Journal of Mitochondria Plastids and Endosymbiosis,
Год журнала:
2024,
Номер
2(1)
Опубликована: Янв. 31, 2024
Redox
medicine
improvement
could
come
from
integrating
insights
both
the
mitochondria
and
redox
fields.
One-step
further
is
finding
new
clues
with
a
comprehensive
discussion
of
two
fields,
their
relationship,
including
through
reactive
species
interactome
(RSI).
Here,
review
provides
platform
for
future
studies
focusing
on
RSI.
Mitochondria
are
discussed
at
length
focus
mitochondrial
permeability
transition
pore,
regulation
cell
death
types,
protein
quality
control
system,
calcium
homoeostasis,
ionome,
metabolome,
carriers,
organelle
interaction.
Then,
RSI
its
relationship
mitochondria.
Finally,
mitochondria-RSI
axis
proposed
as
brand-new
perspective,
involvement
circadian
clock
bacterial
microbiota,
first
stone
concept
MitoRedox
Medicine.
Cancer Cell International,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 9, 2025
Hepatocellular
carcinoma
(HCC)
is
the
main
phenotype
of
liver
cancer
with
a
poor
prognosis.
Copper
vital
in
function,
and
HCC
cells
rely
on
it
for
growth
metastasis,
leading
to
cuproplasia.
Excessive
copper
can
induce
cell
death,
termed
cuproptosis.
Tumor
microenvironment
(TME)
pivotal
HCC,
especially
immunotherapy,
closely
related
TME
pathogenesis.
However,
how
these
two
mechanisms
contribute
intriguing.
We
conducted
latest
progress
literature
cuproplasia
cuproptosis
summarized
their
specific
roles
treatment
strategies.
The
relationship
role
have
been
deeply
summarized.
Cuproplasia
fosters
formation,
angiogenesis,
whereas
may
alleviate
mitochondrial
dysfunction
hypoxic
conditions
TME.
Inhibiting
enhancing
are
essential
achieving
therapeutic
efficacy
HCC.
An
in-depth
analysis
within
unveils
opposing
nature
impact
regulation.
Grasping
equilibrium
between
factors
crucial
deeper
understanding
shed
light
novel
directions
treating
Sustainable Food Proteins,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 12, 2024
Abstract
Bioactive
peptides
that
are
derived
through
the
enzymatic
hydrolysis
of
proteins
have
garnered
significant
attention
for
their
diverse
health‐promoting
properties.
This
article
delves
into
technology
behind
plant‐derived
bioactive
peptide
production
by
emphasizing
principles
enzyme
hydrolysis.
Furthermore,
review
highlights
refinement
techniques,
employing
membrane
ultrafiltration
and
various
forms
column
chromatography
to
isolate
purify
these
effectively.
The
properties
protein
hydrolysates
encompass
a
range
health
benefits,
including
antihypertensive,
antioxidant,
anti‐diabetic,
anti‐obesity,
neuroprotective
effects.
Additionally,
demonstrate
promise
in
inhibiting
cancer
cell
growth,
supporting
bone
health,
modulating
immune
responses.
These
hold
immense
potential
revolutionizing
approaches
conditions.
Continued
research
this
field
promises
further
insights
breakthroughs,
propelling
forefront
nutrition
healthcare
innovation.
convergence
advanced
multifaceted
bioactivity
present
an
exciting
avenue
improving
human
well‐being
addressing
wide
array
challenges.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(24), С. 17578 - 17578
Опубликована: Дек. 17, 2023
Copper
(Cu)
is
an
essential
micronutrient
for
the
correct
development
of
eukaryotic
organisms.
This
metal
plays
a
key
role
in
many
cellular
and
physiological
activities,
including
enzymatic
activity,
oxygen
transport,
cell
signaling.
Although
redox
activity
Cu
crucial
reactions,
this
property
also
makes
it
potentially
toxic
when
found
at
high
levels.
Due
to
dual
action
Cu,
highly
regulated
mechanisms
are
necessary
prevent
both
deficiency
accumulation
since
its
dyshomeostasis
may
favor
multiple
diseases,
such
as
Menkes'
Wilson's
neurodegenerative
diabetes
mellitus,
cancer.
As
relationship
between
cancer
has
been
most
studied,
we
analyze
how
can
affect
three
fundamental
processes
tumor
progression:
proliferation,
angiogenesis,
metastasis.
Gynecological
diseases
characterized
by
prevalence,
morbidity,
mortality,
depending
on
case,
mainly
include
benign
malignant
tumors.
The
that
promote
their
progression
affected
occur
be
similar.
We
crosstalk
deregulation
gynecological
focusing
therapeutic
strategies
derived
from
metal.
Journal of Mitochondria Plastids and Endosymbiosis,
Год журнала:
2024,
Номер
2(1)
Опубликована: Янв. 31, 2024
Redox
medicine
improvement
could
come
from
integrating
insights
both
the
mitochondria
and
redox
fields.
One-step
further
is
finding
new
clues
with
a
comprehensive
discussion
of
two
fields,
their
relationship,
including
through
reactive
species
interactome
(RSI).
Here,
review
provides
platform
for
future
studies
focusing
on
RSI.
Mitochondria
are
discussed
at
length
focus
mitochondrial
permeability
transition
pore,
regulation
cell
death
types,
protein
quality
control
system,
calcium
homoeostasis,
ionome,
metabolome,
carriers,
organelle
interaction.
Then,
RSI
its
relationship
mitochondria.
Finally,
mitochondria-RSI
axis
proposed
as
brand-new
perspective,
involvement
circadian
clock
bacterial
microbiota,
first
stone
concept
MitoRedox
Medicine.
