Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Год журнала: 2024, Номер 829, С. 111868 - 111868
Опубликована: Июнь 12, 2024
Язык: Английский
Pathology - Research and Practice, Год журнала: 2024, Номер 255, С. 155186 - 155186
Опубликована: Фев. 2, 2024
Язык: Английский
Процитировано
18
Pathology - Research and Practice, Год журнала: 2024, Номер 258, С. 155303 - 155303
Опубликована: Апрель 28, 2024
Язык: Английский
Процитировано
16
Biochemical Pharmacology, Год журнала: 2024, Номер 224, С. 116218 - 116218
Опубликована: Апрель 21, 2024
Язык: Английский
Процитировано
11
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 171, С. 116165 - 116165
Опубликована: Янв. 18, 2024
Cancer development is a complex process that primarily results from the combination of genetic alterations and dysregulation major signalling pathways due to interference with epigenetic machinery. As regulators, miRNAs are central players in control many key tumour factors. These have been classified as oncogenic (oncomiRs) when they target suppressor genes (TS miRNAs) inhibit oncogene protein expression. Most mechanisms modulate oncomiR expression linked transcriptional or posttranscriptional regulation. However, non-transcriptional processes, such gene amplification, described alternative processes responsible for increasing The current review summarises different controlling upregulation cancer cells microenvironment (TME). Detailed knowledge mechanism underlying regulation may pave way understanding critical role oncomiRs progression.
Язык: Английский
Процитировано
10
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 264, С. 130426 - 130426
Опубликована: Фев. 28, 2024
Язык: Английский
Процитировано
8
Epigenetics & Chromatin, Год журнала: 2025, Номер 18(1)
Опубликована: Янв. 15, 2025
Colorectal cancer (CRC) remains one of the most common causes cancer-related mortality worldwide. Its progression is influenced by complex interactions involving genetic, epigenetic, and environmental factors. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs), have been identified as key regulators gene expression, affecting diverse biological processes, notably programmed cell death (PCD). This review aims to explore relationship between ncRNAs PCD in CRC, focusing on how influence survival, proliferation, treatment resistance. A comprehensive literature analysis was conducted examine recent findings role modulating various mechanisms, apoptosis, autophagy, necroptosis, pyroptosis, their impact CRC development therapeutic response. were found significantly regulate pathways, impacting tumor growth, metastasis, sensitivity CRC. Their these pathways highlights potential biomarkers for early detection targets innovative interventions. Understanding involvement regulation offers new insights into biology. The targeted modulation ncRNA-PCD presents promising avenues personalized treatment, which may improve patient outcomes enhancing effectiveness reducing
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129658 - 129658
Опубликована: Янв. 22, 2024
Язык: Английский
Процитировано
6
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 267, С. 131388 - 131388
Опубликована: Апрель 11, 2024
Язык: Английский
Процитировано
5
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116833 - 116833
Опубликована: Июнь 5, 2024
Lung cancer poses a significant challenge regarding molecular heterogeneity, as it encompasses wide range of alterations and cancer-related pathways. Recent discoveries made feasible to thoroughly investigate the mechanisms underlying lung cancer, giving rise possibility novel therapeutic strategies relying on molecularly targeted drugs. In this context, forkhead box O3 (FOXO3), member transcription factors, has emerged crucial protein commonly dysregulated in cells. The regulation FOXO3 reacting external stimuli plays key role maintaining cellular homeostasis component machinery that determines whether cells will survive or dies. Indeed, various extrinsic cues regulate FOXO3, affecting its subcellular location transcriptional activity. These regulations are mediated by diverse signaling pathways, non-coding RNAs (ncRNAs), interactions eventually drive post-transcriptional modification FOXO3. Nevertheless, while is no doubt implicated numerous aspects unclear they act tumor suppressors, promotors, both based situation. However, serves an intriguing possible target therapeutics widely used anti-cancer chemo drugs can it. review, we describe summary recent findings clarify targeting activity might hold promise treatment.
Язык: Английский
Процитировано
5
Molecular Pharmaceutics, Год журнала: 2024, Номер 21(3), С. 1027 - 1037
Опубликована: Фев. 5, 2024
Circular RNAs (circRNAs) have been identified as important regulators in different developmental processes and disease pathogenesis. The loop structure of circRNAs makes them very stable conditions microenvironments. can affect microRNA (miRNA) RNA binding protein (RBP) activity, encode functional proteins regulate gene transcription. Recently, two circNFIX variants derived from the same gene, Nuclear Factor I X (NFIX) were determined participants pathological various diseases such heart cancers. Both are exonic circular mainly function by sponging miRNAs. In this review, we summarize current knowledge on circRNAs, elucidate origins properties variants, explore roles diseases, present clinical perspectives.
Язык: Английский
Процитировано
4