Non-coding RNA Research,
Journal Year:
2024,
Volume and Issue:
9(2), P. 388 - 406
Published: Feb. 1, 2024
Long
noncoding
RNAs
(lncRNAs)
are
RNA
transcripts
longer
than
200
nucleotides
that
do
not
code
for
proteins
but
have
been
linked
to
cancer
development
and
metastasis.
Metastasis-associated
lung
adenocarcinoma
transcript
1
(MALAT-1)
influences
crucial
hallmarks
through
intricate
molecular
mechanisms,
including
proliferation,
invasion,
angiogenesis,
apoptosis,
the
epithelial-mesenchymal
transition
(EMT).
The
current
article
highlights
involvement
of
MALAT-1
in
drug
resistance,
making
it
a
potential
target
overcome
chemotherapy
refractoriness.
It
discusses
impact
on
immunomodulatory
molecules,
such
as
major
histocompatibility
complex
(MHC)
PD-L1,
leading
immune
evasion
hindering
anti-tumor
responses.
also
plays
significant
role
immunology
by
regulating
diverse
cell
populations.
In
summary,
is
versatile
regulator,
influencing
tumorigenesis,
chemoresistance,
immunotherapy
Understanding
its
precise
mechanisms
developing
targeted
therapies,
therapeutic
strategies
targeting
show
promise
improving
treatment
outcomes.
However,
further
research
needed
fully
uncover
biology
translate
these
findings
into
clinical
applications.
Cell Death Discovery,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Jan. 18, 2025
A
new
type
of
nonapoptotic,
iron-dependent
cell
death
induced
by
lipid
peroxidation
is
known
as
ferroptosis.
Numerous
pathological
processes,
including
inflammation
and
cancer,
have
been
demonstrated
to
be
influenced
changes
in
the
ferroptosis-regulating
network.
Long
non-coding
RNAs
(LncRNAs)
are
a
group
functional
RNA
molecules
that
not
translated
into
proteins,
which
can
regulate
gene
expression
various
manners.
An
increasing
number
studies
shown
lncRNAs
interfere
with
progression
ferroptosis
modulating
ferroptosis-related
genes
directly
or
indirectly.
Despite
evidence
implicating
cancer
inflammation,
on
their
mechanisms
therapeutic
potential
remain
scarce.
We
investigate
lncRNA-mediated
regulation
immunity,
assessing
feasibility
challenges
targets
these
conditions.
Aging,
Journal Year:
2023,
Volume and Issue:
15(10), P. 4411 - 4428
Published: May 30, 2023
Brevilin
A,
a
natural
sesquiterpene
lactone
extracted
from
Centipeda
minima,
has
been
found
with
antitumor
properties.
Our
study
probed
the
functions
of
A
in
prostate
cancer
cells
and
mechanisms
among
lncRNA
H19,
miR-194,
E2F3
on
biological
behaviors
cells.
CCK8,
Transwell,
TUNEL
staining
assays
examined
impact
cell
proliferation,
migration,
invasion,
apoptosis,
respectively.
qRT-PCR
western
blot
determined
profiles.
The
influence
profiles
was
measured.
xenograft
model
nude
mice
taken
to
confirm
H19
growth.
Consequently,
dampened
suppressed
expressions
E2F3,
enhanced
miR-194
level.
LncRNA
were
uplifted,
whereas
abated
tissues.
targeted
positively
modulate
expression,
boosted
DU145
curbed
apoptosis.
In
model,
repressed
tumor
growth,
fostered
promotive
effect
PC
growth
vivo.
To
conclude,
modulates
via
H19/miR-194/E2F3
axis.
exerts
an
anti-tumor
function
cancer.
Pathology - Research and Practice,
Journal Year:
2024,
Volume and Issue:
263, P. 155604 - 155604
Published: Sept. 25, 2024
Prostate
cancer
is
among
the
most
common
cancers
in
males.
Recent
application
of
system
biology
methods
has
resulted
identification
key
genes
process
carcinogenesis.
In
current
study,
we
selected
two
datasets
related
to
prostate
(PCa)
and
performed
bulk
RNA-seq
analysis
by
selecting
samples
with
Gleason
scores
greater
than
7
combining
them.
Subsequently,
using
several
systems
approaches,
constructed
ceRNA
network
ultimately
identified
axes
PCa.
Our
analyses
revealed
importance
ADAMTS9-AS2/miR-150/PRKCA,
ADAMTS9-AS2/miR-150/MMP14,
MEG3/miR-150/PRKCA
MEG3/miR-150/MMP14
miR-150
being
a
central
component.
Remarkably,
exhibited
strong
statistical
significance
survival
analyses.
Further,
analyzing
expression
levels
from
TCGA
datasets,
associates
significantly
compared
normal
tissue
confirming
bioinformatic
Therefore,
these
can
be
regarded
as
prognostic
markers
pathways
are
potential
targets
for
therapeutic
interventions.
