Non-coding RNA Research,
Год журнала:
2024,
Номер
9(4), С. 1178 - 1189
Опубликована: Май 21, 2024
As
the
deadliest
type
of
primary
brain
tumor,
gliomas
represent
a
significant
worldwide
health
concern.
Circular
RNA
(circRNA),
unique
non-coding
molecule,
seems
to
be
one
most
alluring
target
molecules
involved
in
pathophysiology
many
kinds
cancers.
CircRNAs
have
been
identified
as
prospective
targets
and
biomarkers
for
diagnosis
treatment
numerous
disorders,
particularly
malignancies.
Recent
research
has
established
clinical
link
between
temozolomide
(TMZ)
resistance
certain
circRNA
dysregulations
glioma
tumors.
may
play
therapeutic
role
controlling
or
overcoming
TMZ
provide
guidance
novel
kind
individualized
therapy.
To
address
biological
characteristics
circRNAs
their
potential
induce
TMZ,
this
review
highlighted
summarized
possible
roles
that
molecular
pathways
drug
resistance,
including
Ras/Raf/ERK
PI3K/Akt
signaling
pathway
metabolic
processes
gliomas.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Фев. 17, 2023
Abstract
Drug
resistance
is
mainly
responsible
for
cancer
recurrence
and
poor
prognosis.
Epigenetic
regulation
a
heritable
change
in
gene
expressions
independent
of
nucleotide
sequence
changes.
As
the
common
epigenetic
mechanisms,
DNA
methylation,
histone
modification,
non-coding
RNA
have
been
well
studied.
Increasing
evidence
has
shown
that
aberrant
regulations
contribute
to
tumor
resistance.
Therefore,
targeting
regulators
represents
an
effective
strategy
reverse
drug
In
this
review,
we
summarize
roles
addition,
as
essential
factors
modifications,
demethylases
mediate
or
genomic
modifications.
Herein,
comprehensively
describe
functions
demethylase
family
including
lysine-specific
family,
Jumonji
C-domain-containing
arginine
fully
discuss
their
regulatory
mechanisms
related
therapeutic
strategies,
small-molecule
inhibitors
small
interfering
overcome
resistance,
are
also
described.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114993 - 114993
Опубликована: Июнь 9, 2023
Cardiovascular
disease
(CVD)
is
a
major
contributor
to
increasing
morbidity
and
mortality
worldwide
seriously
threatens
human
health
life.
Cardiomyocyte
death
considered
the
pathological
basis
of
various
CVDs,
including
myocardial
infarction,
heart
failure,
aortic
dissection.
Multiple
mechanisms,
such
as
ferroptosis,
necrosis,
apoptosis,
contribute
cardiomyocyte
death.
Among
them,
ferroptosis
an
iron-dependent
form
programmed
cell
that
plays
vital
role
in
physiological
processes,
from
development
aging
immunity
CVD.
The
dysregulation
has
been
shown
be
closely
associated
with
CVD
progression,
yet
its
underlying
mechanisms
are
still
not
fully
understood.
In
recent
years,
growing
amount
evidence
suggests
non-coding
RNAs
(ncRNAs),
particularly
microRNAs,
long
RNAs,
circular
involved
regulation
thus
affecting
progression.
Some
ncRNAs
also
exhibit
potential
value
biomarker
and/or
therapeutic
target
for
patients
this
review,
we
systematically
summarize
findings
on
their
We
focus
clinical
applications
diagnostic
prognostic
biomarkers
well
targets
treatment.
DATA
AVAILABILITY:
No
new
data
were
created
or
analyzed
study.
Data
sharing
applicable
article.
Translational Oncology,
Год журнала:
2023,
Номер
39, С. 101821 - 101821
Опубликована: Ноя. 4, 2023
Cancer
heterogeneity
and
drug
resistance
remain
pivotal
obstacles
in
effective
cancer
treatment
management.
One
major
contributor
to
these
challenges
is
epigenetic
modifications
-
gene
regulation
that
does
not
involve
changes
the
DNA
sequence
itself
but
significantly
impacts
expression.
As
we
elucidate
phenomena,
underscore
role
of
regulating
expression,
contributing
cellular
diversity,
driving
adaptive
can
instigate
therapeutic
resistance.
This
review
dissects
essential
methylation,
histone
modifications,
chromatin
remodeling
illustrating
their
significant
yet
complex
contributions
biology.
While
offer
potential
avenues
for
intervention
due
reversible
nature,
interplay
genetic
cells
presents
unique
must
be
addressed
harness
full
potential.
By
critically
analyzing
current
research
landscape,
identify
knowledge
gaps
propose
future
directions,
exploring
therapies
discussing
translating
concepts
into
treatments.
comprehensive
aims
stimulate
further
aid
developing
innovative,
patient-centered
therapies.
Understanding
critical
scientific
advancement
paves
way
towards
improving
patient
outcomes
fight
against
this
formidable
disease.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Сен. 8, 2023
Lung
cancer
(LC)
is
a
heterogeneous
disease
with
high
malignant
degree,
rapid
growth,
and
early
metastasis.
The
clinical
outcomes
of
LC
patients
are
generally
poor
due
to
the
insufficient
elucidation
pathological
mechanisms,
low
efficiency
detection
assessment
methods,
lack
individualized
therapeutic
strategies.
Non-coding
RNAs
(ncRNAs),
including
microRNA
(miRNA),
long
non-coding
RNA
(lncRNA),
circular
(circRNA),
endogenous
regulators
that
widely
involved
in
modulation
almost
all
aspects
life
activities,
from
organogenesis
aging
immunity
cancer.
They
commonly
play
vital
roles
various
biological
processes
by
regulating
gene
expression
via
their
interactions
DNA,
RNA,
or
protein.
An
increasing
amount
studies
have
demonstrated
ncRNAs
closely
correlated
initiation
development
LC.
Their
dysregulation
promotes
progression
distinct
such
as
influencing
protein
activity,
activating
oncogenic
signaling
pathways,
altering
specific
expression.
Furthermore,
some
present
certain
values
biomarker
candidates
targets
for
patients.
A
complete
understanding
mechanisms
may
be
highly
beneficial
developing
ncRNA-based
therapeutics
This
review
mainly
focuses
on
intricate
miRNA,
lncRNA,
circRNA
discuss
underlying
applications
treatment.
iScience,
Год журнала:
2024,
Номер
27(6), С. 109979 - 109979
Опубликована: Май 15, 2024
This
review
explores
the
hallmarks
of
cancer
resistance,
including
drug
efflux
mediated
by
ATP-binding
cassette
(ABC)
transporters,
metabolic
reprogramming
characterized
Warburg
effect,
and
dynamic
interplay
between
cells
mitochondria.
The
role
stem
(CSCs)
in
treatment
resistance
regulatory
influence
non-coding
RNAs,
such
as
long
RNAs
(lncRNAs),
microRNAs
(miRNAs),
circular
(circRNAs),
are
studied.
chapter
emphasizes
future
directions,
encompassing
advancements
immunotherapy,
strategies
to
counter
adaptive
integration
artificial
intelligence
for
predictive
modeling,
identification
biomarkers
personalized
treatment.
comprehensive
exploration
these
provides
a
foundation
innovative
therapeutic
approaches,
aiming
navigate
complex
landscape
enhance
patient
outcomes.
Nanoscale,
Год журнала:
2023,
Номер
15(29), С. 12137 - 12156
Опубликована: Янв. 1, 2023
Nanozymes
are
nanomaterials
with
catalytic
properties
similar
to
those
of
natural
enzymes,
and
they
have
recently
been
collectively
identified
as
a
class
innovative
artificial
enzymes.
