Fibrinogen Oxidation and Thrombosis: Shaping Structure and Function

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 390 - 390

Published: March 26, 2025

Fibrinogen, a pivotal plasma glycoprotein, plays an essential role in hemostasis by serving as the precursor to fibrin, which forms structural framework of blood clots. Beyond coagulation, fibrinogen influences immune responses, inflammation, and tissue repair. Oxidative stress, characterized imbalance between reactive oxygen species (ROS) antioxidants, induces oxidation, significantly altering its structure function. This narrative review synthesizes findings from vitro, ex vivo, clinical studies, emphasizing impact oxidation on clot formation, architecture, degradation. modifications result denser fibrin clots with thinner fibers, reduced permeability, heightened resistance fibrinolysis. These changes exacerbate prothrombotic conditions cardiovascular diseases, diabetes, chronic inflammatory disorders cancer. In contrast, “low-dose” oxidative stress may elicit protective adaptations fibrinogen, preserving The also highlights discrepancies experimental due variability protocols patient conditions. Understanding interplay function could unveil therapeutic strategies targeting stress. Antioxidant therapies or selective inhibitors detrimental hold potential for mitigating thrombotic risks. However, further research is pinpoint specific sites, clarify their roles dynamics, bridge gap basic practice.

Language: Английский

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Clonorchis sinensis infection contributes to hepatocellular carcinoma progression via enhancing angiogenesis

PLoS neglected tropical diseases, Journal Year: 2024, Volume and Issue: 18(11), P. e0012638 - e0012638

Published: Nov. 11, 2024

Clonorchis sinensis (C. sinensis) infection plays an important role in the progression of hepatocarcinogenesis. However, its specific HCC remains unclear. This study aimed to investigate whether C. contributes angiogenesis HCC.

Language: Английский

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Establishment and validation of a prediction model for gastric cancer with perineural invasion based on preoperative inflammatory markers

Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(10), P. 5381 - 5394

Published: Oct. 1, 2024

Gastric cancer (GC) is a prevalent malignant tumor of the digestive system, characterized by poor prognosis and high recurrence rate. Perineural invasion (PNI), neoplastic infiltration nerves, significant predictor survival outcome in GC. Accurate preoperative identification PNI could facilitate patient stratification optimal treatment. We therefore established validated risk assessment model for GC patients with PNI.

Language: Английский

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Enhancing outcome prediction of concurrent chemoradiation treatment in patients with locally advanced cervical cancer through plasma extracellular vesicle proteomics

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36374 - e36374

Published: Aug. 1, 2024

Most patients with locally advanced cervical cancer (LACC) are primarily treated using concurrent chemoradiation (CCRT); however, LACC lacks reliable predictive biomarkers. Extracellular vesicles (EVs) could define the dynamic biological response to CCRT. However, relationship between EVs and therapeutic is unestablished. Thus, we aimed determine of plasma pre- post-CCRT in 62 LACC. For proteomic analyses, were isolated ultracentrifugation (UC) size exclusion chromatography or UC alone. We found that particle concentration was significantly increased post-treatment non-responders. After CCRT, there a decrease proteins related serine protease fibrinogen, which contribute tumor microenvironment alteration. This reduction also extended involved innate immune viral responses, correlating reduced burden. Sparse partial least squares discriminant analysis revealed 8, 13, 19 at diagnosis, one month, three months, respectively, influencing CCRT response. Among these, FIBG, TFR1, HBA, FINC prognostic markers according The Cancer Genome Atlas tissue gene expression database. Our model demonstrated excellent specificity negative value, underscoring model's reliability determining responsiveness highlighting potential clinical applicability improving outcomes LACC.Graphical abstract

Language: Английский

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Label-based comparative proteomics of oral mucosal tissue to understand progression of precancerous lesions to oral squamous cell carcinoma

Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101842 - 101842

Published: Oct. 13, 2024

Language: Английский

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