Developing
clinically
meaningful
nanomedicines
for
cancer
therapy
requires
the
drugs
to
be
effective,
safe,
simple,
cheap,
and
easy
store.
In
present
work,
we
report
that
a
simple
cationic
Fe(III)-rich
salt
of
[FeIIICl(TMPPH2)][FeIIICl4]2
(Fe-TMPP)
exhibits
superior
anticancer
performance
toward
broad
spectrum
cell
lines,
including
breast,
colorectal
cancer,
liver,
pancreatic,
prostate,
gastric
cancers,
with
half
maximal
inhibitory
concentration
(IC50)
values
in
range
0.098−3.97
μM
(0.066−2.68
μg
mL−1),
comparable
best-reported
medicines.
Fe-TMPP
can
forms
stand-alone
nanoparticles
water
without
need
extra
surface
modification
or
organic-solvent-assisted
antisolvent
precipitation.
Critically,
is
TME-responsive
(TME
=
tumor
microenvironment),
only
elicit
its
function
TME
overexpressed
H2O2,
converting
H2O2
cytotoxic
•OH
oxidize
phospholipid
membrane,
causing
ferroptosis,
programmed
death
process
cells.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Сен. 8, 2023
Lung
cancer
(LC)
is
a
heterogeneous
disease
with
high
malignant
degree,
rapid
growth,
and
early
metastasis.
The
clinical
outcomes
of
LC
patients
are
generally
poor
due
to
the
insufficient
elucidation
pathological
mechanisms,
low
efficiency
detection
assessment
methods,
lack
individualized
therapeutic
strategies.
Non-coding
RNAs
(ncRNAs),
including
microRNA
(miRNA),
long
non-coding
RNA
(lncRNA),
circular
(circRNA),
endogenous
regulators
that
widely
involved
in
modulation
almost
all
aspects
life
activities,
from
organogenesis
aging
immunity
cancer.
They
commonly
play
vital
roles
various
biological
processes
by
regulating
gene
expression
via
their
interactions
DNA,
RNA,
or
protein.
An
increasing
amount
studies
have
demonstrated
ncRNAs
closely
correlated
initiation
development
LC.
Their
dysregulation
promotes
progression
distinct
such
as
influencing
protein
activity,
activating
oncogenic
signaling
pathways,
altering
specific
expression.
Furthermore,
some
present
certain
values
biomarker
candidates
targets
for
patients.
A
complete
understanding
mechanisms
may
be
highly
beneficial
developing
ncRNA-based
therapeutics
This
review
mainly
focuses
on
intricate
miRNA,
lncRNA,
circRNA
discuss
underlying
applications
treatment.
ACS Nano,
Год журнала:
2024,
Номер
18(18), С. 11560 - 11572
Опубликована: Апрель 29, 2024
Second
near-infrared
(NIR-II)
carbon
dots,
with
absorption
or
emission
between
1000
and
1700
nm,
are
gaining
increasing
attention
in
the
biomaterial
field
due
to
their
distinctive
properties,
which
include
straightforward
preparation
processes,
stable
photophysical
characteristics,
excellent
biocompatibility,
low
cost.
As
a
result,
there
is
growing
focus
on
controlled
synthesis
modulation
of
photochemical
properties
NIR-II
aim
further
expand
biomedical
applications,
current
research
hotspot.
This
account
aims
provide
comprehensive
overview
recent
advancements
dots
within
field.
The
review
will
cover
following
topics:
(i)
design,
synthesis,
purification
(ii)
surface
modification
strategies,
(iii)
particularly
domain
cancer
theranostics.
Additionally,
this
addresses
challenges
encountered
by
outline
future
directions
realm
By
exploring
carbon-based
biomaterials,
we
can
anticipate
that
contribution
garner
increased
contribute
development
next-generation
advanced
functional
thereby
offering
enhanced
tools
strategies
Chemical Society Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
review
provides
a
comprehensive
summary
of
the
dysregulation
redox
metabolism
in
cancer
cells
and
advantages
latest
advances
nanomaterial-assisted
metabolic
regulation
therapy.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 367 - 388
Опубликована: Янв. 1, 2024
Abstract:
Autoimmune
diseases
are
caused
by
the
body's
chronic
immune
responses
to
self-antigens
and
attacks
on
host's
own
cells,
tissues
organs.
The
dysfunction
of
innate
immunity
adaptive
leads
destruction
autoimmune
tolerance,
which
is
most
basic
factor
leading
pathogenesis.
optimal
strategy
for
modify
host
system
restore
tolerance.
ideal
effect
therapeutic
eliminate
autoantigen-specific
spontaneous
response
without
interfering
with
against
other
antigens.
Therapeutic
nanovaccines
that
produce
tolerance
conform
this
principle.
Nanomaterials
provide
a
platform
antigen
loading
modification
due
their
unique
physical
chemical
properties.
Nanovaccines
based
nanomaterial
technology
can
simultaneously
enable
antigens
adjuvants
be
absorbed
cells
induce
rapid
durable
immunity.
have
advantages
being
able
designed
loaded
better
protecting
from
premature
degradation.
also
ability
target
specific
or
through
optimized
design.
We
review
latest
research
progress
design
strategies
promote
development
more
effective
diseases.
Keywords:
nanovaccines,
diseases,
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 28, 2024
Abstract
Doxorubicin
(DOX),
a
potent
antineoplastic
agent,
is
commonly
associated
with
cardiotoxicity,
necessitating
the
development
of
strategies
to
reduce
its
adverse
effects
on
cardiac
function.
Previous
research
has
demonstrated
strong
correlation
between
DOX‐induced
cardiotoxicity
and
activation
oxidative
stress
pathways.
This
work
introduces
novel
antioxidant
therapeutic
approach,
utilizing
libraries
tannic
acid
N‐acetyl‐L‐cysteine‐protected
bimetallic
cluster
nanozymes.
Through
extensive
screening
for
antioxidative
enzyme‐like
activity,
an
optimal
nanozyme
(AuRu)
identified
that
possess
remarkable
characteristics,
mimicking
catalase‐like
enzymes.
Theoretical
calculations
reveal
surface
interactions
prepared
nanozymes
simulate
hydrogen
peroxide
decomposition
process,
showing
these
readily
undergo
OH⁻
adsorption
O₂
desorption.
To
enhance
targeting,
atrial
natriuretic
peptide
conjugated
AuRu
nanozyme.
These
cardiac‐targeted
nanozymes,
their
anchoring
capability,
effectively
cardiomyocyte
ferroptosis
PANoptosis
without
compromising
tumor
treatment
efficacy.
Thus,
approach
demonstrates
significant
reductions
in
chemotherapy‐induced
cell
death
improvements
function,
accompanied
by
exceptional
vivo
biocompatibility
stability.
study
presents
promising
avenue
preventing
offering
potential
clinical
benefits
cancer
patients.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(46)
Опубликована: Июнь 10, 2024
Abstract
Immunotherapy,
one
of
the
most
promising
antitumor
strategies,
is
used
to
treat
prostate
cancer
(PCa).
However,
owing
immunosuppressive
tumor
microenvironment
(TME),
therapeutic
effect
immune
response
greatly
weakened.
Therefore,
there
an
urgent
need
explore
new
methods
enhance
responses.
In
this
study,
a
single‐atom
nanozyme
platform
(Cu
SA‐DOX@COD)
that
can
trigger
pyroptosis
developed
activate
responses
via
gasdermin
E
(GSDME)‐dependent
pathway.
It
triggered
by
catalyzing
production
reactive
oxygen
species
(ROS)
and
depleting
reduced
glutathione
through
intrinsic
multi‐enzyme
simulated
activities
providing
source
for
cholesterol
(CHOL)
oxidation.
Meanwhile,
loaded
CHOL
oxidase
not
only
reduces
content
cells
increase
cell
membrane
permeability
inhibit
proliferation
invasion
but
also
oxidizes
increases
level
H
2
O
in
pyroptosis.
addition,
doxorubicin
activated
caspase‐3
cleave
GSDME
further
augment
Consequently,
Cu
SA‐DOX@COD
enhances
immunocompetence
reshapes
TME
triggering
caused
ROS
storm,
chemotherapy,
CHOL,
thereby
activating
systemic
immunity
PCa.
