Long noncoding RNA MALAT-1: A versatile regulator in cancer progression, metastasis, immunity, and therapeutic resistance

Non-coding RNA Research, Год журнала: 2024, Номер 9(2), С. 388 - 406

Опубликована: Фев. 1, 2024

Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins but have been linked to cancer development and metastasis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) influences crucial hallmarks through intricate molecular mechanisms, including proliferation, invasion, angiogenesis, apoptosis, the epithelial-mesenchymal transition (EMT). The current article highlights involvement of MALAT-1 in drug resistance, making it a potential target overcome chemotherapy refractoriness. It discusses impact on immunomodulatory molecules, such as major histocompatibility complex (MHC) PD-L1, leading immune evasion hindering anti-tumor responses. also plays significant role immunology by regulating diverse cell populations. In summary, is versatile regulator, influencing tumorigenesis, chemoresistance, immunotherapy Understanding its precise mechanisms developing targeted therapies, therapeutic strategies targeting show promise improving treatment outcomes. However, further research needed fully uncover biology translate these findings into clinical applications.

Язык: Английский

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Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 18, 2025

A new type of nonapoptotic, iron-dependent cell death induced by lipid peroxidation is known as ferroptosis. Numerous pathological processes, including inflammation and cancer, have been demonstrated to be influenced changes in the ferroptosis-regulating network. Long non-coding RNAs (LncRNAs) are a group functional RNA molecules that not translated into proteins, which can regulate gene expression various manners. An increasing number studies shown lncRNAs interfere with progression ferroptosis modulating ferroptosis-related genes directly or indirectly. Despite evidence implicating cancer inflammation, on their mechanisms therapeutic potential remain scarce. We investigate lncRNA-mediated regulation immunity, assessing feasibility challenges targets these conditions.

Язык: Английский

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Recent advances of nucleic acid-based cancer biomarkers and biosensors

Coordination Chemistry Reviews, Год журнала: 2023, Номер 497, С. 215456 - 215456

Опубликована: Сен. 26, 2023

Язык: Английский

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Role of long non-coding RNAs and natural products in prostate cancer: insights into key signaling pathways

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 17, 2025

Язык: Английский

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LncRNA LINC01128 promotes prostate cancer cell proliferation, metastasis, and epithelial-mesenchymal transition by modulating miR-27b-3p

Journal of Cancer Research and Clinical Oncology, Год журнала: 2025, Номер 151(3)

Опубликована: Март 4, 2025

Язык: Английский

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Updated review on analysis of long non-coding RNAs as emerging diagnostic and therapeutic targets in prostate cancers

Critical Reviews in Oncology/Hematology, Год журнала: 2024, Номер 196, С. 104275 - 104275

Опубликована: Фев. 1, 2024

Язык: Английский

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Brevilin A shows an anti-tumor role in prostate cancer via the lncRNA H19/miR-194/E2F3 signaling pathway

Aging, Год журнала: 2023, Номер 15(10), С. 4411 - 4428

Опубликована: Май 30, 2023

Brevilin A, a natural sesquiterpene lactone extracted from Centipeda minima, has been found with antitumor properties. Our study probed the functions of A in prostate cancer cells and mechanisms among lncRNA H19, miR-194, E2F3 on biological behaviors cells. CCK8, Transwell, TUNEL staining assays examined impact cell proliferation, migration, invasion, apoptosis, respectively. qRT-PCR western blot determined profiles. The influence profiles was measured. xenograft model nude mice taken to confirm H19 growth. Consequently, dampened suppressed expressions E2F3, enhanced miR-194 level. LncRNA were uplifted, whereas abated tissues. targeted positively modulate expression, boosted DU145 curbed apoptosis. In model, repressed tumor growth, fostered promotive effect PC growth vivo. To conclude, modulates via H19/miR-194/E2F3 axis. exerts an anti-tumor function cancer.

Язык: Английский

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LncRNA taurine upregulated gene 1 in liver disease

Clinica Chimica Acta, Год журнала: 2024, Номер 560, С. 119752 - 119752

Опубликована: Май 29, 2024

Язык: Английский

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Unveiling four axes ADAMTS9-AS2|MEG3/hsa-miR-150/PRKCA|MMP14 within prostate cancer through establishment of the ceRNA network

Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155604 - 155604

Опубликована: Сен. 25, 2024

Prostate cancer is among the most common cancers in males. Recent application of system biology methods has resulted identification key genes process carcinogenesis. In current study, we selected two datasets related to prostate (PCa) and performed bulk RNA-seq analysis by selecting samples with Gleason scores greater than 7 combining them. Subsequently, using several systems approaches, constructed ceRNA network ultimately identified axes PCa. Our analyses revealed importance ADAMTS9-AS2/miR-150/PRKCA, ADAMTS9-AS2/miR-150/MMP14, MEG3/miR-150/PRKCA MEG3/miR-150/MMP14 miR-150 being a central component. Remarkably, exhibited strong statistical significance survival analyses. Further, analyzing expression levels from TCGA datasets, associates significantly compared normal tissue confirming bioinformatic Therefore, these can be regarded as prognostic markers pathways are potential targets for therapeutic interventions.

Язык: Английский

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CRISPR-mediated silencing of non-coding RNAs: a novel putative treatment for prostate cancer

Pathology - Research and Practice, Год журнала: 2024, Номер 264, С. 155710 - 155710

Опубликована: Ноя. 6, 2024

Язык: Английский

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