Journal of Functional Foods,
Год журнала:
2019,
Номер
64, С. 103630 - 103630
Опубликована: Ноя. 7, 2019
Ginsenosides,
the
main
active
ingredients
in
Panax
ginseng,
have
been
used
as
an
adjuvant
to
treat
diabetes
mellitus
for
many
years.
Experimental
and
clinical
data
emerge
support
antidiabetic
efficacy
ginsenosides
ascribe
their
antioxidant,
anti-inflammatory,
anti-hyperglycemic
activities.
Existing
studies
on
mechanisms
of
treatment
mostly
focused
single
ginenosides
hypoglycemic
effect
cells
animal
models.
However,
a
systematical
summary
how
regulate
diabetic-related
transcriptional
factors
signaling
pathways
is
scarce.
Besides,
pharmaceutical
preparations
also
limited.
Therefore,
this
review
dominantly
discusses
roles
intervention
blood
glucose
elevation,
well
current
trials
pharmacology.
The
elucidation
molecular
at
diabetic
status
could
facilitate
application
herbal
medicines.
Biology,
Год журнала:
2020,
Номер
9(9), С. 252 - 252
Опубликована: Авг. 28, 2020
Natural
products,
including
organisms
(plants,
animals,
or
microorganisms)
have
been
shown
to
possess
health
benefits
for
animals
and
humans.
According
the
estimation
of
World
Health
Organization,
in
developing
countries,
80%
population
has
still
depended
on
traditional
medicines
folk
which
are
mostly
prepared
from
plant
prevention
treatment
diseases.
Traditional
medicine
extracts
proved
be
more
affordable,
clinically
effective
relatively
less
adverse
effects
than
modern
drugs.
Literature
shows
that
attention
application
phytochemical
constituents
medicinal
plants
pharmaceutical
industry
increased
significantly.
Plant-derived
secondary
metabolites
small
molecules
macromolecules
biosynthesized
steroids,
alkaloids,
phenolic,
lignans,
carbohydrates
glycosides,
etc.
a
diversity
biological
properties
beneficial
humans,
such
as
their
antiallergic,
anticancer,
antimicrobial,
anti-inflammatory,
antidiabetic
antioxidant
activities
Diabetes
mellitus
is
chronic
disease
result
metabolic
disorders
pancreas
β-cells
hyperglycemia.
Hyperglycemia
can
caused
by
deficiency
insulin
production
pancreatic
(Type
1
diabetes
mellitus)
insufficiency
face
resistance
2
mellitus).
The
current
medications
focus
controlling
lowering
blood
glucose
levels
vessel
normal
level.
However,
most
drugs
many
side
causing
some
serious
medical
problems
during
period
treating.
Therefore,
used
long
time
play
an
important
role
alternative
medicines.
Moreover,
past
few
years,
new
bioactive
isolated
showed
activity
with
efficacy
oral
hypoglycemic
agents
clinical
therapy.
performed
good
practice
showing
bright
future
therapy
mellitus.
Organization
pointed
out
this
its
complications
not
only
major
challenge
future,
but
essential
if
all
attained.
paper
briefly
reviews
active
compounds,
pharmacological
popular
widely
diabetic
treatment.
Morphological
data
V-herb
database
each
species
was
also
included
identification.
Pharmacological Research,
Год журнала:
2020,
Номер
161, С. 105263 - 105263
Опубликована: Окт. 27, 2020
Panax
ginseng
(Meyer)
and
notoginseng
(Burkill),
belonging
to
the
family
Araliaceae,
are
used
worldwide
as
medicinal
functional
herbs.
Numerous
publications
over
past
decades
have
revealed
that
both
P.
contain
important
bioactive
ingredients
such
ginsenosides
exert
multiple
pharmacological
effects
on
nervous
system
immune
diseases.
However,
based
traditional
Chinese
medicine
(TCM)
theory,
their
applications
clearly
differ
reinforces
vital
energy
promotes
blood
circulation.
In
this
article,
we
review
similarities
differences
between
in
terms
of
chemical
composition
effects.
Their
comparisons
indicate
contains
more
polysaccharides
amino
acids,
while
has
saponins,
volatile
oil,
polyacetylenes.
Regarding
effects,
exhibits
better
protective
cardiovascular
disease,
nerve
cancer,
diabetes
mellitus,
whereas
displays
a
superior
effect
cerebrovascular
disease.
The
evidence
presented
facilitates
further
research
clinical
these
two
herbs,
exploration
relationship
components
disease
efficacy
may
be
critical
next
step.
Acta Pharmaceutica Sinica B,
Год журнала:
2021,
Номер
11(7), С. 1813 - 1834
Опубликована: Янв. 2, 2021
Ginsenosides
are
a
series
of
glycosylated
triterpenoids
which
belong
to
protopanaxadiol
(PPD)-,
protopanaxatriol
(PPT)-,
ocotillol
(OCT)-
and
oleanane
(OA)-type
saponins
known
as
active
compounds
Evidence-based Complementary and Alternative Medicine,
Год журнала:
2020,
Номер
2020(1)
Опубликована: Янв. 1, 2020
In
recent
years,
natural
products,
which
originate
from
plants,
animals,
and
fungi,
together
with
their
bioactive
compounds
have
been
intensively
explored
studied
for
therapeutic
potentials
various
diseases
such
as
cardiovascular,
diabetes,
hypertension,
reproductive,
cancer,
neurodegenerative
diseases.
Neurodegenerative
diseases,
including
Alzheimer’s
disease,
Huntington’s
Parkinson’s
amyotrophic
lateral
sclerosis
are
characterized
by
the
progressive
dysfunction
loss
of
neuronal
structure
function
that
resulted
in
cell
death.
Since
multifactorial
pathological
mechanisms
associated
neurodegeneration,
targeting
multiple
actions
neuroprotection
approach,
involves
preventing
death
restoring
to
damaged
neurons,
could
be
promising
strategies
prevention
Natural
products
emerged
potential
neuroprotective
agents
treatment
This
review
focused
on
exert
a
effect
pathologies
Molecules,
Год журнала:
2019,
Номер
24(24), С. 4501 - 4501
Опубликована: Дек. 9, 2019
Ginseng
is
one
of
the
most
valuable
and
commonly
used
Chinese
medicines
not
only
in
ancient
China
but
also
worldwide.
Ginsenosides,
known
as
saponins
or
triterpenoids,
are
thought
to
be
responsible
for
beneficial
effects
ginseng.
In
this
review,
we
summarize
recent
publications
on
anti-diabetic
studies
ginseng
extracts
ginsenosides
cells,
animals,
humans.
It
seems
that
effect
positive
type
2
diabetic
patients
has
no
significant
impact
prediabetes
healthy
adults.
Regulation
insulin
secretion,
glucose
uptake,
anti-oxidative
stress,
anti-inflammatory
pathways
may
mechanisms
involved
with
ginseng’s
effects.
Taken
together,
summary
provides
evidence
anti-diabetes
well
underlying
their
diabetes.
Frontiers in Pharmacology,
Год журнала:
2018,
Номер
9
Опубликована: Сен. 21, 2018
Cardiovascular
disease
is
the
main
cause
of
death
worldwide,
but
its
pathogenesis
not
yet
clear.
Hydrogen
sulphide
(H2S)
considered
to
be
third
most
important
endogenous
gasotransmitter
in
organism
after
carbon
monoxide
(CO)
and
nitric
oxide
(NO).
It
can
synthesized
mammalian
tissues
freely
cross
cell
membrane
exert
many
biological
effects
various
systems
including
cardiovascular
system.
More
more
recent
studies
have
supported
protective
H2S
exogenous
H2S-releasing
compounds
(such
as
NaHS,
Na2S,
GYY4137
etc)
diseases,
such
cardiac
hypertrophy,
heart
failure,
ischemia/reperfusion
injury,
atherosclerosis.
Here,
we
provided
an
up-to-date
overview
mechanistic
actions
well
therapeutic
potential
classes
donors
treating
diseases.
Molecules,
Год журнала:
2021,
Номер
26(14), С. 4333 - 4333
Опубликована: Июль 17, 2021
Recently,
significant
advances
in
modern
medicine
and
therapeutic
agents
have
been
achieved.
However,
the
search
for
effective
antidiabetic
drugs
is
continuous
challenging.
Over
past
decades,
there
has
an
increasing
body
of
literature
related
to
effects
secondary
metabolites
from
botanical
sources
on
diabetes.
Plants-derived
including
alkaloids,
phenols,
anthocyanins,
flavonoids,
stilbenoids,
saponins,
tannins,
polysaccharides,
coumarins,
terpenes
can
target
cellular
molecular
mechanisms
involved
carbohydrate
metabolism.
In
addition,
they
grant
protection
pancreatic
beta
cells
damage,
repairing
abnormal
insulin
signaling,
minimizing
oxidative
stress
inflammation,
activating
AMP-activated
protein
kinase
(AMPK),
inhibiting
digestion
absorption.
Studies
highlighted
many
bioactive
naturally
occurring
plants’
as
candidates
against
This
review
summarizes
current
knowledge
compiled
latest
studies
published
during
decade
mechanism-based
action
plants-derived
that
various
metabolic
pathways
humans
It
worth
mentioning
data
this
will
provide
a
guide
researchers
field,
develop
into
environment-friendly
effective,
yet
safe
antidiabetics.
Antioxidants,
Год журнала:
2021,
Номер
10(1), С. 81 - 81
Опубликована: Янв. 9, 2021
Type
2
diabetes
mellitus
(T2DM)
is
one
of
the
largest
public
health
problems
worldwide.
Insulin
resistance-related
metabolic
dysfunction
and
chronic
hyperglycemia
result
in
devastating
complications
poor
prognosis.
Even
though
there
are
many
conventional
drugs
such
as
metformin
(MET),
Thiazolidinediones
(TZDs),
sulfonylureas
(SUF),
dipeptidyl
peptidase
4
(DPP-4)
inhibitors,
glucagon
like
peptide
1
(GLP-1)
sodium-glucose
cotransporter-2
(SGLT-2)
side
effects
still
exist.
As
numerous
plant
extracts
with
antidiabetic
have
been
widely
reported,
they
potential
to
be
a
great
therapeutic
agent
for
type
less
effects.
In
this
study,
sixty-five
recent
studies
regarding
that
alleviate
were
reviewed.
Plant
regulated
blood
glucose
through
phosphoinositide
3-kinase
(PI3K)/protein
kinase
B
(Akt)
pathway.
The
anti-inflammatory
antioxidant
properties
suppressed
c-Jun
amino
terminal
(JNK)
nuclear
factor
kappa
(NF-κB)
pathways,
which
induce
insulin
resistance.
Lipogenesis
fatty
acid
oxidation,
also
associated
resistance,
by
AMP-activated
protein
(AMPK)
activation.
This
review
focuses
on
discovering
exploring
its
mechanisms.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Окт. 25, 2022
Type
2
diabetes
mellitus
(T2DM)
occurs
that
cannot
effectively
use
the
insulin.
Insulin
Resistance
(IR)
is
a
significant
characteristic
of
T2DM
which
also
an
essential
treatment
target
in
blood
glucose
regulation
to
prevent
and
its
complications.
Bile
acids
(BAs)
are
one
group
bioactive
metabolites
synthesized
from
cholesterol
liver.
BAs
play
important
role
mutualistic
symbiosis
between
host
gut
microbiota.
It
shown
associated
with
altered
bile
acid
metabolism
can
be
regulated
by
Simultaneously,
reshape
microbiota
improve
IR
bidirectional
communications
gut-liver
axis.
This
article
reviewed
findings
on
interaction
improving
T2DM,
focused
debinding
function
through
FXR/TGR5.
Meanwhile,
their
derivatives
effective
for
other
treatments
based
were
summarized.
review
highlighted
critical
may
serve
as
therapeutic
targets
providing
reference
discovering
screening
novel
drugs.
