies and characterized by poor prognosis due to aggressive recurrence profiles. Temozolomide (TMZ) is an auxiliary alkylating agent that extensively used in conjunction with surgical resection forms the mainstay clinical treatment strategies for gliomas. However, frequent occurrence TMZ resistance practice limits its therapeutic efficacy. Accumulating evidence has demonstrated long non‑coding RNAs (lncRNAs) can play key varied roles glioma progression. lncRNAs have been reported inhibit progression targeting various signaling pathways. In addition, differential expression also found mediate several chemotherapeutic agents, particularly TMZ. The present review article therefore summarizes findings previous studies aim report significance function regulating chemoresistance may provide further insight into
Язык: Английский
Процитировано
7
Biomedicines, Год журнала: 2023, Номер 11(5), С. 1364 - 1364
Опубликована: Май 5, 2023
Gliomas are the most common malignant brain tumours. Among them, glioblastoma (GBM) is a grade four tumour with median survival of approximately 15 months and still limited treatment options. Although classical epithelial to mesenchymal transition (EMT) not case in glioma due its non-epithelial origin, EMT-like processes may contribute largely aggressive highly infiltrative nature these tumours, thus promoting invasive phenotype intracranial metastasis. To date, many well-known EMT transcription factors (EMT-TFs) have been described clear, biological functions progression. EMT-related families molecules such as SNAI, TWIST ZEB widely cited, well-established oncogenes considering both In this review, we aimed summarise current knowledge regard functional experiments impact miRNA lncRNA well other epigenetic modifications, main focus on ZEB1 ZEB2 gliomas. explored various molecular interactions pathophysiological processes, cancer stem cell phenotype, hypoxia-induced EMT, microenvironment TMZ-resistant cells, there pressing need elucidate mechanisms by which EMT-TFs regulated gliomas, will enable researchers uncover novel therapeutic targets improve patients’ diagnosis prognostication.
Язык: Английский
Процитировано
3
Tsitologiya, Год журнала: 2023, Номер 65(2), С. 131 - 145
Опубликована: Март 1, 2023
Язык: Английский
Процитировано
1
Cell and Tissue Biology, Год журнала: 2023, Номер 17(4), С. 339 - 352
Опубликована: Авг. 1, 2023
Язык: Английский
Процитировано
0