Discover Food, Год журнала: 2025, Номер 5(1)
Опубликована: Апрель 1, 2025
Язык: Английский
Biology, Год журнала: 2020, Номер 9(9), С. 252 - 252
Опубликована: Авг. 28, 2020
Natural products, including organisms (plants, animals, or microorganisms) have been shown to possess health benefits for animals and humans. According the estimation of World Health Organization, in developing countries, 80% population has still depended on traditional medicines folk which are mostly prepared from plant prevention treatment diseases. Traditional medicine extracts proved be more affordable, clinically effective relatively less adverse effects than modern drugs. Literature shows that attention application phytochemical constituents medicinal plants pharmaceutical industry increased significantly. Plant-derived secondary metabolites small molecules macromolecules biosynthesized steroids, alkaloids, phenolic, lignans, carbohydrates glycosides, etc. a diversity biological properties beneficial humans, such as their antiallergic, anticancer, antimicrobial, anti-inflammatory, antidiabetic antioxidant activities Diabetes mellitus is chronic disease result metabolic disorders pancreas β-cells hyperglycemia. Hyperglycemia can caused by deficiency insulin production pancreatic (Type 1 diabetes mellitus) insufficiency face resistance 2 mellitus). The current medications focus controlling lowering blood glucose levels vessel normal level. However, most drugs many side causing some serious medical problems during period treating. Therefore, used long time play an important role alternative medicines. Moreover, past few years, new bioactive isolated showed activity with efficacy oral hypoglycemic agents clinical therapy. performed good practice showing bright future therapy mellitus. Organization pointed out this its complications not only major challenge future, but essential if all attained. paper briefly reviews active compounds, pharmacological popular widely diabetic treatment. Morphological data V-herb database each species was also included identification.
Язык: Английский
Процитировано
363
Experimental Gerontology, Год журнала: 2022, Номер 161, С. 111731 - 111731
Опубликована: Фев. 7, 2022
Язык: Английский
Процитировано
77
Plants, Год журнала: 2024, Номер 13(4), С. 523 - 523
Опубликована: Фев. 15, 2024
Inflammation is the immune system’s first biological response to infection, injury, or irritation. Evidence suggests that anti-inflammatory effect mediated by regulation of various inflammatory cytokines, such as nitric oxide, interleukins, tumor necrosis factor alpha-α, interferon gamma-γ, well non-cytokine mediator, prostaglandin E2. Currently, mechanism action and clinical usefulness phytochemicals known; their on activity free radicals, oxidative stress. The latter are great relevance in development diseases, evidence collected demonstrates beneficial effects maintaining health. Epidemiological indicates regular consumption fruits vegetables related a low risk developing cancer other chronic diseases.
Язык: Английский
Процитировано
24
Molecules, Год журнала: 2021, Номер 26(14), С. 4333 - 4333
Опубликована: Июль 17, 2021
Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous challenging. Over past decades, there has an increasing body of literature related to effects secondary metabolites from botanical sources on diabetes. Plants-derived including alkaloids, phenols, anthocyanins, flavonoids, stilbenoids, saponins, tannins, polysaccharides, coumarins, terpenes can target cellular molecular mechanisms involved carbohydrate metabolism. In addition, they grant protection pancreatic beta cells damage, repairing abnormal insulin signaling, minimizing oxidative stress inflammation, activating AMP-activated protein kinase (AMPK), inhibiting digestion absorption. Studies highlighted many bioactive naturally occurring plants’ as candidates against This review summarizes current knowledge compiled latest studies published during decade mechanism-based action plants-derived that various metabolic pathways humans It worth mentioning data this will provide a guide researchers field, develop into environment-friendly effective, yet safe antidiabetics.
Язык: Английский
Процитировано
69
Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12
Опубликована: Апрель 25, 2022
Panax ginseng, as the king of Chinese herb, has significant therapeutic effects on obesity, type 2 diabetes mellitus, fatty liver disease, colitis, diarrhea, and many other diseases. This review systematically summarized recent findings, which show that ginseng plays its role by regulating gut microbiota diversity, could also regulate transformation ginsenosides. We conclude characteristics in microbiota, potential targets to prevent treat metabolic diseases, neurological cancer, Ginseng treatment can increase some probiotics such Bifidobacterium , Bacteroides Verrucomicrobia Akkermansia reduce pathogenic bacteria Deferribacters Lactobacillus Helicobacter against various Meanwhile, Eubacterium were found be key for ginsenoside vivo . Overall, microbiome further affect synthesis secondary metabolites, well promote ginsenosides improving absorptivity provide better insight into interaction with multiple disorders transformation.
Язык: Английский
Процитировано
56
Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(7), С. 3472 - 3483
Опубликована: Фев. 8, 2023
Ulcerative colitis (UC) is a recurrent inflammatory disease without specific cure or treatment for improvement. Here, we investigated the potential therapeutic effect and mechanism of ginsenoside Rg3 (Gin Rg3) on UC. We constructed an in vitro cellular model dextran sulfate sodium (DSS)-induced UC mouse model. also used Gin Rg3, MCC950 (NLRP3 inhibitor), MSU activator), fecal transplantation (FMT) to intervene The results showed that inhibited NLRP3 inflammasome activation, pyroptosis, apoptosis vivo. DSS-induced changes abundance gut microbiota at phylum genus level were partially restored by Rg3. Furthermore, gin affected intestinal metabolism mice inhibiting activation inflammasome. treated with was sufficient alleviate In summary, alleviated regulating homeostasis.
Язык: Английский
Процитировано
24
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Март 8, 2024
Cancer stands as a prominent global cause of death. One the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse MDR. Discovering novel potential modulators to reduce MDR by has become popular research area across globe. Numerous mainly focus on natural products including flavonoids, alkaloids, terpenoids, polyphenols and coumarins for their modulatory activity. regulating signaling pathways or relevant expressed protein gene. Here we perform deep review previous achievements, advances in development treatment This aims provide some insights study products.
Язык: Английский
Процитировано
11
Heliyon, Год журнала: 2024, Номер 10(11), С. e32239 - e32239
Опубликована: Май 31, 2024
This study proposes a novel colorimetric method based on the ultraviolet/visible spectrophotometry-colorimetric (UV/Vis-CM) for detecting and quantifying total triterpenoids in traditional Chinese medicine. By incorporating colourants 2-hydroxy-5-methylbenzaldehyde concentrated sulfuric acid, triterpenoid compounds colour development became more sensitive, detection accuracy was significantly improved. acid were incorporated 1:3 volume ratio at room temperature to react with triterpenes 25 min, an ice bath 5 then detected optimal absorption wavelength. The reliability of this verified by comparison high-performance liquid chromatography four other methods. Additionally, approach has advantages not requiring heating during operation, high sensitivity, short usage time, low solvent usage, equipment costs. only offers reliable medicine but also rapid tool on-site testing large-scale screening, laying foundation modernisation research, quality control, drug development.
Язык: Английский
Процитировано
11
Journal of Ginseng Research, Год журнала: 2021, Номер 45(6), С. 654 - 664
Опубликована: Март 14, 2021
Ginsenoside Rg3, isolated from Panax ginseng, has anti-inflammatory and anti-tumor activities. It is known to reduce inflammation in acute lung injury mice, the expression of inflammatory cytokines COX-2 human asthmatic airway epithelium. In this study, we attempted determine whether ginsenoside Rg3 inhibits inflammation, oxidative stress, hyperresponsiveness (AHR) lungs mice. We also investigated its effects on stress response tracheal epithelial cells.Asthma symptoms were induced female BALB/c mice sensitized with ovalbumin (OVA). Mice divided into five groups: normal controls, OVA-induced treated or prednisolone by intraperitoneal injection. Inflammatory BEAS-2B cells (human cells) investigate responses.Ginsenoside treatment significantly reduced eosinophil infiltration, responses, AHR Th2 cytokine chemokine levels bronchoalveolar lavage fluids lung. eotaxin pro-inflammatory expressions, monocyte adherence was as a result decreased ICAM-1 expression. Furthermore, reactive oxygen species cells.Ginsenoside potential immunomodulator that can ameliorate pathological features asthma decreasing inflammation.
Язык: Английский
Процитировано
50
Phytomedicine, Год журнала: 2021, Номер 83, С. 153487 - 153487
Опубликована: Янв. 30, 2021
Язык: Английский
Процитировано
45