Fibrinogen Oxidation and Thrombosis: Shaping Structure and Function

Antioxidants, Год журнала: 2025, Номер 14(4), С. 390 - 390

Опубликована: Март 26, 2025

Fibrinogen, a pivotal plasma glycoprotein, plays an essential role in hemostasis by serving as the precursor to fibrin, which forms structural framework of blood clots. Beyond coagulation, fibrinogen influences immune responses, inflammation, and tissue repair. Oxidative stress, characterized imbalance between reactive oxygen species (ROS) antioxidants, induces oxidation, significantly altering its structure function. This narrative review synthesizes findings from vitro, ex vivo, clinical studies, emphasizing impact oxidation on clot formation, architecture, degradation. modifications result denser fibrin clots with thinner fibers, reduced permeability, heightened resistance fibrinolysis. These changes exacerbate prothrombotic conditions cardiovascular diseases, diabetes, chronic inflammatory disorders cancer. In contrast, “low-dose” oxidative stress may elicit protective adaptations fibrinogen, preserving The also highlights discrepancies experimental due variability protocols patient conditions. Understanding interplay function could unveil therapeutic strategies targeting stress. Antioxidant therapies or selective inhibitors detrimental hold potential for mitigating thrombotic risks. However, further research is pinpoint specific sites, clarify their roles dynamics, bridge gap basic practice.

Язык: Английский

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Clonorchis sinensis infection contributes to hepatocellular carcinoma progression via enhancing angiogenesis

PLoS neglected tropical diseases, Год журнала: 2024, Номер 18(11), С. e0012638 - e0012638

Опубликована: Ноя. 11, 2024

Clonorchis sinensis (C. sinensis) infection plays an important role in the progression of hepatocarcinogenesis. However, its specific HCC remains unclear. This study aimed to investigate whether C. contributes angiogenesis HCC.

Язык: Английский

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Establishment and validation of a prediction model for gastric cancer with perineural invasion based on preoperative inflammatory markers

Translational Cancer Research, Год журнала: 2024, Номер 13(10), С. 5381 - 5394

Опубликована: Окт. 1, 2024

Gastric cancer (GC) is a prevalent malignant tumor of the digestive system, characterized by poor prognosis and high recurrence rate. Perineural invasion (PNI), neoplastic infiltration nerves, significant predictor survival outcome in GC. Accurate preoperative identification PNI could facilitate patient stratification optimal treatment. We therefore established validated risk assessment model for GC patients with PNI.

Язык: Английский

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Enhancing outcome prediction of concurrent chemoradiation treatment in patients with locally advanced cervical cancer through plasma extracellular vesicle proteomics

Heliyon, Год журнала: 2024, Номер 10(16), С. e36374 - e36374

Опубликована: Авг. 1, 2024

Most patients with locally advanced cervical cancer (LACC) are primarily treated using concurrent chemoradiation (CCRT); however, LACC lacks reliable predictive biomarkers. Extracellular vesicles (EVs) could define the dynamic biological response to CCRT. However, relationship between EVs and therapeutic is unestablished. Thus, we aimed determine of plasma pre- post-CCRT in 62 LACC. For proteomic analyses, were isolated ultracentrifugation (UC) size exclusion chromatography or UC alone. We found that particle concentration was significantly increased post-treatment non-responders. After CCRT, there a decrease proteins related serine protease fibrinogen, which contribute tumor microenvironment alteration. This reduction also extended involved innate immune viral responses, correlating reduced burden. Sparse partial least squares discriminant analysis revealed 8, 13, 19 at diagnosis, one month, three months, respectively, influencing CCRT response. Among these, FIBG, TFR1, HBA, FINC prognostic markers according The Cancer Genome Atlas tissue gene expression database. Our model demonstrated excellent specificity negative value, underscoring model's reliability determining responsiveness highlighting potential clinical applicability improving outcomes LACC.Graphical abstract

Язык: Английский

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Label-based comparative proteomics of oral mucosal tissue to understand progression of precancerous lesions to oral squamous cell carcinoma

Biochemistry and Biophysics Reports, Год журнала: 2024, Номер 40, С. 101842 - 101842

Опубликована: Окт. 13, 2024

Язык: Английский

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